IL107342A - Azacycloalkane derivatives, their preparation, pharmaceutical compositions and poultry feed stuffs containing them - Google Patents

Azacycloalkane derivatives, their preparation, pharmaceutical compositions and poultry feed stuffs containing them

Info

Publication number
IL107342A
IL107342A IL107342A IL10734293A IL107342A IL 107342 A IL107342 A IL 107342A IL 107342 A IL107342 A IL 107342A IL 10734293 A IL10734293 A IL 10734293A IL 107342 A IL107342 A IL 107342A
Authority
IL
Israel
Prior art keywords
denotes
group
atom
optionally substituted
alkyl group
Prior art date
Application number
IL107342A
Other versions
IL107342A0 (en
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4235590A external-priority patent/DE4235590A1/en
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of IL107342A0 publication Critical patent/IL107342A0/en
Publication of IL107342A publication Critical patent/IL107342A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Ink Jet (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Cholesterol and ergosterol biosynthesis inhibiting compounds of the formula R2R1 R3R4 N R8 (C)n(CH2)m YCN XAR10(I) R5R6 W1W2(CH2)p R7R9 (wherein: n denotes the numbers 0 or 1; m denotes the numbers 1 or 2; p denotes the numbers 0 or 1; A denotes a single bond, a straight-chain or branched C1-17-alkylene, C217-alkenylene or C2-4-alkynylene group; W1 and W2 each denotes a hydrogen atom or W1 and W2 together denote a carbon- carbon bond; X denotes a carbonyl or sulphonyl group with the proviso that where A denotes a bond and R10 denotes a hydrogen atom then X denotes a carbonyl group; Y denotes an oxygen or sulphur atom or an LNR11 group; R1, R2, R3, R4, R5 and R6 each denotes a hydrogen atom, or one, two or three of the groups R1, R2, R3, R4, R5 and R6, independently denote an alkoxycarbonyl group, or a straight-chain or branched C1-4-alkyl group optionally substituted by a hydroxy, alkoxy, alkylthio or dialkylamino group or by a phenyl group itself optionally substituted by a halogen atom or an alkyl group, and of the groups R1, R3 and R5 one, two or three may also denote a phenyl group optionally substituted by an alkyl group or a halogen atom, and the remaining groups of groups R1, R2, R3, R4, R5 and R6 each denote a hydrogen atom; R7 denotes a hydrogen or halogen atom, or an alkyl or alkoxy group; R8 and R9 independently denote a hydrogen atom or an alkyl group; R10 denotes a hydrogen atom, a C3-6-cycloalkyl group, a phenyl group optionally substituted by a halogen atom, by a straight-chain or branched C1-4-alkyl group, by a trifluoromethyl, alkoxy, cyano, nitro, alkylsulphonyl, or phenyl group, by two trifluoromethyl groups, by two to five halogen atoms, or by a halogen atom and an alkyl group optionally substituted by a fluorine atom, or R10 denotes a pyridyl group or a thienyl group optionally substituted by a halogen atom or by an alkyl group; and R11 denotes a hydrogen atom or an alkyl group; wherein, unless otherwise stated, each alkyl or alkylene moiety contains 1 to 3 carbon atoms and each halogen atom is a fluorine, chlorine or bromine atom) and the isomers, and salts thereof.
IL107342A 1992-10-22 1993-10-21 Azacycloalkane derivatives, their preparation, pharmaceutical compositions and poultry feed stuffs containing them IL107342A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4235590A DE4235590A1 (en) 1992-10-22 1992-10-22 Arylidene-1-aza:cycloalkane derivs. - are inhibitors of cholesterol biosynthesis and hence useful in treating hyper-cholesterolaemia and atherosclerosis.
DE4303840A DE4303840A1 (en) 1992-10-22 1993-02-10 Arylidene-1-azacycloalkanes and arylalkyl-1-azacycloalkanes, their salts, pharmaceutical compositions containing them and their use, and processes for their preparation

Publications (2)

Publication Number Publication Date
IL107342A0 IL107342A0 (en) 1994-01-25
IL107342A true IL107342A (en) 1997-07-13

Family

ID=25919689

Family Applications (1)

Application Number Title Priority Date Filing Date
IL107342A IL107342A (en) 1992-10-22 1993-10-21 Azacycloalkane derivatives, their preparation, pharmaceutical compositions and poultry feed stuffs containing them

Country Status (21)

Country Link
EP (1) EP0596326B1 (en)
JP (1) JP3396517B2 (en)
KR (1) KR100306520B1 (en)
CN (1) CN1040873C (en)
AT (1) ATE126797T1 (en)
AU (1) AU665648B2 (en)
CA (1) CA2108817C (en)
CZ (1) CZ286025B6 (en)
DE (2) DE4303840A1 (en)
DK (1) DK0596326T3 (en)
ES (1) ES2078787T3 (en)
FI (1) FI934665A (en)
GR (1) GR3017692T3 (en)
HK (1) HK1000285A1 (en)
HU (1) HU221630B1 (en)
IL (1) IL107342A (en)
NO (1) NO300843B1 (en)
NZ (1) NZ250018A (en)
PL (1) PL173775B1 (en)
RU (1) RU2126400C1 (en)
SK (1) SK281222B6 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4234295A1 (en) * 1992-10-12 1994-04-14 Thomae Gmbh Dr K Carboxylic acid derivatives, medicaments containing these compounds and process for their preparation
IL110943A (en) * 1994-09-13 1997-02-18 Univ Ramot Compositions comprising an inhibitor of cholesterol synthesis for the treatment of skin disorders
DE19754795A1 (en) 1997-12-10 1999-06-17 Boehringer Ingelheim Pharma New urethanes, their thio and dithio analogues, their salts, medicines containing them and their use, and processes for their preparation
US6228868B1 (en) 1998-07-27 2001-05-08 Abbott Laboratories Oxazoline antiproliferative agents
AU5227999A (en) * 1998-07-27 2000-02-21 Abbott Laboratories Substituted oxazolines as antiproliferative agents
US7667053B2 (en) 2002-04-12 2010-02-23 Merck & Co., Inc. Bicyclic amides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863932A (en) * 1988-03-11 1989-09-05 Somatogenetics International, Inc. Squalene oxide cyclase inhibitors and therapeutic use thereof
CA2025490C (en) * 1989-09-22 2003-09-16 James R. Mccarthy Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis
NZ239022A (en) * 1990-07-25 1993-11-25 Merrell Dow Pharma Piperidyl ethers and thioethers; preparatory processes and pharmaceutical compositions
US5084461A (en) * 1991-03-27 1992-01-28 Merrell Dow Pharmaceuticals Inc. Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis

Also Published As

Publication number Publication date
NO300843B1 (en) 1997-08-04
AU4913593A (en) 1994-05-05
RU2126400C1 (en) 1999-02-20
ATE126797T1 (en) 1995-09-15
HU221630B1 (en) 2002-12-28
DE59300507D1 (en) 1995-09-28
CN1040873C (en) 1998-11-25
CZ223693A3 (en) 1994-05-18
HU9302986D0 (en) 1994-01-28
EP0596326A1 (en) 1994-05-11
DE4303840A1 (en) 1994-08-11
SK281222B6 (en) 2001-01-18
AU665648B2 (en) 1996-01-11
KR100306520B1 (en) 2001-11-30
GR3017692T3 (en) 1996-01-31
DK0596326T3 (en) 1996-01-15
SK107393A3 (en) 1994-09-07
CA2108817A1 (en) 1994-04-23
PL300834A1 (en) 1994-05-16
JP3396517B2 (en) 2003-04-14
PL173775B1 (en) 1998-04-30
NO933790D0 (en) 1993-10-21
CZ286025B6 (en) 1999-12-15
JPH06192256A (en) 1994-07-12
NO933790L (en) 1994-04-25
EP0596326B1 (en) 1995-08-23
FI934665A0 (en) 1993-10-22
IL107342A0 (en) 1994-01-25
HK1000285A1 (en) 1998-02-20
HUT68958A (en) 1995-08-28
NZ250018A (en) 1995-07-26
ES2078787T3 (en) 1995-12-16
FI934665A (en) 1994-04-23
KR940009181A (en) 1994-05-20
CN1090849A (en) 1994-08-17
CA2108817C (en) 2004-12-07

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