WO2000014019A1 - Eau medicale active, sa fabrication et son utilisation - Google Patents

Eau medicale active, sa fabrication et son utilisation Download PDF

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Publication number
WO2000014019A1
WO2000014019A1 PCT/CN1999/000143 CN9900143W WO0014019A1 WO 2000014019 A1 WO2000014019 A1 WO 2000014019A1 CN 9900143 W CN9900143 W CN 9900143W WO 0014019 A1 WO0014019 A1 WO 0014019A1
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WO
WIPO (PCT)
Prior art keywords
water
medical
activated
medical activated
activated water
Prior art date
Application number
PCT/CN1999/000143
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English (en)
Chinese (zh)
Inventor
Lumin Wang
Guanxue Wang
Guocheng Zhang
Original Assignee
Lumin Wang
Guanxue Wang
Guocheng Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lumin Wang, Guanxue Wang, Guocheng Zhang filed Critical Lumin Wang
Priority to AU56159/99A priority Critical patent/AU5615999A/en
Publication of WO2000014019A1 publication Critical patent/WO2000014019A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/34—Treatment of water, waste water, or sewage with mechanical oscillations
    • C02F1/36—Treatment of water, waste water, or sewage with mechanical oscillations ultrasonic vibrations

Definitions

  • the present invention relates to the field of medical water, and more particularly, to a medical activated water, a preparation method and uses thereof. King
  • Water has a large dissolving power and has a large ionization ability, which can make the water-based substances in the body exist in a dissolved state and an electrolyte ion state; and because water has a large fluidity, it is digested, absorbed, circulated and excreted by the human body. In the process, it can help speed up the transportation of some nutrients and the excretion of waste, so that the chemical reaction of metabolism in the human body can proceed smoothly.
  • Water is an important part of cells and body fluids. Each cell of the human body and its most basic units contain water. The various glands of the human body secrete liquid. If there is no water in the body, the secretion of digestive juice will decrease, affecting food digestion and appetite Decreased, slow blood flow, decreased metabolic activity, accumulation of waste toxins in the body, Not only can it cause illness, it can also make it worse.
  • the specific heat value of water is high, 4.18kJ heat is required for each gram of water to rise or fall by 1 ° C. Since the human body contains a large amount of water, the heat generated during the metabolic process can be absorbed by water. The body temperature does not rise significantly. Second, due to the large evaporation value of water, the human body can radiate a large amount of heat as long as a small amount of water is evaporated to maintain a certain body temperature. For example, when the external environment temperature is high, the body heat can follow the moisture Evaporate heat through the skin to maintain constant temperature. Third, water has strong thermal conductivity and is the best good thermal conductor among non-metallic elements. Although the metabolic intensity of various tissues of the human body is different, the heat generated can be passed through. The good thermal conductivity of water keeps the temperature of various tissues and organs consistent and reaches a constant temperature.
  • the water content of human blood is about 80%. If a large amount of water is lost, it can reduce the amount of hemolysis and produce hypotension, which will affect various functional activities of the human body, especially the heart, brain, and kidney. Therefore, the human body The amount of water is closely related to the amount of hemolysis.
  • Water is a lubricant for joints, muscles and body cavities
  • infusion, oxygen, and blood transfusion are the three magic weapons, especially for patients with high fever, diarrhea, and dehydration.
  • 0.9% normal saline or dextrose saline can be injected intravenously, which can often play a role in reviving death.
  • Most diseases are caused by the invasion of various pathogens.
  • the white blood cells and antibodies in the human body will be actively activated.
  • various drugs are taken to destroy the pathogens.
  • the medical water, various medical injection water, and various medicinal solvents currently used in medicine and recorded in the Pharmacopoeia are distilled water that is basically free of impurities.
  • the preparation method is prepared from the traditional distillation method and developed to Reverse osmosis method ("Chinese Journal of Hospital Pharmacy” 1995. 15 Vol. 12 P562) and membrane separation method ("Medical and Health Equipment” 1996 No. 6 P12), however, with the development of science and technology, and people's
  • the application of new technology and the understanding of human beings, from the molecular level to the gene level, and the continuous emergence of new drugs, the continuous application of new medical technology has made us realize that the previous medical distilled water was not the most ideal medical water. This is because its water molecular group is relatively large, which is not conducive to the dissolution of drugs and enters the human body, so it cannot better play the role of water treatment and participation in metabolism.
  • Technical content of the present invention is because its water molecular group is relatively large, which is not conducive to the dissolution of drugs and
  • the object of the present invention is to provide a physiological function that is more compatible with water and a therapeutic effect in medicine. It has strong cell penetration, water dissolving power, metabolic power, and expansion power, which is conducive to drug dissolution and entry into the human body. Better use of water treatment and medical activated water involved in metabolic functions.
  • Another object of the present invention is to provide the above-mentioned method for preparing medical activated water and its application to injection diluents, pharmaceutical solvents, physiological regulators, beauty health water, and medical washing water.
  • the scientific basis of this invention is the medical theory of cell membranes-
  • the chemical composition and molecular structure of the cell membrane is a thin film composed of a liquid lipid bilayer. One side is hydrophilic and the other is a hydrophobic group.
  • lipid-insoluble or very low-solubility substances such as glucose, amino acids, and various ions are difficult to pass through the cell membrane itself, but with the help of some special proteins on the cell membrane, the cell membrane can be made from a high concentration side It is transported to the low concentration side, so if it is dissolved in these ions such as glucose and amino acids with smaller molecular groups, it will be easier to enter the cell membrane during the treatment process, thereby enhancing the treatment effect.
  • the present invention uses the following technical solutions to achieve the object of the invention:
  • the present invention provides a medical activated water having the following characteristics,
  • the relaxation time of the water molecule group is 2. 16 ⁇ 10.5 seconds; or the half width of the water molecule group is 0.5 to 2. 45 Hz;
  • the aforementioned medical activated water may also be an oxygenated medical activated water after an oxygen treatment, and the dissolved oxygen in the water is 7 to 20 mg / L.
  • the present invention also provides a method for preparing the medical activated water, which includes the following steps:
  • A Pass the medical distilled water into the IDM activated water system. After the action of the IDM biological activated stone, a part of the macromolecular water group is destroyed, so that it becomes a part of the small molecular group of water;
  • step B Pass the water obtained in step A into the TKY activated water device to perform TKY activation treatment.
  • the water passes through the TKY tube, it undergoes bipolar discharge treatment to destroy a part of the macromolecular cluster water, so that more water becomes small molecular clusters.
  • step C The water obtained in step B is then passed into an ultrasonic atomization device for ultrasonic atomization. After the water is ultrasonically atomized, another part of the macromolecular water is destroyed, so that the relaxation time of the water is 2. 16 ⁇ : 10. 5 seconds or half width 0.5 5 ⁇ 2. 45 Hz;
  • step D The water obtained in step C is magnetized to realign the water molecules, which meets the requirement of one year for storage, and the product is medical activated water.
  • step C 7 to 20 mg / L of oxygen can also be added in the ultrasonic atomization process of step C to obtain oxygenated activated medical water.
  • the IDM activation system mainly uses negatively charged activated stones extracted from marine organisms.
  • This type of activated stone can physically change with positively charged water molecule groups in fresh water in nature, and can greatly change the movement of positive and negative charges.
  • the water of the molecular group becomes the water of the small molecular group, and after passing through the positive and negative electrodes, the water molecular group is rearranged so that it becomes a relatively stable water.
  • TKY activation treatment simulates the principle of space discharge, and generates an environment like lightning discharge, so that electric ions act on water molecular groups, thereby destroying large molecular groups of water and turning it into water with small molecular groups.
  • Ultrasonic atomization is the use of ultrasonic technology to turn water into atomized water. Under use, the original macromolecular water is destroyed to make it into small molecular water. In the process, appropriate oxygen can also be added to make the water of small molecular groups contain 7 ⁇ 10mg / L of oxygen. Used in medicine.
  • the above medical activated water can be used as a diluent for injections
  • the above-mentioned medically activated water can also be used as a drug solvent.
  • the above-mentioned medical activated water can also be used as a physiological regulator, a beauty care water and a medical washing water.
  • the medical activated water of the present invention adopts modern high-tech means.
  • the original macromolecular clusters are changed into molecular clusters, and the original disordered water molecular clusters are magnetized into
  • the threaded water molecule group is more in line with the physiological function of water and the therapeutic effect in medicine, so that those substances that are not easily soluble in water or those that do not easily penetrate the cell membrane can more easily penetrate the cell membrane, which is in line with the theory of medical physiology and pathology .
  • the medical activated water of the present invention has: 1. Stronger cell permeability; 2. Stronger body diffusion ability; 3. Stronger metabolic ability; 4. Stronger dissolving ability. Therefore, a good medical effect can be achieved.
  • the method for preparing medical activated water according to the present invention in combination with the most advanced technology, can effectively change large molecular groups of water into small molecular groups, thereby achieving the object of the present invention
  • Figure 1 is a NMR spectrum of medical distilled water
  • FIG. 4 is a block diagram of a process for preparing medical activated water according to the present invention. detailed description
  • step 1 above flow into a TKY activated water device (produced by Beijing Yuanheng Lihua High-tech Co., Ltd.). After the TKY tube discharges the water, it flows into another liquid storage tank;
  • the working power source is 220V, 50 Hz, the atomizing power is 40W, the oscillation frequency is 1.6-1.7 MHz, and the atomizing amount is 2n ⁇ / min, completely atomize 10 ⁇ water;
  • step 4 Pass the water flowing out of step 3 into a magnetization device, hold the time for 30 minutes, release the water stream, and collect it with a liquid storage tank.
  • the obtained is medical activated water, a total of 10 liters.
  • Steps 1, 2, and 4 are the same as in Example 1.
  • step 3 except that the water is atomized ultrasonically, oxygen is introduced into the atomizer in the atomization process, and the rate is 4 L / h, and the time is 2.5. hour.
  • oxygenated medical activated water can be obtained, and the oxygen content of the medical activated water in this example is determined to be 15 mg / L.
  • Example 3 the same as in Example 1, the ultrasonic speed of step 3 was changed, the ultrasonic speed was increased to 5m ⁇ / min, the relaxation time of the obtained medical activated water was 9.1 seconds, and the half width was 2.1 Hz (see Figure 3 ).
  • Example 3 The medical activated water obtained in Example 3 was returned, and steps 1 to 4 of Example 1 were repeated to obtain medical activated water with smaller molecular clusters, with a relaxation time of 3S and a half width of 0.7 Hz.
  • a 02ml sample was placed in 0.5ml D 2 0. After shaking, the test was performed using a reverse pulse sequence with the condition of 90 °. Pulse width ⁇ , pulse interval is 40S, sampling times: 1 times, pulse sequence repetition times: 9 times. The measurement results are shown in Table 1.
  • Instrument type used Varian Gemini 300 superconducting nuclear magnetic resonance instrument. The test results are shown in Table 1.
  • mice K and M mice, 80 males, weighing 18-20g, provided by the breeding institute of the Ministry of Health's Pharmaceutical and Biological Product Identification Institute.
  • mice Eighty mice were weighed and randomly divided into four groups of 20 mice each. The mice were perfused with 10ml, 20ml, and 30ml of equal weight. The control group was perfused with an equal volume of normal saline for 7 consecutive days. , And observe for another 7 days.
  • the large dose was 30 times that of adult clinical water. Each dose group was continuously fed with water for 7 days. After the drug was discontinued for 7 days, no abnormalities were found in the animal's diet, behavior, or body weight.
  • Example 1 Formulate the medical activated water prepared in Example 1 into 0.9% physiological saline of medical activated water, batch number 980402;
  • mice Eighty mice were weighed and randomly divided into four groups of 20 mice each. The mice were perfused with ABC D group for 7 consecutive days, 20 ml each time, twice a day, 10 a.m. and 3 p.m. Each point was irrigated once, and the other feeding conditions were the same. Observe the micturition time of the mice.
  • mice were perfused with 20ml saline for 7 consecutive days, and the urination time of the animals was significantly different. Group A was the first, and the other groups had no significant changes.
  • A, medical activated water is formulated into 10% glucose, batch number 980403;
  • mice K and M mice, 80 males, weighing 18-30 g, provided by the breeding institute of the Ministry of Health's Pharmaceutical and Biological Product Identification Institute.
  • mice After weighing 80 mice, they were randomly divided into 4 groups, 20 in each group according to ABC D Groups were arranged, and mice were irrigated for 20 consecutive days for 20 days each time, twice a day at 10 am and 3 pm each time, and the remaining feeding conditions were the same. Observe the micturition time of the mice.
  • the medical activated water prepared by the method of the present invention has smaller water molecular groups, has significantly better medical performance than the original medical water, and can be used as a new generation of medical water products. .
  • the present invention uses distilled water to transform water from large molecular groups to small molecular groups through physical and chemical methods such as biological activation, photoelectric ultrasound, and magnetization, and is applied to the field of medical water.
  • the preparation process is not limited to a specific device. Those skilled in the art and any other specific implementations made in using the technical solutions of the present invention are also within the scope of the present invention. The protection scope of the present invention is defined by the claims. Industrial applicability
  • the medical activated water prepared by the method of the present invention has smaller water molecular groups, has significantly better medical performance than the original medical water, and can be used as a new generation product of medical water.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Mechanical Engineering (AREA)
  • Environmental & Geological Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Water Supply & Treatment (AREA)
  • Hydrology & Water Resources (AREA)
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Abstract

La présente invention concerne une eau active présentant un faible poids moléculaire, cette eau étant plus efficace que les eaux médicales distillées au niveau de ses capacités de dissolution, de perméabilité, de diffusion et de nettoyage, ainsi qu'au niveau de son métabolisme. Cette eau est fabriquée selon un procédé de traitement d'une eau médicale distillée par un système IDM pour eau active, TKY, et pulvérisation ultrasonore. L'eau médicale active de la présente invention peut notamment être utilisée comme agent de dilution injectable et solvant pharmaceutique, être appliquée aux domaines de la physiothérapie, de la coiffure, et des soins de santé, ou employée comme eau médicale nettoyante. Cette eau conserve les même variations physiques aqueuses que d'autres produits du même type mais présente une activité biologique supérieure: elle constitue donc une eau médicale totalement nouvelle.
PCT/CN1999/000143 1998-09-09 1999-09-09 Eau medicale active, sa fabrication et son utilisation WO2000014019A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU56159/99A AU5615999A (en) 1998-09-09 1999-09-09 A medical active water, manufacture and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN 98117689 CN1124988C (zh) 1998-09-09 1998-09-09 一种医用活化水、其制备方法及用途
CN98117689.5 1998-09-09

Publications (1)

Publication Number Publication Date
WO2000014019A1 true WO2000014019A1 (fr) 2000-03-16

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102626455A (zh) * 2012-04-24 2012-08-08 贺宁 一种阴部和宫颈护理液及其应用
CN111718056A (zh) * 2020-06-18 2020-09-29 北京华宇辉煌生态环保科技股份有限公司 一种水产品净化高氧水处理设备
CN116287056A (zh) * 2023-04-04 2023-06-23 广州源潮生物信息技术有限公司 一种植物多糖及其提取方法和应用

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CN104276623A (zh) * 2013-07-12 2015-01-14 袁立新 制造小分子水的方法和装置
CN105640786A (zh) * 2014-11-13 2016-06-08 宋裕平 外用液态水、纳米营养液及其制备方法
CN107050461A (zh) * 2016-05-12 2017-08-18 王许强 新型输液基水
CN106154771A (zh) * 2016-08-31 2016-11-23 珠海顺泽电子实业有限公司 活化水用于显影液中的应用
CN108434563A (zh) * 2018-04-26 2018-08-24 成都吱吖科技有限公司 一种自动化医疗美容养生造水装置
CN110141686B (zh) * 2019-05-07 2021-11-02 吉林省海创生物科技有限公司 一种人脐带间充质干细胞注射液及其面部填充注射方法
CN111423049A (zh) * 2020-04-23 2020-07-17 上海善普生物科技有限公司 一种稳定的小分子团水制备装置及方法

Citations (5)

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Publication number Priority date Publication date Assignee Title
JPH0796282A (ja) * 1993-09-01 1995-04-11 Nippondenso Co Ltd 活水化装置
CN1113891A (zh) * 1994-06-03 1995-12-27 赖呈金 一种磁化活性水的制备方法及其制得的产品
CN1122782A (zh) * 1995-08-15 1996-05-22 谢树海 高纯活性蒸馏水生产工艺
CN1132185A (zh) * 1995-09-07 1996-10-02 济南高新开发区新贵族发展有限公司 磁化高氧水的制备方法
CN1135465A (zh) * 1995-05-08 1996-11-13 陈文成 一种活化水及其用途

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0796282A (ja) * 1993-09-01 1995-04-11 Nippondenso Co Ltd 活水化装置
CN1113891A (zh) * 1994-06-03 1995-12-27 赖呈金 一种磁化活性水的制备方法及其制得的产品
CN1135465A (zh) * 1995-05-08 1996-11-13 陈文成 一种活化水及其用途
CN1122782A (zh) * 1995-08-15 1996-05-22 谢树海 高纯活性蒸馏水生产工艺
CN1132185A (zh) * 1995-09-07 1996-10-02 济南高新开发区新贵族发展有限公司 磁化高氧水的制备方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102626455A (zh) * 2012-04-24 2012-08-08 贺宁 一种阴部和宫颈护理液及其应用
CN111718056A (zh) * 2020-06-18 2020-09-29 北京华宇辉煌生态环保科技股份有限公司 一种水产品净化高氧水处理设备
CN116287056A (zh) * 2023-04-04 2023-06-23 广州源潮生物信息技术有限公司 一种植物多糖及其提取方法和应用
CN116287056B (zh) * 2023-04-04 2023-11-07 广州源潮生物信息技术有限公司 一种植物多糖及其提取方法和应用

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CN1124988C (zh) 2003-10-22
CN1247092A (zh) 2000-03-15

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