IL107342A - Azacycloalkane derivatives, their preparation, pharmaceutical compositions and poultry feed stuffs containing them - Google Patents
Azacycloalkane derivatives, their preparation, pharmaceutical compositions and poultry feed stuffs containing themInfo
- Publication number
- IL107342A IL107342A IL107342A IL10734293A IL107342A IL 107342 A IL107342 A IL 107342A IL 107342 A IL107342 A IL 107342A IL 10734293 A IL10734293 A IL 10734293A IL 107342 A IL107342 A IL 107342A
- Authority
- IL
- Israel
- Prior art keywords
- denotes
- group
- atom
- optionally substituted
- alkyl group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Ink Jet (AREA)
- Developing Agents For Electrophotography (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Cholesterol and ergosterol biosynthesis inhibiting compounds of the formula R2R1 R3R4 N R8 (C)n(CH2)m YCN XAR10(I) R5R6 W1W2(CH2)p R7R9 (wherein: n denotes the numbers 0 or 1; m denotes the numbers 1 or 2; p denotes the numbers 0 or 1; A denotes a single bond, a straight-chain or branched C1-17-alkylene, C217-alkenylene or C2-4-alkynylene group; W1 and W2 each denotes a hydrogen atom or W1 and W2 together denote a carbon- carbon bond; X denotes a carbonyl or sulphonyl group with the proviso that where A denotes a bond and R10 denotes a hydrogen atom then X denotes a carbonyl group; Y denotes an oxygen or sulphur atom or an LNR11 group; R1, R2, R3, R4, R5 and R6 each denotes a hydrogen atom, or one, two or three of the groups R1, R2, R3, R4, R5 and R6, independently denote an alkoxycarbonyl group, or a straight-chain or branched C1-4-alkyl group optionally substituted by a hydroxy, alkoxy, alkylthio or dialkylamino group or by a phenyl group itself optionally substituted by a halogen atom or an alkyl group, and of the groups R1, R3 and R5 one, two or three may also denote a phenyl group optionally substituted by an alkyl group or a halogen atom, and the remaining groups of groups R1, R2, R3, R4, R5 and R6 each denote a hydrogen atom; R7 denotes a hydrogen or halogen atom, or an alkyl or alkoxy group; R8 and R9 independently denote a hydrogen atom or an alkyl group; R10 denotes a hydrogen atom, a C3-6-cycloalkyl group, a phenyl group optionally substituted by a halogen atom, by a straight-chain or branched C1-4-alkyl group, by a trifluoromethyl, alkoxy, cyano, nitro, alkylsulphonyl, or phenyl group, by two trifluoromethyl groups, by two to five halogen atoms, or by a halogen atom and an alkyl group optionally substituted by a fluorine atom, or R10 denotes a pyridyl group or a thienyl group optionally substituted by a halogen atom or by an alkyl group; and R11 denotes a hydrogen atom or an alkyl group; wherein, unless otherwise stated, each alkyl or alkylene moiety contains 1 to 3 carbon atoms and each halogen atom is a fluorine, chlorine or bromine atom) and the isomers, and salts thereof.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4235590A DE4235590A1 (en) | 1992-10-22 | 1992-10-22 | Arylidene-1-aza:cycloalkane derivs. - are inhibitors of cholesterol biosynthesis and hence useful in treating hyper-cholesterolaemia and atherosclerosis. |
DE4303840A DE4303840A1 (en) | 1992-10-22 | 1993-02-10 | Arylidene-1-azacycloalkanes and arylalkyl-1-azacycloalkanes, their salts, pharmaceutical compositions containing them and their use, and processes for their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
IL107342A0 IL107342A0 (en) | 1994-01-25 |
IL107342A true IL107342A (en) | 1997-07-13 |
Family
ID=25919689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL107342A IL107342A (en) | 1992-10-22 | 1993-10-21 | Azacycloalkane derivatives, their preparation, pharmaceutical compositions and poultry feed stuffs containing them |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0596326B1 (en) |
JP (1) | JP3396517B2 (en) |
KR (1) | KR100306520B1 (en) |
CN (1) | CN1040873C (en) |
AT (1) | ATE126797T1 (en) |
AU (1) | AU665648B2 (en) |
CA (1) | CA2108817C (en) |
CZ (1) | CZ286025B6 (en) |
DE (2) | DE4303840A1 (en) |
DK (1) | DK0596326T3 (en) |
ES (1) | ES2078787T3 (en) |
FI (1) | FI934665A (en) |
GR (1) | GR3017692T3 (en) |
HK (1) | HK1000285A1 (en) |
HU (1) | HU221630B1 (en) |
IL (1) | IL107342A (en) |
NO (1) | NO300843B1 (en) |
NZ (1) | NZ250018A (en) |
PL (1) | PL173775B1 (en) |
RU (1) | RU2126400C1 (en) |
SK (1) | SK281222B6 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4234295A1 (en) * | 1992-10-12 | 1994-04-14 | Thomae Gmbh Dr K | Carboxylic acid derivatives, medicaments containing these compounds and process for their preparation |
IL110943A (en) * | 1994-09-13 | 1997-02-18 | Univ Ramot | Compositions comprising an inhibitor of cholesterol synthesis for the treatment of skin disorders |
DE19754795A1 (en) | 1997-12-10 | 1999-06-17 | Boehringer Ingelheim Pharma | New urethanes, their thio and dithio analogues, their salts, medicines containing them and their use, and processes for their preparation |
US6228868B1 (en) | 1998-07-27 | 2001-05-08 | Abbott Laboratories | Oxazoline antiproliferative agents |
AU5227999A (en) * | 1998-07-27 | 2000-02-21 | Abbott Laboratories | Substituted oxazolines as antiproliferative agents |
US7667053B2 (en) | 2002-04-12 | 2010-02-23 | Merck & Co., Inc. | Bicyclic amides |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4863932A (en) * | 1988-03-11 | 1989-09-05 | Somatogenetics International, Inc. | Squalene oxide cyclase inhibitors and therapeutic use thereof |
CA2025490C (en) * | 1989-09-22 | 2003-09-16 | James R. Mccarthy | Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis |
NZ239022A (en) * | 1990-07-25 | 1993-11-25 | Merrell Dow Pharma | Piperidyl ethers and thioethers; preparatory processes and pharmaceutical compositions |
US5084461A (en) * | 1991-03-27 | 1992-01-28 | Merrell Dow Pharmaceuticals Inc. | Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis |
-
1993
- 1993-02-10 DE DE4303840A patent/DE4303840A1/en not_active Ceased
- 1993-10-05 SK SK1073-93A patent/SK281222B6/en unknown
- 1993-10-20 CA CA002108817A patent/CA2108817C/en not_active Expired - Fee Related
- 1993-10-20 EP EP93116959A patent/EP0596326B1/en not_active Expired - Lifetime
- 1993-10-20 ES ES93116959T patent/ES2078787T3/en not_active Expired - Lifetime
- 1993-10-20 DK DK93116959.3T patent/DK0596326T3/en active
- 1993-10-20 DE DE59300507T patent/DE59300507D1/en not_active Expired - Lifetime
- 1993-10-20 AT AT93116959T patent/ATE126797T1/en active
- 1993-10-21 NZ NZ250018A patent/NZ250018A/en unknown
- 1993-10-21 NO NO933790A patent/NO300843B1/en not_active IP Right Cessation
- 1993-10-21 KR KR1019930021923A patent/KR100306520B1/en not_active IP Right Cessation
- 1993-10-21 AU AU49135/93A patent/AU665648B2/en not_active Ceased
- 1993-10-21 IL IL107342A patent/IL107342A/en not_active IP Right Cessation
- 1993-10-21 HU HU9302986A patent/HU221630B1/en not_active IP Right Cessation
- 1993-10-21 JP JP26321493A patent/JP3396517B2/en not_active Expired - Fee Related
- 1993-10-21 RU RU93048154/04A patent/RU2126400C1/en not_active IP Right Cessation
- 1993-10-22 CN CN93119156A patent/CN1040873C/en not_active Expired - Fee Related
- 1993-10-22 PL PL93300834A patent/PL173775B1/en unknown
- 1993-10-22 FI FI934665A patent/FI934665A/en unknown
- 1993-10-22 CZ CZ932236A patent/CZ286025B6/en not_active IP Right Cessation
-
1995
- 1995-10-11 GR GR950402801T patent/GR3017692T3/en unknown
-
1997
- 1997-09-26 HK HK97101852A patent/HK1000285A1/en not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
FF | Patent granted | ||
KB | Patent renewed | ||
RH1 | Patent not in force |