WO2000015784A3 - Recepteur edg6 (gene de differentiation de cellules endotheliales) humain et murin couple a des proteines g et son utilisation - Google Patents

Recepteur edg6 (gene de differentiation de cellules endotheliales) humain et murin couple a des proteines g et son utilisation Download PDF

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Publication number
WO2000015784A3
WO2000015784A3 PCT/DE1999/002871 DE9902871W WO0015784A3 WO 2000015784 A3 WO2000015784 A3 WO 2000015784A3 DE 9902871 W DE9902871 W DE 9902871W WO 0015784 A3 WO0015784 A3 WO 0015784A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
protein
edg6
coupled
terminal
Prior art date
Application number
PCT/DE1999/002871
Other languages
German (de)
English (en)
Other versions
WO2000015784A2 (fr
Inventor
Markus Graeler
Guenter Bernhardt
Martin Lipp
Original Assignee
Max Delbrueck Centrum
Markus Graeler
Guenter Bernhardt
Martin Lipp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19846979A external-priority patent/DE19846979A1/de
Application filed by Max Delbrueck Centrum, Markus Graeler, Guenter Bernhardt, Martin Lipp filed Critical Max Delbrueck Centrum
Priority to EP99948712A priority Critical patent/EP1112365A2/fr
Priority to JP2000570311A priority patent/JP2002525050A/ja
Publication of WO2000015784A2 publication Critical patent/WO2000015784A2/fr
Publication of WO2000015784A3 publication Critical patent/WO2000015784A3/fr
Priority to HK02100072.9A priority patent/HK1039791A1/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne le récepteur EDG6 couplé à des protéines G, et ses fragments, variantes et mutations. ainsi que son utilisation. Les domaines d'application de l'invention sont la biologie moléculaire, la pharmacie et la médecine. L'invention vise à isoler et à identifier un membre supplémentaire de la famille des récepteurs EDG, et à permettre l'utilisation de ce nouveau membre à des fins médicales. Ce nouveau récepteur EDG6 humain comprend 384 acides aminés de la séquence 1 comportant sept domaines transmembranaires. Ce récepteur présente un site de glycosylation potentielle N-terminal, trois sites de palmitoylation potentielle, 12 à 15 acides aminés placés à l'extrémité C-terminale du septième domaine transmembranaire, et quatre sites C-terminaux de phosphorylation potentielle catalysée par la protéine kinase C. L'invention concerne également l'utilisation du récepteur EDG6, de ses fragments, variantes et mutations et éventuellement de ses partenaires de liaison pour des méthodes et traitements thérapeutiques.
PCT/DE1999/002871 1998-09-11 1999-09-10 Recepteur edg6 (gene de differentiation de cellules endotheliales) humain et murin couple a des proteines g et son utilisation WO2000015784A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP99948712A EP1112365A2 (fr) 1998-09-11 1999-09-10 Recepteur edg6 (gene de differentiation de cellules endotheliales) humain et murin couple a des proteines g et son utilisation
JP2000570311A JP2002525050A (ja) 1998-09-11 1999-09-10 ヒト及びマウスｇタンパク質結合受容体ｅｄｇ６（内皮分化遺伝子）及びその用途
HK02100072.9A HK1039791A1 (zh) 1998-09-11 2002-01-04 人類及鼠科動物的g-蛋白質耦合edg6的接收體(內皮鑒別基因)及其使用的方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19843240.2 1998-09-11
DE19843240 1998-09-11
DE19846979A DE19846979A1 (de) 1998-09-11 1998-10-13 G-Protein gekoppelter Rezeptor EDG6 und seine Verwendung
DE19846979.9 1998-10-13

Publications (2)

Publication Number Publication Date
WO2000015784A2 WO2000015784A2 (fr) 2000-03-23
WO2000015784A3 true WO2000015784A3 (fr) 2000-08-17

Family

ID=26048985

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1999/002871 WO2000015784A2 (fr) 1998-09-11 1999-09-10 Recepteur edg6 (gene de differentiation de cellules endotheliales) humain et murin couple a des proteines g et son utilisation

Country Status (3)

Country Link
EP (1) EP1112365A2 (fr)
JP (1) JP2002525050A (fr)
WO (1) WO2000015784A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812335B1 (en) 1999-03-23 2004-11-02 The Regents Of The University Of California Human polypeptide receptors for lysophospholipids and sphingolipids and nucleic acids encoding the same
US7220734B2 (en) 2002-12-20 2007-05-22 Merck & Co., Inc. 1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as Edg receptor agonists
US20050079549A1 (en) * 2003-07-23 2005-04-14 John Castracane Methods for modeling GPCRs and for producing ligand blocking and receptor activating antibodies for same

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998046620A1 (fr) * 1997-04-17 1998-10-22 Millennium Pharmaceuticals, Inc. Nouveau recepteur couple a la proteine g humaine
WO1998048016A1 (fr) * 1997-04-24 1998-10-29 Incyte Pharmaceuticals, Inc. Recepteur de type edg-1
WO1998050549A2 (fr) * 1997-05-07 1998-11-12 Human Genome Sciences, Inc. Deux recepteurs couples par des proteines g: gpcr2 induit par veb (ebi-2) et gpcr de type gde-1
WO1999035106A2 (fr) * 1997-12-30 1999-07-15 Nps Allelix Corp. Homologues de recepteurs edg-7 mammaliens

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998046620A1 (fr) * 1997-04-17 1998-10-22 Millennium Pharmaceuticals, Inc. Nouveau recepteur couple a la proteine g humaine
WO1998048016A1 (fr) * 1997-04-24 1998-10-29 Incyte Pharmaceuticals, Inc. Recepteur de type edg-1
WO1998050549A2 (fr) * 1997-05-07 1998-11-12 Human Genome Sciences, Inc. Deux recepteurs couples par des proteines g: gpcr2 induit par veb (ebi-2) et gpcr de type gde-1
WO1999035106A2 (fr) * 1997-12-30 1999-07-15 Nps Allelix Corp. Homologues de recepteurs edg-7 mammaliens

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1996, ROCA ALFRED L ET AL: "Structure, characterization, and expression of the gene encoding the mouse Me1-1a melatonin receptor.", XP002137157, Database accession no. PREV199699134631 *
ENDOCRINOLOGY 1996, vol. 137, no. 8, 1996, pages 3469 - 3477, ISSN: 0013-7227 *
GRAELER MARKUS H ET AL: "EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue.", GENOMICS OCT. 15, 1998, vol. 53, no. 2, 15 October 1998 (1998-10-15), pages 164 - 169, XP002137156, ISSN: 0888-7543 *

Also Published As

Publication number Publication date
EP1112365A2 (fr) 2001-07-04
JP2002525050A (ja) 2002-08-13
WO2000015784A2 (fr) 2000-03-23

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