WO2000015784A3 - Human and murine g-protein-coupled edg6 receptor (endothelial differentiation gene) and use of same - Google Patents

Human and murine g-protein-coupled edg6 receptor (endothelial differentiation gene) and use of same Download PDF

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Publication number
WO2000015784A3
WO2000015784A3 PCT/DE1999/002871 DE9902871W WO0015784A3 WO 2000015784 A3 WO2000015784 A3 WO 2000015784A3 DE 9902871 W DE9902871 W DE 9902871W WO 0015784 A3 WO0015784 A3 WO 0015784A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
protein
edg6
coupled
terminal
Prior art date
Application number
PCT/DE1999/002871
Other languages
German (de)
French (fr)
Other versions
WO2000015784A2 (en
Inventor
Markus Graeler
Guenter Bernhardt
Martin Lipp
Original Assignee
Max Delbrueck Centrum
Markus Graeler
Guenter Bernhardt
Martin Lipp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19846979A external-priority patent/DE19846979A1/en
Application filed by Max Delbrueck Centrum, Markus Graeler, Guenter Bernhardt, Martin Lipp filed Critical Max Delbrueck Centrum
Priority to EP99948712A priority Critical patent/EP1112365A2/en
Priority to JP2000570311A priority patent/JP2002525050A/en
Publication of WO2000015784A2 publication Critical patent/WO2000015784A2/en
Publication of WO2000015784A3 publication Critical patent/WO2000015784A3/en
Priority to HK02100072.9A priority patent/HK1039791A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The invention relates to the G protein-coupled EDG6 receptor, fragments, variants and mutations thereof, as well as to its use. Areas of application of the invention include molecular biology, pharmacy and medicine. The aim of the invention is to isolate and identify a further member of the family of EDG receptors and to permit its use for medical purposes. The new human EDG6 receptor comprises 384 amino acids of sequence 1 having seven transmembrane domains. The receptor has a possible N-terminal glycolysis site, three possible palmitoylation sites, between 12 and 15 amino acids in the C-terminal position of the seventh transmembrane domain and four possible C-terminal proteinkinase C-phosphorylation sites. The invention further relates to the use of the EDG6 receptor, its fragments, variants and mutations and possibly its binding partners for therapeutic methods and treatments.
PCT/DE1999/002871 1998-09-11 1999-09-10 Human and murine g-protein-coupled edg6 receptor (endothelial differentiation gene) and use of same WO2000015784A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP99948712A EP1112365A2 (en) 1998-09-11 1999-09-10 Human and murine g-protein-coupled edg6 receptor (endothelial differentiation gene) and use of same
JP2000570311A JP2002525050A (en) 1998-09-11 1999-09-10 Human and mouse G protein-coupled receptor EDG6 (endothelial differentiation gene) and uses thereof
HK02100072.9A HK1039791A1 (en) 1998-09-11 2002-01-04 Human and murine g-protein-coupled edg6 receptor (endothelial differentiation gene) and use of same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19843240.2 1998-09-11
DE19843240 1998-09-11
DE19846979A DE19846979A1 (en) 1998-09-11 1998-10-13 New human and murine G-coupled receptor EDG (endothelial differentiation gene) 6, useful for modulating inflammatory and immune reactions and for treatment of allergy or tumors
DE19846979.9 1998-10-13

Publications (2)

Publication Number Publication Date
WO2000015784A2 WO2000015784A2 (en) 2000-03-23
WO2000015784A3 true WO2000015784A3 (en) 2000-08-17

Family

ID=26048985

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1999/002871 WO2000015784A2 (en) 1998-09-11 1999-09-10 Human and murine g-protein-coupled edg6 receptor (endothelial differentiation gene) and use of same

Country Status (3)

Country Link
EP (1) EP1112365A2 (en)
JP (1) JP2002525050A (en)
WO (1) WO2000015784A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812335B1 (en) 1999-03-23 2004-11-02 The Regents Of The University Of California Human polypeptide receptors for lysophospholipids and sphingolipids and nucleic acids encoding the same
AU2003297232B2 (en) 2002-12-20 2010-02-04 Merck Sharp & Dohme Corp. 1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles
US20050079549A1 (en) * 2003-07-23 2005-04-14 John Castracane Methods for modeling GPCRs and for producing ligand blocking and receptor activating antibodies for same

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998046620A1 (en) * 1997-04-17 1998-10-22 Millennium Pharmaceuticals, Inc. A novel human g-protein coupled receptor
WO1998048016A1 (en) * 1997-04-24 1998-10-29 Incyte Pharmaceuticals, Inc. Edg-1-like receptor
WO1998050549A2 (en) * 1997-05-07 1998-11-12 Human Genome Sciences, Inc. Two human g-protein coupled receptors: ebv-induced gpcr 2 (ebi-2) and edg-1-like gpcr
WO1999035106A2 (en) * 1997-12-30 1999-07-15 Nps Allelix Corp. Mammalian edg-7 receptor homologs

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998046620A1 (en) * 1997-04-17 1998-10-22 Millennium Pharmaceuticals, Inc. A novel human g-protein coupled receptor
WO1998048016A1 (en) * 1997-04-24 1998-10-29 Incyte Pharmaceuticals, Inc. Edg-1-like receptor
WO1998050549A2 (en) * 1997-05-07 1998-11-12 Human Genome Sciences, Inc. Two human g-protein coupled receptors: ebv-induced gpcr 2 (ebi-2) and edg-1-like gpcr
WO1999035106A2 (en) * 1997-12-30 1999-07-15 Nps Allelix Corp. Mammalian edg-7 receptor homologs

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1996, ROCA ALFRED L ET AL: "Structure, characterization, and expression of the gene encoding the mouse Me1-1a melatonin receptor.", XP002137157, Database accession no. PREV199699134631 *
ENDOCRINOLOGY 1996, vol. 137, no. 8, 1996, pages 3469 - 3477, ISSN: 0013-7227 *
GRAELER MARKUS H ET AL: "EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue.", GENOMICS OCT. 15, 1998, vol. 53, no. 2, 15 October 1998 (1998-10-15), pages 164 - 169, XP002137156, ISSN: 0888-7543 *

Also Published As

Publication number Publication date
JP2002525050A (en) 2002-08-13
WO2000015784A2 (en) 2000-03-23
EP1112365A2 (en) 2001-07-04

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