WO1999020239A1 - Plaque-inhibiting oral compositions - Google Patents

Plaque-inhibiting oral compositions Download PDF

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Publication number
WO1999020239A1
WO1999020239A1 PCT/DK1998/000452 DK9800452W WO9920239A1 WO 1999020239 A1 WO1999020239 A1 WO 1999020239A1 DK 9800452 W DK9800452 W DK 9800452W WO 9920239 A1 WO9920239 A1 WO 9920239A1
Authority
WO
WIPO (PCT)
Prior art keywords
oral care
strain
plaque
starch
bacillus
Prior art date
Application number
PCT/DK1998/000452
Other languages
English (en)
French (fr)
Inventor
Rie Tsuchiya
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Priority to JP2000516642A priority Critical patent/JP2001520179A/ja
Priority to AU96213/98A priority patent/AU734737B2/en
Priority to CA002305804A priority patent/CA2305804A1/en
Priority to EP98949952A priority patent/EP1023037A1/en
Publication of WO1999020239A1 publication Critical patent/WO1999020239A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures

Definitions

  • GB 2,206,585 (Dental Chem Co. Ltd.) describes a tooth-cleaning agent containing hydroxyapatite as a polishing agent, with a laevanase, dextranase and mutanase immobilized on the hydroxyapatite.
  • US patent No. 5,145,665 (Henkel) discloses a composition for the care of the mouth and teeth comprising a dextranase and/or a 1 ,3-glucanase for cleaving polysaccharides in the mouth.
  • FR 2,651 ,433 (DANA) concerns dentifrice products containing a dextranase to act on recent plaque, a mutanase to act on old and insoluble plaque, and a mixture of other enzymes having bactericidal action
  • the oral care composition comprises a starch-hydrolysing enzyme.
  • This will typically be an ⁇ -amylase, such as a bacterial ⁇ -amylase, such as BANTM or MaltogenaseTM (both available from Novo Nordisk), or an ⁇ -amylase derived from Bacillus subtilis; an ⁇ -amylase derived from Bacillus amy/o/iquefaciens; an ⁇ -amylase derived from Bacillus stearothermophilus; an ⁇ -amylase derived from Aspergillus oryzae; or an ⁇ -amylase derived from a non-pathogenic microorganism.
  • the ⁇ -amylase may also be a fungal ⁇ -amylase, such as FungamylTM, which is available from Novo Nordisk.
  • the mutanase may be derived from a strain of Trichoderma sp., in particular T. harzianum, especially T. harzianum CBS 243.71 (available from Novo Nordisk).
  • oral care product of the invention is defined as a product which can be used for maintaining and/or improving oral hygiene in the mouth of humans and animals, and/or preventing or treating dental diseases.
  • a mouthwash produced from an oral care composition of the invention may e.g. comprise the following ingredients (in weight % of the final mouthwash composition): 0-20% Humectant
  • the mouthwash composition may be buffered with an appropriate buffer, e.g. sodium citrate or phosphate in the pH-range 6-7.5.
  • an appropriate buffer e.g. sodium citrate or phosphate in the pH-range 6-7.5.
  • the oral care product is typically removed from the mouth, e.g. by spitting it out, and the mouth may subsequently be rinsed with a liquid such as tap water.
  • a liquid such as tap water.
  • the surprising plaque-inhibiting effect found according to the present invention may be due to the fact that the starch-hydrolysing and/or starch-modifying enzymes react with sucrose to produce a coupling sugar before enzymes produced by the microorganisms gain access to the sucrose. Regardless of the mechanism of action, the plaque- inhibiting effect observed by use of the enzymes in question is surprising and is not believed to have been described or suggested previously.
  • FungamylTM (a fungal ⁇ -amylase) available from Novo Nordisk A/S.
  • BANTM (a bacterial ⁇ -amylase) available from Novo Nordisk A/S.
  • KDU dextranase activity
  • 1 KDU One Kilo Novo Dextranase Unit (1 KDU) is the amount of enzyme which breaks down dextran forming reducing sugar equivalent to 1 g maltose per hour in the Novo Nordisk method for determination of dextranase based on the following standard conditions: Substrate Dextran 500 (Pharmacia)
PCT/DK1998/000452 1997-10-17 1998-10-16 Plaque-inhibiting oral compositions WO1999020239A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000516642A JP2001520179A (ja) 1997-10-17 1998-10-16 プラーク阻害オーラル組成物
AU96213/98A AU734737B2 (en) 1997-10-17 1998-10-16 Plaque-inhibiting oral compositions
CA002305804A CA2305804A1 (en) 1997-10-17 1998-10-16 Plaque-inhibiting oral compositions
EP98949952A EP1023037A1 (en) 1997-10-17 1998-10-16 Plaque-inhibiting oral compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK119197 1997-10-17
DK1191/97 1997-10-17

Publications (1)

Publication Number Publication Date
WO1999020239A1 true WO1999020239A1 (en) 1999-04-29

Family

ID=8102004

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1998/000452 WO1999020239A1 (en) 1997-10-17 1998-10-16 Plaque-inhibiting oral compositions

Country Status (6)

Country Link
EP (1) EP1023037A1 (ja)
JP (1) JP2001520179A (ja)
CN (1) CN1275906A (ja)
AU (1) AU734737B2 (ja)
CA (1) CA2305804A1 (ja)
WO (1) WO1999020239A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2846881A1 (fr) * 2002-11-13 2004-05-14 Top Pharm Lab Composition dentifrice contenant une enzyme amylolytique
WO2006032477A1 (de) * 2004-09-23 2006-03-30 Henkel Kommanditgesellschaft Auf Aktien Pullulanasen aus psychrophilen organismen
EP1791966A2 (en) * 2004-09-10 2007-06-06 Novozymes North America, Inc. Methods for preventing, removing, reducing, or disrupting biofilm
WO2007085428A2 (de) * 2006-01-28 2007-08-02 Henkel Ag & Co. Kgaa Mund-und zahnpflege und-remigungsmittel mit enzymen'
DE102006001148B4 (de) * 2006-01-06 2008-03-27 Henkel Kgaa Mund- und Zahnpflege und -reinigungsmittel mit Enzym(en)
US9622956B2 (en) 2011-12-21 2017-04-18 Colgate-Palmolive Company Oral care compositions

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104188861A (zh) * 2014-08-26 2014-12-10 华南理工大学 一种消减牙菌斑的复合酶漱口液及其制备方法
CN104207958A (zh) * 2014-08-26 2014-12-17 华南理工大学 一种含有复合酶有效清除牙菌斑的假牙护理液及其制备方法
CN104207983B (zh) * 2014-08-26 2017-08-25 华南理工大学 一种含酶与陈皮提取物的假牙护理液及其制备方法

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3194738A (en) * 1962-03-14 1965-07-13 American Chicle Co Chewing gums and dentifrices containing enzymes
FR7314M (ja) * 1967-08-17 1969-10-06
LU59502A1 (ja) * 1969-09-24 1970-02-26
DE1948468A1 (de) * 1969-09-25 1971-04-01 Blendax Werke Schneider Co Zahnreinigungsmittel
GB1284728A (en) * 1968-10-23 1972-08-09 Aspro Nicholas Ltd Dental caries control
FR2132980A5 (en) * 1971-04-02 1972-11-24 Investigations Sci Pharm Dental and buccal hygiene compsns - contg enzymatic complexes
US4740368A (en) * 1985-12-11 1988-04-26 Plevy Donald J Amylase containing breath cleansing confection
US5145665A (en) * 1989-02-04 1992-09-08 Henkel Kommanditgesellschaft Auf Aktien Preparation for dental and oral hygiene containing polysaccharide splitting enzymes
EP0787482A1 (en) * 1996-01-30 1997-08-06 Kukident GmbH Denture cleansing compositions containing percompounds
WO1998057653A1 (en) * 1997-06-17 1998-12-23 Novo Nordisk A/S An oral care composition comprising a bacillus pullulanase and a dextranase

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3194738A (en) * 1962-03-14 1965-07-13 American Chicle Co Chewing gums and dentifrices containing enzymes
FR7314M (ja) * 1967-08-17 1969-10-06
GB1284728A (en) * 1968-10-23 1972-08-09 Aspro Nicholas Ltd Dental caries control
LU59502A1 (ja) * 1969-09-24 1970-02-26
DE1948468A1 (de) * 1969-09-25 1971-04-01 Blendax Werke Schneider Co Zahnreinigungsmittel
FR2132980A5 (en) * 1971-04-02 1972-11-24 Investigations Sci Pharm Dental and buccal hygiene compsns - contg enzymatic complexes
US4740368A (en) * 1985-12-11 1988-04-26 Plevy Donald J Amylase containing breath cleansing confection
US5145665A (en) * 1989-02-04 1992-09-08 Henkel Kommanditgesellschaft Auf Aktien Preparation for dental and oral hygiene containing polysaccharide splitting enzymes
EP0787482A1 (en) * 1996-01-30 1997-08-06 Kukident GmbH Denture cleansing compositions containing percompounds
WO1998057653A1 (en) * 1997-06-17 1998-12-23 Novo Nordisk A/S An oral care composition comprising a bacillus pullulanase and a dextranase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, 1 January 1900, Columbus, Ohio, US; abstract no. 110:121130, XP002098186 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2846881A1 (fr) * 2002-11-13 2004-05-14 Top Pharm Lab Composition dentifrice contenant une enzyme amylolytique
EP1791966A2 (en) * 2004-09-10 2007-06-06 Novozymes North America, Inc. Methods for preventing, removing, reducing, or disrupting biofilm
EP1791966A4 (en) * 2004-09-10 2008-12-03 Novozymes North America Inc METHODS FOR DESTROYING, REDUCING, ELIMINATING OR PREVENTING THE FORMATION OF BIOLOGICAL FILM
EP2258837A1 (en) * 2004-09-10 2010-12-08 Novozymes North America, Inc. Methods for preventing, removing, reducing, or disrupting biofilm
WO2006032477A1 (de) * 2004-09-23 2006-03-30 Henkel Kommanditgesellschaft Auf Aktien Pullulanasen aus psychrophilen organismen
DE102004046116A1 (de) * 2004-09-23 2006-04-06 Henkel Kgaa Pullulanasen aus psychrophilen Organismen
DE102006001148B4 (de) * 2006-01-06 2008-03-27 Henkel Kgaa Mund- und Zahnpflege und -reinigungsmittel mit Enzym(en)
WO2007085428A2 (de) * 2006-01-28 2007-08-02 Henkel Ag & Co. Kgaa Mund-und zahnpflege und-remigungsmittel mit enzymen'
DE102006004079A1 (de) * 2006-01-28 2007-08-09 Henkel Kgaa Mund- und Zahnpflege und -reinigungsmittel mit Enzymen
WO2007085428A3 (de) * 2006-01-28 2007-09-13 Henkel Kgaa Mund-und zahnpflege und-remigungsmittel mit enzymen'
US9622956B2 (en) 2011-12-21 2017-04-18 Colgate-Palmolive Company Oral care compositions

Also Published As

Publication number Publication date
CN1275906A (zh) 2000-12-06
EP1023037A1 (en) 2000-08-02
AU9621398A (en) 1999-05-10
JP2001520179A (ja) 2001-10-30
CA2305804A1 (en) 1999-04-29
AU734737B2 (en) 2001-06-21

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