WO1999044943A3 - Vektoren und viren zur gentherapie - Google Patents

Vektoren und viren zur gentherapie Download PDF

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Publication number
WO1999044943A3
WO1999044943A3 PCT/DE1999/000647 DE9900647W WO9944943A3 WO 1999044943 A3 WO1999044943 A3 WO 1999044943A3 DE 9900647 W DE9900647 W DE 9900647W WO 9944943 A3 WO9944943 A3 WO 9944943A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene therapy
vectors
viruses used
relates
viruses
Prior art date
Application number
PCT/DE1999/000647
Other languages
English (en)
French (fr)
Other versions
WO1999044943A2 (de
Inventor
Alexander Buerkle
Ralph Meyer
Original Assignee
Deutsches Krebsforsch
Alexander Buerkle
Ralph Meyer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforsch, Alexander Buerkle, Ralph Meyer filed Critical Deutsches Krebsforsch
Priority to AU36986/99A priority Critical patent/AU3698699A/en
Priority to JP2000534497A priority patent/JP2002505855A/ja
Priority to EP99919057A priority patent/EP1066221A2/de
Publication of WO1999044943A2 publication Critical patent/WO1999044943A2/de
Publication of WO1999044943A3 publication Critical patent/WO1999044943A3/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1077Pentosyltransferases (2.4.2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Die vorliegende Erfindung betrifft einen zur Gentherapie geeigneten Vektor, der eine exprimierbare Insert-DNA umfaßt, die für die im wesentlichen vollständige genetische Information der Poly(ADP-Ribose)-Polymerase codiert. Ferner betrifft die Erfindung Verfahren zur Herstellung eines solchen Vektors und Viren, die zur Gentherapie geeignet sind.
PCT/DE1999/000647 1998-03-03 1999-03-03 Vektoren und viren zur gentherapie WO1999044943A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU36986/99A AU3698699A (en) 1998-03-03 1999-03-03 Vectors and viruses used in gene therapy
JP2000534497A JP2002505855A (ja) 1998-03-03 1999-03-03 遺伝子治療に使用されるベクター及びウイルス
EP99919057A EP1066221A2 (de) 1998-03-03 1999-03-03 Vektoren und viren zur gentherapie

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19808889A DE19808889A1 (de) 1998-03-03 1998-03-03 Vektoren und Viren zur Gentherapie
DE19808889.2 1998-03-03

Publications (2)

Publication Number Publication Date
WO1999044943A2 WO1999044943A2 (de) 1999-09-10
WO1999044943A3 true WO1999044943A3 (de) 1999-12-09

Family

ID=7859479

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1999/000647 WO1999044943A2 (de) 1998-03-03 1999-03-03 Vektoren und viren zur gentherapie

Country Status (5)

Country Link
EP (1) EP1066221A2 (de)
JP (1) JP2002505855A (de)
AU (1) AU3698699A (de)
DE (1) DE19808889A1 (de)
WO (1) WO1999044943A2 (de)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996008571A1 (de) * 1994-09-16 1996-03-21 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Identifizierung von dna-schädigenden substanzen durch poly(adp-ribose)-polymerase überexprimierende zellinien
WO1996018737A2 (de) * 1994-12-16 1996-06-20 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Vektoren und viren zur gentherapie

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2150378C (en) * 1992-11-30 2007-10-30 Joel Moss Mammalian muscle nad:arginine adp-ribosyltransferase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996008571A1 (de) * 1994-09-16 1996-03-21 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Identifizierung von dna-schädigenden substanzen durch poly(adp-ribose)-polymerase überexprimierende zellinien
WO1996018737A2 (de) * 1994-12-16 1996-06-20 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Vektoren und viren zur gentherapie

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BERNGES F ET AL: "FUNCTIONAL OVEREXPRESSION OF HUMAN POLY(ADP-RIBOSE) POLYMERASE IN TRANSFECTED RAT TUMOR CELLS", CARCINOGENESIS, vol. 18, no. 4, 1 April 1997 (1997-04-01), pages 663 - 668, XP000789936 *
KUEPPER J -H ET AL: "EXPRESSION OF THE DNA-BINDING DOMAIN OF HUMAN POLY(ADP-RIBOSE) POLYMERASE AS A TRANS-DOMINANT INHIBITOR OF POLY(ADP-RIBOSYL)ATION IN TRANSFECTED EUCARYOTIC CELL LINES", ADP - RIBOSYLATION REACT, 1 January 1992 (1992-01-01), pages 38 - 46, XP000568905 *
KUPPER J H ET AL: "INHIBITION OF POLY(ADP-RIBOSYL)ATION BY OVEREXPRESSING THE POLY(ADP-RIBOSE) POLYMERASE DNA-BINDING DOMAIN IN MAMMALIAN CELLS", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265, no. 31, 5 November 1990 (1990-11-05), pages 18721 - 18724, XP002001544, ISSN: 0021-9258 *
MOLINETE ET AL: "Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells", EMBO JOURNAL, vol. 12, no. 5, 1 May 1993 (1993-05-01), pages 2109 - 2117, XP002090239, ISSN: 0261-4189 *

Also Published As

Publication number Publication date
WO1999044943A2 (de) 1999-09-10
DE19808889A1 (de) 1999-09-09
EP1066221A2 (de) 2001-01-10
JP2002505855A (ja) 2002-02-26
AU3698699A (en) 1999-09-20

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