WO1999016753A3 - Composes 3-oxo-propanenitrile tricycliques - Google Patents

Composes 3-oxo-propanenitrile tricycliques Download PDF

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Publication number
WO1999016753A3
WO1999016753A3 PCT/EP1998/006051 EP9806051W WO9916753A3 WO 1999016753 A3 WO1999016753 A3 WO 1999016753A3 EP 9806051 W EP9806051 W EP 9806051W WO 9916753 A3 WO9916753 A3 WO 9916753A3
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WO
WIPO (PCT)
Prior art keywords
alkyl
phenyl
formylamino
alkanoylamino
nitro
Prior art date
Application number
PCT/EP1998/006051
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English (en)
Other versions
WO1999016753A2 (fr
Inventor
Paolo Pevarello
Mario Varasi
Raffaella Amici
Salvatore Toma
Carmela Speciale
Original Assignee
Pharmacia & Upjohn Spa
Paolo Pevarello
Mario Varasi
Raffaella Amici
Salvatore Toma
Carmela Speciale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa, Paolo Pevarello, Mario Varasi, Raffaella Amici, Salvatore Toma, Carmela Speciale filed Critical Pharmacia & Upjohn Spa
Priority to AU13343/99A priority Critical patent/AU1334399A/en
Priority to JP2000513839A priority patent/JP2001518469A/ja
Priority to CA002302025A priority patent/CA2302025A1/fr
Priority to EP98956836A priority patent/EP1019380A2/fr
Publication of WO1999016753A2 publication Critical patent/WO1999016753A2/fr
Publication of WO1999016753A3 publication Critical patent/WO1999016753A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne des composés 3-oxo-propanenitrile tricycliques correspondant à la formule (I), ainsi qu'un sel de ceux-ci, acceptable sur le plan pharmacologique. Dans cette formule Y représente un atome d'azote ou un groupe CH ou N-oxyde, X représente un atome d'oxygène ou NR2 dans lequel R2 représente alkyle C1-C6, benzyle, pyridyle ou phényle, phényle n'étant pas substitué ou l'étant par un ou deux substituants choisis indépendamment dans le groupe constitué par halogène, trifluorométhyle, alkyle C1-C6, alcoxy C1-C6, nitro, amino, formylamino et alcanoylamino C2-C8, R et R1 représentent chacun indépendamment hydrogène, halogène, CF3, alkyle C1-C6, hydroxy, alcoxy C1-C6, alcényloxy C3-C4, nitro, amino, formylamino, alcanoylamino C2-C8, ou alcanoyloxy C2-C8, m vaut zéro ou est un nombre entier compris entre 1 et 6, Q représente alkyle C1-C14, un noyau phényle ou un noyau hétéromonocyclique pentatomique insaturé contenant deux ou trois hétéroatomes choisis parmi oxygène, soufre et azote, le noyau phényle et le noyau hétéromonocyclique n'étant pas substitués ou l'étant pas un ou deux substituants choisis indépendamment dans le groupe constitué par halogène, CF3, alkyle C1-C6, hydroxy, alcoxy C1-C6, nitro, amino, formylamino, alcanoylamino C2-C8 ou alcanoyloxy C2- C8, et W représente un groupe -CONH- ou -SO2- ou -CO-. Ces composés et leur sel possèdent une activité inhibitrice de l'enzyme kynurénine-3-hydroxylase.
PCT/EP1998/006051 1997-10-01 1998-09-23 Composes 3-oxo-propanenitrile tricycliques WO1999016753A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU13343/99A AU1334399A (en) 1997-10-01 1998-09-23 Tricyclic 3-oxo-propanenitrile compounds
JP2000513839A JP2001518469A (ja) 1997-10-01 1998-09-23 三環式３−オキソ−プロパンニトリル化合物
CA002302025A CA2302025A1 (fr) 1997-10-01 1998-09-23 Composes 3-oxo-propanenitrile tricycliques
EP98956836A EP1019380A2 (fr) 1997-10-01 1998-09-23 Composes 3-oxo-propanenitrile tricycliques

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9720899.5A GB9720899D0 (en) 1997-10-01 1997-10-01 Condensed heterocyclic compounds
GB9720899.5 1997-10-01

Publications (2)

Publication Number Publication Date
WO1999016753A2 WO1999016753A2 (fr) 1999-04-08
WO1999016753A3 true WO1999016753A3 (fr) 1999-05-20

Family

ID=10819928

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/006051 WO1999016753A2 (fr) 1997-10-01 1998-09-23 Composes 3-oxo-propanenitrile tricycliques

Country Status (6)

Country Link
EP (1) EP1019380A2 (fr)
JP (1) JP2001518469A (fr)
AU (1) AU1334399A (fr)
CA (1) CA2302025A1 (fr)
GB (1) GB9720899D0 (fr)
WO (1) WO1999016753A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10021900A1 (de) 2000-05-08 2001-11-15 Bayer Ag Phenyl-substituierte 2-Enamino-Ketonitrile
UY30377A1 (es) * 2006-06-02 2008-01-02 Elan Pharm Inc Inhibidores triciclicos fusionados de sulfonamida de gama-secretasa
CN116535386A (zh) * 2023-04-19 2023-08-04 西南大学 氰乙烯磺酰苯胺类化合物及其制备方法和医药应用

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3842099A (en) * 1969-10-06 1974-10-15 Teikoku Hormune Mfg Co Ltd Naphtho(2,1-d)isoxazole derivatives
EP0021207A1 (fr) * 1979-06-11 1981-01-07 Ciba-Geigy Ag Alphacarbamoyle-pyrrolpropionitriles, procédé pour leur préparation et compositions pharmaceutiques les contenant
US4435407A (en) * 1982-01-07 1984-03-06 Ciba-Geigy Corporation Certain substituted β-oxo-α-carbamoylpyrrolepropionitriles
EP0156091A1 (fr) * 1982-09-28 1985-10-02 Ciba-Geigy Ag Bêta-oxo-alpha-carbamoyl-pyrrolpropionitriles, procédés de leur préparation, composés les contenant et leur utilisation thérapeutique
EP0274443A1 (fr) * 1987-01-09 1988-07-13 FARMITALIA CARLO ERBA S.r.l. Dérivés d'hétéroaryl oxo-3 propanenitrile et procédé pour leur préparation
WO1989012638A1 (fr) * 1988-06-20 1989-12-28 Farmitalia Carlo Erba S.R.L. Derives de 3-oxo-propane-nitrile tricycliques et procede servant a leur preparation
EP0372470A2 (fr) * 1988-12-08 1990-06-13 Ciba-Geigy Ag Cyano-alpha-oxo-bêta-propionamides
DE3940074A1 (de) * 1989-02-06 1990-08-09 Erba Carlo Spa Kondensierte 3-oxo-propannitrilderivate und verfahren zu ihrer herstellung
WO1991001309A1 (fr) * 1989-07-17 1991-02-07 Farmitalia Carlo Erba S.R.L. Derives d'heteroaryl-3-oxo-propanenitrile utiles a la stimulation de la myelopoïese
EP0620489A1 (fr) * 1993-04-12 1994-10-19 Konica Corporation Procédé de formation d'image photographique cyan
JPH0827131A (ja) * 1994-07-11 1996-01-30 Teikoku Hormone Mfg Co Ltd 新規な二環式化合物縮合［２，１−ｄ］イソキサゾール−３−カルボン酸誘導体

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3842099A (en) * 1969-10-06 1974-10-15 Teikoku Hormune Mfg Co Ltd Naphtho(2,1-d)isoxazole derivatives
EP0021207A1 (fr) * 1979-06-11 1981-01-07 Ciba-Geigy Ag Alphacarbamoyle-pyrrolpropionitriles, procédé pour leur préparation et compositions pharmaceutiques les contenant
US4435407A (en) * 1982-01-07 1984-03-06 Ciba-Geigy Corporation Certain substituted β-oxo-α-carbamoylpyrrolepropionitriles
EP0156091A1 (fr) * 1982-09-28 1985-10-02 Ciba-Geigy Ag Bêta-oxo-alpha-carbamoyl-pyrrolpropionitriles, procédés de leur préparation, composés les contenant et leur utilisation thérapeutique
EP0274443A1 (fr) * 1987-01-09 1988-07-13 FARMITALIA CARLO ERBA S.r.l. Dérivés d'hétéroaryl oxo-3 propanenitrile et procédé pour leur préparation
WO1989012638A1 (fr) * 1988-06-20 1989-12-28 Farmitalia Carlo Erba S.R.L. Derives de 3-oxo-propane-nitrile tricycliques et procede servant a leur preparation
EP0372470A2 (fr) * 1988-12-08 1990-06-13 Ciba-Geigy Ag Cyano-alpha-oxo-bêta-propionamides
DE3940074A1 (de) * 1989-02-06 1990-08-09 Erba Carlo Spa Kondensierte 3-oxo-propannitrilderivate und verfahren zu ihrer herstellung
WO1991001309A1 (fr) * 1989-07-17 1991-02-07 Farmitalia Carlo Erba S.R.L. Derives d'heteroaryl-3-oxo-propanenitrile utiles a la stimulation de la myelopoïese
EP0620489A1 (fr) * 1993-04-12 1994-10-19 Konica Corporation Procédé de formation d'image photographique cyan
JPH0827131A (ja) * 1994-07-11 1996-01-30 Teikoku Hormone Mfg Co Ltd 新規な二環式化合物縮合［２，１−ｄ］イソキサゾール−３−カルボン酸誘導体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 96, no. 5 31 May 1996 (1996-05-31) *

Also Published As

Publication number Publication date
WO1999016753A2 (fr) 1999-04-08
JP2001518469A (ja) 2001-10-16
EP1019380A2 (fr) 2000-07-19
AU1334399A (en) 1999-04-23
CA2302025A1 (fr) 1999-04-08
GB9720899D0 (en) 1997-12-03

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