WO2000014019A1

WO2000014019A1 - A medical active water, manufacture and use thereof

Info

Publication number: WO2000014019A1
Application number: PCT/CN1999/000143
Authority: WO
Inventors: Lumin Wang; Guanxue Wang; Guocheng Zhang
Original assignee: Lumin Wang; Guanxue Wang; Guocheng Zhang
Priority date: 1998-09-09
Filing date: 1999-09-09
Publication date: 2000-03-16
Also published as: AU5615999A; CN1124988C; CN1247092A

Abstract

The present invention discloses an active water having smaller molecular mass, in which is superior to medical distilled water in the capacity of dissolving, permeability, diffusion, metabolism and cleaning, it is manufactured by the following method: medical distilled water was treated by IDM active water system, TKY and ultrasonic atomizing. The medical active water according to the present invention may be useful as the diluting agent of injection and the pharmaceutical solvent, may be also useful as the physio-regulator, the hairdressing and health care water as well as the medical cleaning water. It is superior to the prior same-type products in biological activity, and it is consonant with the aqueous physic variation. Thus, it is a full-new medical water.

Description

Medical activated water, preparation method and application thereof

The present invention relates to the field of medical water, and more particularly, to a medical activated water, a preparation method and uses thereof. King

The functions of Shui Sheng Ning based on the traditional Chinese medicine theory and modern medical cell theory are: Water is the source of human life. According to scientists, two-thirds of an adult's weight is water, and children's water can reach 80%. In the body, water is the medium for all material exchange. When people eat, they need saliva to chew food, and gastric juice, intestinal juice, pancreatic juice, and bile fluid to digest food. Most of these digestive juices are composed of water. In the process of metabolism, the toxic substances and wastes generated need to be excreted from the body, such as stool, urination, sweating, sneezing, breathing, etc. All require water to perform. If the human body is dehydrated, nutrients cannot be absorbed, waste cannot be excreted, blood cannot flow, body temperature cannot be constant, various physiological activities in the body cannot be performed, water participates in all physiological and biochemical processes in the body, and water in the body is dehydrated to a certain extent. Life It ended. The main physiological functions of water are:

1. Water participates in the metabolism process in the body

Water has a large dissolving power and has a large ionization ability, which can make the water-based substances in the body exist in a dissolved state and an electrolyte ion state; and because water has a large fluidity, it is digested, absorbed, circulated and excreted by the human body. In the process, it can help speed up the transportation of some nutrients and the excretion of waste, so that the chemical reaction of metabolism in the human body can proceed smoothly. Water is an important part of cells and body fluids. Each cell of the human body and its most basic units contain water. The various glands of the human body secrete liquid. If there is no water in the body, the secretion of digestive juice will decrease, affecting food digestion and appetite Decreased, slow blood flow, decreased metabolic activity, accumulation of waste toxins in the body, Not only can it cause illness, it can also make it worse.

2. Water plays an important role in regulating body temperature

Because the specific heat value of water is high, 4.18kJ heat is required for each gram of water to rise or fall by 1 ° C. Since the human body contains a large amount of water, the heat generated during the metabolic process can be absorbed by water. The body temperature does not rise significantly. Second, due to the large evaporation value of water, the human body can radiate a large amount of heat as long as a small amount of water is evaporated to maintain a certain body temperature. For example, when the external environment temperature is high, the body heat can follow the moisture Evaporate heat through the skin to maintain constant temperature. Third, water has strong thermal conductivity and is the best good thermal conductor among non-metallic elements. Although the metabolic intensity of various tissues of the human body is different, the heat generated can be passed through. The good thermal conductivity of water keeps the temperature of various tissues and organs consistent and reaches a constant temperature.

3. Water maintains a certain amount of hemolysis in the human body

The water content of human blood is about 80%. If a large amount of water is lost, it can reduce the amount of hemolysis and produce hypotension, which will affect various functional activities of the human body, especially the heart, brain, and kidney. Therefore, the human body The amount of water is closely related to the amount of hemolysis.

4. Water is a lubricant for joints, muscles and body cavities

If there is no water in the body, digestion and absorption, blood circulation, waste metabolism, joint activity, body temperature regulation, organ function, etc. will be affected, so water can play a certain buffer and protection role on various organs and tissues of the human body.

5. Water is one of the three magic weapons of medical treatment

In medical treatment, infusion, oxygen, and blood transfusion are the three magic weapons, especially for patients with high fever, diarrhea, and dehydration. Commonly, 0.9% normal saline or dextrose saline can be injected intravenously, which can often play a role in reviving death. Most diseases are caused by the invasion of various pathogens. In order to eliminate the pathogens, the white blood cells and antibodies in the human body will be actively activated. In addition, various drugs are taken to destroy the pathogens. In order to excrete pathogens, metabolic wastes, and excess medicines, a large amount of water is needed to produce a large amount of urine and sweat, which can expel dead pathogens and metabolic wastes to the outside, and promote the drug's Metabolism, reduce the toxic and side effects of drugs on the human body.

In terms of treatment, both traditional medicine and modern medicine attach great importance to water quality. In traditional Chinese medicine, the water used for decoction in traditional Chinese medicine is rain, dew, and a kind of boiling water. In essence, it is to increase the degree of activation of water, improve the solubility of water, purity, and the ability to adsorb oxygen in order to achieve better prevention of disease and disease. The requirements for water in modern medicine are getting higher and higher, and the process of processing water is also getting higher and higher. From distilled water, purified water, etc., all are based on ensuring the purity of water in medical treatment, which is more conducive to treating diseases as a starting point.

The medical water, various medical injection water, and various medicinal solvents currently used in medicine and recorded in the Pharmacopoeia are distilled water that is basically free of impurities. The preparation method is prepared from the traditional distillation method and developed to Reverse osmosis method ("Chinese Journal of Hospital Pharmacy" 1995. 15 Vol. 12 P562) and membrane separation method ("Medical and Health Equipment" 1996 No. 6 P12), however, with the development of science and technology, and people's The application of new technology and the understanding of human beings, from the molecular level to the gene level, and the continuous emergence of new drugs, the continuous application of new medical technology has made us realize that the previous medical distilled water was not the most ideal medical water. This is because its water molecular group is relatively large, which is not conducive to the dissolution of drugs and enters the human body, so it cannot better play the role of water treatment and participation in metabolism. Technical content of the present invention

The object of the present invention is to provide a physiological function that is more compatible with water and a therapeutic effect in medicine. It has strong cell penetration, water dissolving power, metabolic power, and expansion power, which is conducive to drug dissolution and entry into the human body. Better use of water treatment and medical activated water involved in metabolic functions.

Another object of the present invention is to provide the above-mentioned method for preparing medical activated water and its application to injection diluents, pharmaceutical solvents, physiological regulators, beauty health water, and medical washing water. The scientific basis of this invention is the medical theory of cell membranes-

1. Chemical composition and structure theory of the cell membrane: The chemical composition and molecular structure of the cell membrane is a thin film composed of a liquid lipid bilayer. One side is hydrophilic and the other is a hydrophobic group.

2. Cell membrane material transport theory:

(1) Simple diffusion-Most electrolytes in body fluids have a low permeability to the membrane. The electrolyte must enter the cell by dissociation into ions, and there is a hydration layer around the ions. This shows that the state of the hydration layer and water can affect the combination of electrolyte ions, and thus the permeability of the cell membrane to it. Therefore, in medical treatment, a water molecule group with fewer molecular chains can affect cell metabolism as soon as possible.

(2) Facilitating diffusion:

In the body, some lipid-insoluble or very low-solubility substances such as glucose, amino acids, and various ions are difficult to pass through the cell membrane itself, but with the help of some special proteins on the cell membrane, the cell membrane can be made from a high concentration side It is transported to the low concentration side, so if it is dissolved in these ions such as glucose and amino acids with smaller molecular groups, it will be easier to enter the cell membrane during the treatment process, thereby enhancing the treatment effect.

According to the above theory, the present invention uses the following technical solutions to achieve the object of the invention:

The present invention provides a medical activated water having the following characteristics,

① Does not contain any harmful, toxic and odorous substances to the human body, and basically does not contain any elements other than H and 0 elements;

② PH value is 5. 0 ~ 7.0;

③ The relaxation time of the water molecule group is 2. 16 ~ 10.5 seconds; or the half width of the water molecule group is 0.5 to 2. 45 Hz;

④The dissolving power, osmotic power, expansion power, metabolic power and washing power of water are better than medical distillation Water

⑤ The above characteristics remain stable for 1 year.

The aforementioned medical activated water may also be an oxygenated medical activated water after an oxygen treatment, and the dissolved oxygen in the water is 7 to 20 mg / L.

The present invention also provides a method for preparing the medical activated water, which includes the following steps:

A: Pass the medical distilled water into the IDM activated water system. After the action of the IDM biological activated stone, a part of the macromolecular water group is destroyed, so that it becomes a part of the small molecular group of water;

B: Pass the water obtained in step A into the TKY activated water device to perform TKY activation treatment. When the water passes through the TKY tube, it undergoes bipolar discharge treatment to destroy a part of the macromolecular cluster water, so that more water becomes small molecular clusters. Water

C: The water obtained in step B is then passed into an ultrasonic atomization device for ultrasonic atomization. After the water is ultrasonically atomized, another part of the macromolecular water is destroyed, so that the relaxation time of the water is 2. 16 ~: 10. 5 seconds or half width 0.5 5 ~ 2. 45 Hz;

D: The water obtained in step C is magnetized to realign the water molecules, which meets the requirement of one year for storage, and the product is medical activated water.

In the above method, 7 to 20 mg / L of oxygen can also be added in the ultrasonic atomization process of step C to obtain oxygenated activated medical water.

In the above method, the IDM activation system mainly uses negatively charged activated stones extracted from marine organisms. This type of activated stone can physically change with positively charged water molecule groups in fresh water in nature, and can greatly change the movement of positive and negative charges. The water of the molecular group becomes the water of the small molecular group, and after passing through the positive and negative electrodes, the water molecular group is rearranged so that it becomes a relatively stable water.

TKY activation treatment simulates the principle of space discharge, and generates an environment like lightning discharge, so that electric ions act on water molecular groups, thereby destroying large molecular groups of water and turning it into water with small molecular groups.

Ultrasonic atomization is the use of ultrasonic technology to turn water into atomized water. Under use, the original macromolecular water is destroyed to make it into small molecular water. In the process, appropriate oxygen can also be added to make the water of small molecular groups contain 7 ~ 10mg / L of oxygen. Used in medicine.

The above medical activated water can be used as a diluent for injections;

The above-mentioned medically activated water can also be used as a drug solvent.

The above-mentioned medical activated water can also be used as a physiological regulator, a beauty care water and a medical washing water.

It can be known from the above technical solution that the medical activated water of the present invention adopts modern high-tech means. After the original medical distilled water is further processed, the original macromolecular clusters are changed into molecular clusters, and the original disordered water molecular clusters are magnetized into The threaded water molecule group is more in line with the physiological function of water and the therapeutic effect in medicine, so that those substances that are not easily soluble in water or those that do not easily penetrate the cell membrane can more easily penetrate the cell membrane, which is in line with the theory of medical physiology and pathology .

Compared with the original medical distilled water, the medical activated water of the present invention has: 1. Stronger cell permeability; 2. Stronger body diffusion ability; 3. Stronger metabolic ability; 4. Stronger dissolving ability. Therefore, a good medical effect can be achieved.

The method for preparing medical activated water according to the present invention, in combination with the most advanced technology, can effectively change large molecular groups of water into small molecular groups, thereby achieving the object of the present invention;

At the same time, various injections, glucose, physiological saline, other water for injection, medicinal solvents, physiological regulators, beauty care water, and medical washing water prepared with medical activated water are better than the original various injections, water for injection, and medicine. It is more biologically active with solvents, etc., and conforms to the physiological changes of water in the human body. Its advantages are: activated water with small molecular groups, easier to dissolve glucose, physiological saline, easier access to cell membranes, enhance the effect of the drug, improve the effect of the drug, reduce the energy consumption of the human body, especially for patients, Patients with heart, brain, lung, and kidney disease have reduced side effects. Overview of the drawings

The invention includes the following drawings:

Figure 1 is a NMR spectrum of medical distilled water;

2 is a nuclear magnetic resonance spectrum of medical activated water according to a first embodiment of the present invention;

3 is a nuclear magnetic resonance spectrum of medical activated water according to the third embodiment of the present invention;

FIG. 4 is a block diagram of a process for preparing medical activated water according to the present invention. detailed description

The present invention is described in detail below with reference to examples.

Example 1: Preparation of Medical Activated Water

1. 10 ^ of medical distilled water at room temperature and pressure is passed into the IDM activated water system (developed by Beijing Edman Biotechnology Research Institute), and collected in a reservoir 30 minutes later;

2. Let step 1 above flow into a TKY activated water device (produced by Beijing Yuanheng Lihua High-tech Co., Ltd.). After the TKY tube discharges the water, it flows into another liquid storage tank;

3. Continue to make the water flowing out of the TKY tube enter an ultrasonic atomizing device. (Utility model ZL94215801. 6) The working power source is 220V, 50 Hz, the atomizing power is 40W, the oscillation frequency is 1.6-1.7 MHz, and the atomizing amount is 2n ^ / min, completely atomize 10 ^ water;

4. Pass the water flowing out of step 3 into a magnetization device, hold the time for 30 minutes, release the water stream, and collect it with a liquid storage tank. The obtained is medical activated water, a total of 10 liters.

When the medical activated water was measured, the relaxation time of the water molecule group was 10. 356 seconds and the half width was 2.4 Hz (measured by the Institute of Photographic Chemistry of the Chinese Academy of Sciences) (see Figure 2). Example two: preparation of oxygenated medical activated water

Steps 1, 2, and 4 are the same as in Example 1. In step 3, except that the water is atomized ultrasonically, oxygen is introduced into the atomizer in the atomization process, and the rate is 4 L / h, and the time is 2.5. hour. In this way, oxygenated medical activated water can be obtained, and the oxygen content of the medical activated water in this example is determined to be 15 mg / L. Example 3, the same as in Example 1, the ultrasonic speed of step 3 was changed, the ultrasonic speed was increased to 5m ^ / min, the relaxation time of the obtained medical activated water was 9.1 seconds, and the half width was 2.1 Hz (see Figure 3 ).

Embodiment 4

The medical activated water obtained in Example 3 was returned, and steps 1 to 4 of Example 1 were repeated to obtain medical activated water with smaller molecular clusters, with a relaxation time of 3S and a half width of 0.7 Hz.

The following tests and experiments were performed on the medical activated water obtained from the above examples:

I. Nuclear magnetic resonance measurement was performed by the Institute of Photographic Chemistry of the Chinese Academy of Sciences, and the following conclusions were obtained: The conventional ¹ H nuclear magnetic resonance spectrum (see Figure 1, Figure 2, Figure 3) shows that distilled water and medically activated water are relatively pure, and no impurities are seen.

Determination of relaxation time

A 02ml sample was placed in 0.5ml D ₂ 0. After shaking, the test was performed using a reverse pulse sequence with the condition of 90 °. Pulse width μΞ, pulse interval is 40S, sampling times: 1 times, pulse sequence repetition times: 9 times. The measurement results are shown in Table 1.

Determination of half-width of water molecule clusters:

The test conditions are: 0.02π ^ sample dissolved in 0.5 π ^ heavy water, PW = 2 S, TPWR = 36, SW = 4500 Hz, AT = 2 seconds. Instrument type used: Varian Gemini 300 superconducting nuclear magnetic resonance instrument. The test results are shown in Table 1.

Table 1 Test results

2. Acute toxicology experiment of medical activated water: Sample: medical activated water, saline bottle,

Animals: K and M mice, 80 males, weighing 18-20g, provided by the breeding institute of the Ministry of Health's Pharmaceutical and Biological Product Identification Institute.

Methods: Eighty mice were weighed and randomly divided into four groups of 20 mice each. The mice were perfused with 10ml, 20ml, and 30ml of equal weight. The control group was perfused with an equal volume of normal saline for 7 consecutive days. , And observe for another 7 days.

Results: (see Table 2)

Table 2. Changes in body weight of mice before and after medical activated water administration (mean g / head, N = 20)

summary:

The large dose was 30 times that of adult clinical water. Each dose group was continuously fed with water for 7 days. After the drug was discontinued for 7 days, no abnormalities were found in the animal's diet, behavior, or body weight.

3. The efficacy test of medical activated water physiological saline. The experimental unit is Beijing Xiangyang Medical Technology Institute. The test methods and results are as follows:

Sample:

A. Formulate the medical activated water prepared in Example 1 into 0.9% physiological saline of medical activated water, batch number 980402;

B. Normal saline injection, batch number 970506, (Shijiazhuang Fourth Medicine Co., Ltd.). (. 0.9% saline injection (China Otsuka Pharmaceutical Co., Ltd.), lot number 5G820.

D. Control group, ordinary medical distilled water was formulated into 0.9% saline, batch number 980403, (distilled water provided by Beijing Hospital of Integrated Traditional Chinese and Western Medicine). Animals: K and M mice, 80 males, weighing 18-20g, provided by the breeding institute of the Ministry of Health's Pharmaceutical and Biological Product Identification Institute.

Methods: Eighty mice were weighed and randomly divided into four groups of 20 mice each. The mice were perfused with ABC D group for 7 consecutive days, 20 ml each time, twice a day, 10 a.m. and 3 p.m. Each point was irrigated once, and the other feeding conditions were the same. Observe the micturition time of the mice.

Results: (see Table 3)

Experimental value of pharmacological effect of physiological saline prepared from medical activated water

summary:

Mice were perfused with 20ml saline for 7 consecutive days, and the urination time of the animals was significantly different. Group A was the first, and the other groups had no significant changes.

4. Pharmacodynamic experiments of 10% glucose injection prepared from medical activated water:

Sample:

A, medical activated water is formulated into 10% glucose, batch number 980403;

B. 10% glucose injection, batch number 98062321, (Shijiazhuang Fourth Medicine Co., Ltd.).

C 10% glucose injection, batch number 7H99C, (China Otsuka Pharmaceutical Co., Ltd.).

D. 10% dextrose solution prepared with ordinary distilled water, batch number 980402 (water provided by Beijing Traditional Chinese and Western Medicine Combined Hospital).

Animals: K and M mice, 80 males, weighing 18-30 g, provided by the breeding institute of the Ministry of Health's Pharmaceutical and Biological Product Identification Institute.

Methods: After weighing 80 mice, they were randomly divided into 4 groups, 20 in each group according to ABC D Groups were arranged, and mice were irrigated for 20 consecutive days for 20 days each time, twice a day at 10 am and 3 pm each time, and the remaining feeding conditions were the same. Observe the micturition time of the mice.

Results: (see Table 4)

Table 4.Experimental value of glucose injection prepared by medical activated water

summary:

Mice were perfused with 10% glucose for 20 m for 7 consecutive days. The urination time of the animals showed a significant difference, with group A as the first, and other differences were not obvious. According to the above-mentioned several sets of experiments, it can be clearly shown that the medical activated water prepared by the method of the present invention has smaller water molecular groups, has significantly better medical performance than the original medical water, and can be used as a new generation of medical water products. .

The present invention uses distilled water to transform water from large molecular groups to small molecular groups through physical and chemical methods such as biological activation, photoelectric ultrasound, and magnetization, and is applied to the field of medical water. The preparation process is not limited to a specific device. Those skilled in the art and any other specific implementations made in using the technical solutions of the present invention are also within the scope of the present invention. The protection scope of the present invention is defined by the claims. Industrial applicability

The medical activated water prepared by the method of the present invention has smaller water molecular groups, has significantly better medical performance than the original medical water, and can be used as a new generation product of medical water.

Claims

Rights request

1. A kind of medical activated water with the following characteristics,

② PH value is 5. 0 ~ 7. 0;

③ The relaxation time of the water molecule group is 2. 16 ~: L0. 5 seconds; or the half-width of the water molecule group is 0.5 to 2. 45 Hz;

④The dissolving power, penetrating power, expansion power, metabolic power and washing power of water are better than medical distilled water;

⑤ The above-mentioned technical indicators remain stable for 1 year.

2. The medical activated water according to claim 1, characterized in that it is an oxygenated medical activated water after an oxygen treatment, and the dissolved oxygen in the water is 7 to 20 mg / L.

3. A method for preparing medical activated water according to claim 1, comprising the following steps: A: Passing medical distilled water into the IDM living water system, after the action of the IDM biological activated stone, a part of the macromolecular water group is destroyed, so that it becomes A portion of small molecular clusters of water;

B: the water obtained in step A is subjected to TKY activation treatment, wherein when the water passes through the TKY tube, it undergoes bipolar discharge treatment to destroy a part of the macromolecular cluster water, so that more water becomes small molecular cluster water;

C: The water obtained in step B is further subjected to ultrasonic atomization treatment, after the water is subjected to ultrasonic atomization, another part of the macromolecular water is destroyed, and the relaxation time reaches 2. 16 ~ 10.5 seconds or half width reaches 0.5 ~ 2. 45 Hz;

D: The water obtained in step C is magnetized to rearrange the water molecular groups to reach a relatively stable state, which meets the requirement of a shelf life of 1 year. The product obtained is medical activated water.

4. The method according to claim 3, characterized in that during the ultrasonic atomization in step C, 7 to 20 mg / L of oxygen is added to obtain oxygenated activated medical water. Use of the medically activated water as claimed in claim 1 or 2 as a diluent for injections. The use of medical activated water as claimed in claim 1 or 2 as a solvent for medicine.

Use of the medical activated water as claimed in claim 1 or 2 as a physiological regulator.

Use of the medical activated water as claimed in claim 1 or 2 as a cosmetic health water.

The use of medical activated water as claimed in claim 1 or 2 as medical washing water.