WO1999059541A3 - Preparations de cyclosporine - Google Patents

Preparations de cyclosporine Download PDF

Info

Publication number
WO1999059541A3
WO1999059541A3 PCT/EP1999/003002 EP9903002W WO9959541A3 WO 1999059541 A3 WO1999059541 A3 WO 1999059541A3 EP 9903002 W EP9903002 W EP 9903002W WO 9959541 A3 WO9959541 A3 WO 9959541A3
Authority
WO
WIPO (PCT)
Prior art keywords
cyclosporin
preparations
solid
cyclosporin preparations
presented
Prior art date
Application number
PCT/EP1999/003002
Other languages
German (de)
English (en)
Other versions
WO1999059541A2 (fr
Inventor
Robert Heger
Helmut Auweter
Peter Pflueger
Joerg Breitenbach
Rudolf Binder
Juergen Zeidler
Gunther Berndl
Original Assignee
Basf Ag
Robert Heger
Helmut Auweter
Peter Pflueger
Joerg Breitenbach
Rudolf Binder
Juergen Zeidler
Gunther Berndl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag, Robert Heger, Helmut Auweter, Peter Pflueger, Joerg Breitenbach, Rudolf Binder, Juergen Zeidler, Gunther Berndl filed Critical Basf Ag
Priority to EP99922158A priority Critical patent/EP1077676A2/fr
Priority to AU39303/99A priority patent/AU3930399A/en
Priority to CA002332270A priority patent/CA2332270A1/fr
Priority to JP2000549206A priority patent/JP2002515415A/ja
Publication of WO1999059541A2 publication Critical patent/WO1999059541A2/fr
Publication of WO1999059541A3 publication Critical patent/WO1999059541A3/fr
Priority to NO20005769A priority patent/NO20005769D0/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

Abstract

L'invention concerne des préparations de cyclosporine solides ou liquides destinées à être administrées par voie orale et dans lesquelles la cyclosporine se présente sous forme de particules solides amorphes aux rayons X encapsulées en dispersion colloïdale dans une matrice d'enrobage.
PCT/EP1999/003002 1998-05-15 1999-05-04 Preparations de cyclosporine WO1999059541A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP99922158A EP1077676A2 (fr) 1998-05-15 1999-05-04 Preparations de cyclosporine
AU39303/99A AU3930399A (en) 1998-05-15 1999-05-04 Cyclosporin preparations
CA002332270A CA2332270A1 (fr) 1998-05-15 1999-05-04 Preparations de cyclosporine
JP2000549206A JP2002515415A (ja) 1998-05-15 1999-05-04 シクロスポリン製剤
NO20005769A NO20005769D0 (no) 1998-05-15 2000-11-14 Cyklosporinderivater

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19821951A DE19821951A1 (de) 1998-05-15 1998-05-15 Cyclosporin-Zubereitungen
DE19821951.2 1998-05-15

Publications (2)

Publication Number Publication Date
WO1999059541A2 WO1999059541A2 (fr) 1999-11-25
WO1999059541A3 true WO1999059541A3 (fr) 2000-01-20

Family

ID=7867961

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/003002 WO1999059541A2 (fr) 1998-05-15 1999-05-04 Preparations de cyclosporine

Country Status (8)

Country Link
EP (1) EP1077676A2 (fr)
JP (1) JP2002515415A (fr)
CN (1) CN1301171A (fr)
AU (1) AU3930399A (fr)
CA (1) CA2332270A1 (fr)
DE (1) DE19821951A1 (fr)
NO (1) NO20005769D0 (fr)
WO (1) WO1999059541A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920558D0 (en) * 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
GB2381453A (en) * 1999-08-31 2003-05-07 Bradford Particle Design Ltd Active/polymer coformulations
US20020034525A1 (en) 2000-06-30 2002-03-21 Kao Corporation Skin cosmetic composition
PT2079456E (pt) * 2007-04-04 2013-03-13 Sigmoid Pharma Ltd Composições farmacêuticas de ciclosporina
JP6627380B2 (ja) * 2015-09-30 2020-01-08 ユーハ味覚糖株式会社 アスコルビン酸もしくはアスコルビン酸誘導体の浸透性を向上させたナノ粒子分散液
CN106173799B (zh) * 2016-07-08 2019-08-16 武汉轻工大学 纳他霉素微乳液及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018105A1 (fr) * 1991-04-19 1992-10-29 Sandoz Ltd. Perfectionnements apportes aux compositions pharmaceutiques
WO1993013753A1 (fr) * 1992-01-17 1993-07-22 Alfatec-Pharma Gmbh Comprimes contenant des medicaments peptidiques, leur fabrication et leur application
WO1996014079A1 (fr) * 1994-11-03 1996-05-17 Arzneimittelwerk Dresden Gmbh Nouvelles formes de preparations de cycylosporines pour administration par voie orale, de composition simple et haute biodisponibilite, et leur procede de production
WO1996022103A1 (fr) * 1995-01-21 1996-07-25 Cheil Foods & Chemicals, Inc. Formulations solides pour l'administration de cyclosporine a par voie orale
WO1996031202A1 (fr) * 1995-04-03 1996-10-10 Elan Corporation, Plc Microspheres et nanospheres biodegradables a liberation lente renfermant de la cyclosporine
WO1997035603A1 (fr) * 1996-03-25 1997-10-02 Sangstat Medical Corporation Formulations de cyclosporine a sous forme de nanoparticules

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018105A1 (fr) * 1991-04-19 1992-10-29 Sandoz Ltd. Perfectionnements apportes aux compositions pharmaceutiques
WO1993013753A1 (fr) * 1992-01-17 1993-07-22 Alfatec-Pharma Gmbh Comprimes contenant des medicaments peptidiques, leur fabrication et leur application
WO1996014079A1 (fr) * 1994-11-03 1996-05-17 Arzneimittelwerk Dresden Gmbh Nouvelles formes de preparations de cycylosporines pour administration par voie orale, de composition simple et haute biodisponibilite, et leur procede de production
WO1996022103A1 (fr) * 1995-01-21 1996-07-25 Cheil Foods & Chemicals, Inc. Formulations solides pour l'administration de cyclosporine a par voie orale
WO1996031202A1 (fr) * 1995-04-03 1996-10-10 Elan Corporation, Plc Microspheres et nanospheres biodegradables a liberation lente renfermant de la cyclosporine
WO1997035603A1 (fr) * 1996-03-25 1997-10-02 Sangstat Medical Corporation Formulations de cyclosporine a sous forme de nanoparticules

Also Published As

Publication number Publication date
CA2332270A1 (fr) 1999-11-25
CN1301171A (zh) 2001-06-27
DE19821951A1 (de) 1999-11-18
JP2002515415A (ja) 2002-05-28
EP1077676A2 (fr) 2001-02-28
WO1999059541A2 (fr) 1999-11-25
NO20005769L (no) 2000-11-14
NO20005769D0 (no) 2000-11-14
AU3930399A (en) 1999-12-06

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