WO1999021589A3 - Verwendung von vektoren wie adenoviren und/oder adeno-assoziierten viren und/oder retroviren und/oder herpes-simplex-viren und/oder liposomen und/oder plasmiden als vehikel für genetische information zur befähigung von säugetierzellen mittel, zur behandlung von knochenpathologien zu produzieren - Google Patents

Verwendung von vektoren wie adenoviren und/oder adeno-assoziierten viren und/oder retroviren und/oder herpes-simplex-viren und/oder liposomen und/oder plasmiden als vehikel für genetische information zur befähigung von säugetierzellen mittel, zur behandlung von knochenpathologien zu produzieren Download PDF

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Publication number
WO1999021589A3
WO1999021589A3 PCT/EP1998/006849 EP9806849W WO9921589A3 WO 1999021589 A3 WO1999021589 A3 WO 1999021589A3 EP 9806849 W EP9806849 W EP 9806849W WO 9921589 A3 WO9921589 A3 WO 9921589A3
Authority
WO
WIPO (PCT)
Prior art keywords
viruses
adenoviruses
retroviruses
plasmids
liposomes
Prior art date
Application number
PCT/EP1998/006849
Other languages
English (en)
French (fr)
Other versions
WO1999021589A2 (de
Inventor
Axel Wilhelm August Baltzer
Christian Lattermann
Janey Desales Whalen
Paul David Robbins
Christopher Howard Evans
Original Assignee
Axel Wilhelm August Baltzer
Christian Lattermann
Janey Desales Whalen
Paul David Robbins
Christopher Howard Evans
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1997147718 external-priority patent/DE19747718A1/de
Priority claimed from DE1997147719 external-priority patent/DE19747719A1/de
Application filed by Axel Wilhelm August Baltzer, Christian Lattermann, Janey Desales Whalen, Paul David Robbins, Christopher Howard Evans filed Critical Axel Wilhelm August Baltzer
Priority to EP98959810A priority Critical patent/EP1027076A2/de
Priority to AU15579/99A priority patent/AU750803B2/en
Priority to CA2308511A priority patent/CA2308511C/en
Publication of WO1999021589A2 publication Critical patent/WO1999021589A2/de
Publication of WO1999021589A3 publication Critical patent/WO1999021589A3/de
Priority to US09/561,524 priority patent/US7105494B1/en
Priority to US11/300,698 priority patent/US20060099182A1/en
Priority to US13/160,403 priority patent/US20110280935A1/en
Priority to US13/586,685 priority patent/US20120309817A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Offenbart wird die Verwendung von Vektoren wie Adenoviren und/oder Adeno-assoziierten Viren und/oder Retroviren und/oder Herpes-Simplex-Viren und/oder Liposomen und/oder Plasmiden als säugerzellenstimulierendes Mittel zur Herstellung von therapeutischen, als Arzneimittel wirkenden Proteinen auf zellulärem Niveau zur genetischen Behandlung von Knochenpathologien.
PCT/EP1998/006849 1997-10-29 1998-10-29 Verwendung von vektoren wie adenoviren und/oder adeno-assoziierten viren und/oder retroviren und/oder herpes-simplex-viren und/oder liposomen und/oder plasmiden als vehikel für genetische information zur befähigung von säugetierzellen mittel, zur behandlung von knochenpathologien zu produzieren WO1999021589A2 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP98959810A EP1027076A2 (de) 1997-10-29 1998-10-29 Verwendung von vektoren wie adenoviren und/oder adeno-assoziierten viren und/oder retroviren und/oder herpes-simplex-viren und/oder liposomen und/oder plasmiden als vehikel für genetische information zur befähigung von säugetierzellen mittel, zur behandlung von knochenpathologien zu produzieren
AU15579/99A AU750803B2 (en) 1997-10-29 1998-10-29 Use of vectors such as adenoviruses and/or adeno associated viruses and/or retroviruses and/or herpes simplex viruses and/or liposomes and/or plasmids as a vehicle for genetic information enabling mammal cells to produce agents for the treatment of bone pathologies
CA2308511A CA2308511C (en) 1997-10-29 1998-10-29 Use of transfected or transduced mammalian cells for treating bone pathologies
US09/561,524 US7105494B1 (en) 1997-10-29 2000-04-28 Viral and non-viral vectors as vehicles for delivering transgenes for treating bone pathologies
US11/300,698 US20060099182A1 (en) 1998-10-29 2005-12-14 Viral and non-viral vectors as vehicles for delivering transgenes for treating bone pathologies
US13/160,403 US20110280935A1 (en) 1998-10-29 2011-06-14 Viral and non-viral vectors as vehicles for delivering transgenes for treating bone pathologies
US13/586,685 US20120309817A1 (en) 1998-10-29 2012-08-15 Viral and non-viral vectors as vehicles for delivering transgenes for treating bone pathologies

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE1997147718 DE19747718A1 (de) 1997-10-29 1997-10-29 Verfahren zur Therapie knochenresorbierender Erkrankungen mit der molekularbiologischen Methode der Gentherapie
DE19747719.4 1997-10-29
DE19747718.6 1997-10-29
DE1997147719 DE19747719A1 (de) 1997-10-29 1997-10-29 Verfahren zur Verbesserung der Knochenheilung mit der molekularbiologischen Methode der Genübertragung

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/561,524 Continuation-In-Part US7105494B1 (en) 1997-10-29 2000-04-28 Viral and non-viral vectors as vehicles for delivering transgenes for treating bone pathologies

Publications (2)

Publication Number Publication Date
WO1999021589A2 WO1999021589A2 (de) 1999-05-06
WO1999021589A3 true WO1999021589A3 (de) 1999-10-14

Family

ID=26041170

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/006849 WO1999021589A2 (de) 1997-10-29 1998-10-29 Verwendung von vektoren wie adenoviren und/oder adeno-assoziierten viren und/oder retroviren und/oder herpes-simplex-viren und/oder liposomen und/oder plasmiden als vehikel für genetische information zur befähigung von säugetierzellen mittel, zur behandlung von knochenpathologien zu produzieren

Country Status (5)

Country Link
US (1) US7105494B1 (de)
EP (1) EP1027076A2 (de)
AU (1) AU750803B2 (de)
CA (1) CA2308511C (de)
WO (1) WO1999021589A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU750803B2 (en) 1997-10-29 2002-07-25 University Of Pittsburgh Use of vectors such as adenoviruses and/or adeno associated viruses and/or retroviruses and/or herpes simplex viruses and/or liposomes and/or plasmids as a vehicle for genetic information enabling mammal cells to produce agents for the treatment of bone pathologies
WO2001082973A2 (en) * 2000-04-28 2001-11-08 University Of Pittsburgh Of The Commonwealth System Of Higher Education Viral and non-viral vectors as vehicles for delivering transgenes for treating bone pathologies
US6579522B1 (en) 2000-06-27 2003-06-17 Genvec, Inc. Replication deficient adenoviral TNF vector
AU2002243307A1 (en) * 2000-11-08 2002-07-24 Tissuegene, Inc. Gene therapy using tgf-beta
AU2002221339B2 (en) 2001-02-06 2006-04-27 The Sydney Children's Hospitals Network (Randwick And Westmead) (Incorporating The Royal Alexandra Hospital For Children) A drug for the treatment of osteonecrosis and for the management of patients at risk of developing osteonecrosis
US20030086903A1 (en) 2001-11-02 2003-05-08 Genvec, Inc. Therapeutic regimen for treating cancer
WO2007124148A2 (en) * 2006-04-21 2007-11-01 The University Of North Carolina At Chapel Hill Treatment of connective tissue disorders
US8138160B2 (en) 2006-08-03 2012-03-20 Warsaw Orthopedic, Inc. Reagents, methods and systems to suppress pro-inflammatory cytokines
WO2018125970A1 (en) * 2016-12-30 2018-07-05 Salk Institute For Biological Studies Synthetic adenoviruses targeting bone tissue and uses thereof
WO2019070546A1 (en) * 2017-10-03 2019-04-11 The Johns Hopkins University PULMONARY CELL TREATMENTS FOR PREVENTING OR TREATING DISEASE

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018047A2 (en) * 1990-05-24 1991-11-28 Genentech, Inc. Mammalian expression of the bmp-2 family
WO1995027518A1 (en) * 1994-04-11 1995-10-19 Plasma Biotal Limited Bone regeneration
WO1996023001A1 (en) * 1995-01-24 1996-08-01 Shoukat Dedhar New pharmaceuticals for modulating hormone responsiveness
WO1997022623A1 (en) * 1995-12-19 1997-06-26 Human Genome Sciences, Inc. Osteo antiviral protein
WO1998013383A1 (en) * 1996-09-24 1998-04-02 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Adenoviral vectors for mutants of human interleukin 6 (hil-6) with hil-6 antagonist activity, pharmaceutical compositions therewith and their uses

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032407A (en) 1987-01-16 1991-07-16 Ohio University Edison Animal Biotechnology Center Gene transfer using transformed, neodetermined, embryonic cells
DE3852823T2 (de) 1987-09-11 1995-05-24 Hughes Howard Med Inst Transduktionsveränderte fibroblasten und ihre anwendung.
US6090790A (en) * 1989-12-14 2000-07-18 Eriksson; Elof Gene delivery by microneedle injection
US5670488A (en) 1992-12-03 1997-09-23 Genzyme Corporation Adenovirus vector for gene therapy
US5618531A (en) 1990-10-19 1997-04-08 New York University Method for increasing the viability of cells which are administered to the brain or spinal cord
AU656544B2 (en) 1990-10-31 1995-02-09 Brigham And Women's Hospital Genetic modification of endothelial cells
US5858355A (en) 1990-12-20 1999-01-12 University Of Pittsburgh Of The Commonwealth System Of Higher Education IRAP gene as treatment for arthritis
US5674844A (en) 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5789543A (en) 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
DE4339352A1 (de) 1993-11-18 1995-05-24 Univ Ludwigs Albert Verfahren zur Markierung von Zellen, mit diesem Verfahren markierte Zellen, Verwendung des Wildtyp-Adeno-assoziierten Virus zur Markierung von Zellen und Testkits zum Nachweis des Wildtyp-Adeno-assoziierten Virus in Zellen
US5763416A (en) 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
US5942496A (en) 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US5665350A (en) 1994-11-23 1997-09-09 University Of Massachusetts Medical Center Cell cycle dependent transplantation and ex vivo gene therapy
US6143878A (en) * 1994-11-29 2000-11-07 The University Of Queensland Sox-9 gene and protein and use in the regeneration of bone or cartilage
US5719131A (en) 1994-12-09 1998-02-17 Genzyme Corporation Cationic amphiphiles containing dialkylamine lipophilic groups for intracellular delivery of therapeutic molecules
US5910487A (en) 1994-12-09 1999-06-08 Genzyme Corporation Cationic amphiphiles and plasmids for intracellular delivery of therapeutic molecules
US5767099A (en) 1994-12-09 1998-06-16 Genzyme Corporation Cationic amphiphiles containing amino acid or dervatized amino acid groups for intracellular delivery of therapeutic molecules
US5650096A (en) 1994-12-09 1997-07-22 Genzyme Corporation Cationic amphiphiles for intracellular delivery of therapeutic molecules
US5948767A (en) 1994-12-09 1999-09-07 Genzyme Corporation Cationic amphiphile/DNA complexes
US5824655A (en) 1995-02-15 1998-10-20 The University Of Utah Anti-transforming growth factor-β gene therapy
AU728881B2 (en) 1996-08-13 2001-01-18 Zymogenetics Inc. Expression vectors, cells, and methods for preparing thrombopoietin polypeptides
US5912239A (en) 1997-04-04 1999-06-15 Genzyme Corporation Imidazole-containing cationic amphiphiles for intracellular delivery of therapeutic molecules
US5981275A (en) 1997-04-14 1999-11-09 Genzyme Corporation Transgene expression system for increased persistence
US5948925A (en) 1997-05-06 1999-09-07 Genzyme Corporation Cationic amphiphiles containing linkers derived from neutral or positively charged amino acids
US5952516A (en) 1997-05-08 1999-09-14 Genzyme Corporation Cationic amphiphiles containing multiplesteroid lipophilic groups
EP0890639A3 (de) 1997-07-09 2001-10-10 Gesellschaft für biotechnologische Forschung mbH (GBF) BPM2-induziertes cDNA und seine Verwendung
AU750803B2 (en) 1997-10-29 2002-07-25 University Of Pittsburgh Use of vectors such as adenoviruses and/or adeno associated viruses and/or retroviruses and/or herpes simplex viruses and/or liposomes and/or plasmids as a vehicle for genetic information enabling mammal cells to produce agents for the treatment of bone pathologies

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018047A2 (en) * 1990-05-24 1991-11-28 Genentech, Inc. Mammalian expression of the bmp-2 family
WO1995027518A1 (en) * 1994-04-11 1995-10-19 Plasma Biotal Limited Bone regeneration
WO1996023001A1 (en) * 1995-01-24 1996-08-01 Shoukat Dedhar New pharmaceuticals for modulating hormone responsiveness
WO1997022623A1 (en) * 1995-12-19 1997-06-26 Human Genome Sciences, Inc. Osteo antiviral protein
WO1998013383A1 (en) * 1996-09-24 1998-04-02 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Adenoviral vectors for mutants of human interleukin 6 (hil-6) with hil-6 antagonist activity, pharmaceutical compositions therewith and their uses

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ARTHRITIS AND RHEUMATISM, (1997 JUN) 40 (6) 1012-9 *
BARAGI V M ET AL: "Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation.", JOURNAL OF CLINICAL INVESTIGATION, (1995 NOV) 96 (5) 2454-60. JOURNAL CODE: HS7. ISSN: 0021-9738., United States, XP002101322 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; KIMBLE ET AL: "Interleukin-1 receptor antagonist decreases bone loss and bone resorption in ovariectomized rats", XP002110337, retrieved from STN Database accession no. 94237958 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; PELLETIER ET AL: "In vivo suppression of early experimental osteoarthritis by interleukin - 1 receptor antagonist using gene therapy", XP002110336, retrieved from STN Database accession no. 97325898 *
EVANS, C. H. ET AL: "Possible Orthopaedic Applications of Gene Therapy.", JOURNAL OF BONE AND JOINT SURGERY AMERICAN VOLUME, (1995) VOL. 77, NO. 7, PP. 1103-1114. ISSN: 0021-9355., XP002101321 *
JOURNAL OF CLINICAL INVESTIGATION, (1994 MAY) 93 (5) 1959-67 *
KANG R ET AL: "Gene therapy for arthritis: principles and clinical practice.", BIOCHEMICAL SOCIETY TRANSACTIONS, (1997 MAY) 25 (2) 533-7. REF: 37 JOURNAL CODE: E48. ISSN: 0300-5127., ENGLAND: United Kingdom, XP002101324 *
SCHWARZ, Y. A. (1) ET AL: "IL-1 receptor antagonist ( IRAP ) inhibits IL-8 production in A549 cells infected with a replication deficient recombinant adenovirus.", FASEB JOURNAL, (1994) VOL. 8, NO. 4-5, PP. A136. MEETING INFO.: EXPERIMENTAL BIOLOGY 94, PARTS I AND II ANAHEIM, CALIFORNIA, USA APRIL 24-28, 1994 ISSN: 0892-6638., XP002101323 *

Also Published As

Publication number Publication date
US7105494B1 (en) 2006-09-12
AU750803B2 (en) 2002-07-25
AU1557999A (en) 1999-05-17
EP1027076A2 (de) 2000-08-16
CA2308511C (en) 2016-01-19
CA2308511A1 (en) 1999-05-06
WO1999021589A2 (de) 1999-05-06

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