WO1999033980A3 - Membres de familles de tnf et de tnfr - Google Patents
Membres de familles de tnf et de tnfr Download PDFInfo
- Publication number
- WO1999033980A3 WO1999033980A3 PCT/US1998/027474 US9827474W WO9933980A3 WO 1999033980 A3 WO1999033980 A3 WO 1999033980A3 US 9827474 W US9827474 W US 9827474W WO 9933980 A3 WO9933980 A3 WO 9933980A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tnf
- members
- proteins
- tnfr
- tnfr families
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU20934/99A AU2093499A (en) | 1997-12-30 | 1998-12-22 | Members of tnf and tnfr families |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6895997P | 1997-12-30 | 1997-12-30 | |
US60/068,959 | 1997-12-30 | ||
US21227098A | 1998-12-16 | 1998-12-16 | |
US09/212,270 | 1998-12-16 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1999033980A2 WO1999033980A2 (fr) | 1999-07-08 |
WO1999033980A9 WO1999033980A9 (fr) | 1999-10-14 |
WO1999033980A3 true WO1999033980A3 (fr) | 1999-11-18 |
Family
ID=26749548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/027474 WO1999033980A2 (fr) | 1997-12-30 | 1998-12-22 | Membres de familles de tnf et de tnfr |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2093499A (fr) |
WO (1) | WO1999033980A2 (fr) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6541224B2 (en) | 1996-03-14 | 2003-04-01 | Human Genome Sciences, Inc. | Tumor necrosis factor delta polypeptides |
US7217788B2 (en) | 1996-03-14 | 2007-05-15 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta polypeptides |
US6812327B1 (en) | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
US6689579B1 (en) | 1996-10-25 | 2004-02-10 | Human Genome Sciences, Inc. | Polynucleotides encoding neutrokine-α |
US7285267B2 (en) | 1997-01-14 | 2007-10-23 | Human Genome Sciences, Inc. | Tumor necrosis factor receptors 6α & 6β |
EP1007659B1 (fr) | 1997-01-14 | 2007-06-27 | Human Genome Sciences, Inc. | Recepteurs 6 alpha & 6 beta du facteur de necrose tumorale |
DE69837606T2 (de) | 1997-09-12 | 2008-02-14 | Biogen Idec Ma Inc., Cambridge | Cystein-reiche rezeptoren-train |
US6297367B1 (en) * | 1997-12-30 | 2001-10-02 | Chiron Corporation | Polynucleotide encoding TNFL1 |
AU2472899A (en) * | 1998-01-27 | 1999-08-09 | Millennium Pharmaceuticals, Inc. | Novel molecules of the tnf receptor superfamily and uses therefor |
CN100340292C (zh) | 1999-01-25 | 2007-10-03 | 比奥根艾迪克Ma公司 | Baff,其封闭剂以及它们在b细胞应答的调节中的应用 |
US20030095967A1 (en) | 1999-01-25 | 2003-05-22 | Mackay Fabienne | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders |
US6475986B1 (en) * | 1999-02-02 | 2002-11-05 | Research Development Foundation | Uses of THANK, a TNF homologue that activates apoptosis |
AU2574200A (en) * | 1999-02-19 | 2000-09-04 | Toshio Kitamura | Novel tnf receptor-like proteins |
AU777536B2 (en) * | 1999-02-23 | 2004-10-21 | Human Genome Sciences, Inc. | Neutrokine-alpha and neutrokine-alpha splice variant |
US20030022233A1 (en) | 1999-04-30 | 2003-01-30 | Raymond G. Goodwin | Methods of use of the taci/taci-l interaction |
EP2314694A3 (fr) | 1999-08-17 | 2013-12-11 | Biogen Idec MA Inc. | Récepteur BAFF (BCMA), agent immunorégulateur |
UA74798C2 (uk) | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
DE60028830T2 (de) | 2000-02-16 | 2007-01-18 | Genentech, Inc., South San Francisco | Anti-april antikörper und hybridomazellen |
NZ521540A (en) | 2000-04-11 | 2004-09-24 | Genentech Inc | Multivalent antibodies and uses therefor |
CA2408617A1 (fr) | 2000-05-12 | 2001-11-22 | Amgen Inc. | Procedes et compositions d'une matiere relative a april/g70, bcma, blys/agp-3, et taci |
US7220840B2 (en) | 2000-06-16 | 2007-05-22 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator protein |
AU6842701A (en) | 2000-06-16 | 2002-01-14 | Human Genome Sciences Inc | Antibodies that immunospecifically bind to blys |
AU2001279055A1 (en) | 2000-07-27 | 2002-02-13 | Genentech, Inc. | Apo-2L receptor agonist and CPT-11 synergism |
US20030091565A1 (en) | 2000-08-18 | 2003-05-15 | Beltzer James P. | Binding polypeptides and methods based thereon |
UA83458C2 (uk) | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
EP1401870A4 (fr) | 2001-05-24 | 2006-04-19 | Human Genome Sciences | Anticorps contre le facteur de necrose tumorale delta (april) |
AU2002366430B2 (en) | 2001-07-03 | 2008-09-18 | Genentech, Inc. | Human DR4 antibodies and uses thereof |
DE10221018A1 (de) | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
WO2004094620A2 (fr) | 2003-03-28 | 2004-11-04 | Biogen Idec Ma Inc. | Recepteurs baff tronques |
KR20060027801A (ko) | 2003-06-05 | 2006-03-28 | 제넨테크, 인크. | B 세포 장애에 대한 조합 요법 |
CA2554526A1 (fr) | 2004-01-29 | 2005-08-18 | Genentech, Inc. | Variants du domaine extracellulaire de bcma et utilisations de ceux-ci |
US20050186577A1 (en) | 2004-02-20 | 2005-08-25 | Yixin Wang | Breast cancer prognostics |
CN101014245A (zh) | 2004-08-03 | 2007-08-08 | 比奥根艾迪克Ma公司 | 神经元功能中的taj |
ZA200702335B (en) | 2004-10-05 | 2009-05-27 | Genentech Inc | Method for treating vasculitis |
JP2008525002A (ja) | 2004-12-23 | 2008-07-17 | ラボラトワール セローノ ソシエテ アノニム | Bcmaポリペプチド及びその使用 |
US9168286B2 (en) | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
CA2629244C (fr) | 2005-11-11 | 2014-08-05 | Boehringer Ingelheim International Gmbh | Derives de quinazoline pour le traitement des affections cancereuses |
MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
AU2006318539B2 (en) | 2005-11-23 | 2012-09-13 | Genentech, Inc. | Methods and compositions related to B cell assays |
WO2007123765A2 (fr) | 2006-03-31 | 2007-11-01 | Human Genome Sciences Inc. | NEUTROKINE-ALPHA et variant d'epissage de la neutrokine-alpha |
WO2008034776A1 (fr) | 2006-09-18 | 2008-03-27 | Boehringer Ingelheim International Gmbh | Procédé de traitement du cancer présentant des mutations egfr |
WO2010075249A2 (fr) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | Méthode de traitement de la polyarthrite rhumatoïde avec des antagonistes de cellules b |
ES2731901T3 (es) | 2009-07-06 | 2019-11-19 | Boehringer Ingelheim Int | Proceso para el secado de BIBW2992, de sus sales y de formulaciones farmacéuticas sólidas que comprenden este ingrediente activo |
MX2012002766A (es) | 2009-09-03 | 2012-04-02 | Genentech Inc | Metodos para el tratamiento, diagnosis y monitoreo de artritis reumatoide. |
WO2011109280A1 (fr) | 2010-03-05 | 2011-09-09 | Lerner Research Institute | Procédés et compositions permettant de traiter les troubles d'origines immunes |
CA2827859A1 (fr) | 2011-02-28 | 2012-09-07 | Genentech, Inc. | Marqueurs biologiques et procedes de prediction de reponse a des antagonistes de lymphocytes b |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997033902A1 (fr) * | 1996-03-14 | 1997-09-18 | Human Genome Sciences, Inc. | Facteurs de necrose tumorale delta et epsilon chez l'homme |
WO1998018921A1 (fr) * | 1996-10-25 | 1998-05-07 | Human Genome Sciences, Inc. | Neutrokine alpha |
WO1998027114A2 (fr) * | 1996-12-17 | 1998-06-25 | Schering Corporation | Antigenes de surface mammaliens et reactifs associes |
EP0869180A1 (fr) * | 1997-04-02 | 1998-10-07 | Smithkline Beecham Corporation | Un homologue de TNF, TL5 |
WO1998055621A1 (fr) * | 1997-06-06 | 1998-12-10 | Regeneron Pharmaceuticals, Inc. | Membre ntn-2 de la famille des ligands du facteur de necrose tumorale (tnf) |
WO1998055620A1 (fr) * | 1997-06-06 | 1998-12-10 | Regeneron Pharmaceuticals, Inc. | Element ntn-2 de la famille des ligands du tnf |
WO1999011791A2 (fr) * | 1997-09-05 | 1999-03-11 | University Of Washington | Recepteurs et ligands de la famille du facteur de necrose tumorale, acides nucleiques codants et agents de liaison associes |
WO1999012964A2 (fr) * | 1997-09-12 | 1999-03-18 | Biogen, Inc. | Kay, nouvelle proteine du systeme immunitaire |
-
1998
- 1998-12-22 AU AU20934/99A patent/AU2093499A/en not_active Abandoned
- 1998-12-22 WO PCT/US1998/027474 patent/WO1999033980A2/fr active Application Filing
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997033902A1 (fr) * | 1996-03-14 | 1997-09-18 | Human Genome Sciences, Inc. | Facteurs de necrose tumorale delta et epsilon chez l'homme |
WO1998018921A1 (fr) * | 1996-10-25 | 1998-05-07 | Human Genome Sciences, Inc. | Neutrokine alpha |
WO1998027114A2 (fr) * | 1996-12-17 | 1998-06-25 | Schering Corporation | Antigenes de surface mammaliens et reactifs associes |
EP0869180A1 (fr) * | 1997-04-02 | 1998-10-07 | Smithkline Beecham Corporation | Un homologue de TNF, TL5 |
WO1998055621A1 (fr) * | 1997-06-06 | 1998-12-10 | Regeneron Pharmaceuticals, Inc. | Membre ntn-2 de la famille des ligands du facteur de necrose tumorale (tnf) |
WO1998055620A1 (fr) * | 1997-06-06 | 1998-12-10 | Regeneron Pharmaceuticals, Inc. | Element ntn-2 de la famille des ligands du tnf |
WO1999011791A2 (fr) * | 1997-09-05 | 1999-03-11 | University Of Washington | Recepteurs et ligands de la famille du facteur de necrose tumorale, acides nucleiques codants et agents de liaison associes |
WO1999012964A2 (fr) * | 1997-09-12 | 1999-03-18 | Biogen, Inc. | Kay, nouvelle proteine du systeme immunitaire |
Non-Patent Citations (4)
Title |
---|
AGGARWAL B.B. AND NATARAJAN K.: "Tumor necrosis factor: developments during the last decade", EUROPEAN CYTOKINE NETWORK, vol. 7, no. 2, April 1996 (1996-04-01) - June 1996 (1996-06-01), pages 93 - 124, XP002094503 * |
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002101204, Database accession no. AA682496 * |
GRUSS H.-J. AND DOWER S.K.: "Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas", BLOOD, vol. 85, no. 12, 15 June 1995 (1995-06-15), pages 3378 - 3404, XP002094502 * |
GRUSS H.-J.: "Molecular, structural, and biological characteristics of the tumor necrosis factor ligand superfamily", INTERNATIONAL JOURNAL OF CLINICAL AND LABORATORY RESEARCH, vol. 26, no. 3, 1996, pages 143 - 159, XP002094504 * |
Also Published As
Publication number | Publication date |
---|---|
AU2093499A (en) | 1999-07-19 |
WO1999033980A2 (fr) | 1999-07-08 |
WO1999033980A9 (fr) | 1999-10-14 |
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