IL107342A0 - Azacycloalkane derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

Azacycloalkane derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL107342A0
IL107342A0 IL107342A IL10734293A IL107342A0 IL 107342 A0 IL107342 A0 IL 107342A0 IL 107342 A IL107342 A IL 107342A IL 10734293 A IL10734293 A IL 10734293A IL 107342 A0 IL107342 A0 IL 107342A0
Authority
IL
Israel
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
azacycloalkane derivatives
azacycloalkanes
Prior art date
Application number
IL107342A
Other versions
IL107342A (en
Original Assignee
Karl Thomae Ghbh Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4235590A external-priority patent/DE4235590A1/en
Application filed by Karl Thomae Ghbh Dr filed Critical Karl Thomae Ghbh Dr
Publication of IL107342A0 publication Critical patent/IL107342A0/en
Publication of IL107342A publication Critical patent/IL107342A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Ink Jet (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Catalysts (AREA)

Abstract

The invention relates to arylidene-1-azacycloalkanes and arylalkyl-1-azacycloalkanes of the general formula <IMAGE> in which n, m, p, A, W<1>, W<2>, X, Y and R<1> to R<11> are defined as in Claim 1, their isomers and isomer mixtures and their salts, which have useful properties and in particular exert an inhibitory action on cholesterol biosynthesis.
IL107342A 1992-10-22 1993-10-21 Azacycloalkane derivatives, their preparation, pharmaceutical compositions and poultry feed stuffs containing them IL107342A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4235590A DE4235590A1 (en) 1992-10-22 1992-10-22 Arylidene-1-aza:cycloalkane derivs. - are inhibitors of cholesterol biosynthesis and hence useful in treating hyper-cholesterolaemia and atherosclerosis.
DE4303840A DE4303840A1 (en) 1992-10-22 1993-02-10 Arylidene-1-azacycloalkanes and arylalkyl-1-azacycloalkanes, their salts, pharmaceutical compositions containing them and their use, and processes for their preparation

Publications (2)

Publication Number Publication Date
IL107342A0 true IL107342A0 (en) 1994-01-25
IL107342A IL107342A (en) 1997-07-13

Family

ID=25919689

Family Applications (1)

Application Number Title Priority Date Filing Date
IL107342A IL107342A (en) 1992-10-22 1993-10-21 Azacycloalkane derivatives, their preparation, pharmaceutical compositions and poultry feed stuffs containing them

Country Status (21)

Country Link
EP (1) EP0596326B1 (en)
JP (1) JP3396517B2 (en)
KR (1) KR100306520B1 (en)
CN (1) CN1040873C (en)
AT (1) ATE126797T1 (en)
AU (1) AU665648B2 (en)
CA (1) CA2108817C (en)
CZ (1) CZ286025B6 (en)
DE (2) DE4303840A1 (en)
DK (1) DK0596326T3 (en)
ES (1) ES2078787T3 (en)
FI (1) FI934665A (en)
GR (1) GR3017692T3 (en)
HK (1) HK1000285A1 (en)
HU (1) HU221630B1 (en)
IL (1) IL107342A (en)
NO (1) NO300843B1 (en)
NZ (1) NZ250018A (en)
PL (1) PL173775B1 (en)
RU (1) RU2126400C1 (en)
SK (1) SK281222B6 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4234295A1 (en) * 1992-10-12 1994-04-14 Thomae Gmbh Dr K Carboxylic acid derivatives, medicaments containing these compounds and process for their preparation
IL110943A (en) * 1994-09-13 1997-02-18 Univ Ramot Compositions comprising an inhibitor of cholesterol synthesis for the treatment of skin disorders
DE19754795A1 (en) 1997-12-10 1999-06-17 Boehringer Ingelheim Pharma New urethanes, their thio and dithio analogues, their salts, medicines containing them and their use, and processes for their preparation
WO2000006556A1 (en) * 1998-07-27 2000-02-10 Abbott Laboratories Substituted oxazolines as antiproliferative agents
US6228868B1 (en) 1998-07-27 2001-05-08 Abbott Laboratories Oxazoline antiproliferative agents
CA2481313A1 (en) 2002-04-12 2003-10-23 Merck & Co., Inc. Bicyclic amides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863932A (en) * 1988-03-11 1989-09-05 Somatogenetics International, Inc. Squalene oxide cyclase inhibitors and therapeutic use thereof
CA2025490C (en) * 1989-09-22 2003-09-16 James R. Mccarthy Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis
ZA915659B (en) * 1990-07-25 1992-05-27 Merrell Dow Pharma Novel piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis
US5084461A (en) * 1991-03-27 1992-01-28 Merrell Dow Pharmaceuticals Inc. Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis

Also Published As

Publication number Publication date
DK0596326T3 (en) 1996-01-15
SK281222B6 (en) 2001-01-18
JPH06192256A (en) 1994-07-12
FI934665A (en) 1994-04-23
HU9302986D0 (en) 1994-01-28
IL107342A (en) 1997-07-13
AU665648B2 (en) 1996-01-11
NO933790D0 (en) 1993-10-21
PL300834A1 (en) 1994-05-16
CN1090849A (en) 1994-08-17
JP3396517B2 (en) 2003-04-14
ATE126797T1 (en) 1995-09-15
EP0596326A1 (en) 1994-05-11
ES2078787T3 (en) 1995-12-16
PL173775B1 (en) 1998-04-30
NO933790L (en) 1994-04-25
NZ250018A (en) 1995-07-26
KR940009181A (en) 1994-05-20
GR3017692T3 (en) 1996-01-31
HUT68958A (en) 1995-08-28
AU4913593A (en) 1994-05-05
NO300843B1 (en) 1997-08-04
DE59300507D1 (en) 1995-09-28
HK1000285A1 (en) 1998-02-20
DE4303840A1 (en) 1994-08-11
HU221630B1 (en) 2002-12-28
CZ223693A3 (en) 1994-05-18
CN1040873C (en) 1998-11-25
EP0596326B1 (en) 1995-08-23
CZ286025B6 (en) 1999-12-15
CA2108817C (en) 2004-12-07
FI934665A0 (en) 1993-10-22
CA2108817A1 (en) 1994-04-23
SK107393A3 (en) 1994-09-07
KR100306520B1 (en) 2001-11-30
RU2126400C1 (en) 1999-02-20

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
FF Patent granted
KB Patent renewed
RH1 Patent not in force