JP7315969B2 - Vascular plug and therapeutic device - Google Patents

Description

The present invention relates to a vascular plug and therapeutic device comprising the same.

Conventionally, in order to prevent rupture of an aneurysm formed in a patient's blood vessel, a treatment has been performed in which a coil is indwelled inside the aneurysm. In recent years, a treatment of embolizing an aneurysm with a vascular plug instead of a coil has also been performed. As this type of vascular plug, a vascular plug including a pusher wire and a mesh portion has been proposed. The mesh portion of this vascular plug is housed in a catheter in a reduced diameter state, and is configured to expand when pushed out of the catheter (see, for example, Patent Document 1).

Japanese Patent No. 6750045

If the size of the expanded mesh portion of the vascular plug does not match the size of the aneurysm, not only is it difficult to embolize the aneurysm appropriately, but other problems are likely to occur. For example, if the size of the mesh portion is smaller than the size of the aneurysm, blood will easily enter the interior of the aneurysm, which may lead to further expansion of the aneurysm. In addition, if the size of the mesh portion is larger than the size of the aneurysm, part of the mesh portion may protrude toward the blood vessel and block blood flow. Therefore, in the treatment using conventional vascular plugs, it is necessary to prepare multiple vascular plugs of different sizes and to select the optimal sized vascular plug from among them, which complicates preoperative work. There was a problem.

In addition, the vascular plug described in Patent Document 1 (hereinafter also referred to as "conventional vascular plug") may cause the following problems. FIG. 6A and FIG. 6B are diagrams for explaining how the mesh part 104 is placed in the bifurcation aneurysm AN using the treatment device 101 having the conventional blood vessel plug 102 . As shown in FIG. 6A, in the conventional treatment device 101, when the distal end of the catheter 103 is fed into the bifurcation aneurysm AN and the pusher wire 105 is operated in that state, it is housed in the catheter 3. The mesh part 104 is extruded from the tip side. At this time, the pusher wire 105 is pushed out little by little so that the mesh part 104 does not inadvertently protrude from the distal end of the catheter 103 . However, when more than half of the mesh portion 104 is pushed out, the expansion force of the mesh portion 104 pushed out earlier may cause the remaining mesh portion 104 to be pulled out of the catheter 103 . When such a pull-out force acts, as shown in FIG. 6B, the mesh part 104 suddenly pops out, weakening the bifurcation aneurysm AN and possibly breaking through it. In order to avoid problems caused by such abrupt deployment of the mesh part 104, the tip of the catheter 103 must be carefully pulled out from the bifurcation aneurysm AN while pushing the pusher wire 105 distally. However, the degree of difficulty of the operation becomes even higher. Therefore, conventionally, it has been demanded to have a high degree of freedom in the size of the aneurysm and to suppress rapid expansion of the expanded portion such as the mesh portion 104 .

SUMMARY OF THE INVENTION An object of the present invention is to provide a vascular plug and a therapeutic device that have a high degree of freedom in size for an aneurysm and suppress rapid expansion of an enlarged portion.

One embodiment of the present invention is a vascular plug for embolizing an aneurysm formed in a blood vessel, comprising: a pusher wire; The expansion part is a vascular plug that is reduced in diameter and has a substantially cylindrical shape when housed in the catheter, and curls outward from the distal end side when not housed.

In the vascular plug described above, the expanded portion may be configured such that the curled shape changes according to the size of the indwelling aneurysm.

In the above-described vascular plug, the expansion portion may be open at least on a distal end side.

In the above invention relating to the blood vessel plug, the extension portion may be configured such that the distal end side curls outward more than two times when not retracted.

The blood vessel plug of the invention may be configured to include a connecting portion that separably connects the pusher wire and the expansion portion.

In the above vascular plug invention, the expansion portion may be mesh-like.

In the above vascular plug invention, the expansion portion may be non-mesh.

The vascular plug may be used to embolize a bifurcation aneurysm.

Another aspect of the present invention is a therapeutic device comprising the vascular plug according to any one of the above inventions and a catheter that houses the vascular plug.

In the above-described therapeutic device, the blood vessel plug may be housed in the catheter, and the expanded portion may be expanded with the distal end of the catheter positioned within the aneurysm.

According to the present invention, it is possible to provide a vascular plug and a therapeutic device that have a high degree of freedom in terms of size for an aneurysm and suppress rapid expansion of the expanded portion.

1 is a perspective view of a therapeutic device 1 comprising a vascular plug 2 of a first embodiment; FIG. Fig. 3 is a cross-sectional view of the blood vessel plug 2, which is not housed in the catheter 3, cut along the axis. Fig. 3 is a cross-sectional view of the blood vessel plug 2 housed in the catheter 3, cut along the center of the axis. FIG. 3 is a schematic diagram illustrating a procedure for placing a stent 4 in a bifurcation aneurysm AN using the therapeutic device 1 of the first embodiment; FIG. 3 is a schematic diagram illustrating a procedure for placing a stent 4 in a bifurcation aneurysm AN using the therapeutic device 1 of the first embodiment; FIG. 3 is a schematic diagram illustrating a procedure for placing a stent 4 in a bifurcation aneurysm AN using the therapeutic device 1 of the first embodiment; FIG. 3 is a schematic diagram illustrating a procedure for placing a stent 4 in a bifurcation aneurysm AN using the therapeutic device 1 of the first embodiment; Fig. 2 is a perspective view of a therapeutic device 1 comprising a second embodiment of a vascular plug 12; Fig. 10 is a perspective view of a therapeutic device 1 comprising a vascular plug 22 of a third embodiment; FIG. 10 is a view for explaining how a mesh part 104 is placed in a bifurcation aneurysm AN using a treatment device 101 having a conventional blood vessel plug 102. FIG. FIG. 10 is a view for explaining how a mesh part 104 is placed in a bifurcation aneurysm AN using a treatment device 101 having a conventional blood vessel plug 102. FIG.

Embodiments of vascular plugs and therapeutic devices according to the present invention are described below. The drawings attached to this specification are all schematic diagrams, and the shapes, scales, vertical-to-horizontal dimensional ratios, etc. of each part are changed or exaggerated from the actual ones in consideration of ease of understanding. Also, in the drawings, hatching indicating cross sections of members is appropriately omitted.

In this specification and the like, terms that specify shapes, geometric conditions, and degrees of these, such as terms such as "perpendicular" and "direction", in addition to the strict meaning of the terms, the degree to which they can be regarded as almost perpendicular , including the range that can be roughly regarded as the direction. In this specification, the axial direction (central axis direction) in a state where the pusher wire 5 (described later) is linearly extended is defined as the X direction. In the X direction, the proximal side (rear end side) closer to the operator is the X1 side, the distal side (front end side) farther from the operator is the X2 side, and the direction perpendicular to the X direction is the radial direction (Y direction). described as.

(First embodiment)
FIG. 1 is a perspective view of a therapeutic device 1 comprising a vascular plug 2 of a first embodiment. FIG. 2A is a cross-sectional view of the blood vessel plug 2 cut along the axis when it is not housed in the catheter 3 (when not housed). FIG. 2B is a cross-sectional view of the blood vessel plug 2 in a state (at the time of storage) housed in the catheter 3, cut along the center of the axis.
As shown in FIG. 1, therapeutic device 1 comprises a vascular plug 2 and a catheter 3 . The treatment device 1 is used for embolizing an aneurysm by enclosing a vascular plug 2 in a catheter 3 and expanding a stent 4 (described later) inside the aneurysm by pushing it out of the catheter 3 .

The vascular plug 2 comprises a stent (extension) 4, a pusher wire 5 and a connector 6, as shown in FIG. 2A.
The stent 4 is a structure placed inside the aneurysm. The stent 4 of this embodiment is used to suppress the inflow of blood into an aneurysm by expansion, unlike a general stent that secures the lumen of a blood vessel by expansion. As shown in FIGS. 1 and 2A, the stent 4 is three-dimensional in the axial direction (X direction) X and the radial direction (Y direction) when it is not housed (hereinafter also referred to as “during expansion”). self-expands into a nearly spherical shape.

Here, the substantially spherical shape is not limited to a spherical shape in a general sense, and may be a cylindrical shape with spherical ends, a disc shape bulging in the thickness direction, an ellipsoid, or the like. That is, the term “substantially spherical” as used herein means not only a general spherical shape, but also a shape that can be regarded as generally spherical or a three-dimensional shape (three-dimensional shape) that is similar to a spherical shape, and suppresses the inflow of blood into the aneurysm. It can be of any shape as long as it is possible. In addition, the stent 4 at the time of expansion may have unevenness formed on a part or the entire surface thereof.
On the other hand, as shown in FIG. 2B, the stent 4 is reduced in diameter and has an elongated tubular shape when housed in the catheter 3 . The stent 4 self-expands into a substantially spherical shape as shown in FIG. 2A by being pushed out of the catheter 3 from the contracted state shown in FIG. 2B.

As shown in FIG. 2B, the proximal side (X1 side) of the stent 4 is connected to the pusher wire 5 via a connecting portion 6 (described later). As shown in FIG. 2A, the proximal side of the stent 4 is located on the distal side (X2 side) when expanded. Moreover, as shown in FIG. 2B, the distal side (X2 side) of the stent 4 is open. As shown in FIG. 2A, the distal side of the stent 4 is located on the proximal side (X1 side) when expanded. Therefore, the stent 4 has a shape in which the distal end portion 31 (described later) located on the proximal side is not closed when expanded. When the stent 4 is expanded, it self-expands so that the tip side portion (hereinafter also referred to as "tip portion") 41 curls outward three-dimensionally. The stent 4 has a substantially spherical shape as a whole by curling the distal end portion 41 outward.

Note that FIG. 2A shows the shape of the stent 4 in a naturally expanded state. A naturally expanded state refers to a state in which the stent 4 is expanded in an open space. In the naturally expanded state, the stent 4 is in its most expanded state. In FIG. 2A, the stent 4 in a naturally expanded state in which the distal end portion 41 is curled in a single line is indicated by a solid line. , the tip portion 41 is double curled. Specifically, when the nodule is large, the amount of curling of the distal end portion 41 is reduced (for example, single fold), so the overall shape of the stent 4 is increased. On the other hand, when the nodule is small, as indicated by the phantom line, the tip portion 41 is curled more (for example, double or more), so the overall shape of the stent 4 becomes smaller. In this way, the stent 4 changes its curl shape according to the size of the aneurysm, so that the shape can be changed according to the size of the indwelling aneurysm.

In the stent 4, the characteristic that the curled shape of the distal end portion 41 changes according to the size of the aneurysm can be imparted, for example, by subjecting the stent 4 formed in a substantially spherical shape to a shape memory treatment, as described later. . In the stent 4 in the naturally expanded state shown in FIG. 2A, the length L between the connecting portion 6 and the distal side (X2 side) of the stent 4 (hereinafter also referred to as "protrusion length") is set appropriately. be able to. For example, by shortening the protrusion length L of the stent 4 in the naturally expanded state, the distal end of the catheter 3 can be fed deeper into the aneurysm when the stent 4 is placed inside the aneurysm. Therefore, the stent 4 can be expanded while the position of the distal end of the catheter 3 is stabilized.

The stent 4 of the first embodiment is made of metal or resin material in a mesh shape. In the stent 4, the size, density, etc. of the openings of the mesh portion can be appropriately set. The stent 4 can be produced, for example, by laser machining a tube made of a biocompatible material, particularly preferably a superelastic alloy, into a mesh. In the case of manufacturing from a superelastic alloy tube, in order to reduce the cost, a tube of about several mm is expanded into a desired shape (for example, a substantially spherical shape shown in FIG. 1) after laser processing, and shape memory is obtained in the tube material of that shape. It is preferably produced by applying a treatment. In addition, the stent 4 can be manufactured not only by laser processing but also by other methods such as cutting, or by weaving wire-shaped metal wires.

As a material for forming the stent 4, a material having high rigidity and high biocompatibility is preferable. Examples of such materials include titanium, nickel, stainless steel, platinum, gold, silver, copper, iron, chromium, cobalt, aluminum, molybdenum, manganese, tantalum, tungsten, niobium, magnesium, calcium, and alloys containing these. is mentioned. As such materials, polyolefins such as polyethylene (PE) and polypropylene (PP), and synthetic resin materials such as polyamide, polyvinyl chloride, polyphenylene sulfide, polycarbonate, polyether, and polymethyl methacrylate can also be used. Furthermore, as such materials, biodegradable resins (biodegradable polymers) such as polylactic acid (PLA), polyhydroxybutyrate (PHB), polyglycolic acid (PGA), polyε-caprolactone, etc. may be used. can.

Among these, titanium, nickel, stainless steel, platinum, gold, silver, copper, magnesium, or alloys containing these are desirable. Examples of alloys include Ni--Ti alloys, Cu--Mn alloys, Cu--Cd alloys, Co--Cr alloys, Cu--Al--Mn alloys, Au--Cd--Ag alloys and Ti--Al--V alloys. Examples of alloys include alloys of magnesium with Zr, Y, Ti, Ta, Nd, Nb, Zn, Ca, Al, Li, Mn, and the like. Among these alloys, Ni--Ti alloys are desirable.

The pusher wire 5 is a linear member that is manipulated by the practitioner when moving the stent 4 within the catheter 3 or within the blood vessel. The practitioner pushes or pulls the pusher wire 5 through an operation unit (not shown) connected to the proximal side (X1 side) of the pusher wire 5, thereby moving the inside of the catheter 3, blood vessel, aneurysm, etc. , the stent 4 can be advanced or retracted.

The connecting portion 6 is a member that separably connects the pusher wire 5 and the stent 4 (vascular plug 2). The connection part 6 is provided between the distal side (X2 side) of the pusher wire 5 and the proximal side (X1 side) of the stent 4, as shown in FIG. 2B. The connecting portion 6 is configured by, for example, a heater coil, a filament, or the like (not shown). When the heater coil is energized through the pusher wire 5, the heater coil is heated, and the heating melts and cuts the filament. The pusher wire 5 and the stent 4 are separated by cutting the filament. After expanding the stent 4 inside the aneurysm, the practitioner can withdraw only the pusher wire 5 while leaving the stent 4 in the aneurysm by energizing the heater coil via the pusher wire 5 . In FIG. 3D (described later) showing the stent 4 and the pusher wire 5 after the connecting portion 6 has been cut, the cut connecting portion 6 is omitted. Moreover, the connection portion 6 may be configured to be mechanically cut when a rotational force is applied to the pusher wire 5 in the circumferential direction. As long as the pusher wire 5 and the stent 4 can be separated by the operator's operation, the connection part 6 is not limited to the above example, and may have any configuration.

Catheter 3 is an elongated cylindrical tube in which vascular plug 2 is housed. The catheter 3 is inserted into, for example, a cerebral artery with the vascular plug 2 housed therein. A contrast marker (not shown) is provided at the distal end (X2 side) of the catheter 3 . The marker is a member that serves as a mark for confirming the position of the distal side of the catheter 3 within the blood vessel, and is made of a radiopaque material. In the following description, the distal end of the catheter 3 is also referred to as "the distal end 31 of the catheter 3" or "the distal end 31".

Next, a procedure for placing the stent 4 in the bifurcation aneurysm AN formed in vivo by treatment using the treatment device 1 of the first embodiment will be described.
3A to 3D are schematic diagrams illustrating the procedure for placing the stent 4 in the bifurcation aneurysm AN using the therapeutic device 1 of the first embodiment. The therapeutic device 1 is inserted into the living body with the vascular plug 2 housed in the catheter 3 (see FIG. 2B). A guide wire, a guiding catheter (not shown), and the like are used to guide the treatment device 1 to the bifurcation aneurysm AN, but the description of the work using these devices is omitted here.

First, as shown in FIG. 3A, the distal end portion 31 of the catheter 3 (treatment device 1) is guided to the vicinity of the blood vessel bifurcation B, and then the distal end portion 31 is fed into the bifurcation aneurysm AN. It is desirable that the distal end portion 31 of the catheter 3 be fed from the middle to the far side in the depth direction of the bifurcation aneurysm AN.

Next, while the proximal side (X1 side) of the catheter 3 is held, the pusher wire 5 is operated to push the stent 4 distally (X2 side). As a result, as shown in FIG. 3B, the distal end portion 41 of the stent 4 housed in the catheter 3 is pushed out from the distal end portion 31 of the catheter 3 and expanded while curling outward. The stent 4 expands while curling outward immediately after being pushed out from the distal end portion 31 of the catheter 3 . When the pusher wire 5 is operated to push the stent 4 further distally, the distal end portion 41 of the stent 4 expands while curling further outward as shown in FIG. 3C. As a result, the stent 4 expands while changing its shape according to the size of the bifurcation aneurysm AN, and finally assumes a substantially spherical shape that matches the size of the bifurcation aneurysm AN. The length by which the stent 4 protrudes from the distal end portion 31 of the catheter 3 is substantially the same regardless of the amount of pushing the stent 4 distally. That is, even if the stent 4 continues to be pushed distally, the stent 4 will not protrude beyond a certain length from the distal end portion 31 of the catheter 3 .

Next, the connecting portion 6 (see FIG. 2A) is energized to separate the pusher wire 5 and the stent 4 as shown in FIG. 3D. Then, the pusher wire 5 is pulled from the blood vessel bifurcation B to the proximal side (X1 side) together with the catheter 3 . Thereby, the catheter 3 and the pusher wire 5 can be recovered from the living body. When the catheter and pusher wire 5 are pulled out from the expanded stent 4, the distal end portion 41 of the stent 4 bulges toward the center, closing the hole through which the catheter and pusher wire 5 were inserted. Therefore, as will be described later, the inflow of blood from the opening (portion on the blood vessel side) of the bifurcation aneurysm AN is suppressed, and the outflow of blood remaining inside is suppressed to form a blood clot within the stent. can be done.

By the above procedure, the substantially spherical stent 4 can be indwelled inside the bifurcation aneurysm AN. 3A to 3D schematically show the procedures for placing the stent 4 in the bifurcation aneurysm AN. For actually placing the stent 4 in the bifurcation aneurysm AN, various treatments are performed depending on the site where the aneurysm is formed.

According to the blood vessel plug 2 of the first embodiment described above and the treatment device 1 including the same, the following effects can be obtained, for example.
In the vascular plug 2 of the first embodiment, the stent 4 curls outward from the tip 41 during expansion. Therefore, as shown in FIGS. 3A to 3D, for example, by expanding the stent 4 inside the bifurcation aneurysm AN, the shape of the stent 4 can be changed according to the size of the bifurcation aneurysm AN. can. As described above, the vascular plug 2 of the first embodiment has a high degree of freedom in terms of size for the aneurysm. Since there is no need to select the optimal stent size from among others, preoperative work can be simplified.

In the stent 4 of the first embodiment, one size can be applied to aneurysms of various sizes, but a plurality of sizes are prepared, and the stent 4 having a size suitable for the size of the aneurysm is prepared. You may make it select. In such a mode of use, it is desirable to increase the mesh density of the portion covering the opening of the aneurysm when the stent 4 is expanded. Moreover, when one stent 4 is used to treat aneurysms of various sizes, it is preferable to make the density of the mesh uniform throughout. This is because it is difficult to predict which part of the expanded stent 4 will cover the opening of the aneurysm.

In the vascular plug 2 of the first embodiment, the proximal side (X1 side) of the expanded stent 4 is in a state in which the curled distal end portions 41 are single (or double or more) overlapped, as shown in FIG. 2A, for example. Become. Then, when the pusher wire 5 is separated from the stent 4, the distal end portion 41 of the stent 4 is densely overlapped in a complicated manner. Therefore, according to the vascular plug 2 of the first embodiment, the inflow of blood from the opening (portion on the blood vessel side) of the bifurcation aneurysm AN is suppressed by the stent 4 placed inside the bifurcation aneurysm AN. In addition, blood clots can be formed in the stent 4 by suppressing outflow of blood remaining inside. It should be noted that how the distal end portion 41 of the stent 4 is curled during expansion can be set when the stent 4 is manufactured. That is, when the stent 4 is manufactured, the curled shape of the distal end portion 41 of the stent 4 can be memorized by subjecting the distal end portion 41 of the stent 4 to curling in a single or double or more curled state. .

The advantages of expanding the vascular plug 2 inside the bifurcation aneurysm AN will now be described.
The conventional blood vessel plug described in the above-mentioned Patent Document 1 is configured such that the mesh portion pushed out from the catheter expands forward in the pushing direction. Therefore, if the movement of the pusher wire inside the catheter is slowed down due to complicated bends in the blood vessel, when the pusher wire is strongly pushed distally, the mesh part suddenly pops out and the artery at the bifurcation is blocked. It can make the aneurysm brittle and possibly even pierce it. Also, even if no problem occurs when pushing the pusher wire distally, as described above with reference to FIG. The expansive force of the portion 104 can cause the mesh portion 104 to pop out abruptly, weakening the bifurcation aneurysm and possibly breaking through it.

In the conventional blood vessel plug, in order to avoid the above problems, for example, the pusher wire is pushed distally (X2 side), and at the same time, the pusher wire and catheter are pulled proximally (X1 side). can be considered. However, a high level of skill is required to perform the above operation in a complicatedly curved blood vessel, which further increases the difficulty of the operation. As another method, it is conceivable to expand the mesh part while the distal end of the catheter is advanced to the vicinity of the bifurcation aneurysm. However, since a vascular bifurcation with a bifurcation aneurysm has a complicated shape and also has blood flow, it is difficult to stabilize the position of the tip of the catheter, and the tip of the catheter detaches from the bifurcation aneurysm. Sometimes it turns in a direction. Therefore, when the mesh part is pushed out from the distal end of the catheter, the mesh part may pop out in an unintended direction.

In contrast, as shown in FIG. 3B, the stent 4 of the first embodiment expands while curling outward immediately after being pushed out from the distal end portion 31 of the catheter 3 . According to this, even if the distal end portion 41 of the stent 4 suddenly protrudes from the catheter 3, the distal end portion 41 expands while curling outward as indicated by the arrow in the figure, so the expansion force is reduced. Acts away from the distal inner wall surface of the aneurysm. Therefore, the risk of the distal end portion 41 of the stent 4 breaking through the bifurcation aneurysm AN can be greatly reduced.

Further, according to the stent 4 of the first embodiment, after the stent 4 is pushed out more than half, the pusher wire 5 is pulled proximally (X1 side) in order to prevent the stent 4 from suddenly popping out. No need. Therefore, while pushing the pusher wire 5 to the distal side (X2 side), there is no need to temporarily pull the pusher wire 5 to the proximal side. It is possible to use a method of separating the pusher wire 5 after expanding the entirety of the wire 4 .

Further, in the vascular plug 2 of the first embodiment, as shown in FIG. The stent 4 can be expanded while the position of the distal end portion 31 of the stent 4 is stabilized. Therefore, it is possible to prevent the distal end portion 31 of the catheter 3 from being oriented away from the bifurcation aneurysm AN, thereby preventing the stent 4 from protruding from the catheter 3 in an unintended direction.

(Other embodiments)
FIG. 4 is a perspective view of a therapeutic device 1 comprising a vascular plug 12 of a second embodiment. As shown in FIG. 4, in the vascular plug 12 of the second embodiment, the stent (expansion portion) 14 is formed in a more dense mesh than the stent 4 of the first embodiment. Although not shown, the mesh pattern may have a shape in which vertical and horizontal wires are perpendicular to each other, or may have a shape in which wavy wires are overlapped.
FIG. 5 is a perspective view of a therapeutic device 1 comprising a vascular plug 22 of a third embodiment. As shown in FIG. 5, in the vascular plug 22 of the third embodiment, the stent (expansion) 24 is formed in a uniform surface and substantially non-porous (non-mesh). The stent 24 of this embodiment can be made of, for example, a resin material.

Although the embodiments of the present invention have been described above, the present invention is not limited to the above-described embodiments, and various modifications and changes such as the modified embodiments described later are possible. included within the technical scope of Moreover, the effects described in the embodiments are merely enumerations of the most suitable effects produced by the present invention, and are not limited to those described in the embodiments. Although the above-described embodiment and modified embodiments described later can be used in combination as appropriate, detailed description thereof will be omitted.

(deformed form)
In the stent 4 of the first embodiment, the density of the mesh may be uniform throughout, or may be partially uneven. This variation can also be applied to the stent 14 of the second embodiment.
In the stent 24 of the third embodiment, a part may be mesh-like, and openings may be formed regularly or irregularly. The opening may be, for example, circular, oval, triangular, square, or the like.

In the vascular plug 2 of the first embodiment, the stent 4 may have a double structure. This variant can also be applied to the stent 14 of the second embodiment and the stent 24 of the third embodiment.
In the first embodiment, an example of indwelling the blood vessel plug 2 (stent 4) in the bifurcation aneurysm AN was shown, but the blood vessel plug 2 can also be applied to other embolizations. Such usage patterns are common to the stent 14 of the second embodiment and the stent 24 of the third embodiment.

Reference Signs List 1: therapeutic device 2, 12, 22: vascular plug 3: catheter 4, 14, 24: stent 5: pusher wire 6: connector 31: tip of catheter 3 41: tip of stent 4

Claims (8)

A vascular plug for embolizing an aneurysm formed in a blood vessel,
a pusher wire;
a mesh-shaped expansion part connected to the distal side of the pusher wire and indwelled in the aneurysm;
a connection section that separably connects the distal side of the pusher wire and the proximal side of the extension section;
with
The expanded portion has a reduced diameter and a substantially cylindrical shape when stored in the catheter, and curls outward from the distal end side when not stored.When the pusher wire is separated, the curled tip closes the hole through which the pusher wire is inserted.vascular plug. 2. The vascular plug according to claim 1 , further comprising a connecting portion detachably connecting the pusher wire and the extension portion. The blood vessel plug according to claim 1 or 2 , wherein the expanded portion changes in curl shape according to the size of the indwelling aneurysm. 4. The blood vessel plug according to any one of claims 1 to 3 , wherein at least the distal end side of the expansion part is open when housed in the catheter . 5. The vascular plug according to any one of claims 1 to 4 , wherein the distal end side of the expanded portion curls outward twice or more when it is not housed. The vascular plug according to any one of claims 1 to 5, which is used for embolizing a bifurcation aneurysm. a vascular plug according to any one of claims 1 to 6;
a catheter housing the vascular plug;
A therapeutic device comprising: 8. The therapeutic device according to claim 7, wherein the vascular plug is housed in the catheter, and the expanded portion is expanded with the distal end of the catheter positioned within the aneurysm.

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