WO1999059541A3 - Cyclosporin preparations - Google Patents

Cyclosporin preparations Download PDF

Info

Publication number
WO1999059541A3
WO1999059541A3 PCT/EP1999/003002 EP9903002W WO9959541A3 WO 1999059541 A3 WO1999059541 A3 WO 1999059541A3 EP 9903002 W EP9903002 W EP 9903002W WO 9959541 A3 WO9959541 A3 WO 9959541A3
Authority
WO
WIPO (PCT)
Prior art keywords
cyclosporin
preparations
solid
cyclosporin preparations
presented
Prior art date
Application number
PCT/EP1999/003002
Other languages
German (de)
French (fr)
Other versions
WO1999059541A2 (en
Inventor
Robert Heger
Helmut Auweter
Peter Pflueger
Joerg Breitenbach
Rudolf Binder
Juergen Zeidler
Gunther Berndl
Original Assignee
Basf Ag
Robert Heger
Helmut Auweter
Peter Pflueger
Joerg Breitenbach
Rudolf Binder
Juergen Zeidler
Gunther Berndl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag, Robert Heger, Helmut Auweter, Peter Pflueger, Joerg Breitenbach, Rudolf Binder, Juergen Zeidler, Gunther Berndl filed Critical Basf Ag
Priority to CA002332270A priority Critical patent/CA2332270A1/en
Priority to JP2000549206A priority patent/JP2002515415A/en
Priority to EP99922158A priority patent/EP1077676A2/en
Priority to AU39303/99A priority patent/AU3930399A/en
Publication of WO1999059541A2 publication Critical patent/WO1999059541A2/en
Publication of WO1999059541A3 publication Critical patent/WO1999059541A3/en
Priority to NO20005769A priority patent/NO20005769L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to solid or liquid cyclosporin preparations for oral administration in which the cyclosporin is presented in the form of solid X-amorphous particles embedded in a coating matrix in a colloidally dispersed manner.
PCT/EP1999/003002 1998-05-15 1999-05-04 Cyclosporin preparations WO1999059541A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002332270A CA2332270A1 (en) 1998-05-15 1999-05-04 Cyclosporin preparations
JP2000549206A JP2002515415A (en) 1998-05-15 1999-05-04 Cyclosporine preparation
EP99922158A EP1077676A2 (en) 1998-05-15 1999-05-04 Cyclosporin preparations
AU39303/99A AU3930399A (en) 1998-05-15 1999-05-04 Cyclosporin preparations
NO20005769A NO20005769L (en) 1998-05-15 2000-11-14 cyclosporin derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19821951A DE19821951A1 (en) 1998-05-15 1998-05-15 Orally administered solid or liquid cyclosporin compositions
DE19821951.2 1998-05-15

Publications (2)

Publication Number Publication Date
WO1999059541A2 WO1999059541A2 (en) 1999-11-25
WO1999059541A3 true WO1999059541A3 (en) 2000-01-20

Family

ID=7867961

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/003002 WO1999059541A2 (en) 1998-05-15 1999-05-04 Cyclosporin preparations

Country Status (8)

Country Link
EP (1) EP1077676A2 (en)
JP (1) JP2002515415A (en)
CN (1) CN1301171A (en)
AU (1) AU3930399A (en)
CA (1) CA2332270A1 (en)
DE (1) DE19821951A1 (en)
NO (1) NO20005769L (en)
WO (1) WO1999059541A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2381453A (en) * 1999-08-31 2003-05-07 Bradford Particle Design Ltd Active/polymer coformulations
GB9920558D0 (en) * 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
US20020034525A1 (en) * 2000-06-30 2002-03-21 Kao Corporation Skin cosmetic composition
JP2010523554A (en) * 2007-04-04 2010-07-15 シグモイド・ファーマ・リミテッド Pharmaceutical composition of tacrolimus
JP6627380B2 (en) * 2015-09-30 2020-01-08 ユーハ味覚糖株式会社 Nanoparticle dispersion liquid with improved permeability of ascorbic acid or ascorbic acid derivative
CN106173799B (en) * 2016-07-08 2019-08-16 武汉轻工大学 Natamycin microemulsion and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018105A1 (en) * 1991-04-19 1992-10-29 Sandoz Ltd. Improvements in pharmaceutical compositions
WO1993013753A1 (en) * 1992-01-17 1993-07-22 Alfatec-Pharma Gmbh Pellets containing peptide drugs, their manufacture and use
WO1996014079A1 (en) * 1994-11-03 1996-05-17 Arzneimittelwerk Dresden Gmbh Novel cyclosporine preparation forms for oral administration of simple composition and high bio-availability, and process for producing them
WO1996022103A1 (en) * 1995-01-21 1996-07-25 Cheil Foods & Chemicals, Inc. Solid formulations for oral administration of cyclosporine a
WO1996031202A1 (en) * 1995-04-03 1996-10-10 Elan Corporation, Plc Controlled release biodegradable micro- and nanospheres containing cyclosporin
WO1997035603A1 (en) * 1996-03-25 1997-10-02 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018105A1 (en) * 1991-04-19 1992-10-29 Sandoz Ltd. Improvements in pharmaceutical compositions
WO1993013753A1 (en) * 1992-01-17 1993-07-22 Alfatec-Pharma Gmbh Pellets containing peptide drugs, their manufacture and use
WO1996014079A1 (en) * 1994-11-03 1996-05-17 Arzneimittelwerk Dresden Gmbh Novel cyclosporine preparation forms for oral administration of simple composition and high bio-availability, and process for producing them
WO1996022103A1 (en) * 1995-01-21 1996-07-25 Cheil Foods & Chemicals, Inc. Solid formulations for oral administration of cyclosporine a
WO1996031202A1 (en) * 1995-04-03 1996-10-10 Elan Corporation, Plc Controlled release biodegradable micro- and nanospheres containing cyclosporin
WO1997035603A1 (en) * 1996-03-25 1997-10-02 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles

Also Published As

Publication number Publication date
WO1999059541A2 (en) 1999-11-25
EP1077676A2 (en) 2001-02-28
DE19821951A1 (en) 1999-11-18
NO20005769D0 (en) 2000-11-14
CA2332270A1 (en) 1999-11-25
AU3930399A (en) 1999-12-06
CN1301171A (en) 2001-06-27
JP2002515415A (en) 2002-05-28
NO20005769L (en) 2000-11-14

Similar Documents

Publication Publication Date Title
AU1211397A (en) Shampoo composition containing capsules or particles
AU4151099A (en) Cosmetic or dermopharmaceutical composition in the form of beads and methods forpreparing same
AU3136897A (en) Compositions, methods and devices for the transdermal delivery of drugs
CA2294783A1 (en) Pharmaceutical compositions for oral administration, comprising an active substance and a cyclodextrin
AU6076198A (en) Specific antibodies for use in preparation of pharmaceutical compositions useful in the prevention or treatment of gastritis, gastric ulcers and duodenal ulcers
CA2270177A1 (en) Transdermal administration of ment
AU6190298A (en) Liquid antacid compositions
AU1800600A (en) Ume extract having medicinal effects and compositions containing the same
AU5910199A (en) Valve assembly for preventing liquid ingestion and methods
ZA983849B (en) Pharmaceutical compositions of tizoxanide and nitazoxanide.
AU2543399A (en) Anticonvulsant drugs and pharmaceutical compositions thereof
AU7497798A (en) 3-epi compounds of vitamin d3 and uses thereof
WO1999059541A3 (en) Cyclosporin preparations
HK1042424A1 (en) Preparations containing virus-like particles as immunopotentiators administered through the mucosa
AU2002358418A1 (en) Pharmaceutical preparation containing micro-encapsulated or nano-encapsulated ginsenosides
AU4218400A (en) Lyophilized solid dosage forms and methods of making
CA2348474A1 (en) Pharmaceutically active composition and dispensing device
AU8447498A (en) Prosthetic valve sinus
WO1999021574A3 (en) Enhancement of morphogen activity
IL116828A0 (en) Use of 3,4-diphenyl chromans for the preparation of pharmaceutical compositions
HK1025907A1 (en) Pharmaceutical compositions of tizoxanide and nitazoxanide.
IL116745A0 (en) Use of 3,4-diphenyl chromans for the preparation of pharmaceutical compositions
AU2002252981A1 (en) Pharmaceutical compositions containing beta-mimetic agents and having few side-effects
AU5072000A (en) Pharmaceutical composition for nasally administering water-soluble active substances
AUPP307398A0 (en) Fluid pump and actuating system incorporating piezoceramic elements

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 99806202.2

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AL AU BG BR BY CA CN CZ GE HU ID IL IN JP KR KZ LT LV MK MX NO NZ PL RO RU SG SI SK TR UA US ZA

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AU BG BR BY CA CN CZ GE HU ID IL IN JP KR KZ LT LV MK MX NO NZ PL RO RU SG SI SK TR UA US ZA

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 1999922158

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 09674923

Country of ref document: US

ENP Entry into the national phase

Ref document number: 2332270

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: KR

WWP Wipo information: published in national office

Ref document number: 1999922158

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: CA

WWW Wipo information: withdrawn in national office

Ref document number: 1999922158

Country of ref document: EP