WO2000018501A1 - Procede pour former des gouttes - Google Patents

Procede pour former des gouttes Download PDF

Info

Publication number
WO2000018501A1
WO2000018501A1 PCT/EP1999/007240 EP9907240W WO0018501A1 WO 2000018501 A1 WO2000018501 A1 WO 2000018501A1 EP 9907240 W EP9907240 W EP 9907240W WO 0018501 A1 WO0018501 A1 WO 0018501A1
Authority
WO
WIPO (PCT)
Prior art keywords
guide
substance
outlet
drops
drive element
Prior art date
Application number
PCT/EP1999/007240
Other languages
German (de)
English (en)
Inventor
Martin Reuter
Original Assignee
Marco Systemanalyse Und Entwicklung Gmbh
Medsym Ärzteservice- Informations- Und Veranstaltungsdienst Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marco Systemanalyse Und Entwicklung Gmbh, Medsym Ärzteservice- Informations- Und Veranstaltungsdienst Gmbh filed Critical Marco Systemanalyse Und Entwicklung Gmbh
Priority to AU61985/99A priority Critical patent/AU6198599A/en
Publication of WO2000018501A1 publication Critical patent/WO2000018501A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/18—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using a vibrating apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J4/00—Feed or outlet devices; Feed or outlet control devices
    • B01J4/02—Feed or outlet devices; Feed or outlet control devices for feeding measured, i.e. prescribed quantities of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0657—Pipetting powder

Definitions

  • the present invention relates to a method or a device for droplet formation, in particular of substances which are difficult to atomize.
  • the pressing of powdery substances is a production process that includes plays an important role in the pharmaceutical industry as well as in the ceramic industry.
  • the pressed product is usually a finished tablet, while in the field of ceramics, pressing the raw materials is a preliminary step of the subsequent sintering process.
  • Various solid substances should be well mixed in a well-defined ratio in the compact. In order to be able to keep the ratio of the mixture components within narrow tolerances, even with small quantities, the substances must be ground to very small particles with dimensions of a few ⁇ m. However, it is difficult to handle dust-like powders without loss and to avoid segregation. Furthermore, many mixtures do not result in a self-adhering compact, even at high compression pressures, without the addition of binders. Also, very fine-grained powders can hardly be pressed into a homogeneous body due to the high frictional forces on the grain surfaces.
  • an intermediate process namely the granulation
  • the aim of this process is a free-flowing powder with grains in the dimension of a few 1/10 mm, in which the desired material ratio already exists. It is achieved by means of binders that granular agglomerates (secondary granules) are formed.
  • the energy required to break up into small droplets due to the surface tension is not introduced by pressure, but by means of mechanical vibration.
  • the substance for droplet formation is moved through a guide which is provided with an inlet and an outlet, the guide being set directly or indirectly into mechanical vibrations, so that the substance is shaken off in drop form at the outlet.
  • the leadership or the outlet of the leadership can accelerate strongly positive and negative, so that the
  • the mechanical vibrations can be introduced into the guide in the region of the inlet become.
  • the guide itself which has a certain extension, acts as a lever, so that the guide as a whole can be used as a vibrating body, as a result of which the stroke at the outlet can be increased.
  • the guide swings about an axis that is approximately at right angles to a longitudinal extent of the guide.
  • this axis is provided in the area of the inlet, the entire guide acts as an elastic vibrating body.
  • the guide is tapered, since in this case the substance can be slowly moved out of the guide or can flow out under the influence of gravity. It is particularly advantageous here if the substance is only moved in the guide by means of gravity, since this complies with the properties of the rheopexic substances. In principle, these substances flow better when exposed to ultrasound. So ultrasound can also be used to support the flow. In principle, it is of course also possible to pump substances through the guide.
  • a piezoelectric drive element has proven to be a particularly advantageous vibration generator, in particular a drive element that generates a tilting moment due to its structure.
  • An actuator element as described in German Patent 196 46 511.7 is particularly advantageous in connection with the present invention. The content of this patent is hereby expressly made the subject of the disclosure of this application.
  • FIG. 1 is a perspective view of a first embodiment for drop generation
  • FIG. 2 shows a perspective view of a second embodiment for generating drops
  • Fig. 3 is an enlarged view of the exit of a guide.
  • FIG. 1 shows a perspective view of a first embodiment for drop formation, in particular for rheopexic substances.
  • a guide in the form of a tapered tube 10 is provided, which is flattened on both sides.
  • the outlet opening 12 of the tube 10 is thus designed as a slot.
  • the tube 10 is fastened to a drive head 14, into which a feed line 16 opens.
  • the desired substance can be fed into the drive head 14 through the feed line 16. From there, the substance flows into the inlet of the tube 10 and from there to the outlet opening 12 of the tube 10.
  • the drive head 14 is clamped to a base plate 20 via a piezoelectric drive element 18, two bolts 22 serving as clamping means.
  • a piezoelectric drive element 18 By driving the drive element 18 with an alternating voltage, the two partial stacks 18a and 18b of the drive element 18 contract alternately in opposite directions, as a result of which a tilting moment is exerted on the drive head 14.
  • This tilting movement is transmitted to the guide tube 10, so that the outlet opening 12 or the outlet 12 is set in vibration in the direction of the arrow shown.
  • the achievable stroke in the region of the outlet opening 12 is increased by the longitudinal extension of the guide tube 10.
  • the feed line 16 is connected to a storage vessel, whereby the mass slowly swells under the influence of gravity through the feed line 16 and the guide tube 10.
  • the drive element 18 By driving the drive element 18 with a high-frequency alternating voltage in the range from 0.5 to 5 kHz, the guide tube 10 is caused to oscillate, whereby 12 individual drops 24 are shaken off in the area of the outlet opening.
  • the feed line 16 can be elastically connected to the drive head 14 or, due to the thin wall thickness, can be elastic in itself, so that vibration transmission to the feed line 16 is avoided.
  • the size of the droplets formed can be influenced by the opening cross section, the oscillation frequency, the stroke, the moisture content and the length of the guide tube and by the design of the opening edge of the outlet opening 12.
  • Fig. 3 shows an enlarged view of the outlet opening 12 'of an alternative embodiment of a guide tube 10'.
  • the outlet edge is provided with teeth 26 ', 28', the teeth 26 'on one side of the slot-like outlet opening 12' being offset from the teeth 28 'on the other side of the outlet opening 12', ie the teeth are on gap.
  • Fig. 2 shows a further embodiment of a device according to the invention, the same parts being provided with the same reference numerals.
  • the guide for the substance is designed as a channel 11, which is open at the top and forms an outlet opening 12 at its front end.
  • the front end of the trough 11 or the outlet opening 12 is also set in tilting vibrations in the direction of the arrow by driving the drive element 18 at high frequency.
  • the feed is also carried out through a feed line 16 via the cutter head 14.
  • it is also possible to feed the substance by simple means Lead dripping from a vessel into the gutter so that the substance can be shaken off in drops at the end of the gutter. It is also possible to make the outlet opening 12 of the channel comparable to the embodiment shown in FIG. 3.
  • the drops produced according to the invention can be dried in hot air over a relatively short flight distance so that they hit the bottom of the drying tower as solid agglomerate.
  • amplitudes of a few 0.1 to 2 mm can be achieved.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Drying Of Solid Materials (AREA)
  • Special Spraying Apparatus (AREA)

Abstract

L'invention concerne un procédé permettant de former des gouttes, selon lequel une substance est déplacée à travers une glissière (10) qui est soumise à des vibrations mécaniques qui agitent la substance à la sortie (12) t la font sortir sous forme de gouttes (24).
PCT/EP1999/007240 1998-09-30 1999-09-30 Procede pour former des gouttes WO2000018501A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU61985/99A AU6198599A (en) 1998-09-30 1999-09-30 Method for forming drops

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19845126.1 1998-09-30
DE1998145126 DE19845126A1 (de) 1998-09-30 1998-09-30 Verfahren zur Tropfenbildung

Publications (1)

Publication Number Publication Date
WO2000018501A1 true WO2000018501A1 (fr) 2000-04-06

Family

ID=7882989

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/007240 WO2000018501A1 (fr) 1998-09-30 1999-09-30 Procede pour former des gouttes

Country Status (3)

Country Link
AU (1) AU6198599A (fr)
DE (1) DE19845126A1 (fr)
WO (1) WO2000018501A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008132695A2 (fr) * 2007-04-30 2008-11-06 The Procter & Gamble Company Buse ultrasonore

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH486273A (fr) * 1967-10-19 1970-02-28 Max Kaltenbach Roger Procédé de formation de gouttelettes uniformes d'un diamètre déterminé, appareil pour la mise en oeuvre de ce procédé et application de ce procédé à la fabrication d'un produit granulé
US4043507A (en) * 1971-05-05 1977-08-23 United Kingdom Atomic Energy Authority Apparatus for the formation of liquid droplets
GB1503504A (en) * 1974-04-29 1978-03-15 Fisons Ltd Prilling process
US5720985A (en) * 1994-05-05 1998-02-24 Santrade Ltd. Apparatus for the manufacture of solid particles from a flowable mass

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH565586A5 (fr) * 1972-05-12 1975-08-29 Battelle Memorial Institute
CH557698A (fr) * 1972-08-23 1975-01-15 Ciba Geigy Ag Procede de fractionnement d'un liquide, dispositif mettant en oeuvre ce procede et application de ce procede a la granulation d'un produit liquefie au prealable.
DE2610175C2 (de) * 1976-03-11 1978-05-11 Deutsche Forschungs- Und Versuchsanstalt Fuer Luft- Und Raumfahrt E.V., 5000 Koeln Vorrichtung zur Erzeugung von Tropfen
DE2725849C3 (de) * 1977-06-08 1980-11-13 Hobeg Hochtemperaturreaktor-Brennelement Gmbh, 6450 Hanau Vorrichtung zur Herstellung von kugelförmigen Teilchen
DE3126854C2 (de) * 1981-07-08 1984-09-27 Nukem Gmbh, 6450 Hanau Verfahren und Vorrichtung zur Herstellung kugelförmiger Teilchen aus spontan reagierenden flüssigen Komponenten
FI84357C (fi) * 1989-10-20 1991-11-25 Neste Oy Foerfarande och apparatur foer framstaellning av baerare foer polymerisationskatalysatorer.
FR2657257B1 (fr) * 1990-01-19 1994-09-02 Rhone Poulenc Sante Procede de preparation de medicaments sous forme de perles.
DE4022648C2 (de) * 1990-07-17 1994-01-27 Nukem Gmbh Verfahren und Vorrichtung zur Herstellung von kugelförmigen Teilchen aus flüssiger Phase
DE4042594A1 (de) * 1990-11-05 1992-07-02 Nukem Gmbh Verfahren zur herstellung von aluminiumoxidkugeln
DE4125133C2 (de) * 1991-07-30 1993-09-30 Nukem Gmbh Verfahren und Vorrichtung zur Herstellung von Alginatkugeln
US5843347A (en) * 1993-03-23 1998-12-01 Laboratoire L. Lafon Extrusion and freeze-drying method for preparing particles containing an active ingredient
FR2720631B1 (fr) * 1994-06-03 1996-07-12 Rhone Poulenc Rorer Sa Procédé de préparation et perles obtenues contenant un principe actif présentant un point de fusion non défini.
DE19617924A1 (de) * 1996-05-05 1997-11-13 Brace Gmbh Chemie Plastics Dat Verfahren und Vorrichtung zur Schwingungsanregung von flüssigen Medien bei der Herstellung von sphärischen Granulaten
DE19646511C1 (de) * 1996-11-12 1998-05-14 Marco Systemanalyse Entw Piezoaktuatorisches Antriebs- oder Verstellelement

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH486273A (fr) * 1967-10-19 1970-02-28 Max Kaltenbach Roger Procédé de formation de gouttelettes uniformes d'un diamètre déterminé, appareil pour la mise en oeuvre de ce procédé et application de ce procédé à la fabrication d'un produit granulé
US4043507A (en) * 1971-05-05 1977-08-23 United Kingdom Atomic Energy Authority Apparatus for the formation of liquid droplets
GB1503504A (en) * 1974-04-29 1978-03-15 Fisons Ltd Prilling process
US5720985A (en) * 1994-05-05 1998-02-24 Santrade Ltd. Apparatus for the manufacture of solid particles from a flowable mass

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008132695A2 (fr) * 2007-04-30 2008-11-06 The Procter & Gamble Company Buse ultrasonore
WO2008132695A3 (fr) * 2007-04-30 2009-01-29 Procter & Gamble Buse ultrasonore

Also Published As

Publication number Publication date
DE19845126A1 (de) 2000-04-06
AU6198599A (en) 2000-04-17

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