Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
  • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
  • A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
  • A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
  • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
  • A61K8/9783—Angiosperms [Magnoliophyta]
  • A61K8/9789—Magnoliopsida [dicotyledons]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/10—Washing or bathing preparations
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
  • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
  • A61K2800/59—Mixtures
  • A61K2800/596—Mixtures of surface active compounds

Definitions

• the invention relates to water-containing liquid, pasty or cream-shaped hand cleaning agents with improved dermatological compatibility and the use of the agents for removing extreme soiling.
• Coarse hand cleaners are preferably used where soiling, such as paints, greases, oils, lubricants, metal dusts, graphite, soot and the like. ⁇ ., is to be expected.
• soiling such as paints, greases, oils, lubricants, metal dusts, graphite, soot and the like. ⁇ ., is to be expected.
• cleaning agents are known, for example, from H. Tronnier, J. Kresken, K. Jablonski, B. Komp, Haut undb, Grosse Verlag, Berlin, 1989, pp. 75-108.
• such preparations which contain an abrasive, surfactant / surfactant mixtures, thickeners and, if appropriate, auxiliaries for regulating the consistency, appearance, smell and stability, such as pigments, fragrances, stabilizers and preservatives.
• organic solvents e.g. B. aliphatic hydrocarbons, terpenes, carboxylic acid esters of the dimethyl adipate type, dimethyl glutarate, dimethyl succinate (DBE) and di-n-butyl adipate or di-isopropyl adipate, as described in DE 43 35 933 AI.
• Coarse hand cleaners have been known in recent times which, in addition to the surfactants coconut fatty acid monoethanolamide, cocamidopropyldimethylglycine, C9-l l-Pareth-6 and sulfated castor oil, contain a grape seed oil. These agents are limited in their diversity and their cleaning power. A sensitization risk is also known for the surfactants coconut fatty acid monoethanolamide and cocamidopropylbetaine.
• DE 44 24 210 AI describes water-free shower oils which contain at least 45% by weight of oil selected from the group of oils with a high content of triglycerides, saturated and / or unsaturated fatty acids, such as, for. B. Soybean oil, sunflower oil, wheat germ oil, and a maximum of 55
• surfactants preferably monoisopropanolamine lauryl ether sulfate,
• Water-containing shower preparations are known from EP 0 769 292 A1, with rapeseed oil or rapeseed oil derivatives being used as skin care components in addition to surfactant mixtures. These agents are also unsuitable as coarse hand cleaners due to the lack of cleaning power.
• component b preference is given to using fatty alcohol ethoxylates having the structure RO- (CH 2 -CH 2 -O) n H
• Alkali or alkaline earth salts of C 8 -C 30 preferably C 10 -C 22 fatty acids, particularly preferably castor oil sulfates, in particular Na + or NH t + sulfates, are used as salts of sulfated, preferably sulfonated fatty acids.
• Suitable as castor oil sulfonate is Monobrilliantöl® (Stockhausen GmbH & Co. KG) or Standapol SCO® (Henkel KGaA),
• the surfactant compositions used according to the invention have no (or only an extremely low) sensitizing effect.
• the present object can only be achieved if the condition is met that the content of vegetable oil in the composition of the coarse hand cleaners is greater than or equal to the content of fatty alcohol ethoxylates and the content of fatty alcohol ethoxylates is greater than or equal to the content of the two components is fatty alcohol ether sulfate and sulfated fatty acids.
• the content of 10-30% by weight of surfactant composition is 5-28% by weight, preferably 7-25% by weight, of component ⁇ , 1.9-15% by weight, preferably 3-10% by weight. of component ß and 0.1-10% by weight, preferably 0.5-6% by weight of component ⁇ .
• the proportion of 10-30% by weight of the surfactant composition very particularly preferably consists of 5-28% by weight Laureth-6,
• the hand cleaning agents according to the invention contain no organic solvents.
• the hand cleaning agents are produced continuously or in batches using known devices. Suitable devices are kettles and agitators, mixers and extruders.
• the hand cleaning agents according to the invention are used by first distributing the cleaning agent on the skin, preferably without water, whereupon cleaning is continued with water and terminated with rinsing with water.
• the hand cleaning agents according to the invention have good foaming power, a good cleaning action and have improved dermatological compatibility compared to conventional products.
• the invention is described by the following examples and investigations, such as the skin compatibility test using the Duhring chamber test or the elbow-wash test, the skin drying out using the corneometer and the cleaning power using the hand-washing test and stability test.
• This method is an in vivo test model for checking the skin tolerance of different test products in a direct comparison.
• the test subjects are applied the products to be tested in air-impermeable aluminum chambers (Duhring chambers) on the volar side of the forearms for 5 hours in succession for 6 hours each (last day 5 hours) on the same test area.
• the Duhring chambers are fastened with plaster strips.
• the test for the respective test field is also ended before the total application time of 29 hours has been reached. The resulting skin irritation is assessed according to the scale given below or the application time.
• Irritation ⁇ as the mean of the sum of the irritation values of R, S and F of the n subjects
• Application time h as the mean value of the tolerated application time in hours of the n subjects.
• the relative skin tolerance (A value) can be calculated from these two values using the following formula:
• the elbow wash test is used, among other things, to check the skin tolerance of rough hand cleaners. This test is particularly suitable for the assessment of test products containing abrasives. Due to the mechanical friction in the elbow, various products containing abrasives can be tested for their skin irritation. On four consecutive days, controlled washes with the test products are carried out on the particularly sensitive skin of the elbow, until a subjective assessment of the skin irritation is possible
• the test collective consists of at least 6 skin-healthy men and women aged
• Liquid products are dropped on cellulose and massaged in
• test products are tested in an amount of 1 g or 1 ml
• test products are applied randomly - the order is made as follows
• test manager determines the frequency of the
• test product is placed on the elbow and rubbed with the index and middle fingers for 2 minutes. The product is then left on the elbow for 2 minutes and then washed off
• the evaluation is carried out visually by the person carrying out the test 24 hours after the last tolerated wash in a right-left comparison according to the following evaluation criteria:
• the evaluation according to the point scale enables a direct comparison of the skin tolerance of the products. If there is an evaluation between two evaluation points, an evaluation in 0.5 steps is possible for further differentiation.
• the comeometer measurement is a non-invasive capacitive measurement method for assessing the moisture status of the uppermost layers of the skin of the stratum corneum. For skin-healthy subjects, this is largely determined by external influences.
• the change in skin moisture C is calculated as follows:
• Negative values mean an increase in skin moisture
• positive values mean a decrease in skin moisture
• test model of the hand wash test with standardized dirt or varnish provides information about the cleaning effect of the products to be tested.
• Two products are compared with at least eight test subjects. The prerequisite is that all subjects have a characteristic skin structure of the palms of their hands caused by manual work. The following test is carried out in the morning and in the afternoon with one product each:
• test product - 1.2 g test product are applied and rubbed in
• the percentage cleaning effect is calculated using the following formula: ⁇ - (RV.nnen + RVau //
• RVi nnen mean residual contamination on the palms of the hands from n series of measurements
• RVau ß average value of the residual dirt on the outer surfaces of hands from n series of measurements
• Hand cleaning agents according to the compositions given in Table 1 were prepared by mixing all the components with stirring and at room temperature. The agents were characterized by determining their skin tolerance, skin drying out and cleaning effect against model dirt and paint. The results obtained are summarized in Table 1.
• recipe 1 and 2 have a comparable cleaning action compared to recipes 13 and 14 containing DBE-2 or di-n-butyl adipate.
• the hand cleaning agents according to the invention as shown by Example 5, also surprisingly show a better cleaning effect on model dirt and paint than hand cleaning agents, which are known from DE-C-4038076, in particular Example 6, and better skin tolerance was determined with the help of the elbow wash test.
• Comparative example 17 corresponds to example 6 from DE-C-4038076

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Veterinary Medicine (AREA)
• Public Health (AREA)
• General Health & Medical Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• Epidemiology (AREA)
• Birds (AREA)
• Mycology (AREA)
• Microbiology (AREA)
• Botany (AREA)
• Biotechnology (AREA)
• Engineering & Computer Science (AREA)
• Emergency Medicine (AREA)
• Dermatology (AREA)
• Chemical & Material Sciences (AREA)
• Oil, Petroleum & Natural Gas (AREA)
• Detergent Compositions (AREA)
• Cosmetics (AREA)

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• 1997
  • 1997-10-30 DE DE19748921A patent/DE19748921C2/de not_active Expired - Fee Related
• 1998
  • 1998-10-21 AT AT98958227T patent/ATE229795T1/de not_active IP Right Cessation
  • 1998-10-21 JP JP2000518646A patent/JP2001521884A/ja active Pending
  • 1998-10-21 US US09/529,417 patent/US6376438B1/en not_active Expired - Lifetime
  • 1998-10-21 AU AU14348/99A patent/AU734145B2/en not_active Ceased
  • 1998-10-21 ES ES98958227T patent/ES2188031T3/es not_active Expired - Lifetime
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  • 1998-10-21 DK DK98958227T patent/DK1024786T3/da active
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  • 1998-10-21 WO PCT/EP1998/006680 patent/WO1999022712A1/de not_active Ceased
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