WO1999056636A1 - Method and apparatus for occlusion and reinforcement of aneurysms - Google Patents

Method and apparatus for occlusion and reinforcement of aneurysms Download PDF

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Publication number
WO1999056636A1
WO1999056636A1 PCT/US1999/007952 US9907952W WO9956636A1 WO 1999056636 A1 WO1999056636 A1 WO 1999056636A1 US 9907952 W US9907952 W US 9907952W WO 9956636 A1 WO9956636 A1 WO 9956636A1
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WO
WIPO (PCT)
Prior art keywords
aneurysm
occlusive
vasoocclusive
strut members
occlusive apparatus
Prior art date
Application number
PCT/US1999/007952
Other languages
French (fr)
Other versions
WO1999056636A8 (en
Inventor
Christopher G. M. Ken
David A. Ferrera
Original Assignee
Micrus Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22106829&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1999056636(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Micrus Corporation filed Critical Micrus Corporation
Priority to DE69928794T priority Critical patent/DE69928794T2/en
Priority to JP2000546673A priority patent/JP4108273B2/en
Priority to EP99917418A priority patent/EP1076518B1/en
Priority to AU35547/99A priority patent/AU3554799A/en
Publication of WO1999056636A1 publication Critical patent/WO1999056636A1/en
Publication of WO1999056636A8 publication Critical patent/WO1999056636A8/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12027—Type of occlusion
    • A61B17/12036—Type of occlusion partial occlusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A61B17/12172—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A61B2017/12054—Details concerning the detachment of the occluding device from the introduction device
    • A61B2017/12068—Details concerning the detachment of the occluding device from the introduction device detachable by heat
    • A61B2017/12072—Details concerning the detachment of the occluding device from the introduction device detachable by heat the heat created by laser light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A61B2017/12054—Details concerning the detachment of the occluding device from the introduction device
    • A61B2017/12068—Details concerning the detachment of the occluding device from the introduction device detachable by heat
    • A61B2017/12077—Joint changing shape upon application of heat, e.g. bi-metal or reversible thermal memory

Definitions

  • This invention relates generally to implantable devices for interventional therapeutic treatment of defects in the vasculature, and more particularly concerns a detachable device having multiple strut members with collapsed and expanded configurations to be used in combination with a catheter for the occlusion and reinforcement of aneurysms.
  • vasoocclusive devices are typically placed within the vasculature of the human body by use of a catheter, either to block the flow of blood through a vessel making up that portion of the vasculature through the formation of an embolus, or to form such an embolus within an aneurysm sterrrming from the vessel.
  • Vasoocclusive devices used for these procedures can have a variety of configurations, and are generally formed of one or more elements that are larger in the deployed configuration than when they are within the delivery catheter prior to placement.
  • One anatomically shaped vasoocclusive device that forms itself into a shape of an anatomical cavity such as an aneurysm is made of a preformed strand of flexible material such as a nickel-titanium alloy.
  • One or more of such vasoocclusive members can be wound to form a generally spherical or oval shape in a relaxed, expanded state, and can be readily deformed to fit within a small diameter catheter from which they can be deployed at a treatment site.
  • Aneurysms have been treated with external surgically placed clips, or using vascular catheters, by detachable vasoocclusive balloons or an embolus generating vasoocclusive device such as one or more vasoocclusive coils.
  • the delivery of such vasoocclusive devices can be accomplished by a variety of means, including via a catheter in which the device is pushed through an opening at the distal end of the catheter by a pusher to deploy the device.
  • the vasoocclusive devices can be produced in such a way that they will readily pass through the lumen of a catheter in a linear shape and take on a complex shape as originally formed after being deployed into the area of interest, such as an aneurysm.
  • One vasoocclusive device used to treat aneurysms is a tightly wound coil that is pushed into the aneurysm through the neck of the aneurysm so that the coil forms a complex shape with the aneurysm.
  • an embolus generating vasoocclusive device such as a vasoocclusive coil
  • the success of the treatment depends upon whether the embolus generating vasoocclusive device can migrate out of the aneurysm through the neck of the aneurysm, which in turn is somewhat dependent upon whether the ratio of the diameter of the dome portion of the aneurysm to the diameter of the neck of the aneurysm is less than approximately 2:1. If the dome to neck ratio is larger than approximately 2: 1, the possibility that the embolus generating vasoocclusive device will migrate out of the aneurysm into the parent vessel becomes greater, posing a risk to the success of the procedure.
  • vasoocclusive device that can be used with or without a stent, coil or the like, that can be delivered to an aneurysm or other body vessel in a primary collapsed configuration, where the vasoocclusive device can be deployed and released to assume a secondary, expanded configuration which partially occludes the neck of the aneurysm and which also allows deployment of an additional embolus generating vasoocclusive device such as an embolic coil within the aneurysm, and blocks migration of the embolus generating vasoocclusive device from the aneurysm to the vessel.
  • an additional embolus generating vasoocclusive device such as an embolic coil within the aneurysm
  • a shape memory alloy such as a nickel-titanium alloy
  • radiopaque material in a stable configuration that is not subject to fracture during use of the device, so that the device can be visualized under fluoroscopy.
  • One problem present in the treatment of saccular aneurysms by use of interventional therapy is presented when the aneurysm is formed such that the neck of the aneurysm is relatively large in at least one dimension compared to the maximum width of the dome of the aneurysm.
  • an embolus generating occluding device such as an embolic coil without raising the risk that the device will partially, or fully, deploy outside of the aneurysm and into the vessel, thereby presenting a risk to the patient.
  • the present invention provides for an improved method and apparatus which solves these and other problems by providing, in its broadest aspect, a partially occlusive vasoocclusive apparatus with a plurality of strut members that can be deployed in an expanded configuration across the neck of a body vessel such as an aneurysm, either alone, or to additionally allow deployment of a secondary vasoocclusive device or substance within the vessel, and to block migration of the secondary vasoocclusive device into the vessel.
  • the vasoocclusive apparatus can be deployed across the neck of an aneurysm having a less than favorable dome to neck ratio to prevent migration of a secondarily placed embolus generating vasoocclusive device from the aneurysm.
  • a presently preferred embodiment of the present invention provides for a vasoocclusive apparatus for use in interventional therapy and vascular surgery which is adapted to be inserted into a portion of a vasculature for treatment of a body vessel such as an aneurysm.
  • the invention can be used in conjunction with secondary vasoocclusive devices such as embolic coils that can be placed within the aneurysm and partially retained by the apparatus.
  • the vasoocclusive apparatus of the invention comprises a plurality of strut members or spokes extending from a central hub that can be deployed within an aneurysm, and that are radially extended in an expanded configuration to cross the neck of the aneurysm, dividing the neck into smaller openings, and thus allowing the deployment of the secondary vasoocclusive device by a catheter extending through the smaller openings in the invention within the aneurysm but preventing migration of the secondary vasoocclusive device from the aneurysm once it is deployed.
  • the device is made from a twisted cable of superelastic strands made of a suitable material, with the cable including at least one radiopaque strand, made of platinum, tungsten or gold, in order to serve as a marker during a procedure.
  • the super-elastic material comprises a shape memory material such as nickel titanium alloy, that can be heat treated to remain superelastic or to have shape memory behavior such that the alloy is highly flexible at a temperature appropriate for introduction into the body via a catheter, and after placement, the device will take on a shape designed to optimize the therapeutic purposes desired for the device.
  • the disclosures of co-pending applications serial numbered and describe such radiopaque strands and three dimensional vasoocclusive devices formed therefrom, are incorporated by reference herein.
  • the plurality of strut members are connected together at a central hub, and extend radially from the central hub from a first collapsed configuration to an expanded configuration.
  • the strut members can be arranged in a variety of configurations providing for a variety of occlusive properties.
  • the strut members are arrayed in a spiral configuration extending from the central hub. When the spiral strut members are configured, they may also be made so that they overlap at some point near their periphery in order to reinforce one another in the direction perpendicular to the strut, while retaining the resilience of the struts, so as to conform to the shape of the aneurysm opening.
  • the strut members have curvilinear radial struts extending from the central hub.
  • the strut members have an umbrella-like configuration of spokes extending from the central hub, the strut members additionally are crosslinked to adjacent strut members by cross-struts of shape memory material.
  • the openings in the device can be tailored to provide an area suitable for insertion of a placement catheter shaft to deploy embolic coils and the like within the aneurysm which will be held in place by the invention, thus preventing the embolic devices from entering the vessel and the resultant risk to the patient.
  • the invention can allow for the deployment of other embolic agents within the aneurysm through the invention and lower or eliminate the migration of the embolic agent out of the aneurysm prior to being activated.
  • embolic agents such as polymers, glues, gels, micro- balloons and foams through openings in the device of the invention and into the aneurysm in which it is deployed, is contemplated as a preferred method in the use of this invention.
  • mounting means are also provided for detachably mounting the vasoocclusive apparatus to a placement catheter shaft and for detaching the vasoocclusive apparatus for deployment when a desired placement within an aneurysm to be treated and out of a parent vessel is achieved.
  • the mounting preferably comprises a collar of shape memory material disposed on one part of the vasoocclusive apparatus and mating with a distal portion of the placement catheter shaft and connecting the vasoocclusive apparatus and the placement catheter shaft.
  • the shape memory collar can be heated to thereby assume a configuration disconnecting the vasoocclusive apparatus and the placement catheter shaft.
  • the placement catheter shaft comprises a fiber optic compatible catheter shaft connected to an optical light source for conducting light energy to the collar to heat the collar and to thereby induce the collar to assume an enlarged configuration to detach the vasoocclusive device from the placement collar.
  • a device is formed which includes a plurality of flexible radial elements from a central hub, at least a portion of the radial elements being formed of a highly flexible material. The device is then deformed to fit within a placement catheter distally from a pusher element within the catheter. The catheter is then placed within the vasculature so that the distal opening of the catheter extends into an aneurysm or other deformation to be treated.
  • the pusher is then used to expel the device into the aneurysm.
  • the pusher is an optional fiber which is coupled to the device by a shape memory material which can be heated by the energy transmitted through the optional fiber to cause the shape memory material to assume a shape which releases the device from the optional fiber.
  • the device can be released by other means, such as thermo-mechanical, electromagnetic or disolution of an adhesive bond of the coupling between the device and the pusher.
  • the method of the invention for closing and occluding an opening of an aneurysm from a parent blood vessel accordingly thus comprises the steps of attaching an occlusive apparatus to the distal end of a linear pusher device, enclosing the pusher device and occlusive apparatus in a lumen of a catheter, with the pusher device proximal of the occlusive apparatus, positioning the catheter so that the distal opening of the catheter is in the opening between the aneurysm and the parent blood vessel, pushing the occlusive apparatus into the aneurysm by extending the pusher device towards the distal end of the catheter, and disconnecting the occlusive apparatus from the pusher device, thereby deploying the occlusive apparatus within the aneurysm and at least partially occluding the opening between the aneurysm and the parent blood vessel.
  • the step of disconnecting the occlusive apparatus from the pusher device comprises causing energy to be transmitted through the pusher device to release the connection between the pusher device and the occlusive apparatus.
  • the method of the invention also provides for closing and occluding an opening of an aneurysm from a parent blood vessel, the steps of deploying a first occlusive apparatus within the aneurysm and at least partially occluding the opening between the aneurysm and the parent blood vessel; and deploying a secondary occlusive apparatus through said first occlusive apparatus within the aneurysm, whereby said first occlusive apparatus prevents migration of said secondary vasoocclusive device from the aneurysm into the parent blood vessel.
  • the secondary occlusive apparatus can accordingly be deployed by the steps of attaching a secondary occlusive apparatus to the distal end of a linear pusher device; enclosing the pusher device and secondary occlusive apparatus in a lumen of a catheter, with the pusher device proximal of the secondary occlusive apparatus; positioning the catheter so that the distal opening of the catheter is in the opening between the aneurysm and the parent blood vessel; pushing the secondary occlusive apparatus into the aneurysm through the first occlusive apparatus by extending the pusher device towards the distal end of the catheter; and disconnecting the secondary occlusive apparatus from the pusher device, thereby deploying the secondary occlusive apparatus within the aneurysm, whereby the first occlusive apparatus prevents migration of the secondary vasoocclusive device from the aneurysm into the parent blood vessel.
  • Figure 1 is a top plan view of a first embodiment of a vasoocclusive apparatus according to the invention, having a spiral configuration of strut members shown in a primary collapsed configuration;
  • Figure 2 is a top plan view of the vasoocclusive apparatus of Fig. 1, showing the spiral configuration of strut members in a secondary, expanded configuration within the dome of an aneurysm;
  • Figure 2 A is a top plan view of the vasoocclusive apparatus of Fig. 1 , showing the spiral configuration of strut members in a an alternative randomly arranged secondary, expanded configuration within the dome of an aneurysm;
  • Figure 3 is a side view of the vasoocclusive apparatus of Fig. 1 , showing the spiral configuration of strut members in a primary, collapsed configuration;
  • Figure 4 a side view of the vasoocclusive apparatus of Fig. 2, showing the spiral configuration of strut members in a secondary, expanded configuration within the dome of an aneurysm;
  • Figure 5 is a top plan view of a fourth embodiment of a vasoocclusive apparatus according to the invention, having a web-like configuration of strut members, shown in a secondary, expanded configuration;
  • Figure 6 is an illustration of a vasoocclusive apparatus of the invention attached to a placement catheter shaft, in a collapsed configuration ready for delivery for deployment within an aneurysm;
  • Figure 7 is an illustration of a vasoocclusive apparatus of the invention attached to a placement catheter shaft, being deployed within an aneurysm;
  • Figure 8 is a side sectional view of a vasoocclusive apparatus of the invention attached to a placement catheter shaft showing a first embodiment of a means for mounting the vasoocclusive apparatus to the catheter shaft;
  • Figure 9 is an exploded sectional view of a portion of Fig. 10, showing the connection of the vasoocclusive apparatus to the catheter shaft;
  • Figure 10 is an exploded sectional view of a portion of Fig. 8, similar to that of Fig. 9, showing the release of the vasoocclusive apparatus from the catheter shaft; and
  • Figure 11 is a side sectional view of a second embodiment of a means for mounting the vasoocclusive apparatus to the catheter shaft.
  • an aneurysm can be treated by placement of an embolus-generating vasoocclusive device such as a vasoocclusive coil within the aneurysm
  • an embolus-generating vasoocclusive device can migrate out of the aneurysm, particularly if the ratio of the diameter of the dome portion of the aneurysm to the diameter of the neck of the aneurysm is unfavorable, i.e., less than approximately 2:1, posing a risk to the success of the procedure.
  • the invention is embodied in a vasoocclusive apparatus adapted to be radially extended in an expanded configuration to cross the neck of a hollow body vessel such as an aneurysm, dividing the neck into a plurality of smaller openings, and thus to prevent migration of a secondary vasoocclusive device to be placed within the body vessel in conjunction with the vasoocclusive apparatus for treatment of the body vessel.
  • a secondary embolus-generating vasoocclusive device such as a vasoocclusive coil is deployed within the body vessel through the strut members.
  • the vasoocclusive apparatus operates to prevent migration of the secondary vasoocclusive device from the aneurysm.
  • the vasoocclusive apparatus 18 includes a plurality of strut members 20 connected together at a central hub 22, and extending radially from the central hub from a first collapsed configuration, illustrated for example in Fig. 1, to a corresponding expanded configuration such as is illustrated in Figs.2 and 4 within an aneurysm 24 having a dome portion 25, a neck portion 26, and a parent vessel 27.
  • the strut members are arrayed in a spiral configuration extending from the central hub.
  • the strut members can be arranged in a random or unsymmetrical configuration, extending from the central hub.
  • the spiral struts are designed to overlap over at least a portion of their periphery to thereby reinforce one another at their periphery, while maintaining flexibility and conformability to the internal structure of the aneurysm.
  • Extending from the central hub 22 can be a stem 23 used to attach the vasoocclusive apparatus to a pusher used to push the apparatus into the aneurysm and to detach the apparatus from the pusher after deployment.
  • the strut members 30 of the vasoocclusive apparatus have an umbrella-like configuration of spokes extending from the central hub 22, the strut members 34 of the vasoocclusive apparatus being additionally crosslinked to adjacent strut members by cross-struts 36 also formed of shape memory material.
  • the struts may also advantageously be of unequal length to allow the medical practitioners to chose a configuration of vasoocclusive device for specific desired shapes.
  • each of the optional configurations of the strut members above are adapted to be deployed within an aneurysm 38, via a catheter in which the device is pushed through an opening at the distal end of the catheter by a pusher to deploy the device.
  • Mounting means 40 are preferably provided for detachably mounting the vasoocclusive apparatus 42 and placement of the vasoocclusive apparatus via a placement catheter 44, and for detaching the vasoocclusive apparatus for deployment when a desired placement within an aneurysm 38 to be treated and out of a parent vessel 46 is achieved.
  • the mounting means preferably comprises a shape memory collar 48 preferably formed of shape memory material and disposed on the vasoocclusive apparatus and a placement shaft of the pusher and connecting the vasoocclusive apparatus and the pusher shaft.
  • Figs. 6-8 illustrate an embodiment in which the collar is attached to the distal end 50 of a fiber optic pusher member 52 of the placement catheter 44.
  • the shape memory collar is attached to the fiber optic pusher member by an adhesive which retains high strength at temperatures beyond the shape memory material transition point.
  • the central hub 54 of the vasoocclusive apparatus preferably includes a stem 56 to which a wire coil 58 is mechanically attached, although the wire coil could also be suitably soldered or welded to the stem.
  • the shape memory collar is preferably heat treated in an unextended position illustrated in Fig. 8, and can be heated to a temperature that allows it to be worked and crimped into an extended position shown in Fig. 7 gripping over the end of the stem and wire coil to connect the vasoocclusive apparatus to the fiber optic pusher member of the placement catheter shaft.
  • the shape memory collar can be heated, and thereby induced to shrink and pull back to assume a configuration shown in Fig. 10, disconnecting the vasoocclusive apparatus and the placement catheter shaft.
  • the proximal end of the fiber optic catheter shaft (not shown) is preferably connected to an optical light source (not shown) for conducting light energy propagated at the distal end of the fiber optic pusher member to the shape memory collar and to thus heat the collar to return to its previous shape and induce the collar to detach the vasoocclusive device from the placement collar. Heating of the collar can at the same time heat the vasoocclusive apparatus to cause the vasoocclusive apparatus to expand within the aneurysm.
  • the collar 60 can be disposed on the stem 62 of the central hub 64 of the vasoocclusive apparatus, adapted to be crimped to the distal end 66 of the fiber optic pusher member 68 of the placement catheter.
  • the distal end of the fiber optic pusher member of the catheter shaft optionally can have a surface defining a plurality of ridges and grooves 70 to aid in the connection of the collar to the fiber optic pusher member.
  • vasoocclusive devices of the invention can be accomplished by a variety of means.
  • the vasoocclusive devices can be produced in such a way that they will readily pass through the lumen of a catheter in a linear shape and take on a complex shape as originally formed after being deployed into the area of interest, such as an aneurysm.
  • the strut members of the vasoocclusive device of the invention are preferably made from a twisted cable of superelastic strands made of a suitable material, with the cable including at least one radiopaque strand, made of platinum, tungsten or gold, in order to serve as a marker during the vascular surgical procedure.
  • the super-elastic material comprises a shape memory material such as nickel titanium alloy, that can be heat treated to remain superelastic or have shape memory behavior, such that the alloy is highly flexible at a temperature appropriate for introduction into the body via a catheter, and after placement, the device will take on a shape designed to optimize the therapeutic purposes desired for the device.
  • the multi-stranded micro-cable from which the strut members are formed is approximately from .0021 to .006 inches in diameter, and comprises a plurality of flexible strands of nickel-titanium alloy, with at least one radiopaque wire which is approximately from .0007 to .002 inches in diameter. While the above stated diameters represent those presently known to be compatible with the invention, larger or smaller diameters may be useful for particular applications.
  • the radiopaque wire can be formed of platinum or gold, for example, or other similar suitable radiopaque metals, in order to provide a radiopaque marker of the deployed configuration of a device made of the cable during vascular surgery.

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Abstract

The vasoocclusive apparatus can be used in a method of interventional therapy and vascular surgery by inserting the apparatus into a portion of a vasculature, for treatment of a body vessel such as an aneurysm in conjunction with a secondary vasoocclusive device to be placed within the vessel. The vasoocclusive apparatus includes a plurality of strut members connected together at a central hub that extend from a collapsed position to an expanded configuration to cross the neck of the aneurysm, dividing the neck into smaller openings, allowing the deployment of the secondary vasoocclusive device within the aneurysm but preventing migration of the secondary vasoocclusive device from the aneurysm. The strut members can be made from a twisted cable of strands of a superelastic material, such as a shape memory nickel titanium alloy, with at least one radiopaque strand. A shape memory collar is provided for detachably mounting the vasoocclusive apparatus to a pusher member and for detaching the vasoocclusive apparatus for deployment when a desired placement within an aneurysm to be treated and out of a parent vessel is achieved.

Description

METHOD AND APPARATUS FOR OCCLUSION AND REINFORCEMENT OF ANEURYSMS
BACKGROUND OF THE INVENTION Field of the Invention:
This invention relates generally to implantable devices for interventional therapeutic treatment of defects in the vasculature, and more particularly concerns a detachable device having multiple strut members with collapsed and expanded configurations to be used in combination with a catheter for the occlusion and reinforcement of aneurysms.
Description of Related Art:
Recently developed interventional procedures have been used to treat defects in the vasculature which are not easily reached by surgical procedures. More particularly, such interventional procedures have been developed to treat defects that are located in small and remote vessels such as those within the brain. During such interventional procedures, vasoocclusive devices are typically placed within the vasculature of the human body by use of a catheter, either to block the flow of blood through a vessel making up that portion of the vasculature through the formation of an embolus, or to form such an embolus within an aneurysm sterrrming from the vessel. Vasoocclusive devices used for these procedures can have a variety of configurations, and are generally formed of one or more elements that are larger in the deployed configuration than when they are within the delivery catheter prior to placement. One anatomically shaped vasoocclusive device that forms itself into a shape of an anatomical cavity such as an aneurysm is made of a preformed strand of flexible material such as a nickel-titanium alloy. One or more of such vasoocclusive members can be wound to form a generally spherical or oval shape in a relaxed, expanded state, and can be readily deformed to fit within a small diameter catheter from which they can be deployed at a treatment site.
Aneurysms have been treated with external surgically placed clips, or using vascular catheters, by detachable vasoocclusive balloons or an embolus generating vasoocclusive device such as one or more vasoocclusive coils. The delivery of such vasoocclusive devices can be accomplished by a variety of means, including via a catheter in which the device is pushed through an opening at the distal end of the catheter by a pusher to deploy the device. By using highly flexible materials for the vasoocclusive devices, the vasoocclusive devices can be produced in such a way that they will readily pass through the lumen of a catheter in a linear shape and take on a complex shape as originally formed after being deployed into the area of interest, such as an aneurysm. One vasoocclusive device used to treat aneurysms is a tightly wound coil that is pushed into the aneurysm through the neck of the aneurysm so that the coil forms a complex shape with the aneurysm. When an embolus generating vasoocclusive device such as a vasoocclusive coil is used to treat an aneurysm, the success of the treatment depends upon whether the embolus generating vasoocclusive device can migrate out of the aneurysm through the neck of the aneurysm, which in turn is somewhat dependent upon whether the ratio of the diameter of the dome portion of the aneurysm to the diameter of the neck of the aneurysm is less than approximately 2:1. If the dome to neck ratio is larger than approximately 2: 1, the possibility that the embolus generating vasoocclusive device will migrate out of the aneurysm into the parent vessel becomes greater, posing a risk to the success of the procedure. It would, therefore, be desirable to provide a vasoocclusive device that can be used with or without a stent, coil or the like, that can be delivered to an aneurysm or other body vessel in a primary collapsed configuration, where the vasoocclusive device can be deployed and released to assume a secondary, expanded configuration which partially occludes the neck of the aneurysm and which also allows deployment of an additional embolus generating vasoocclusive device such as an embolic coil within the aneurysm, and blocks migration of the embolus generating vasoocclusive device from the aneurysm to the vessel. It would also be desirable to provide a device which offers the advantages of a shape memory alloy such as a nickel-titanium alloy, and that incorporates radiopaque material in a stable configuration that is not subject to fracture during use of the device, so that the device can be visualized under fluoroscopy. The present invention meets these and other needs.
SUMMARY OF THE INVENTION
One problem present in the treatment of saccular aneurysms by use of interventional therapy is presented when the aneurysm is formed such that the neck of the aneurysm is relatively large in at least one dimension compared to the maximum width of the dome of the aneurysm. In such a case, it is difficult to employ an embolus generating occluding device such as an embolic coil without raising the risk that the device will partially, or fully, deploy outside of the aneurysm and into the vessel, thereby presenting a risk to the patient.
The present invention provides for an improved method and apparatus which solves these and other problems by providing, in its broadest aspect, a partially occlusive vasoocclusive apparatus with a plurality of strut members that can be deployed in an expanded configuration across the neck of a body vessel such as an aneurysm, either alone, or to additionally allow deployment of a secondary vasoocclusive device or substance within the vessel, and to block migration of the secondary vasoocclusive device into the vessel. Specifically, with respect to the treatment of aneurysms, the vasoocclusive apparatus can be deployed across the neck of an aneurysm having a less than favorable dome to neck ratio to prevent migration of a secondarily placed embolus generating vasoocclusive device from the aneurysm.
Briefly, and in general terms, a presently preferred embodiment of the present invention provides for a vasoocclusive apparatus for use in interventional therapy and vascular surgery which is adapted to be inserted into a portion of a vasculature for treatment of a body vessel such as an aneurysm. The invention can be used in conjunction with secondary vasoocclusive devices such as embolic coils that can be placed within the aneurysm and partially retained by the apparatus. The vasoocclusive apparatus of the invention comprises a plurality of strut members or spokes extending from a central hub that can be deployed within an aneurysm, and that are radially extended in an expanded configuration to cross the neck of the aneurysm, dividing the neck into smaller openings, and thus allowing the deployment of the secondary vasoocclusive device by a catheter extending through the smaller openings in the invention within the aneurysm but preventing migration of the secondary vasoocclusive device from the aneurysm once it is deployed. In one presently preferred aspect of the invention, the device is made from a twisted cable of superelastic strands made of a suitable material, with the cable including at least one radiopaque strand, made of platinum, tungsten or gold, in order to serve as a marker during a procedure. In one presently preferred embodiment, the super-elastic material comprises a shape memory material such as nickel titanium alloy, that can be heat treated to remain superelastic or to have shape memory behavior such that the alloy is highly flexible at a temperature appropriate for introduction into the body via a catheter, and after placement, the device will take on a shape designed to optimize the therapeutic purposes desired for the device. In this regard, the disclosures of co-pending applications serial numbered and describe such radiopaque strands and three dimensional vasoocclusive devices formed therefrom, are incorporated by reference herein.
In a presently preferred configuration of the vasoocclusive apparatus, the plurality of strut members are connected together at a central hub, and extend radially from the central hub from a first collapsed configuration to an expanded configuration. The strut members can be arranged in a variety of configurations providing for a variety of occlusive properties. In a first preferred embodiment, the strut members are arrayed in a spiral configuration extending from the central hub. When the spiral strut members are configured, they may also be made so that they overlap at some point near their periphery in order to reinforce one another in the direction perpendicular to the strut, while retaining the resilience of the struts, so as to conform to the shape of the aneurysm opening. In a second preferred option, the strut members have curvilinear radial struts extending from the central hub. In a third preferred option, the strut members have an umbrella-like configuration of spokes extending from the central hub, the strut members additionally are crosslinked to adjacent strut members by cross-struts of shape memory material.
By use of the above configurations, and combinations of them, it can be seen that the openings in the device, represented by the areas between the struts, can be tailored to provide an area suitable for insertion of a placement catheter shaft to deploy embolic coils and the like within the aneurysm which will be held in place by the invention, thus preventing the embolic devices from entering the vessel and the resultant risk to the patient.
Similarly, the invention can allow for the deployment of other embolic agents within the aneurysm through the invention and lower or eliminate the migration of the embolic agent out of the aneurysm prior to being activated. In such a regard, it is specifically contemplated that the deployment of embolic agents such as polymers, glues, gels, micro- balloons and foams through openings in the device of the invention and into the aneurysm in which it is deployed, is contemplated as a preferred method in the use of this invention.
In another presently preferred aspect of the invention, mounting means are also provided for detachably mounting the vasoocclusive apparatus to a placement catheter shaft and for detaching the vasoocclusive apparatus for deployment when a desired placement within an aneurysm to be treated and out of a parent vessel is achieved. The mounting preferably comprises a collar of shape memory material disposed on one part of the vasoocclusive apparatus and mating with a distal portion of the placement catheter shaft and connecting the vasoocclusive apparatus and the placement catheter shaft. The shape memory collar can be heated to thereby assume a configuration disconnecting the vasoocclusive apparatus and the placement catheter shaft. In a currently preferred embodiment, the placement catheter shaft comprises a fiber optic compatible catheter shaft connected to an optical light source for conducting light energy to the collar to heat the collar and to thereby induce the collar to assume an enlarged configuration to detach the vasoocclusive device from the placement collar. In a presently preferred embodiment of the method of using the invention, a device is formed which includes a plurality of flexible radial elements from a central hub, at least a portion of the radial elements being formed of a highly flexible material. The device is then deformed to fit within a placement catheter distally from a pusher element within the catheter. The catheter is then placed within the vasculature so that the distal opening of the catheter extends into an aneurysm or other deformation to be treated. The pusher is then used to expel the device into the aneurysm. In a presently preferred aspect of the invention, the pusher is an optional fiber which is coupled to the device by a shape memory material which can be heated by the energy transmitted through the optional fiber to cause the shape memory material to assume a shape which releases the device from the optional fiber. In other presently preferred embodiments, the device can be released by other means, such as thermo-mechanical, electromagnetic or disolution of an adhesive bond of the coupling between the device and the pusher. The method of the invention for closing and occluding an opening of an aneurysm from a parent blood vessel accordingly thus comprises the steps of attaching an occlusive apparatus to the distal end of a linear pusher device, enclosing the pusher device and occlusive apparatus in a lumen of a catheter, with the pusher device proximal of the occlusive apparatus, positioning the catheter so that the distal opening of the catheter is in the opening between the aneurysm and the parent blood vessel, pushing the occlusive apparatus into the aneurysm by extending the pusher device towards the distal end of the catheter, and disconnecting the occlusive apparatus from the pusher device, thereby deploying the occlusive apparatus within the aneurysm and at least partially occluding the opening between the aneurysm and the parent blood vessel. In a presently preferred aspect of the method, the step of disconnecting the occlusive apparatus from the pusher device comprises causing energy to be transmitted through the pusher device to release the connection between the pusher device and the occlusive apparatus. Advantageously, the method of the invention also provides for closing and occluding an opening of an aneurysm from a parent blood vessel, the steps of deploying a first occlusive apparatus within the aneurysm and at least partially occluding the opening between the aneurysm and the parent blood vessel; and deploying a secondary occlusive apparatus through said first occlusive apparatus within the aneurysm, whereby said first occlusive apparatus prevents migration of said secondary vasoocclusive device from the aneurysm into the parent blood vessel. The secondary occlusive apparatus can accordingly be deployed by the steps of attaching a secondary occlusive apparatus to the distal end of a linear pusher device; enclosing the pusher device and secondary occlusive apparatus in a lumen of a catheter, with the pusher device proximal of the secondary occlusive apparatus; positioning the catheter so that the distal opening of the catheter is in the opening between the aneurysm and the parent blood vessel; pushing the secondary occlusive apparatus into the aneurysm through the first occlusive apparatus by extending the pusher device towards the distal end of the catheter; and disconnecting the secondary occlusive apparatus from the pusher device, thereby deploying the secondary occlusive apparatus within the aneurysm, whereby the first occlusive apparatus prevents migration of the secondary vasoocclusive device from the aneurysm into the parent blood vessel.
These and other aspects and advantages of the invention will become apparent from the following detailed description and the accompanying drawings, which illustrate by way of example the features of the invention.
BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a top plan view of a first embodiment of a vasoocclusive apparatus according to the invention, having a spiral configuration of strut members shown in a primary collapsed configuration;
Figure 2 is a top plan view of the vasoocclusive apparatus of Fig. 1, showing the spiral configuration of strut members in a secondary, expanded configuration within the dome of an aneurysm;
Figure 2 A is a top plan view of the vasoocclusive apparatus of Fig. 1 , showing the spiral configuration of strut members in a an alternative randomly arranged secondary, expanded configuration within the dome of an aneurysm;
Figure 3 is a side view of the vasoocclusive apparatus of Fig. 1 , showing the spiral configuration of strut members in a primary, collapsed configuration;
Figure 4 a side view of the vasoocclusive apparatus of Fig. 2, showing the spiral configuration of strut members in a secondary, expanded configuration within the dome of an aneurysm; Figure 5 is a top plan view of a fourth embodiment of a vasoocclusive apparatus according to the invention, having a web-like configuration of strut members, shown in a secondary, expanded configuration;
Figure 6 is an illustration of a vasoocclusive apparatus of the invention attached to a placement catheter shaft, in a collapsed configuration ready for delivery for deployment within an aneurysm;
Figure 7 is an illustration of a vasoocclusive apparatus of the invention attached to a placement catheter shaft, being deployed within an aneurysm;
Figure 8 is a side sectional view of a vasoocclusive apparatus of the invention attached to a placement catheter shaft showing a first embodiment of a means for mounting the vasoocclusive apparatus to the catheter shaft;
Figure 9 is an exploded sectional view of a portion of Fig. 10, showing the connection of the vasoocclusive apparatus to the catheter shaft;
Figure 10 is an exploded sectional view of a portion of Fig. 8, similar to that of Fig. 9, showing the release of the vasoocclusive apparatus from the catheter shaft; and Figure 11 is a side sectional view of a second embodiment of a means for mounting the vasoocclusive apparatus to the catheter shaft.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
While an aneurysm can be treated by placement of an embolus-generating vasoocclusive device such as a vasoocclusive coil within the aneurysm, such an embolus- generating vasoocclusive device can migrate out of the aneurysm, particularly if the ratio of the diameter of the dome portion of the aneurysm to the diameter of the neck of the aneurysm is unfavorable, i.e., less than approximately 2:1, posing a risk to the success of the procedure. As is illustrated in the drawings, which are provided for the purposes of illustration and not by way of limitation, the invention is embodied in a vasoocclusive apparatus adapted to be radially extended in an expanded configuration to cross the neck of a hollow body vessel such as an aneurysm, dividing the neck into a plurality of smaller openings, and thus to prevent migration of a secondary vasoocclusive device to be placed within the body vessel in conjunction with the vasoocclusive apparatus for treatment of the body vessel. According to the method of the invention, following deployment of the vasoocclusive apparatus within the body vessel, a secondary embolus-generating vasoocclusive device such as a vasoocclusive coil is deployed within the body vessel through the strut members. When the secondary vasoocclusive device assumes an expanded configuration, the vasoocclusive apparatus operates to prevent migration of the secondary vasoocclusive device from the aneurysm.
With reference to Figs. 1-4, the vasoocclusive apparatus 18 includes a plurality of strut members 20 connected together at a central hub 22, and extending radially from the central hub from a first collapsed configuration, illustrated for example in Fig. 1, to a corresponding expanded configuration such as is illustrated in Figs.2 and 4 within an aneurysm 24 having a dome portion 25, a neck portion 26, and a parent vessel 27. In a first preferred embodiment illustrated in Figs. 1-4, the strut members are arrayed in a spiral configuration extending from the central hub. Alternatively, as is illustrated in Fig.2 A, the strut members can be arranged in a random or unsymmetrical configuration, extending from the central hub. In a presently preferred embodiment, the spiral struts are designed to overlap over at least a portion of their periphery to thereby reinforce one another at their periphery, while maintaining flexibility and conformability to the internal structure of the aneurysm. Extending from the central hub 22 can be a stem 23 used to attach the vasoocclusive apparatus to a pusher used to push the apparatus into the aneurysm and to detach the apparatus from the pusher after deployment.
Referring to Fig.5, the strut members 30 of the vasoocclusive apparatus have an umbrella-like configuration of spokes extending from the central hub 22, the strut members 34 of the vasoocclusive apparatus being additionally crosslinked to adjacent strut members by cross-struts 36 also formed of shape memory material. In this embodiment, the struts may also advantageously be of unequal length to allow the medical practitioners to chose a configuration of vasoocclusive device for specific desired shapes.
As is illustrated in Figs. 6 and 7, each of the optional configurations of the strut members above are adapted to be deployed within an aneurysm 38, via a catheter in which the device is pushed through an opening at the distal end of the catheter by a pusher to deploy the device. Mounting means 40 are preferably provided for detachably mounting the vasoocclusive apparatus 42 and placement of the vasoocclusive apparatus via a placement catheter 44, and for detaching the vasoocclusive apparatus for deployment when a desired placement within an aneurysm 38 to be treated and out of a parent vessel 46 is achieved.
Referring to Figs. 8- 11 , the mounting means preferably comprises a shape memory collar 48 preferably formed of shape memory material and disposed on the vasoocclusive apparatus and a placement shaft of the pusher and connecting the vasoocclusive apparatus and the pusher shaft. Figs. 6-8 illustrate an embodiment in which the collar is attached to the distal end 50 of a fiber optic pusher member 52 of the placement catheter 44. The shape memory collar is attached to the fiber optic pusher member by an adhesive which retains high strength at temperatures beyond the shape memory material transition point. In this embodiment of the mounting means, the central hub 54 of the vasoocclusive apparatus preferably includes a stem 56 to which a wire coil 58 is mechanically attached, although the wire coil could also be suitably soldered or welded to the stem. The shape memory collar is preferably heat treated in an unextended position illustrated in Fig. 8, and can be heated to a temperature that allows it to be worked and crimped into an extended position shown in Fig. 7 gripping over the end of the stem and wire coil to connect the vasoocclusive apparatus to the fiber optic pusher member of the placement catheter shaft.
When the vasoocclusive apparatus is delivered within the dome of an aneurysm as illustrated in Fig. 7, and when an operator is satisfied that the device is properly deployed, the shape memory collar can be heated, and thereby induced to shrink and pull back to assume a configuration shown in Fig. 10, disconnecting the vasoocclusive apparatus and the placement catheter shaft. The proximal end of the fiber optic catheter shaft (not shown) is preferably connected to an optical light source (not shown) for conducting light energy propagated at the distal end of the fiber optic pusher member to the shape memory collar and to thus heat the collar to return to its previous shape and induce the collar to detach the vasoocclusive device from the placement collar. Heating of the collar can at the same time heat the vasoocclusive apparatus to cause the vasoocclusive apparatus to expand within the aneurysm.
In an alternative embodiment of the mounting means illustrated in Fig. 11, the collar 60 can be disposed on the stem 62 of the central hub 64 of the vasoocclusive apparatus, adapted to be crimped to the distal end 66 of the fiber optic pusher member 68 of the placement catheter. In this embodiment, the distal end of the fiber optic pusher member of the catheter shaft optionally can have a surface defining a plurality of ridges and grooves 70 to aid in the connection of the collar to the fiber optic pusher member. Those skilled in the art will recognize that the invention can also be used with a variety of other placement catheter systems, and it is not intended that the invention be limited to the placement concepts illustrated by way of example.
It should be readily apparent that the delivery of the vasoocclusive devices of the invention can be accomplished by a variety of means. By using highly flexible materials for the vasoocclusive devices, the vasoocclusive devices can be produced in such a way that they will readily pass through the lumen of a catheter in a linear shape and take on a complex shape as originally formed after being deployed into the area of interest, such as an aneurysm.
In each of the foregoing embodiments, the strut members of the vasoocclusive device of the invention are preferably made from a twisted cable of superelastic strands made of a suitable material, with the cable including at least one radiopaque strand, made of platinum, tungsten or gold, in order to serve as a marker during the vascular surgical procedure. In a presently preferred aspect of the invention, the super-elastic material comprises a shape memory material such as nickel titanium alloy, that can be heat treated to remain superelastic or have shape memory behavior, such that the alloy is highly flexible at a temperature appropriate for introduction into the body via a catheter, and after placement, the device will take on a shape designed to optimize the therapeutic purposes desired for the device. In one presently preferred embodiment, the multi-stranded micro-cable from which the strut members are formed is approximately from .0021 to .006 inches in diameter, and comprises a plurality of flexible strands of nickel-titanium alloy, with at least one radiopaque wire which is approximately from .0007 to .002 inches in diameter. While the above stated diameters represent those presently known to be compatible with the invention, larger or smaller diameters may be useful for particular applications. The radiopaque wire can be formed of platinum or gold, for example, or other similar suitable radiopaque metals, in order to provide a radiopaque marker of the deployed configuration of a device made of the cable during vascular surgery.
While the invention is described in the context of shape memory metal materials, it is also contemplated that the invention could advantageously be made of other shape memory or superelastic materials, including shape memory plastics or superelastic metal alloys or plastics. Plastic materials may also more readily allow for the configuration of the invention in a variety of shapes and with simplified manufacturing, including molding of the vasoocclusive device, rather than fabrication from a number of component parts. -l ilt will be apparent from the foregoing that while particular forms of the invention have been illustrated and described, various modifications can be made without departing from the spirit and scope of the invention. Accordingly, it is not intended that the invention be limited, except as by the appended claims.

Claims

WHAT IS CLAIMED IS:
1. An occlusive apparatus for treatment of a body vessel, the vessel having a dome portion and a neck opening into another vessel, the apparatus comprising: a plurality of strut members connected together that extend from a collapsed configuration to an expanded configuration to cross the neck of the vessel, dividing the neck into smaller openings.
2. The occlusive apparatus of Claim 1, wherein said plurality of strut members are connected together at a central hub, and extend curvilinealy from the central hub from said first collapsed configuration to said expanded configuration.
3. The occlusive apparatus of Claim 2, wherein said strut members are arrayed in a spiral configuration extending from said central hub.
4. The occlusive apparatus of Claim 2, wherein said strut members have an umbrella-like configuration of spokes extending from the central hub.
5. The occlusive apparatus of Claim 4, wherein said strut members additionally are crosslinked to adjacent strut members.
6. The occlusive apparatus of Claim 2, wherein said strut members are randomly arranged.
7. The occlusive apparatus of Claim 1 , wherein said strut members are made from a twisted cable comprising strands of a superelastic material.
8. The occlusive apparatus of Claim 7, wherein said cable further comprises at least one radiopaque strand of a metal selected from the group consisting of platinum, tungsten and gold.
9. The occlusive apparatus of Claim 1, wherein said strut members are made from a twisted cable comprising strands of a shape memory nickel titanium alloy.
10. The occlusive apparatus of Claim 9, wherein said strut members are heat treated to remain superelastic.
11. The occlusive apparatus of Claim 9, wherein said strut members are heat treated to have shape memory behavior such that the alloy is highly flexible at a temperature appropriate for introduction into the body via a placement catheter, and after placement in the vessel, the apparatus will assume said expanded configuration.
12. The occlusive apparatus of Claim 1, further comprising mounting means for detachably mounting the plurality of strut members to a placement catheter shaft and for detaching the plurality of strut members from the placement catheter shaft for deployment within the vessel to be treated.
13. The occlusive apparatus of Claim 12, wherein said mounting means comprises a collar of shape memory material and said placement catheter shaft comprises a fiber optic pusher member, and wherein said collar is disposed on one of the occlusive apparatus and the fiber optic pusher member and connects the occlusive apparatus and the fiber optic pusher member.
14. The occlusive apparatus of Claim 13, wherein said collar can be heated to be induced to assume a configuration disconnecting the occlusive apparatus and the fiber optic pusher member.
15. The occlusive apparatus of Claim 14, wherein said fiber optic pusher member is connected to an optical light source for conducting coherent light energy to the collar to heat the collar to induce the collar to detach the occlusive device from the fiber optic pusher member.
16. The occlusive apparatus of Claim 13, wherein said central hub comprises a stem having a proximal end adjacent to said strut members and a distal end, and further comprising a coil mechanically attached to the distal end of the stem.
17. The occlusive apparatus of Claim 16, wherein the distal end of the fiber optic pusher member has a surface defining a plurality of ridges.
18. The occlusive apparatus of Claim 1, wherein said apparatus is formed of a shape memory plastic material.
19. A vasoocclusive apparatus for treatment of an aneurysm in the vasculature in conjunction with a secondary vasoocclusive device to be placed within the aneurysm, the aneurysm having a dome portion and a neck opening into a parent vessel, the apparatus comprising: a plurality of strut members centrally connected together adapted to be deployed within the aneurysm, said strut members extending radially from a collapsed configuration to an expanded configuration to cross the neck of the aneurysm, dividing the neck into smaller openings, allowing the deployment of the secondary vasoocclusive device within the aneurysm and preventing migration of the deployed secondary vasoocclusive device from the aneurysm into the parent vessel.
20. The vasoocclusive apparatus of Claim 19, wherein said plurality of strut members are connected together at a central hub, and extend radially from the central hub from said first collapsed configuration to said expanded configuration.
21. The vasoocclusive apparatus of Claim 20, wherein said strut members are arrayed in a spiral configuration extending from said central hub.
22. The vasoocclusive apparatus of Claim 20, wherein said strut members have an umbrella-like configuration of spokes extending from the central hub, said strut members additionally are crosslinked to adjacent strut members.
23. The occlusive apparatus of Claim 20, wherein said strut members are randomly arranged.
24. The vasoocclusive apparatus of Claim 19, wherein said strut members are made from a twisted cable comprising strands of a superelastic material.
25. The vasoocclusive apparatus of Claim 24, wherein said cable further comprises at least one radiopaque strand of a metal selected from the group consisting of platinum, tungsten and gold.
26. The vasoocclusive apparatus of Claim 19, wherein said strut members are made from a twisted cable comprising strands of a shape memory nickel titanium alloy.
27. The occlusive apparatus of Claim 26, wherein said strut members are heat treated to remain superelastic.
28. The occlusive apparatus of Claim 26, wherein said strut members are heat treated to have shape memory behavior such that the alloy is highly flexible at a temperature appropriate for introduction into the body via a catheter, and after placement in the vessel, the apparatus will assume said expanded configuration.
29. The vasoocclusive apparatus of Claim 19, further comprising mounting means for detachably mounting the plurality of strut members to a pusher member and for detaching the plurality of strut members from the pusher member for deployment within the vessel to be treated.
30. The vasoocclusive apparatus of Claim 29, wherein said mounting means comprises a collar of shape memory material disposed on one of the vasoocclusive apparatus and the pusher member and connecting the vasoocclusive apparatus and the pusher member.
31. The vasoocclusive apparatus of Claim 30, wherein said collar can be heated to be induced to assume a configuration disconnecting the occlusive apparatus and the pusher member.
32. The vasoocclusive apparatus of Claim 31, wherein the pusher member comprises a fiber optic catheter shaft connected to an optical light source for conducting coherent light energy to the collar to heat the collar to induce the collar to detach the occlusive device from the fiber optic catheter shaft.
33. The vasoocclusive apparatus of Claim 20, wherein said central hub comprises a stem having a proximal end adjacent to said strut members and a distal end, and further comprising a coil soldered to the distal end of the stem.
34. The vasoocclusive apparatus of Claim 33, wherein the distal end of the fiber optic catheter shaft has a surface defining a plurality of ridges.
35. A method of closing and occluding an opening of an aneurysm from a parent blood vessel, comprising the steps of: attaching an occlusive apparatus having radial members extending from a central hub to the distal end of a linear pusher device; enclosing the pusher device and occlusive apparatus in a lumen of a catheter, with the pusher device proximal of the occlusive apparatus; positioning the catheter so that the distal opening of the catheter is in the opening between the aneurysm and the parent blood vessel; pushing the occlusive apparatus into the aneurysm by extending the pusher device towards the distal end of the catheter; and disconnecting the occlusive apparatus from the pusher device, thereby deploying the occlusive apparatus within the aneurysm and at least partially occluding the opening between the aneurysm and the parent blood vessel.
36. The method of Claim 35, wherein said step of disconnecting the occlusive apparatus from the pusher device comprises causing energy to be transmitted through the pusher device to release the connection between the pusher device and the occlusive apparatus.
37. The method of Claim 35, further including the steps of: attaching a secondary occlusive apparatus to the distal end of a linear pusher device; enclosing the pusher device and secondary occlusive apparatus in a lumen of a catheter, with the pusher device proximal of the secondary occlusive apparatus; positioning the catheter so that the distal opening of the catheter is in the opening between the aneurysm and the parent blood vessel; pushing the secondary occlusive apparatus into the aneurysm through said first occlusive apparatus by extending the pusher device towards the distal end of the catheter; and disconnecting the secondary occlusive apparatus from the pusher device, thereby deploying the secondary occlusive apparatus within the aneurysm, whereby said first occlusive apparatus prevents migration of said secondary vasoocclusive device from the aneurysm into the parent blood vessel.
38. A method of closing and occluding an opening of an aneurysm from a parent blood vessel, comprising the steps of: deploying a first occlusive apparatus within the aneurysm and at least partially occluding the opening between the aneurysm and the parent blood vessel; and deploying a secondary occlusive apparatus through said first occlusive apparatus within the aneurysm, whereby said first occlusive apparatus prevents migration of said secondary vasoocclusive device from the aneurysm into the parent blood vessel.
39. A method of closing and occluding an opening of an aneurysm from a parent blood vessel, comprising the steps of: attaching a first occlusive apparatus having radial members extending from a central hub to the distal end of a linear pusher device; enclosing the pusher device and first occlusive apparatus in a lumen of a catheter, with the pusher device proximal of the first occlusive apparatus; positioning the catheter so that the distal opening of the catheter is in the opening between the aneurysm and the parent blood vessel; pushing the first occlusive apparatus into the aneurysm by extending the pusher device towards the distal end of the catheter; disconnecting the first occlusive apparatus from the pusher device, thereby deploying the first occlusive apparatus within the aneurysm and at least partially occluding the opening between the aneurysm and the parent blood vessel; attaching a secondary occlusive apparatus to the distal end of a linear pusher device; enclosing the pusher device and secondary occlusive apparatus in a lumen of a catheter, with the pusher device proximal of the secondary occlusive apparatus; positioning the catheter so that the distal opening of the catheter is in the opening between the aneurysm and the parent blood vessel; pushing the secondary occlusive apparatus into the aneurysm through said first occlusive apparatus by extending the pusher device towards the distal end of the catheter; and disconnecting the secondary occlusive apparatus from the pusher device, thereby deploying the secondary occlusive apparatus within the aneurysm, whereby said first occlusive apparatus prevents migration of said secondary vasoocclusive device from the aneurysm into the parent blood vessel.
40. The method of Claim 39, wherein said step of disconnecting the first occlusive apparatus from the pusher device comprises causing energy to be transmitted through the pusher device to release the connection between the pusher device and the first occlusive apparatus.
PCT/US1999/007952 1998-05-04 1999-04-12 Method and apparatus for occlusion and reinforcement of aneurysms WO1999056636A1 (en)

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DE69928794T DE69928794T2 (en) 1998-05-04 1999-04-12 DEVICE FOR CLOSING AND ENHANCING ANEURYSMAS
JP2000546673A JP4108273B2 (en) 1998-05-04 1999-04-12 Aneurysm occlusion and reinforcement method and device
EP99917418A EP1076518B1 (en) 1998-05-04 1999-04-12 Apparatus for occlusion and reinforcement of aneurysms
AU35547/99A AU3554799A (en) 1998-05-04 1999-04-12 Method and apparatus for occlusion and reinforcement of aneurysms

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US09/072,314 US6168615B1 (en) 1998-05-04 1998-05-04 Method and apparatus for occlusion and reinforcement of aneurysms

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* Cited by examiner, † Cited by third party
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US9579104B2 (en) 2011-11-30 2017-02-28 Covidien Lp Positioning and detaching implants
US9687245B2 (en) 2012-03-23 2017-06-27 Covidien Lp Occlusive devices and methods of use
US9713475B2 (en) 2014-04-18 2017-07-25 Covidien Lp Embolic medical devices
WO2018005042A1 (en) * 2016-06-28 2018-01-04 Covidien Lp Implant detachment with thermal activation
WO2019199640A1 (en) * 2018-04-10 2019-10-17 Medstar Health Embolization scaffold devices
US10893868B2 (en) 2012-01-20 2021-01-19 Covidien Lp Aneurysm treatment coils
US11382633B2 (en) 2019-03-06 2022-07-12 DePuy Synthes Products, Inc. Strut flow diverter for cerebral aneurysms and methods for preventing strut entanglement

Families Citing this family (170)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083220A (en) 1990-03-13 2000-07-04 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
USRE42625E1 (en) 1990-03-13 2011-08-16 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
USRE41029E1 (en) 1990-03-13 2009-12-01 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US5928260A (en) * 1997-07-10 1999-07-27 Scimed Life Systems, Inc. Removable occlusion system for aneurysm neck
US7569066B2 (en) * 1997-07-10 2009-08-04 Boston Scientific Scimed, Inc. Methods and devices for the treatment of aneurysms
US20040130599A1 (en) * 1997-07-15 2004-07-08 Silverbrook Research Pty Ltd Ink jet printhead with amorphous ceramic chamber
US6511468B1 (en) 1997-10-17 2003-01-28 Micro Therapeutics, Inc. Device and method for controlling injection of liquid embolic composition
US7128073B1 (en) * 1998-11-06 2006-10-31 Ev3 Endovascular, Inc. Method and device for left atrial appendage occlusion
US6214016B1 (en) * 1999-04-29 2001-04-10 Medtronic, Inc. Medical instrument positioning device internal to a catheter or lead and method of use
US8048104B2 (en) 2000-10-30 2011-11-01 Dendron Gmbh Device for the implantation of occlusion spirals
US7033374B2 (en) * 2000-09-26 2006-04-25 Microvention, Inc. Microcoil vaso-occlusive device with multi-axis secondary configuration
US6605101B1 (en) * 2000-09-26 2003-08-12 Microvention, Inc. Microcoil vaso-occlusive device with multi-axis secondary configuration
US6589265B1 (en) * 2000-10-31 2003-07-08 Endovascular Technologies, Inc. Intrasaccular embolic device
US6454780B1 (en) 2001-06-21 2002-09-24 Scimed Life Systems, Inc. Aneurysm neck obstruction device
US8715312B2 (en) * 2001-07-20 2014-05-06 Microvention, Inc. Aneurysm treatment device and method of use
US7572288B2 (en) 2001-07-20 2009-08-11 Microvention, Inc. Aneurysm treatment device and method of use
US8252040B2 (en) * 2001-07-20 2012-08-28 Microvention, Inc. Aneurysm treatment device and method of use
US7695488B2 (en) * 2002-03-27 2010-04-13 Boston Scientific Scimed, Inc. Expandable body cavity liner device
US20030195553A1 (en) 2002-04-12 2003-10-16 Scimed Life Systems, Inc. System and method for retaining vaso-occlusive devices within an aneurysm
US20040034386A1 (en) * 2002-08-19 2004-02-19 Michael Fulton Aneurysm stent
US8227411B2 (en) * 2002-08-20 2012-07-24 BioSurface Engineering Technologies, Incle FGF growth factor analogs
US7598224B2 (en) * 2002-08-20 2009-10-06 Biosurface Engineering Technologies, Inc. Dual chain synthetic heparin-binding growth factor analogs
US20040111112A1 (en) * 2002-11-20 2004-06-10 Hoffmann Gerard Von Method and apparatus for retaining embolic material
US20050043585A1 (en) * 2003-01-03 2005-02-24 Arindam Datta Reticulated elastomeric matrices, their manufacture and use in implantable devices
CA2525792C (en) 2003-05-15 2015-10-13 Biomerix Corporation Reticulated elastomeric matrices, their manufacture and use in implantable devices
US7763077B2 (en) 2003-12-24 2010-07-27 Biomerix Corporation Repair of spinal annular defects and annulo-nucleoplasty regeneration
DE102004003265A1 (en) 2004-01-21 2005-08-11 Dendron Gmbh Device for the implantation of electrically isolated occlusion coils
ATE482228T1 (en) 2004-02-20 2010-10-15 Biosurface Eng Tech Inc POSITIVE MODULATOR OF BONE MORPHOGENETIC PROTEIN-2 (BMP-2)
US8398670B2 (en) * 2004-03-19 2013-03-19 Aga Medical Corporation Multi-layer braided structures for occluding vascular defects and for occluding fluid flow through portions of the vasculature of the body
US9039724B2 (en) * 2004-03-19 2015-05-26 Aga Medical Corporation Device for occluding vascular defects
US8747453B2 (en) * 2008-02-18 2014-06-10 Aga Medical Corporation Stent/stent graft for reinforcement of vascular abnormalities and associated method
US20050228434A1 (en) * 2004-03-19 2005-10-13 Aga Medical Corporation Multi-layer braided structures for occluding vascular defects
US8313505B2 (en) 2004-03-19 2012-11-20 Aga Medical Corporation Device for occluding vascular defects
US8777974B2 (en) 2004-03-19 2014-07-15 Aga Medical Corporation Multi-layer braided structures for occluding vascular defects
US20070190108A1 (en) * 2004-05-17 2007-08-16 Arindam Datta High performance reticulated elastomeric matrix preparation, properties, reinforcement, and use in surgical devices, tissue augmentation and/or tissue repair
US8267985B2 (en) 2005-05-25 2012-09-18 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
EP1793743B1 (en) 2004-09-22 2009-11-18 Dendron GmbH Micro-spiral implantation device
US20060116714A1 (en) * 2004-11-26 2006-06-01 Ivan Sepetka Coupling and release devices and methods for their assembly and use
US20060155323A1 (en) 2005-01-07 2006-07-13 Porter Stephen C Intra-aneurysm devices
US20060212113A1 (en) * 2005-02-24 2006-09-21 Shaolian Samuel M Externally adjustable endovascular graft implant
US8273101B2 (en) 2005-05-25 2012-09-25 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
WO2006127005A1 (en) 2005-05-25 2006-11-30 Chestnut Medical Technologies, Inc. System and method for delivering and deploying and occluding device within a vessel
US7591833B2 (en) * 2005-06-30 2009-09-22 Codman & Shurtleff, Inc. Laser-based vascular occlusion device detachment system
AU2014200427B2 (en) * 2005-10-19 2016-01-14 Pulsar Vascular, Inc. Methods and systems for endovascularly clipping and repairing lumen and tissue defects
US8545530B2 (en) 2005-10-19 2013-10-01 Pulsar Vascular, Inc. Implantable aneurysm closure systems and methods
WO2007047851A2 (en) 2005-10-19 2007-04-26 Pulsar Vascular, Inc. Methods and systems for endovascularly clipping and repairing lumen and tissue defects
US20070112372A1 (en) * 2005-11-17 2007-05-17 Stephen Sosnowski Biodegradable vascular filter
US20070142907A1 (en) * 2005-12-16 2007-06-21 Micardia Corporation Adjustable prosthetic valve implant
CA2644847A1 (en) * 2006-04-06 2007-10-11 Reva Medical, Inc. Embolic prosthesis for treatment of vascular aneurysm
US8777979B2 (en) 2006-04-17 2014-07-15 Covidien Lp System and method for mechanically positioning intravascular implants
KR20090008347A (en) 2006-04-17 2009-01-21 마이크로 테라퓨틱스 인코포레이티드 System and method for mechanically positioning intravascular implants
EP2046350A4 (en) 2006-06-22 2011-09-14 Biosurface Eng Tech Inc Composition and method for delivery of bmp-2 amplifier/co-activator for enhancement of osteogenesis
US20080221600A1 (en) * 2006-08-17 2008-09-11 Dieck Martin S Isolation devices for the treatment of aneurysms
WO2008074027A1 (en) * 2006-12-13 2008-06-19 Biomerix Corporation Aneurysm occlusion devices
KR20100015521A (en) 2007-03-13 2010-02-12 마이크로 테라퓨틱스 인코포레이티드 An implant, a mandrel, and a method of forming an implant
WO2008112435A2 (en) * 2007-03-13 2008-09-18 Micro Therapeutics, Inc. An implant including a coil and a stretch-resistant member
US20110022149A1 (en) 2007-06-04 2011-01-27 Cox Brian J Methods and devices for treatment of vascular defects
US20080319527A1 (en) * 2007-06-22 2008-12-25 Lee Jeffrey A Shaped multi-durometer filler
CN105943208B (en) * 2007-06-25 2019-02-15 微仙美国有限公司 Self-expanding prosthesis
US20090171386A1 (en) 2007-12-28 2009-07-02 Aga Medical Corporation Percutaneous catheter directed intravascular occlusion devices
WO2009121006A1 (en) * 2008-03-27 2009-10-01 Nfocus Neuromedical, Inc. Friction-release distal latch implant delivery system and components
CA2722037C (en) * 2008-04-21 2016-03-22 Nfocus Neuromedical, Inc. Braid-ball embolic devices and delivery systems
US20090318948A1 (en) * 2008-04-22 2009-12-24 Coherex Medical, Inc. Device, system and method for aneurysm embolization
US10028747B2 (en) 2008-05-01 2018-07-24 Aneuclose Llc Coils with a series of proximally-and-distally-connected loops for occluding a cerebral aneurysm
US10716573B2 (en) 2008-05-01 2020-07-21 Aneuclose Janjua aneurysm net with a resilient neck-bridging portion for occluding a cerebral aneurysm
CN102119040A (en) * 2008-05-02 2011-07-06 斯昆特医疗公司 Filamentary devices for treatment of vascular defects
US9675482B2 (en) 2008-05-13 2017-06-13 Covidien Lp Braid implant delivery systems
EP2310035B1 (en) 2008-06-16 2015-08-26 University Of Rochester Fibroblast growth factor (fgf) analogs and uses thereof
RU2011102994A (en) 2008-07-22 2012-08-27 Микро Терапьютикс, Инк. (Us) VESSEL RECONSTRUCTION DEVICE
EP2444116B1 (en) 2008-08-19 2016-01-06 Covidien LP Detachable tip microcatheter
KR101652804B1 (en) 2008-09-05 2016-08-31 펄사 배스큘라, 아이엔씨. Systems and methods for supporting or occluding a physiological opening or cavity
EP2805680B1 (en) 2009-09-04 2017-10-25 Pulsar Vascular, Inc. Systems for enclosing an anatomical opening
US20110152993A1 (en) * 2009-11-05 2011-06-23 Sequent Medical Inc. Multiple layer filamentary devices or treatment of vascular defects
US9814562B2 (en) 2009-11-09 2017-11-14 Covidien Lp Interference-relief type delivery detachment systems
ES2534192T3 (en) * 2009-11-09 2015-04-20 Covidien Lp Features of mesh ball embolic device
US9358140B1 (en) 2009-11-18 2016-06-07 Aneuclose Llc Stent with outer member to embolize an aneurysm
CN105361976B (en) 2009-11-30 2017-08-18 恩多斯潘有限公司 For implantation into the multi-part overlay film frame system in the blood vessel with multiple branches
WO2011094634A1 (en) * 2010-01-28 2011-08-04 Micro Therapeutics, Inc. Vascular remodeling device
US9468442B2 (en) * 2010-01-28 2016-10-18 Covidien Lp Vascular remodeling device
CA2789304C (en) * 2010-02-08 2018-01-02 Endospan Ltd. Thermal energy application for prevention and management of endoleaks in stent-grafts
US8998947B2 (en) 2010-09-10 2015-04-07 Medina Medical, Inc. Devices and methods for the treatment of vascular defects
US8974512B2 (en) 2010-09-10 2015-03-10 Medina Medical, Inc. Devices and methods for the treatment of vascular defects
WO2012078678A1 (en) 2010-12-06 2012-06-14 Tyco Healthcare Group Lp Vascular remodeling device
US9526638B2 (en) 2011-02-03 2016-12-27 Endospan Ltd. Implantable medical devices constructed of shape memory material
CA2825774C (en) 2011-02-11 2017-02-28 Frank P. Becking Two-stage deployment aneurysm embolization devices
WO2012117395A1 (en) 2011-03-02 2012-09-07 Endospan Ltd. Reduced-strain extra- vascular ring for treating aortic aneurysm
WO2012134990A1 (en) 2011-03-25 2012-10-04 Tyco Healthcare Group Lp Vascular remodeling device
JP2014522263A (en) 2011-05-11 2014-09-04 マイクロベンション インコーポレイテッド Device for occluding a lumen
CA2837717C (en) 2011-06-03 2019-07-09 Pulsar Vascular, Inc. Systems and methods for enclosing an anatomical opening, including shock absorbing aneurysm devices
EP2713904B1 (en) 2011-06-03 2018-01-10 Pulsar Vascular, Inc. Aneurysm devices with additional anchoring mechanisms and associated systems
EP2729095B1 (en) 2011-07-07 2016-10-26 Endospan Ltd. Stent fixation with reduced plastic deformation
US9839510B2 (en) 2011-08-28 2017-12-12 Endospan Ltd. Stent-grafts with post-deployment variable radial displacement
US8945171B2 (en) 2011-09-29 2015-02-03 Covidien Lp Delivery system for implantable devices
US9060886B2 (en) 2011-09-29 2015-06-23 Covidien Lp Vascular remodeling device
US8795313B2 (en) 2011-09-29 2014-08-05 Covidien Lp Device detachment systems with indicators
JP6174033B2 (en) 2011-10-05 2017-08-02 パルサー バスキュラー インコーポレイテッド Aneurysm device
WO2013065040A1 (en) 2011-10-30 2013-05-10 Endospan Ltd. Triple-collar stent-graft
WO2013169380A1 (en) 2012-05-10 2013-11-14 Pulsar Vascular, Inc. Coil-tipped aneurysm devices
US10568589B2 (en) * 2012-06-04 2020-02-25 Ge Medical Systems Israel, Ltd Method and system for performing an imaging scan of a subject
US10124087B2 (en) 2012-06-19 2018-11-13 Covidien Lp Detachable coupling for catheter
US9155647B2 (en) 2012-07-18 2015-10-13 Covidien Lp Methods and apparatus for luminal stenting
US9326774B2 (en) 2012-08-03 2016-05-03 Covidien Lp Device for implantation of medical devices
US9186267B2 (en) 2012-10-31 2015-11-17 Covidien Lp Wing bifurcation reconstruction device
US9314248B2 (en) 2012-11-06 2016-04-19 Covidien Lp Multi-pivot thrombectomy device
KR102309795B1 (en) 2012-11-13 2021-10-08 코비디엔 엘피 Occlusive devices
CN107456297A (en) 2013-01-08 2017-12-12 恩多斯潘有限公司 The minimum of Stent Graft Migration during implantation
US9295571B2 (en) 2013-01-17 2016-03-29 Covidien Lp Methods and apparatus for luminal stenting
WO2014141232A1 (en) 2013-03-11 2014-09-18 Endospan Ltd. Multi-component stent-graft system for aortic dissections
US9463105B2 (en) 2013-03-14 2016-10-11 Covidien Lp Methods and apparatus for luminal stenting
CN105142545B (en) 2013-03-15 2018-04-06 柯惠有限合伙公司 Locking device
EP2967576B1 (en) 2013-03-15 2023-02-15 Covidien LP Delivery and detachment mechanisms for vascular implants
US9907684B2 (en) 2013-05-08 2018-03-06 Aneuclose Llc Method of radially-asymmetric stent expansion
US9078658B2 (en) 2013-08-16 2015-07-14 Sequent Medical, Inc. Filamentary devices for treatment of vascular defects
US9955976B2 (en) 2013-08-16 2018-05-01 Sequent Medical, Inc. Filamentary devices for treatment of vascular defects
US10603197B2 (en) 2013-11-19 2020-03-31 Endospan Ltd. Stent system with radial-expansion locking
US9730701B2 (en) 2014-01-16 2017-08-15 Boston Scientific Scimed, Inc. Retrieval wire centering device
US11154302B2 (en) 2014-03-31 2021-10-26 DePuy Synthes Products, Inc. Aneurysm occlusion device
US11076860B2 (en) 2014-03-31 2021-08-03 DePuy Synthes Products, Inc. Aneurysm occlusion device
US9629635B2 (en) 2014-04-14 2017-04-25 Sequent Medical, Inc. Devices for therapeutic vascular procedures
US9814466B2 (en) 2014-08-08 2017-11-14 Covidien Lp Electrolytic and mechanical detachment for implant delivery systems
US9808256B2 (en) 2014-08-08 2017-11-07 Covidien Lp Electrolytic detachment elements for implant delivery systems
WO2016098113A1 (en) 2014-12-18 2016-06-23 Endospan Ltd. Endovascular stent-graft with fatigue-resistant lateral tube
US10857012B2 (en) 2015-01-20 2020-12-08 Neurogami Medical, Inc. Vascular implant
US10925611B2 (en) 2015-01-20 2021-02-23 Neurogami Medical, Inc. Packaging for surgical implant
US11484319B2 (en) 2015-01-20 2022-11-01 Neurogami Medical, Inc. Delivery system for micrograft for treating intracranial aneurysms
US10736730B2 (en) 2015-01-20 2020-08-11 Neurogami Medical, Inc. Vascular implant
US9999413B2 (en) 2015-01-20 2018-06-19 Neurogami Medical, Inc. Micrograft for the treatment of intracranial aneurysms and method for use
EP3247311B1 (en) 2015-01-22 2020-03-18 Koninklijke Philips N.V. Endograft visualization with pre-integrated optical shape sensing attachments
US9375333B1 (en) 2015-03-06 2016-06-28 Covidien Lp Implantable device detachment systems and associated devices and methods
US9717503B2 (en) 2015-05-11 2017-08-01 Covidien Lp Electrolytic detachment for implant delivery systems
US10478194B2 (en) 2015-09-23 2019-11-19 Covidien Lp Occlusive devices
US10828037B2 (en) 2016-06-27 2020-11-10 Covidien Lp Electrolytic detachment with fluid electrical connection
US10828039B2 (en) 2016-06-27 2020-11-10 Covidien Lp Electrolytic detachment for implantable devices
US10420563B2 (en) 2016-07-08 2019-09-24 Neurogami Medical, Inc. Delivery system insertable through body lumen
US10478195B2 (en) 2016-08-04 2019-11-19 Covidien Lp Devices, systems, and methods for the treatment of vascular defects
KR20190115474A (en) 2017-02-23 2019-10-11 디퍼이 신테스 프로덕츠, 인코포레이티드 Aneurysm device and delivery system
US10675036B2 (en) 2017-08-22 2020-06-09 Covidien Lp Devices, systems, and methods for the treatment of vascular defects
CN110753521A (en) * 2017-09-01 2020-02-04 美它克医药公司 Medical devices including a detachable balloon and methods of making and using
US10905430B2 (en) 2018-01-24 2021-02-02 DePuy Synthes Products, Inc. Aneurysm device and delivery system
US11596412B2 (en) 2018-05-25 2023-03-07 DePuy Synthes Products, Inc. Aneurysm device and delivery system
US11058430B2 (en) 2018-05-25 2021-07-13 DePuy Synthes Products, Inc. Aneurysm device and delivery system
US10939915B2 (en) 2018-05-31 2021-03-09 DePuy Synthes Products, Inc. Aneurysm device and delivery system
US11051825B2 (en) 2018-08-08 2021-07-06 DePuy Synthes Products, Inc. Delivery system for embolic braid
US11123077B2 (en) 2018-09-25 2021-09-21 DePuy Synthes Products, Inc. Intrasaccular device positioning and deployment system
US11076861B2 (en) 2018-10-12 2021-08-03 DePuy Synthes Products, Inc. Folded aneurysm treatment device and delivery method
US11406392B2 (en) 2018-12-12 2022-08-09 DePuy Synthes Products, Inc. Aneurysm occluding device for use with coagulating agents
WO2020131976A2 (en) 2018-12-17 2020-06-25 Covidien Lp Devices, systems, and methods for the treatment of vascular defects
US11272939B2 (en) 2018-12-18 2022-03-15 DePuy Synthes Products, Inc. Intrasaccular flow diverter for treating cerebral aneurysms
US11134953B2 (en) 2019-02-06 2021-10-05 DePuy Synthes Products, Inc. Adhesive cover occluding device for aneurysm treatment
WO2020190620A1 (en) 2019-03-15 2020-09-24 Sequent Medical, Inc. Filamentary devices for treatment of vascular defects
CN113573765B (en) 2019-03-15 2024-08-13 美科微先股份有限公司 Silk device for treating vascular defects
CN113573650B (en) 2019-03-15 2024-05-28 后续医疗股份有限公司 Wire device with flexible connection for treating vascular defects
US11337706B2 (en) 2019-03-27 2022-05-24 DePuy Synthes Products, Inc. Aneurysm treatment device
US11602350B2 (en) 2019-12-05 2023-03-14 DePuy Synthes Products, Inc. Intrasaccular inverting braid with highly flexible fill material
US11672542B2 (en) 2019-05-21 2023-06-13 DePuy Synthes Products, Inc. Aneurysm treatment with pushable ball segment
US11278292B2 (en) 2019-05-21 2022-03-22 DePuy Synthes Products, Inc. Inverting braided aneurysm treatment system and method
US11413046B2 (en) 2019-05-21 2022-08-16 DePuy Synthes Products, Inc. Layered braided aneurysm treatment device
US11497504B2 (en) 2019-05-21 2022-11-15 DePuy Synthes Products, Inc. Aneurysm treatment with pushable implanted braid
US10653425B1 (en) 2019-05-21 2020-05-19 DePuy Synthes Products, Inc. Layered braided aneurysm treatment device
US11607226B2 (en) 2019-05-21 2023-03-21 DePuy Synthes Products, Inc. Layered braided aneurysm treatment device with corrugations
EP4403118A3 (en) 2019-07-17 2024-10-09 Boston Scientific Scimed, Inc. Left atrial appendage implant with continuous covering
CN114340516A (en) 2019-08-30 2022-04-12 波士顿科学医学有限公司 Left atrial appendage implant with sealing disk
US11504816B2 (en) 2019-11-04 2022-11-22 Covidien Lp Systems and methods for treating aneurysms
US11457926B2 (en) 2019-12-18 2022-10-04 DePuy Synthes Products, Inc. Implant having an intrasaccular section and intravascular section
US12070220B2 (en) 2020-03-11 2024-08-27 Microvention, Inc. Devices having multiple permeable shells for treatment of vascular defects
US12023034B2 (en) 2020-03-11 2024-07-02 Microvention, Inc. Devices for treatment of vascular defects
EP4125634A1 (en) 2020-03-24 2023-02-08 Boston Scientific Scimed Inc. Medical system for treating a left atrial appendage
US11931041B2 (en) 2020-05-12 2024-03-19 Covidien Lp Devices, systems, and methods for the treatment of vascular defects
JP7315969B2 (en) * 2021-01-27 2023-07-27 株式会社SG-1Medical Vascular plug and therapeutic device
CN113796912A (en) * 2021-10-09 2021-12-17 上海励楷科技有限公司 Intratumoral embolization device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997026939A1 (en) * 1994-07-08 1997-07-31 Microvena Corporation Method and apparatus for occluding aneurysms
WO1997031672A1 (en) * 1996-02-28 1997-09-04 B. Braun Medical, Inc. Self-expanding cardiovascular occlusion device
EP0820726A2 (en) * 1996-07-26 1998-01-28 Target Therapeutics, Inc. Aneurysm closure device assembly
WO1999005977A1 (en) * 1997-08-04 1999-02-11 Boston Scientific Corporation Occlusion system for aneurysm repair
WO1999007294A1 (en) * 1997-08-05 1999-02-18 Boston Scientific, Limited Detachable aneurysm neck bridge (ii)

Family Cites Families (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1667730A (en) 1928-05-01 of chicago
US1341052A (en) 1916-06-15 1920-05-25 Francis G Gale Chain
FR592182A (en) 1924-03-24 1925-07-28 Urethral probe
US2078182A (en) 1935-08-09 1937-04-20 Sirian Wire And Contact Compan Tungsten manufacture
US2549335A (en) 1947-04-18 1951-04-17 Rahthus Max Ornamental chain
US3334629A (en) 1964-11-09 1967-08-08 Bertram D Cohn Occlusive device for inferior vena cava
US3452740A (en) 1966-05-31 1969-07-01 Us Catheter & Instr Corp Spring guide manipulator
US3649224A (en) 1968-04-18 1972-03-14 Sylvania Electric Prod Method of making nonsag filaments for electric lamps
US3868956A (en) 1972-06-05 1975-03-04 Ralph J Alfidi Vessel implantable appliance and method of implanting it
US3874388A (en) 1973-02-12 1975-04-01 Ochsner Med Found Alton Shunt defect closure system
US4007743A (en) 1975-10-20 1977-02-15 American Hospital Supply Corporation Opening mechanism for umbrella-like intravascular shunt defect closure device
GB2066839B (en) 1979-12-29 1984-03-14 Vysoka Skola Chem Tech Method of manufacture of perfumed detergents
DE3133814C2 (en) 1981-08-25 1983-12-22 Helopharm W. Petrik & Co Kg, 1000 Berlin 2- [2'-Hydroxy-3 '- (1,1-dimethylpropylamino) -propoxy] -β-phenylpropiophenone, its acid addition salts and drugs
CA1204643A (en) 1981-09-16 1986-05-20 Hans I. Wallsten Device for application in blood vessels or other difficulty accessible locations and its use
SE445884B (en) 1982-04-30 1986-07-28 Medinvent Sa DEVICE FOR IMPLANTATION OF A RODFORM PROTECTION
US4638803A (en) 1982-09-30 1987-01-27 Rand Robert W Medical apparatus for inducing scar tissue formation in a body
US4494531A (en) 1982-12-06 1985-01-22 Cook, Incorporated Expandable blood clot filter
US4512338A (en) 1983-01-25 1985-04-23 Balko Alexander B Process for restoring patency to body vessels
DK151404C (en) 1984-05-23 1988-07-18 Cook Europ Aps William FULLY FILTER FOR IMPLANTATION IN A PATIENT'S BLOOD
EP0183372A1 (en) 1984-10-19 1986-06-04 RAYCHEM CORPORATION (a Delaware corporation) Prosthetic stent
US4718907A (en) 1985-06-20 1988-01-12 Atrium Medical Corporation Vascular prosthesis having fluorinated coating with varying F/C ratio
US4748986A (en) 1985-11-26 1988-06-07 Advanced Cardiovascular Systems, Inc. Floppy guide wire with opaque tip
DE3786721D1 (en) 1986-02-24 1993-09-02 Fischell Robert DEVICE FOR DETECTING BLOOD VESSELS AND SYSTEM FOR ITS INTRODUCTION.
US4800882A (en) 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US4813925A (en) 1987-04-21 1989-03-21 Medical Engineering Corporation Spiral ureteral stent
US4795458A (en) 1987-07-02 1989-01-03 Regan Barrie F Stent for use following balloon angioplasty
US4850960A (en) 1987-07-08 1989-07-25 Joseph Grayzel Diagonally tapered, bevelled tip introducing catheter and sheath and method for insertion
US4813934A (en) 1987-08-07 1989-03-21 Target Therapeutics Valved catheter device and method
US5133732A (en) 1987-10-19 1992-07-28 Medtronic, Inc. Intravascular stent
US4820298A (en) 1987-11-20 1989-04-11 Leveen Eric G Internal vascular prosthesis
FR2632864B2 (en) 1987-12-31 1990-10-19 Biomat Sarl ANTI-EMBOLIC ELASTIC FILTERING SYSTEM FOR CELLAR VEIN AND ASSEMBLY OF MEANS FOR ITS PLACEMENT
JP2561853B2 (en) 1988-01-28 1996-12-11 株式会社ジェイ・エム・エス Shaped memory molded article and method of using the same
US4830003A (en) 1988-06-17 1989-05-16 Wolff Rodney G Compressive stent and delivery system
US5176661A (en) 1988-09-06 1993-01-05 Advanced Cardiovascular Systems, Inc. Composite vascular catheter
US4957479A (en) 1988-10-17 1990-09-18 Vance Products Incorporated Indwelling ureteral stent placement apparatus
US4994069A (en) 1988-11-02 1991-02-19 Target Therapeutics Vaso-occlusion coil and method
US4856516A (en) 1989-01-09 1989-08-15 Cordis Corporation Endovascular stent apparatus and method
US5203772A (en) 1989-01-09 1993-04-20 Pilot Cardiovascular Systems, Inc. Steerable medical device
CH678393A5 (en) 1989-01-26 1991-09-13 Ulrich Prof Dr Med Sigwart
US4990155A (en) 1989-05-19 1991-02-05 Wilkoff Howard M Surgical stent method and apparatus
NL8901350A (en) 1989-05-29 1990-12-17 Wouter Matthijs Muijs Van De M CLOSURE ASSEMBLY.
EP0408245B1 (en) 1989-07-13 1994-03-02 American Medical Systems, Inc. Stent placement instrument
CA2026604A1 (en) 1989-10-02 1991-04-03 Rodney G. Wolff Articulated stent
GB2238485B (en) 1989-11-28 1993-07-14 Cook William Europ A collapsible filter for introduction in a blood vessel of a patient
DE4102550A1 (en) 1990-02-02 1991-08-08 Stephan Prof Dr Bockenheimer Sealing blood vessel fistula - involves inserted sleeve with spiral support with turns bridged by impervious elastic material
DE69108423T2 (en) 1990-02-08 1995-07-27 Howmedica Inflatable dilator.
US5186992A (en) 1990-03-12 1993-02-16 The Bentley-Harris Manufacturing Company Braided product and method of making same
US5122136A (en) 1990-03-13 1992-06-16 The Regents Of The University Of California Endovascular electrolytically detachable guidewire tip for the electroformation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US5569245A (en) 1990-03-13 1996-10-29 The Regents Of The University Of California Detachable endovascular occlusion device activated by alternating electric current
US5354295A (en) 1990-03-13 1994-10-11 Target Therapeutics, Inc. In an endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US5071407A (en) 1990-04-12 1991-12-10 Schneider (U.S.A.) Inc. Radially expandable fixation member
US5108407A (en) 1990-06-08 1992-04-28 Rush-Presbyterian St. Luke's Medical Center Method and apparatus for placement of an embolic coil
US5578071A (en) 1990-06-11 1996-11-26 Parodi; Juan C. Aortic graft
US5064435A (en) 1990-06-28 1991-11-12 Schneider (Usa) Inc. Self-expanding prosthesis having stable axial length
US5041084A (en) 1990-08-09 1991-08-20 Dlp, Inc. Single stage venous catheter
US5176625A (en) 1990-10-25 1993-01-05 Brisson A Glen Stent for ureter
US5160341A (en) 1990-11-08 1992-11-03 Advanced Surgical Intervention, Inc. Resorbable urethral stent and apparatus for its insertion
US5133731A (en) 1990-11-09 1992-07-28 Catheter Research, Inc. Embolus supply system and method
US5347052A (en) 1991-04-15 1994-09-13 Occidental Chemical Corporation Preparation of 3,5-diaminobenzotrifluoride
US5228453A (en) 1991-05-07 1993-07-20 Target Therapeutics, Inc. Catheter guide wire
US5217484A (en) 1991-06-07 1993-06-08 Marks Michael P Retractable-wire catheter device and method
US5147370A (en) 1991-06-12 1992-09-15 Mcnamara Thomas O Nitinol stent for hollow body conduits
US5141502A (en) 1991-08-28 1992-08-25 Macaluso Jr Joseph N Ureteral stent
CA2078530A1 (en) 1991-09-23 1993-03-24 Jay Erlebacher Percutaneous arterial puncture seal device and insertion tool therefore
US5183085A (en) 1991-09-27 1993-02-02 Hans Timmermans Method and apparatus for compressing a stent prior to insertion
US5304194A (en) 1991-10-02 1994-04-19 Target Therapeutics Vasoocclusion coil with attached fibrous element(s)
US5226911A (en) 1991-10-02 1993-07-13 Target Therapeutics Vasoocclusion coil with attached fibrous element(s)
US5151105A (en) 1991-10-07 1992-09-29 Kwan Gett Clifford Collapsible vessel sleeve implant
CA2082090C (en) 1991-11-05 2004-04-27 Jack Fagan Improved occluder for repair of cardiac and vascular defects
DE69229539T2 (en) 1991-11-05 2000-02-17 Children's Medical Center Corp., Boston Occlusion device for repairing heart and vascular defects
US5234437A (en) 1991-12-12 1993-08-10 Target Therapeutics, Inc. Detachable pusher-vasoocclusion coil assembly with threaded coupling
US5261916A (en) 1991-12-12 1993-11-16 Target Therapeutics Detachable pusher-vasoocclusive coil assembly with interlocking ball and keyway coupling
US5258042A (en) 1991-12-16 1993-11-02 Henry Ford Health System Intravascular hydrogel implant
US5243996A (en) 1992-01-03 1993-09-14 Cook, Incorporated Small-diameter superelastic wire guide
US5507767A (en) 1992-01-15 1996-04-16 Cook Incorporated Spiral stent
US5222969A (en) 1992-03-16 1993-06-29 Rolando Gillis Intravascular stent for cardiovascular intervention
US5342387A (en) 1992-06-18 1994-08-30 American Biomed, Inc. Artificial support for a blood vessel
US5643339A (en) * 1992-08-06 1997-07-01 William Cook Europe A/S Prosthetic device for sustaining a blood-vessel or hollow organ lumen
US5527338A (en) 1992-09-02 1996-06-18 Board Of Regents, The University Of Texas System Intravascular device
US5443478A (en) 1992-09-02 1995-08-22 Board Of Regents, The University Of Texas System Multi-element intravascular occlusion device
US5250071A (en) 1992-09-22 1993-10-05 Target Therapeutics, Inc. Detachable embolic coil assembly using interlocking clasps and method of use
US5312415A (en) 1992-09-22 1994-05-17 Target Therapeutics, Inc. Assembly for placement of embolic coils using frictional placement
US5350397A (en) 1992-11-13 1994-09-27 Target Therapeutics, Inc. Axially detachable embolic coil assembly
US5382259A (en) 1992-10-26 1995-01-17 Target Therapeutics, Inc. Vasoocclusion coil with attached tubular woven or braided fibrous covering
US5690666A (en) 1992-11-18 1997-11-25 Target Therapeutics, Inc. Ultrasoft embolism coils and process for using them
US5423849A (en) 1993-01-15 1995-06-13 Target Therapeutics, Inc. Vasoocclusion device containing radiopaque fibers
US5370691A (en) 1993-01-26 1994-12-06 Target Therapeutics, Inc. Intravascular inflatable stent
US5336205A (en) 1993-02-25 1994-08-09 Target Therapeutics, Inc. Flow directed catheter
US5800453A (en) 1993-04-19 1998-09-01 Target Therapeutics, Inc. Detachable embolic coil assembly using interlocking hooks and slots
IL105828A (en) 1993-05-28 1999-06-20 Medinol Ltd Medical stent
CA2125258C (en) 1993-08-05 1998-12-22 Dinah B Quiachon Multicapsule intraluminal grafting system and method
US5423829A (en) 1993-11-03 1995-06-13 Target Therapeutics, Inc. Electrolytically severable joint for endovascular embolic devices
US5624449A (en) 1993-11-03 1997-04-29 Target Therapeutics Electrolytically severable joint for endovascular embolic devices
IL108832A (en) 1994-03-03 1999-12-31 Medinol Ltd Urological stent and deployment device therefor
AU690237B2 (en) 1994-03-03 1998-04-23 Target Therapeutics, Inc. Method for detecting separation of a vasoocclusion device
US5441516A (en) 1994-03-03 1995-08-15 Scimed Lifesystems Inc. Temporary stent
US5549663A (en) 1994-03-09 1996-08-27 Cordis Corporation Endoprosthesis having graft member and exposed welded end junctions, method and procedure
US5417708A (en) 1994-03-09 1995-05-23 Cook Incorporated Intravascular treatment system and percutaneous release mechanism therefor
US5634942A (en) * 1994-04-21 1997-06-03 B. Braun Celsa Assembly comprising a blood filter for temporary or definitive use and a device for implanting it
US5549624A (en) 1994-06-24 1996-08-27 Target Therapeutics, Inc. Fibered vasooclusion coils
US5725546A (en) 1994-06-24 1998-03-10 Target Therapeutics, Inc. Detachable microcoil delivery catheter
US5522836A (en) 1994-06-27 1996-06-04 Target Therapeutics, Inc. Electrolytically severable coil assembly with movable detachment point
US5725552A (en) 1994-07-08 1998-03-10 Aga Medical Corporation Percutaneous catheter directed intravascular occlusion devices
US5433727A (en) 1994-08-16 1995-07-18 Sideris; Eleftherios B. Centering buttoned device for the occlusion of large defects for occluding
JP3669378B2 (en) 1994-09-08 2005-07-06 株式会社ニコン Optical material and manufacturing method thereof
US5601595A (en) * 1994-10-25 1997-02-11 Scimed Life Systems, Inc. Remobable thrombus filter
US5549662A (en) 1994-11-07 1996-08-27 Scimed Life Systems, Inc. Expandable stent using sliding members
US5690671A (en) 1994-12-13 1997-11-25 Micro Interventional Systems, Inc. Embolic elements and methods and apparatus for their delivery
US5637113A (en) 1994-12-13 1997-06-10 Advanced Cardiovascular Systems, Inc. Polymer film for wrapping a stent structure
US5814062A (en) 1994-12-22 1998-09-29 Target Therapeutics, Inc. Implant delivery assembly with expandable coupling/decoupling mechanism
US5514176A (en) 1995-01-20 1996-05-07 Vance Products Inc. Pull apart coil stent
ATE226804T1 (en) 1995-03-30 2002-11-15 Boston Scient Ltd SYSTEM FOR IMPLANTING LIQUID SPIRALS WITH SECONDARY STRUCTURE
US5645558A (en) 1995-04-20 1997-07-08 Medical University Of South Carolina Anatomically shaped vasoocclusive device and method of making the same
US6638291B1 (en) 1995-04-20 2003-10-28 Micrus Corporation Three dimensional, low friction vasoocclusive coil, and method of manufacture
US5639277A (en) 1995-04-28 1997-06-17 Target Therapeutics, Inc. Embolic coils with offset helical and twisted helical shapes
US5766160A (en) 1995-06-06 1998-06-16 Target Therapeutics, Inc. Variable stiffness coils
NO962336L (en) 1995-06-06 1996-12-09 Target Therapeutics Inc Vaso-occlusive spiral
US5624461A (en) 1995-06-06 1997-04-29 Target Therapeutics, Inc. Three dimensional in-filling vaso-occlusive coils
US5582619A (en) 1995-06-30 1996-12-10 Target Therapeutics, Inc. Stretch resistant vaso-occlusive coils
US5601600A (en) 1995-09-08 1997-02-11 Conceptus, Inc. Endoluminal coil delivery system having a mechanical release mechanism
WO1997016119A1 (en) 1995-10-30 1997-05-09 Children's Medical Center Corporation Self-centering umbrella-type septal closure device
AU690862B2 (en) 1995-12-04 1998-04-30 Target Therapeutics, Inc. Fibered micro vaso-occlusive devices
US5749894A (en) 1996-01-18 1998-05-12 Target Therapeutics, Inc. Aneurysm closure method
US5690643A (en) 1996-02-20 1997-11-25 Leocor, Incorporated Stent delivery system
US5649949A (en) 1996-03-14 1997-07-22 Target Therapeutics, Inc. Variable cross-section conical vasoocclusive coils
US6190402B1 (en) 1996-06-21 2001-02-20 Musc Foundation For Research Development Insitu formable and self-forming intravascular flow modifier (IFM) and IFM assembly for deployment of same
US5676697A (en) 1996-07-29 1997-10-14 Cardiovascular Dynamics, Inc. Two-piece, bifurcated intraluminal graft for repair of aneurysm
US5690667A (en) 1996-09-26 1997-11-25 Target Therapeutics Vasoocclusion coil having a polymer tip
US6447530B1 (en) * 1996-11-27 2002-09-10 Scimed Life Systems, Inc. Atraumatic anchoring and disengagement mechanism for permanent implant device
US5733329A (en) 1996-12-30 1998-03-31 Target Therapeutics, Inc. Vaso-occlusive coil with conical end
FR2758078B1 (en) * 1997-01-03 1999-07-16 Braun Celsa Sa BLOOD FILTER WITH IMPROVED PERMEABILITY
US6137060A (en) * 1997-05-02 2000-10-24 General Science And Technology Corp Multifilament drawn radiopaque highly elastic cables and methods of making the same
DE69834920T2 (en) 1997-08-05 2007-05-24 Boston Scientific Ltd., St. Michael REMOVABLE SYSTEM FOR CLOSING AN ANEURYSMAS NECK
US6159165A (en) 1997-12-05 2000-12-12 Micrus Corporation Three dimensional spherical micro-coils manufactured from radiopaque nickel-titanium microstrand
US6036720A (en) 1997-12-15 2000-03-14 Target Therapeutics, Inc. Sheet metal aneurysm neck bridge

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997026939A1 (en) * 1994-07-08 1997-07-31 Microvena Corporation Method and apparatus for occluding aneurysms
WO1997031672A1 (en) * 1996-02-28 1997-09-04 B. Braun Medical, Inc. Self-expanding cardiovascular occlusion device
EP0820726A2 (en) * 1996-07-26 1998-01-28 Target Therapeutics, Inc. Aneurysm closure device assembly
WO1999005977A1 (en) * 1997-08-04 1999-02-11 Boston Scientific Corporation Occlusion system for aneurysm repair
WO1999007294A1 (en) * 1997-08-05 1999-02-18 Boston Scientific, Limited Detachable aneurysm neck bridge (ii)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9050095B2 (en) 2004-09-22 2015-06-09 Covidien Lp Medical implant
US9579104B2 (en) 2011-11-30 2017-02-28 Covidien Lp Positioning and detaching implants
US10335155B2 (en) 2011-11-30 2019-07-02 Covidien Lp Positioning and detaching implants
US10893868B2 (en) 2012-01-20 2021-01-19 Covidien Lp Aneurysm treatment coils
US9687245B2 (en) 2012-03-23 2017-06-27 Covidien Lp Occlusive devices and methods of use
US9713475B2 (en) 2014-04-18 2017-07-25 Covidien Lp Embolic medical devices
WO2018005042A1 (en) * 2016-06-28 2018-01-04 Covidien Lp Implant detachment with thermal activation
WO2019199640A1 (en) * 2018-04-10 2019-10-17 Medstar Health Embolization scaffold devices
US11103253B2 (en) 2018-04-10 2021-08-31 Medstar Health Embolization scaffold devices
US11382633B2 (en) 2019-03-06 2022-07-12 DePuy Synthes Products, Inc. Strut flow diverter for cerebral aneurysms and methods for preventing strut entanglement

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DE69928794D1 (en) 2006-01-12
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EP1076518A1 (en) 2001-02-21
DE69928794T2 (en) 2006-07-06
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JP2002513612A (en) 2002-05-14
JP4108273B2 (en) 2008-06-25

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