WO1999022808A1 - Feuille chargee negativement et procede de production - Google Patents

Feuille chargee negativement et procede de production Download PDF

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Publication number
WO1999022808A1
WO1999022808A1 PCT/JP1998/004501 JP9804501W WO9922808A1 WO 1999022808 A1 WO1999022808 A1 WO 1999022808A1 JP 9804501 W JP9804501 W JP 9804501W WO 9922808 A1 WO9922808 A1 WO 9922808A1
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WO
WIPO (PCT)
Prior art keywords
sheet
negatively charged
adhesive layer
skin
nonwoven fabric
Prior art date
Application number
PCT/JP1998/004501
Other languages
English (en)
Japanese (ja)
Inventor
Fumio Kamiyama
Original Assignee
Ryukoku Extension Center (Rec)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP34051397A external-priority patent/JPH11169465A/ja
Priority claimed from JP37048297A external-priority patent/JPH11192311A/ja
Application filed by Ryukoku Extension Center (Rec) filed Critical Ryukoku Extension Center (Rec)
Priority to AU92839/98A priority Critical patent/AU9283998A/en
Publication of WO1999022808A1 publication Critical patent/WO1999022808A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/10—Applying static electricity

Definitions

  • the present invention relates to an improvement in an analgesic treatment method by applying a weak electric current from the body surface to the body.
  • transcutaneous electrical nerve stimulation TENS for short
  • TENS transcutaneous electrical nerve stimulation
  • USP5607454 and USP5620470 attempt to enhance treatment by, for example, reflecting feedback from the living body on the output of the device.
  • an electric current of several tens of milliamps is applied to the skin on a body part where pain is felt by applying an electrode made of a conductive gel, and is applied percutaneously directly from an output device.
  • the drawback is that the skin where the electrode is attached may be painful, burnt, etc.
  • a method of applying a current of several microamps or tens of microamps transdermally to provide analgesia has also been developed mainly in the United States.
  • MENS Microcurrent electrical nerve stimulators, abbreviated as MENS
  • USP5397338, USP527231, etc. describe equipment improvements related to MENS.
  • this method solves the above-mentioned drawbacks of TENS, it still requires current output devices, lead wires, electrodes for applying conductive skin, etc., and quality of life is required for long-term treatment with these devices attached. There are many problems in terms of.
  • transcutaneous electrical analgesic treatments without a current output device are also known.
  • Battery-powered healing plasters (GHP) are described in USP5354321.
  • the present invention relates to a transcutaneous electrical analgesic treatment method, which solves all of the above-mentioned drawbacks of various currently known methods and is effective for a long term without deteriorating the quality of life. Is to provide a law.
  • the present inventor has conducted intensive studies on a new transcutaneous electrical analgesic treatment method that overcomes the above-mentioned drawbacks of TENS.MENS and GHP and enables long-term effective treatment without reducing the quality of life.
  • a negative charge of several kilovolts (KV) or more to the flexible sheet-like structure. It is assumed that a negative current of the order of a few microamps will flow from the sheet into the body when pressed.
  • the present invention relates to a flexible sheet-like structure including a continuous air layer made of a material having a low energy surface such as polyolefin, polytetrafluoroethylene, and the like, and has an apparent specific gravity in the range of 0.01 to 0.5.
  • the negatively charged sheet-like structure is characterized in that the sheet-like structure is subjected to a negative charge treatment so that a negative charge is generated in the sheet-like structure. It is also important that the negatively charged sheet be maintained in a state in which air permeability through the charged sheet surface is sufficiently ensured in a use state in which the sheet is used in close contact with the skin.
  • the material having a low energy surface means a material having a critical surface tension (TC) of 35 (dyn / Cm , 20 ° C) or less.
  • Materials having a critical surface tension of 35 or more such as polyvinyl alcohol (37) and polyethylene terephthalate (43), have relatively high electrical conductivity and charge decay quickly even when a negative charge is applied by discharge treatment. This causes a problem in the stability over time of the negatively charged sheet-like structure.
  • a flexible sheet-like structure containing a continuous air layer is, for example, a nonwoven fabric (wet Type nonwoven fabric, meltblown nonwoven fabric, spunbond nonwoven fabric, spunlace nonwoven fabric, etc.), woven fabric, polymer foam, etc. can be used.
  • a film-like charged sheet without air permeability cannot be used for the purpose of the present invention.
  • the air permeability of the negatively charged sheet made of non-woven fabric, woven fabric or polymer foam must be at least 5.000 g / m 2 / 24H in terms of water vapor transmission rate (measured by ASTM ⁇ 96-80 method). It is.
  • the water vapor transmission rate is 5,000 g / m 2 / 24H or less, there is a possibility that moisture during sweating will condense between the skin and the negatively charged sheet-like structure.
  • the measurement of apparent specific gravity is obtained by dividing the weight per unit area of the sheet-like structure by the volume per unit area calculated using the thickness value under no load measured by reading and measuring with a microscope. .
  • the apparent specific gravity is higher than 0.5, the rigidity of the sheet-like structure increases, and a problem occurs in the adhesion to the skin.
  • the apparent specific gravity is lower than 0.01, it is difficult to generate a sufficient negative charge of the sheet-like structure, that is, 5 KV or more.
  • a negative charge is generated on the surface of the fibrous or honeycomb-like polymer material constituting the porous surface of the sheet-like structure containing a continuous air phase. This is because the absolute amount of charge per unit volume of the 82cam-shaped polymer is insufficient.
  • a commercially available corona treatment device or a commercially available charging device can be used. When the conditions specific to the apparatus are appropriately set and the sheet-like structure is processed for an appropriate time (several seconds to several tens of seconds), a negatively charged sheet-like structure having a negative surface potential of 5 KV or more is obtained.
  • the negative surface potential is less than 5 KV, although it has some effect, its duration is short (negative charges disappear in a few hours), which is not practically preferable. Therefore, in the present invention, in consideration of storage stability, a condition that can maintain a negative surface potential of 5 KV or more when the negatively charged sheet-like structure is stored in a sealed state for 4 months is a requirement of the invention.
  • the negatively-charged sheet-like structure is actually used as a medical device electric potential treatment device, it is important to use it in close contact with the skin.
  • the negatively charged sheet-like structure is actually In order to adhere to the negatively charged sheet-like structure, a flexible sheet or a pressure-sensitive adhesive sheet coated with an adhesive on a film having a slightly larger area than the negatively-charged sheet-like structure to be used is prepared separately.
  • the sheet-like structure is attached from the back to the skin with extra adhesive margin.
  • the negatively-charged sheet-like structure may be directly pressed against the affected skin and then adhered to the skin with a bandage or the like.
  • a pattern coating of an adhesive may be used on the negatively charged sheet described in detail below.
  • the negatively charged sheet-like structure is It is extremely effective to apply a pressure-sensitive adhesive pattern on an object. That is, the pressure-sensitive adhesive is applied directly to the negatively charged surface of the sheet (the side of the negatively charged sheet that is in close contact with the skin) within a range that does not significantly reduce the water vapor transmission rate of the charged sheet.
  • the negative potential of the negatively-charged sheet can be reduced without significantly impairing the negative potential of the negatively-charged sheet.
  • the pattern adhesive layer may be formed by directly applying a pattern to the negatively charged surface of the negatively charged sheet and drying it at an appropriate temperature if necessary.
  • An adhesive is pattern-coated on release paper and, if necessary, dried to form a patterned adhesive layer. Then, the negatively-charged surface of the negatively-charged sheet-like structure is attached to this patterned adhesive layer.
  • the pattern adhesive layer may be formed by transfer coating. For actual application, a screen method, a gravure method, or a mesh method is conveniently used.
  • a negatively charged sheet-like structure made of nonwoven fabric or woven fabric with a continuous air phase is directly coated with an adhesive containing water, solvent, etc.
  • the adhesive will seep into the charged sheet and get through.
  • the required thickness of the adhesive layer cannot be formed on the surface of the charged sheet due to rubbing or infiltration beyond necessity, and it may not be possible to secure firm attachment of the charged sheet to the skin.
  • the formation of the pattern adhesive layer by transfer coating is preferred.
  • the adhesive may be applied before the negatively charged treatment is performed on the sheet-like structure including a continuous gas phase made of a material having a low energy surface. It may be after the charging process.
  • the pattern adhesive layer formed on the surface of the negatively charged sheet has resistance to water vapor transmission, it is essential to satisfy the following two conditions.
  • the pattern adhesive layer is preferably formed so as to act as a uniform resistance per unit surface area to the water vapor permeation flow rate of the negatively charged sheet.
  • the water vapor permeation flow velocity of an arbitrary portion of the negatively charged sheet having the adhesive layer formed on the surface is expressed as the permeation flow velocity per unit area, the values agree within an error range indicated by a normal distribution. Is desirable. In this case, a unit of 1 cm 2 may be sufficient as the surface area unit although it depends on the case.
  • the other is to design the coating so that the area occupied by the negatively charged surface occupied by the patterned adhesive layer does not significantly reduce the water vapor transmission performance of the negatively charged sheet. That is to be done.
  • the area occupancy of the pattern adhesive layer should be designed in the range of 10-90%, depending on the type of woven or non-woven fabric used for the negatively charged sheet. If the pattern adhesive layer occupancy exceeds 90%, the water vapor permeability of the negatively charged sheet will be greatly affected, and if the adhesive layer occupancy is 10% or less, sufficient adhesion to human skin will be ensured. become unable. Any adhesive layer pattern may be used as long as the above two conditions are satisfied, but usually simple patterns such as a polka dot pattern, a square pattern, a grid pattern, a triangular pattern, and a stripe pattern are selected due to structural reasons. .
  • Figure 1 shows an example of the design. This drawing is an example, and the present invention is not limited to this design.
  • pressure-sensitive adhesive for the pressure-sensitive adhesive sheet and the pattern coating used in the present invention known pressure-sensitive adhesives such as a solvent type, an emulsion type, a hot melt type and a reaction type can be used. If the adhesive meets the above general conditions, The type may be a natural polymer such as gum arabic or carboxymethylcellulose, an acrylic adhesive, or a rubber adhesive.
  • a type of pressure-sensitive adhesive that facilitates pattern coating is preferably used.
  • the adhesive of hot melt type which can hot Tomeruto coated with 50-200 Q C and the like.
  • the pressure-sensitive adhesive that can be hot-melt-coated is easy to apply a pattern, and any hot-melt-type pressure-sensitive adhesive may be acrylic or rubber-based.
  • a hot-melt adhesive based on an adhesive polymer based on a block copolymer type hot-melt rubber of styrene-butadiene-styrene or styrene-isoprene-styrene is preferably used.
  • the pressure-sensitive adhesive layer may contain an appropriately selected tackifier or the like in order to further impart appropriate tackiness.
  • the tackifier used in this case is appropriately selected from rosin-based, terpene-based, coumarone-based, phenol-based, styrene-based, and petroleum-based, but there is no particular limitation.
  • the pressure-sensitive adhesive layer used for the pressure-sensitive adhesive sheet and the pressure-sensitive adhesive for pattern coating used in the present invention is such that the entire pressure-sensitive adhesive layer is crosslinked, and 5-75% of the components constituting the pressure-sensitive adhesive layer are water or solvent. May form a gel-like insoluble material that is not dissolved and eluted.
  • One of the crosslinking methods in this case is a method by adding a crosslinking agent.
  • a cross-linking agent a polyvalent epoxy compound such as ethylene glycol diglycidyl ether and triglycidyl isocyanurate, and a polyvalent isocyanate compound such as Coronet Sharonet HL (both manufactured by Nippon Polyurethane Co., Ltd.) are used.
  • the amount of these crosslinking agents to be added is usually selected within the range of 0.01 to 5 parts by weight based on 100 parts by weight of the adhesive constituting the adhesive layer.
  • an crosslinking method for example, insolubilization by radiation crosslinking such as electron beam, ultraviolet ray or gamma ray can be mentioned.
  • the irradiation dose is preferably 1 KGY or more and 50 KGY or less in the case of, for example, an acrylic copolymer. If it exceeds 50 KGY, the adhesive layer is undesirably remarkably deteriorated and changed.
  • the adhesive strength of the adhesive layer should be designed to be not less than 5 g / 12 mni width, preferably not less than 20 g / 12 mm width and not more than 500/12 mm width at 180 ° peel adhesion.
  • Adhesion is less than 5 g / 12 m m width there is a risk of causing the peeling is insufficient adhesion to negatively charged zone electrostatic Sea Bok skin, 500 g / 12 mm width or more This is because there is a possibility that the adhesive may adhere to the skin more than necessary and damage the skin.
  • the thickness of the pressure-sensitive adhesive layer and the pattern pressure-sensitive adhesive layer of the pressure-sensitive adhesive sheet be kept to a minimum as long as the adhesion of the negatively charged sheet to the skin can be ensured.
  • the range is preferably 0.5 to 100 um, more preferably 5 to 50 um. If the thickness of the adhesive layer is less than 0.5 ⁇ m, the negatively charged sheet will not have sufficient adhesiveness to the skin. Sexuality.
  • the pressure-sensitive adhesive composition of the pressure-sensitive adhesive layer of the pressure-sensitive adhesive sheet and the pattern pressure-sensitive adhesive layer in the present invention the above description has described in detail the pressure-sensitive adhesive containing no drug.
  • the pressure-sensitive adhesive composition of the present invention does not prevent containing a drug that supports the electrical transdermal analgesic treatment which is the main object of the present invention. That is, the pressure-sensitive adhesive composition includes an anti-inflammatory analgesic such as indomethacin and ketoprofen; a local analgesic such as lidocaine; a systemic analgesic such as morphine and hydromorphone; a muscle relaxant such as eperisone hydrochloride. And the like may be contained in an adhesive in an appropriate amount and absorbed percutaneously to exert a medicinal effect.
  • an anti-inflammatory analgesic such as indomethacin and ketoprofen
  • a local analgesic such as lidocaine
  • a systemic analgesic such as morphine and hydromorphone
  • a muscle relaxant such as eperisone hydrochloride.
  • the like may be contained in an adhesive in an appropriate amount and absorbed percutaneously to exert a medicinal effect.
  • the adhesive force of the pressure-sensitive adhesive composition is reduced and the adhesion of the charged sheet to the skin is lowered.
  • the adhesive force of the pressure-sensitive adhesive composition is reduced and the adhesion of the charged sheet to the skin is lowered.
  • the adhesive force of the pressure-sensitive adhesive composition is reduced and the adhesion of the charged sheet to the skin is lowered.
  • the adhesive force of the pressure-sensitive adhesive composition is reduced and the adhesion of the charged sheet to the skin is lowered.
  • the adhesive force of the pressure-sensitive adhesive composition is reduced and the adhesion of the charged sheet to the skin is lowered.
  • the adhesive force of the pressure-sensitive adhesive composition is reduced and the adhesion of the charged sheet to the skin is lowered.
  • the adhesive force of the pressure-sensitive adhesive composition is reduced and the adhesion of the charged sheet to the skin is lowered.
  • the adhesive force of the pressure-sensitive adhesive composition is reduced and the adhesion of the charged sheet to the skin is lowered.
  • the adhesive force of the pressure-sensitive adhesive composition is reduced and the
  • the negatively-charged sheet-like structure of the present invention adheres well to the bent part of the skin, and the wearing feeling is also very good. Very good. It is expected that the quality of life of the patient will not be greatly impaired, and that confusion will be improved, and that the therapeutic effect will be improved.
  • FIG. 1 shows a patterned adhesive layer.
  • the black part indicates the pattern adhesive layer, and the white part indicates the negative charge sheet layer.
  • Polka dots, dice, lattices, pyramids, and stripes were named from left to right, depending on the type of pattern.
  • Styrene-isoprene-styrene copolymer rubber SIS (manufactured by Shell Co .; Califrex 110 7) 100 parts by weight of petroleum resin 150 parts by weight, terpene softener 50 parts by weight, antioxidant 2 parts by weight were added, and the mixture was heated and mixed in a nitrogen stream to prepare a hot-melt adhesive. This is applied to a heat-resistant commercially available release paper to a thickness of 40 m by the heat-melt coating method, and then bonded to a commercially available polyester-based nonwoven fabric (manufactured by Nippon Vilene Co., Ltd .: Vifreshier) to transfer by pressure. An adhesive sheet was used.
  • a polypropylene (PP) resin was sprayed in a planar manner by the melt blown method to produce a melt blown nonwoven fabric with a thickness of 0.3 mm and an apparent specific gravity of 0.11.
  • This nonwoven fabric was cut into a rectangle of 8 cm to 13 cm and bonded to the center of the above-mentioned pressure-sensitive adhesive sheet cut to 10 cm x 15 cm.
  • the PP meltblown nonwoven fabric side of this product was treated for 10 seconds under a voltage of 115 KV using a commercially available electrification treatment device (Kasuga Electric; ZHO-125T). The negatively charged sheet thus obtained
  • the structure had an immediate surface negative potential of between 120 KV and 135 KV.
  • the water vapor transmission rate (measured by the ASTM E96-80 method) of the portion of the negatively charged sheet-like structure having the melt blown nonwoven fabric layer was 7,700 g / m 2 / 24H.
  • the surface potential after 4 months was between 115 KV and 120 KV.
  • a hot-melt pressure-sensitive adhesive was prepared in the same composition and production method as in Example 1. This was also applied to the same release paper as in Example 1, and then bonded to a commercially available polyester-based nonwoven fabric (Sontara, manufactured by DuPont) to transfer it under pressure to form an adhesive sheet.
  • the above-mentioned adhesive sheet which was obtained by cutting a commercially available polyethylene nonwoven fabric (Nippon Vilene EW-6500, thickness 0.8 mm, apparent specific gravity 0.08) into a rectangle of 8 cm x 13 cm, and cutting it to 10 cm x 15 cm On top of the center.
  • the polyethylene nonwoven fabric (EW-650) surface of this product was treated in the same manner as in Example 1 with a voltage of 15 KV using a commercially available electrification treatment device (Kasuga Electric; ZHO-125T). For 5 seconds.
  • the thus-obtained negatively-charged sheet-like structure had a surface negative potential immediately after that of from 115 KV to 120 KV.
  • the water vapor transmission rate (measured by the ASTM E96-80 method) of a portion of the present negatively charged sheet-like structure having the polyethylene-based nonwoven fabric layer was 9,20 Og / m 2 / 24H.
  • a hot-melt pressure-sensitive adhesive was prepared in the same composition and production method as in Example 1. This was also applied to the same release paper as in Example 1, and then bonded to a commercially available polyester-based nonwoven fabric (Sontara, manufactured by DuPont) to transfer it under pressure to form an adhesive sheet.
  • Commercially available polyethylene nonwoven fabric Japanese Vilene EW-6500, thickness 0.8 mm, The specific gravity of 0.08) was cut into a rectangle of 8 cm x 13 cm, and bonded to the center of the pressure-sensitive adhesive sheet cut to 10 cm and 15 cm.
  • the polyethylene-based non-woven fabric (EW-650) surface of this product was exposed to a voltage of 17 KV using a commercially available electrostatic treatment device (Kasuga Electric; ZHO-125T) in the same manner as in Example 1. Treated for 3 seconds.
  • the negatively-charged sheet-like structure thus obtained had a surface negative potential of 15 KV to 17 KV immediately after.
  • the water vapor transmission rate of a portion of the negatively charged sheet-like structure having the polyethylene-based nonwoven fabric layer was measured, it was 8.50 Og / raV24H.
  • the negatively charged sheet-like structure was covered with release paper and stored tightly in a bag made of aluminum laminate film by heat sealing, the surface potential after 4 months was 13 to 14 KV. Comparative Example 2
  • a hot-melt pressure-sensitive adhesive was prepared in the same composition and production method as in Example 1. This was also applied to the same release paper as in Example 1, and then bonded to a commercially available polyester-based nonwoven fabric (Sontara, manufactured by DuPont) to transfer it under pressure to form an adhesive sheet.
  • the above-mentioned adhesive sheet which was cut from a commercially available polyester nonwoven fabric (Nippon Vilene El-5006, thickness 1.2 mm, apparent specific gravity 0.05) into a rectangle of 8 cm 13 cm, and cut into 10 cm x 15 cm On top of the center.
  • the polyester nonwoven fabric (E 1 — 506) side of this product was treated in the same manner as in Example 1 using a commercially available electrostatic treatment device (Kasuga Denki; ZHO-125 T).
  • a hot-melt pressure-sensitive adhesive was prepared in the same composition and production method as in Example 1. After all this After being applied to the same release paper as in Example 1, it was adhered to a commercially available polyester-based nonwoven fabric (manufactured by DuPont; Sontara) so as to be pressure-transferred to form an adhesive sheet. Separately, a polypropylene (PP) resin was sprayed in a plane by the melt blown method to produce a melt blown nonwoven fabric with a thickness of 0.9 mm and an apparent specific gravity of 0.008. This nonwoven fabric was cut into a rectangle of 8 cm to 13 cm and bonded to the center of the above-mentioned pressure-sensitive adhesive sheet cut to 10 cm x 15 cm.
  • PP polypropylene
  • the PP melt blown nonwoven fabric side of this product was treated in the same manner as in Example 1 for 5 seconds under a voltage of 15 KV using a commercially available charging device (ZHO-125T, manufactured by Kasuga Electric).
  • the negatively-charged sheet-like structure thus obtained had a surface negative potential of 14 KV to 17 KV immediately after.
  • the water vapor transmission rate of the portion of the negatively charged sheet-like structure having the melt blown nonwoven fabric layer was measured, it was 14,10 Og / m 2 / 24H.
  • the negatively charged sheet-like structure was covered with release paper and stored tightly in a bag made of aluminum laminated film by heat sealing, the surface potential after 4 months was from 12 KV to 14 KV.
  • styrene-soprene-styrene copolymer rubber S1S manufactured by Shell Co., Ltd .: Force Reflex 11057
  • 150 parts by weight of a petroleum resin 50 parts by weight of a terpene-based softener, and 2 parts by weight of an aging inhibitor are added.
  • the mixture was heated and mixed in a nitrogen stream to produce a hot-tlt adhesive.
  • a polka dot pattern was applied to a heat-resistant commercially available template paper by a heat-melt screen printing method to obtain a polka dot pattern adhesive layer having an adhesive layer thickness of 32 ⁇ m and an adhesive layer occupying area ratio of about 33%.
  • a polypropylene (PP) resin was sprayed onto the surface by the sootblown method to produce a meltblown nonwoven fabric with a thickness of 0.13 mm and an apparent specific gravity of 0.11.
  • a negative charge processor Kasuga Electric: ZHO-125T
  • ZHO-125T negative charge processor
  • the negatively charged sheet thus obtained measured -18 KV to -32 KV immediately after the surface negative potential.
  • the water vapor transmission rate of this negatively charged sheet (Measured by the ASTM 96-80 method), it was 13000 g / m 2 / 24H.
  • the negatively charged surface of the negatively charged sheet is transfer-coated in such a manner that the negatively charged surface is adhered to the polka dot adhesive layer formed on the release paper.
  • a charged sheet on which an evening adhesive layer was formed was obtained.
  • the surface negative potential of the negatively charged sheet on which the polka dot pattern adhesive layer was formed was measured to be ⁇ 14 KV to ⁇ 19 KV, and the water vapor transmission rate was 10300 g / m 2 / 24H.
  • the 180 ° peeling adhesive force of the negatively charged sheet on which the polka dot pattern adhesive layer was formed was measured, it was 120 g / 12 mm width.
  • melt-spun nonwoven fabric having a thickness of 0.13 mm and an apparent specific gravity of 0.11 obtained in exactly the same manner as in Example 3 was formed into a rectangle of 8 cm x 13 cm.
  • the other side is adhered to the polka dot pattern adhesive layer formed on the template paper in the same manner as in Example 3, and one side thereof is applied by transfer coating, whereby the area occupied by the adhesive layer on one side is about 33%.
  • a melt blown nonwoven fabric having a polka dot pattern adhesive layer was obtained.
  • the same release paper as in Example 1 was obtained by using a commercially available acrylic adhesive (Acronal YJ8655D, manufactured by Mitsubishi Chemical BASF) using a gravure roll obtained by engraving a polka dot group with a fixed density pad.
  • a polka-dot pattern adhesive layer was obtained by applying a pattern so that the thickness of the adhesive layer was 35 ⁇ m and the area occupancy of the adhesive was 45%.
  • the gel fraction of this adhesive layer was 65%.
  • the negative electrode charged sheet of the same negative charge sheet as that obtained in Example 1 was adhered to the surface of the pattern adhesive layer obtained above, whereby the pattern adhesive layer was pressure-transferred to obtain a product of the present invention.
  • the surface negative potential of the charged surface of the negatively charged sheet on which the obtained polka dot pattern adhesive layer was formed was measured to be ⁇ 10 to ⁇ 17 KV.
  • the water vapor transmission rate of the negatively charged sheet on which the polka dot pattern adhesive layer was formed was measured, it was 7100 g / m 2 / 24H, and its 180 peel adhesion was measured to be 90 g / l 2 mm width. It adhered tightly when applied to the skin surface of the human joint.
  • a commercially available acryl-based pressure-sensitive adhesive for pattern coating (UVTAC2800, manufactured by Teikoku Ink Manufacturing Co., Ltd.) was pattern-coated on release paper of PET substrate using a screen printing machine to form a pattern adhesive layer. Then, after bonding the negatively charged surface of the same negatively charged sheet as that obtained in Example 1, the product of the present invention was obtained by irradiation with UV light.
  • the gel fraction of the thus obtained patterned adhesive layer was 50%, the area occupied by the adhesive layer was about 50%, and the thickness of the adhesive layer was 40 ⁇ m.
  • the surface negative potential of the charged surface of the negatively charged sheet on which the obtained pattern adhesive layer was formed was measured to be -8 KV to -14 KV.
  • Example 7 A hot-melt pressure-sensitive adhesive prepared in Example 3 was mixed with a hot-melt adhesive base obtained by mixing a hot-melt pressure-sensitive adhesive prepared so that the content of indomethacin was exactly 1.5%.
  • a polka dot pattern was applied to a heat-resistant commercially available release paper by a lean printing method to obtain a polka dot pattern adhesive layer containing indomethacin having an adhesive layer thickness of 32 ⁇ m and an adhesive layer occupying area ratio of about 33%.
  • a PP meltblown nonwoven fabric having a thickness of 0.13 mm and an apparent specific gravity of 0.11 was prepared in exactly the same procedure as in Example 3, and then the average value of the surface negative potential immediately after the negative charge treatment was performed. As a result, a negatively charged sheet having a voltage of 126 V was obtained. The water vapor transmission rate of this negatively charged sheet was measured to be 12400 g / m 2 / 24H.
  • the negatively charged surface of the negatively charged sheet is transfer-coated in such a manner as to be adhered to the polka dot pattern pressure-sensitive adhesive layer containing the ink formed on the release paper described above.
  • a charged sheet having a thin polka dot pattern adhesive layer formed thereon was obtained.
  • the surface negative potential of the negatively charged sheet on which the polka dot pattern adhesive layer containing the ink thin film thus obtained was formed was measured, the average value was measured to be 18 KV.
  • the water vapor transmission rate was 9300 g / m 2 / 24H.
  • the 180 ° peel adhesion of the negatively charged sheet was measured, it was 118 g / 12 mm in width.
  • the present invention relates to a transcutaneous electrical analgesic treatment, and eliminates all the drawbacks of various similar therapies known at present (eg, TENS, MENS, GHP, etc.). It also provides a transdermal electrical analgesic treatment that works effectively for a long time without deteriorating the quality of life.

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Abstract

Cette feuille chargée négativement à utiliser en thérapie électroanalgésique percutanée, qui permet de supprimer les inconvénients liés à l'application de diverses méthodes actuellement pratiquées, agit efficacement pendant longtemps et sans porter atteinte à la qualité de la vie quotidienne. L'invention concerne, plus précisément, une structure à feuille chargée négativement, se caractérisant par le fait qu'on la produit en électrifiant négativement une structure à feuille souple renfermant une couche à alvéoles ouverts comprenant une substance à faible tension superficielle, une polyoléfine ou un polytétrafluoréthylène, et dont la densité relative apparente est comprise entre 0,01 et 0,5. Cette invention concerne également un article consistant en un revêtement cutané auto-adhésif à vocation analgésique comprenant la structure à feuille susmentionnée, recouverte d'une couche adhésive auto-collante de manière à ne pas réduire de façon significative la vitesse de pénétration de la vapeur d'eau à travers cette structure.
PCT/JP1998/004501 1997-11-04 1998-10-05 Feuille chargee negativement et procede de production WO1999022808A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU92839/98A AU9283998A (en) 1997-11-04 1998-10-05 Negatively charged sheet and process for preparing the same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP9/340513 1997-11-04
JP34051397A JPH11169465A (ja) 1997-11-04 1997-11-04 負電荷帯電シート及びその製造方法
JP9/370482 1997-12-26
JP37048297A JPH11192311A (ja) 1997-12-26 1997-12-26 自着性負電荷帯電シート及びその製造方法

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WO1999022808A1 true WO1999022808A1 (fr) 1999-05-14

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WO (1) WO1999022808A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150375561A1 (en) * 2012-09-28 2015-12-31 Nitto Denko Corporation Patterned pressure-sensitive adhesive body and producing method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5666266A (en) * 1979-11-05 1981-06-04 Mitsui Petrochemical Ind Pad material for medical treatment
JPS57183862A (en) * 1981-05-01 1982-11-12 Mitsui Petrochemical Ind Electlet sheet like article for treating rheumatism and rheumatism like desease
JPS62268568A (ja) * 1986-05-19 1987-11-21 東レ株式会社 医療用エレクトレツトシ−ト
JPS6354175A (ja) * 1986-08-26 1988-03-08 東レ株式会社 医療用被覆部材

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5666266A (en) * 1979-11-05 1981-06-04 Mitsui Petrochemical Ind Pad material for medical treatment
JPS57183862A (en) * 1981-05-01 1982-11-12 Mitsui Petrochemical Ind Electlet sheet like article for treating rheumatism and rheumatism like desease
JPS62268568A (ja) * 1986-05-19 1987-11-21 東レ株式会社 医療用エレクトレツトシ−ト
JPS6354175A (ja) * 1986-08-26 1988-03-08 東レ株式会社 医療用被覆部材

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150375561A1 (en) * 2012-09-28 2015-12-31 Nitto Denko Corporation Patterned pressure-sensitive adhesive body and producing method thereof

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