WO1999060938A1 - Method of treatment for premature rupture of membranes in pregnancy (prom) - Google Patents

Method of treatment for premature rupture of membranes in pregnancy (prom) Download PDF

Info

Publication number
WO1999060938A1
WO1999060938A1 PCT/US1999/011352 US9911352W WO9960938A1 WO 1999060938 A1 WO1999060938 A1 WO 1999060938A1 US 9911352 W US9911352 W US 9911352W WO 9960938 A1 WO9960938 A1 WO 9960938A1
Authority
WO
WIPO (PCT)
Prior art keywords
cervix
fluent
fluent material
patient
uterine wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/011352
Other languages
English (en)
French (fr)
Inventor
Stephen J. Herman
Glenn M. Kazo
David J. Enscore
J. Jeffrey Kablik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Focal Inc
Original Assignee
Focal Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Focal Inc filed Critical Focal Inc
Priority to EP99924451A priority Critical patent/EP1079749A1/en
Priority to CA002332978A priority patent/CA2332978A1/en
Priority to JP2000550406A priority patent/JP2002516140A/ja
Priority to AU40948/99A priority patent/AU745302B2/en
Publication of WO1999060938A1 publication Critical patent/WO1999060938A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00491—Surgical glue applicators

Definitions

  • the invention involves use of a fluent material for the manufacture of a medicament for use in a method of providing therapeutic treatment to an amniotic membrane of a patient or a uterine wall or cervix of a pregnant patient, the method comprising applying the fluent material to the amniotic membrane of the patient or the uterine wall or cervix of the pregnant patient, and causing the fluent material to become non fluent.
  • the invention involves use of a gelling material for the manufacture of a medicament for use in a method of treating premature rupture of the membranes of pregnancy (PROM) by instilling a gelling material to form a layer in a treatment space, wherein the treatment space is bounded by one or more of the amniotic membrane, the cervix and the uterine wall, and causing the material to form a hydrogel, thereby providing a hydraulic seal which retains amniotic fluid.
  • PROM premature rupture of the membranes of pregnancy
  • FIG. 1 is a schematic diagram of a gravid uterus for the purpose of illustrating techniques of the invention.
  • Another aspect of the invention provides methods and materials for repair or resealing of an amniotic membrane puncture or incision made for diagnostic or surgical purposes.
  • trans-vaginal route a route by which material of the invention could be placed in the uterus, especially near the proximal cervix.
  • trans-abdominal route a route by which material of the invention could be placed in the uterus, especially near the proximal cervix.
  • the application instrument After passage to the treatment space, the application instrument operates in essentially the same manner as the transvaginal applicator, and has the same set of options in terms of mechanisms of application and of visualization. In addition, visualization or light delivery or both could be provided transvaginally.
  • the patient can be placed in the appropriate position, and the volume of the treatment space is then estimated from ultrasound measurements. Then, as an option for some polymerizable systems, a similar volume of a priming solution is injected through a first lumen in the instrument, to stain the walls of the treatment space with an initiator or catalyst of polymerization and other polymerization aids, or in general a material designed to increase adherence of the barrier to the tissue may be used. Excess initiator or other solution is removed by application of mild suction to the primer lumen. Then a polymerizable gel- forming solution, of about the estimated treatment space volume or with a small excess, is injected through a lumen, which may be the primer lumen or a different lumen.
  • a gel- forming macromer is synthesized according to methods known in the art, for example U.S. Patent No. 5,410,016 or any of the other cited applications.
  • the gel-forming solution should preferably be of high viscosity, or even of a paste-like consistency when in the body, to prevent unwanted spreading of the agent beyond the treatment space.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Materials For Medical Uses (AREA)
  • Surgical Instruments (AREA)
  • Prostheses (AREA)
PCT/US1999/011352 1998-05-23 1999-05-21 Method of treatment for premature rupture of membranes in pregnancy (prom) Ceased WO1999060938A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99924451A EP1079749A1 (en) 1998-05-23 1999-05-21 Method of treatment for premature rupture of membranes in pregnancy (prom)
CA002332978A CA2332978A1 (en) 1998-05-23 1999-05-21 Method of treatment for premature rupture of membranes in pregnancy (prom)
JP2000550406A JP2002516140A (ja) 1998-05-23 1999-05-21 妊娠の早期破水（ｐｒｏｍ）を治療する方法
AU40948/99A AU745302B2 (en) 1998-05-23 1999-05-21 Method of treatment for premature rupture of membranes in pregnancy (PROM)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8662498P 1998-05-23 1998-05-23
US60/086,624 1998-05-23

Publications (1)

Publication Number Publication Date
WO1999060938A1 true WO1999060938A1 (en) 1999-12-02

Family

ID=22199813

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/011352 Ceased WO1999060938A1 (en) 1998-05-23 1999-05-21 Method of treatment for premature rupture of membranes in pregnancy (prom)

Country Status (6)

Country Link
US (1) US6350463B1 (enExample)
EP (1) EP1079749A1 (enExample)
JP (1) JP2002516140A (enExample)
AU (1) AU745302B2 (enExample)
CA (1) CA2332978A1 (enExample)
WO (1) WO1999060938A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104771778A (zh) * 2015-03-26 2015-07-15 昆明理工大学 一种微纳米级魔芋葡苷聚糖纤维支架材料的制备方法
CN110573193A (zh) * 2017-04-28 2019-12-13 三洋化成工业株式会社 生殖器用密封剂

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6165193A (en) * 1998-07-06 2000-12-26 Microvention, Inc. Vascular embolization with an expansible implant
US7175647B2 (en) * 2000-04-18 2007-02-13 David Berry Repair of ruptured membrane by injection of naturally occurring protein in amniotic fluid sac
US6391047B1 (en) * 2000-04-18 2002-05-21 David Berry Repair of ruptured membrane by injection of naturally occurring protein in amniotic fluid sac
EP1497387A1 (de) * 2002-04-24 2005-01-19 BASF Coatings Aktiengesellschaft Carbamat- und/oder allophanatgruppen enthaltende, thermisch härtbare, thixotrope gemische
US7497864B2 (en) * 2003-04-30 2009-03-03 Marctec, Llc. Tissue fastener and methods for using same
US7479112B2 (en) * 2003-08-26 2009-01-20 Cardiac Pacemakers, Inc. Acoustic physiological sensor
US20050233400A1 (en) * 2004-03-03 2005-10-20 Weiner Carl P Proteomic method for predicting success of rescue cerclage
US8182647B2 (en) 2007-07-23 2012-05-22 Cohera Medical, Inc. Hydrophilic biodegradable adhesives
CN101322858B (zh) * 2008-07-14 2013-06-12 昆明理工大学 一种引导骨组织再生修复的可降解多孔支架材料及其制备方法
CN102368966B (zh) * 2008-08-18 2014-12-03 约翰·M·奥布莱恩 子宫颈阻塞体
US8409602B2 (en) * 2009-07-30 2013-04-02 Northwestern University Sealants for fetal membrane repair
WO2011057131A1 (en) 2009-11-09 2011-05-12 Spotlight Technology Partners Llc Polysaccharide based hydrogels
JP2013509963A (ja) 2009-11-09 2013-03-21 スポットライト テクノロジー パートナーズ エルエルシー 断片化ヒドロゲル
US12076047B2 (en) 2012-03-15 2024-09-03 Alydia Health, Inc. Uterine hemorrhage controlling system and method
US10064651B2 (en) 2012-03-15 2018-09-04 Inpress Technologies, Inc. Uterine hemorrhage controlling system and method
ES2756332T3 (es) 2012-09-10 2020-04-27 Univ Wake Forest Health Sciences Membrana amniótica y su uso en cicatrización de heridas y construcciones de ingeniería tisular
JP2017530153A (ja) 2014-10-02 2017-10-12 ウェイク フォレスト ユニバーシティー ヘルス サイエンシズ 羊膜粉末ならびに創傷治癒および組織工学構築物におけるその使用
CA2970831C (en) 2015-01-10 2024-01-09 Nine Medical, Inc. Methods and devices to prevent premature birth
US11517336B2 (en) 2016-08-24 2022-12-06 Alydia Health, Inc. Uterine hemorrhage controlling system and method
KR102837199B1 (ko) 2018-12-10 2025-07-21 알리디아 헬스 인코포레이티드 산후 자궁 출혈 디바이스
EP3902506A4 (en) 2018-12-28 2022-09-28 Nine Medical, Inc. METHODS AND DEVICES FOR THE PREVENTION OF PREMATURE CHILDREN, STILL CHILDREN, MISSORBORSHIP, INFECTION OR PREGNANCY
US20200258426A1 (en) * 2019-02-08 2020-08-13 Caldera Medical, Inc. Uterine Model With Pathology
CN113171164B (zh) * 2021-04-13 2023-02-17 清华大学 用于体内原位生物制造的胎膜早破修补装置

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4007249A (en) * 1974-07-15 1977-02-08 The Franklin Institute Research Laboratories Method of forming a removable cervical cap
US4100923A (en) * 1976-12-16 1978-07-18 The Upjohn Company Extra-amniotic administration device
US4128100A (en) * 1976-10-08 1978-12-05 Wendorff Erwin R Suture
US4693704A (en) * 1982-10-12 1987-09-15 Sumitomo Bakelite Company Limited Cervical canal catheter
US4722730A (en) * 1986-02-27 1988-02-02 Michael Reese Hospital And Med. Center Apparatus for relief of fetal distress during labor
US5338297A (en) * 1993-03-19 1994-08-16 Kocur Medical Associates Cervical canal balloon catheter
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5575815A (en) 1988-08-24 1996-11-19 Endoluminal Therapeutics, Inc. Local polymeric gel therapy
US5612050A (en) 1993-03-23 1997-03-18 Focal, Inc. Apparatus and method for local application of polymeric material to tissue
US5752974A (en) * 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US5800373A (en) 1995-03-23 1998-09-01 Focal, Inc. Initiator priming for improved adherence of gels to substrates
US5900245A (en) 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188951A (en) 1972-08-17 1980-02-19 Alza Corporation Intrauterine system embracing selected copolymeric membranes for administering beneficial agent
US5201745A (en) 1988-03-15 1993-04-13 Imedex Visceral surgery patch
US5634946A (en) 1988-08-24 1997-06-03 Focal, Inc. Polymeric endoluminal paving process
US5328471A (en) 1990-02-26 1994-07-12 Endoluminal Therapeutics, Inc. Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens
US5674192A (en) 1990-12-28 1997-10-07 Boston Scientific Corporation Drug delivery
US5283063A (en) 1992-01-31 1994-02-01 Eagle Vision Punctum plug method and apparatus
US5469867A (en) 1992-09-02 1995-11-28 Landec Corporation Cast-in place thermoplastic channel occluder
US5749968A (en) 1993-03-01 1998-05-12 Focal, Inc. Device for priming for improved adherence of gels to substrates
ATE169483T1 (de) 1993-04-28 1998-08-15 Focal Inc Vorrichtung, produkt und verwendung betreffend die intraluminale photothermoformgebung
US5769091A (en) 1993-09-20 1998-06-23 Uromed Corporation Urethral plug having adhesive for enhanced sealing capabilities and method of using said plug
US5474065A (en) 1994-04-04 1995-12-12 Graphic Controls Corporation Non-invasive fetal probe
ATE247933T1 (de) 1994-06-06 2003-09-15 Univ Case Western Reserve Biomatrix für geweberegenaration
US5583114A (en) 1994-07-27 1996-12-10 Minnesota Mining And Manufacturing Company Adhesive sealant composition
US5516532A (en) 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
DE69520044T2 (de) 1994-10-12 2001-06-13 Focal, Inc. Zielgerichte verabreichung mittels biologisch abbaubarer polymere
US5906934A (en) 1995-03-14 1999-05-25 Morphogen Pharmaceuticals, Inc. Mesenchymal stem cells for cartilage repair
US5612052A (en) 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US5779673A (en) 1995-06-26 1998-07-14 Focal, Inc. Devices and methods for application of intraluminal photopolymerized gels
US5810721A (en) 1996-03-04 1998-09-22 Heartport, Inc. Soft tissue retractor and method for providing surgical access
US5863551A (en) 1996-10-16 1999-01-26 Organogel Canada Ltee Implantable polymer hydrogel for therapeutic uses
US5993856A (en) 1997-01-24 1999-11-30 Femmepharma Pharmaceutical preparations and methods for their administration

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4007249A (en) * 1974-07-15 1977-02-08 The Franklin Institute Research Laboratories Method of forming a removable cervical cap
US4128100A (en) * 1976-10-08 1978-12-05 Wendorff Erwin R Suture
US4100923A (en) * 1976-12-16 1978-07-18 The Upjohn Company Extra-amniotic administration device
US4693704A (en) * 1982-10-12 1987-09-15 Sumitomo Bakelite Company Limited Cervical canal catheter
US4722730A (en) * 1986-02-27 1988-02-02 Michael Reese Hospital And Med. Center Apparatus for relief of fetal distress during labor
US5575815A (en) 1988-08-24 1996-11-19 Endoluminal Therapeutics, Inc. Local polymeric gel therapy
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5338297A (en) * 1993-03-19 1994-08-16 Kocur Medical Associates Cervical canal balloon catheter
US5612050A (en) 1993-03-23 1997-03-18 Focal, Inc. Apparatus and method for local application of polymeric material to tissue
US5800373A (en) 1995-03-23 1998-09-01 Focal, Inc. Initiator priming for improved adherence of gels to substrates
US5752974A (en) * 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US5900245A (en) 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104771778A (zh) * 2015-03-26 2015-07-15 昆明理工大学 一种微纳米级魔芋葡苷聚糖纤维支架材料的制备方法
CN110573193A (zh) * 2017-04-28 2019-12-13 三洋化成工业株式会社 生殖器用密封剂
EP3620187A4 (en) * 2017-04-28 2021-01-13 Sanyo Chemical Industries, Ltd. SEALANT FOR GENITALS
US20220040386A1 (en) * 2017-04-28 2022-02-10 Sanyo Chemical Industries, Ltd. Sealing agent for genitals
US12109336B2 (en) * 2017-04-28 2024-10-08 Sanyo Chemical Industries, Ltd. Sealing agent for genitals

Also Published As

Publication number Publication date
AU745302B2 (en) 2002-03-21
JP2002516140A (ja) 2002-06-04
EP1079749A1 (en) 2001-03-07
AU4094899A (en) 1999-12-13
US6350463B1 (en) 2002-02-26
CA2332978A1 (en) 1999-12-02

Similar Documents

Publication Publication Date Title
US6350463B1 (en) Method of treatment for premature rupture of membranes in pregnancy (PROM)
US5411475A (en) Directly visualized method for deploying a detachable balloon at a target site in vivo
US7780980B2 (en) Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US20160243272A1 (en) Surgical adhesive and uses therefore
JP2010227563A (ja) 低膨潤性生体適合性ヒドロゲル
JP2010227564A (ja) 低膨潤性生体適合性ヒドロゲル
BR9711537B1 (pt) macrâmero polimerizÁvel biodegradÁvel, mÉtodo para aumentar a elasticidade de um gel de polÍmero hidrofÍlico e mÉtodo para melhorar a biodegradabilidade de um macrâmero quimicamente reativo compreendendo carbonato.
JP2008212683A (ja) 低膨潤性生体適合性ヒドロゲル
CA2728186A1 (en) Methods and devices for use with sealants
KR20230107626A (ko) 자궁 내 사용을 위한 인시튜로 형성된 하이드로겔 및 조성물 설계
US20240100091A1 (en) Method and kit for treating abnormal hollowed space
US20220142653A1 (en) Transcervical access systems for intrauterine fluid exchange, such as placement of hydrogels formed in situ
CA2787138C (en) Composition for producing a temporary intestinal occlusion
Moriarty et al. Use of FloSeal™ haemostatic gel in massive obstetric haemorrhage: a case report.
JPH10174711A (ja) コンプライアントな組織シーラント
US8691245B2 (en) Composition for forming a temporary obstruction and method of forming the same
RU2283057C1 (ru) Способ временной эндоскопической обтурации перфорации желудка
CN120529921A (zh) 利用水凝胶基体的化学组织消融与相关医疗应用
EP4450074A1 (en) Composition for use in tissue reconstruction and tissue regrowth

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 40948/99

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2332978

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: KR

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 550406

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1999924451

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1999924451

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 40948/99

Country of ref document: AU

WWW Wipo information: withdrawn in national office

Ref document number: 1999924451

Country of ref document: EP