WO2000015645A1 - Derives d'esters phosphoniques et leur procede de production - Google Patents

Derives d'esters phosphoniques et leur procede de production Download PDF

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Publication number
WO2000015645A1
WO2000015645A1 PCT/JP1999/004913 JP9904913W WO0015645A1 WO 2000015645 A1 WO2000015645 A1 WO 2000015645A1 JP 9904913 W JP9904913 W JP 9904913W WO 0015645 A1 WO0015645 A1 WO 0015645A1
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WO
WIPO (PCT)
Prior art keywords
ring
optionally substituted
integer
carbon atoms
group
Prior art date
Application number
PCT/JP1999/004913
Other languages
English (en)
Japanese (ja)
Inventor
Yasushi Kono
Takayuki Sawada
Masahiro Nomura
Yukie Takahashi
Takeshi Tsubuki
Yasuhiko Sakoe
Kazuhiko Kuriyama
Original Assignee
Kyorin Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co., Ltd. filed Critical Kyorin Pharmaceutical Co., Ltd.
Priority to AU56485/99A priority Critical patent/AU5648599A/en
Publication of WO2000015645A1 publication Critical patent/WO2000015645A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur des dérivés d'esters phosphoniques de formule générale (1) et sur leurs sels pharmacocompatibles agissant comme inhibiteurs des liaisons entre molécules à adhésion cellulaire, et utiles de ce fait comme immunosuppresseurs, comme agents anti-inflammatoires, comme agent anti-allergique, et comme inhibiteurs des métastases cancéreuses.
PCT/JP1999/004913 1998-09-11 1999-09-10 Derives d'esters phosphoniques et leur procede de production WO2000015645A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU56485/99A AU5648599A (en) 1998-09-11 1999-09-10 Phosphonic ester derivatives and process for producing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10/258841 1998-09-11
JP25884198 1998-09-11

Publications (1)

Publication Number Publication Date
WO2000015645A1 true WO2000015645A1 (fr) 2000-03-23

Family

ID=17325778

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1999/004913 WO2000015645A1 (fr) 1998-09-11 1999-09-10 Derives d'esters phosphoniques et leur procede de production

Country Status (2)

Country Link
AU (1) AU5648599A (fr)
WO (1) WO2000015645A1 (fr)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001010854A1 (fr) * 1999-08-09 2001-02-15 Ciba Specialty Chemicals Holding Inc. Composes a base de benzothiazole et leur utilisation en tant qu'azureurs optiques
WO2001021598A1 (fr) * 1999-09-23 2001-03-29 Astrazeneca Ab Composes therapeutiques de quinazoline
US6521619B2 (en) 2000-06-29 2003-02-18 Icos Corporation Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents
US6787542B2 (en) 2000-06-29 2004-09-07 Icos Corporation Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents
US6878700B1 (en) 1998-12-29 2005-04-12 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
US6878697B2 (en) * 2001-06-21 2005-04-12 Ariad Pharmaceuticals, Inc. Phenylamino-pyrimidines and uses thereof
WO2005007672A3 (fr) * 2003-06-20 2005-09-15 Coley Pharm Gmbh Antagonistes des recepteurs toll (tlr) pour petites molecules
USRE39197E1 (en) 1998-12-29 2006-07-18 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
US7214704B2 (en) 2004-11-15 2007-05-08 Bristol-Myers Squibb Company 2-Amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
US7223786B2 (en) 2004-11-15 2007-05-29 Bristol-Myers Squibb Company 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors
US7226942B2 (en) 2004-11-15 2007-06-05 Bristol-Myers Squibb Company 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
US7365061B2 (en) 2004-11-15 2008-04-29 Bristol-Myers Squibb Company 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
CN1809357B (zh) * 2003-06-20 2010-12-22 科勒制药有限公司 小分子Toll样受体(TLR)拮抗剂
US20110092499A1 (en) * 2007-11-15 2011-04-21 Ym Biosciences Australia Pty Ltd N-containing heterocyclic compounds
US7973069B2 (en) 2004-07-14 2011-07-05 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US8030334B2 (en) 2008-06-27 2011-10-04 Novartis Ag Organic compounds
US8188254B2 (en) 2003-10-30 2012-05-29 Coley Pharmaceutical Gmbh C-class oligonucleotide analogs with enhanced immunostimulatory potency
EP2583678A2 (fr) 2004-06-24 2013-04-24 Novartis Vaccines and Diagnostics, Inc. Immunopotentiateurs de petites molécules et dosages pour leur détection
WO2014066659A1 (fr) * 2012-10-25 2014-05-01 Tetra Discovery Partners, Llc. Inhibiteurs hétéroaryle de pde4
US9012462B2 (en) 2008-05-21 2015-04-21 Ariad Pharmaceuticals, Inc. Phosphorous derivatives as kinase inhibitors
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
US9834518B2 (en) 2011-05-04 2017-12-05 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in EGFR-driven cancers
US9834571B2 (en) 2012-05-05 2017-12-05 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in EGFR-driven cancers

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5998099A (ja) * 1982-11-05 1984-06-06 Fujisawa Pharmaceut Co Ltd 新規テトラヒドロフランカルボン酸誘導体、その製造法およびその医薬組成物
US4685952A (en) * 1986-02-07 1987-08-11 Teijin Limited Benzoylaminoalkylenephosphonic acids or esters thereof, herbicidal compositions containing same and their herbicidal use
JPH0892268A (ja) * 1994-09-21 1996-04-09 Wakamoto Pharmaceut Co Ltd 新規なリン酸誘導体
WO1996040760A2 (fr) * 1995-06-07 1996-12-19 Schering Aktiengesellschaft Peptides iodes et leur utilisation comme opacifiants radiologiques

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5998099A (ja) * 1982-11-05 1984-06-06 Fujisawa Pharmaceut Co Ltd 新規テトラヒドロフランカルボン酸誘導体、その製造法およびその医薬組成物
US4685952A (en) * 1986-02-07 1987-08-11 Teijin Limited Benzoylaminoalkylenephosphonic acids or esters thereof, herbicidal compositions containing same and their herbicidal use
JPH0892268A (ja) * 1994-09-21 1996-04-09 Wakamoto Pharmaceut Co Ltd 新規なリン酸誘導体
WO1996040760A2 (fr) * 1995-06-07 1996-12-19 Schering Aktiengesellschaft Peptides iodes et leur utilisation comme opacifiants radiologiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PENICAUD VIRGINIE ET AL.: "New water-soluble diamine complexes as catalysts for the hydrogenation of ketones under hydrogen pressure", EUR. J. ORG. CHEM.,, no. 7, 1999, pages 1745 - 1748, XP002927001 *

Cited By (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6878700B1 (en) 1998-12-29 2005-04-12 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
USRE39197E1 (en) 1998-12-29 2006-07-18 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
WO2001010854A1 (fr) * 1999-08-09 2001-02-15 Ciba Specialty Chemicals Holding Inc. Composes a base de benzothiazole et leur utilisation en tant qu'azureurs optiques
WO2001021598A1 (fr) * 1999-09-23 2001-03-29 Astrazeneca Ab Composes therapeutiques de quinazoline
US6399603B1 (en) 1999-09-23 2002-06-04 Astrazeneca Ab Therapeutic heterocycles
US6521619B2 (en) 2000-06-29 2003-02-18 Icos Corporation Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents
US6787542B2 (en) 2000-06-29 2004-09-07 Icos Corporation Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents
US7129247B2 (en) 2000-06-29 2006-10-31 Abbott Laboratories Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents
US6878697B2 (en) * 2001-06-21 2005-04-12 Ariad Pharmaceuticals, Inc. Phenylamino-pyrimidines and uses thereof
CN1809357B (zh) * 2003-06-20 2010-12-22 科勒制药有限公司 小分子Toll样受体(TLR)拮抗剂
WO2005007672A3 (fr) * 2003-06-20 2005-09-15 Coley Pharm Gmbh Antagonistes des recepteurs toll (tlr) pour petites molecules
US8188254B2 (en) 2003-10-30 2012-05-29 Coley Pharmaceutical Gmbh C-class oligonucleotide analogs with enhanced immunostimulatory potency
EP2583678A2 (fr) 2004-06-24 2013-04-24 Novartis Vaccines and Diagnostics, Inc. Immunopotentiateurs de petites molécules et dosages pour leur détection
US7973069B2 (en) 2004-07-14 2011-07-05 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7365061B2 (en) 2004-11-15 2008-04-29 Bristol-Myers Squibb Company 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
US7223786B2 (en) 2004-11-15 2007-05-29 Bristol-Myers Squibb Company 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors
US7214704B2 (en) 2004-11-15 2007-05-08 Bristol-Myers Squibb Company 2-Amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
US7226942B2 (en) 2004-11-15 2007-06-05 Bristol-Myers Squibb Company 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
US8765755B2 (en) 2007-11-15 2014-07-01 Ym Biosciences Australia Pty Ltd. N-containing heterocyclic compounds
US20110092499A1 (en) * 2007-11-15 2011-04-21 Ym Biosciences Australia Pty Ltd N-containing heterocyclic compounds
US9499560B2 (en) 2007-11-15 2016-11-22 Ym Biosciences Australia Pty Ltd N-containing heterocyclic compounds
US8354408B2 (en) * 2007-11-15 2013-01-15 Ym Biosciences Australia Pty Ltd N-containing heterocyclic compounds
US9012462B2 (en) 2008-05-21 2015-04-21 Ariad Pharmaceuticals, Inc. Phosphorous derivatives as kinase inhibitors
US8030334B2 (en) 2008-06-27 2011-10-04 Novartis Ag Organic compounds
US8791141B2 (en) 2008-06-27 2014-07-29 Novartis Ag Organic compounds
US9242963B2 (en) 2008-06-27 2016-01-26 Novartis Ag Organic compounds
US9834518B2 (en) 2011-05-04 2017-12-05 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in EGFR-driven cancers
US9834571B2 (en) 2012-05-05 2017-12-05 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in EGFR-driven cancers
JP2016505512A (ja) * 2012-10-25 2016-02-25 テトラ ディスカバリー パートナーズ エルエルシー Ｐｄｅ４のヘテロアリール阻害剤
US9777024B2 (en) 2012-10-25 2017-10-03 Tetra Discovery Partners, LLC Heteroaryl inhibitors of PDE4
US9221843B2 (en) 2012-10-25 2015-12-29 Tetra Discovery Partners, LLC Heteroaryl inhibitors of PDE4
WO2014066659A1 (fr) * 2012-10-25 2014-05-01 Tetra Discovery Partners, Llc. Inhibiteurs hétéroaryle de pde4
US10093686B2 (en) 2012-10-25 2018-10-09 Tetra Discovery Partners, LLC Heteroaryl inhibitors of PDE4
US10364258B2 (en) 2012-10-25 2019-07-30 Tetra Discovery Partners, LLC Heteroaryl inhibitors of PDE4
US10626129B2 (en) 2012-10-25 2020-04-21 Tetra Discovery Partners, LLC Heteroaryl inhibitors of PDE4
US11401286B2 (en) 2012-10-25 2022-08-02 Tetra Discovery Partners, LLC Heteroaryl inhibitors of PDE4
US11767334B2 (en) 2012-10-25 2023-09-26 Tetra Discovery Partners, LLC Heteroaryl inhibitors of PDE4
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers

Also Published As

Publication number Publication date
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