AU665648B2 - Azacycloalkane derivatives - Google Patents

Azacycloalkane derivatives

Info

Publication number
AU665648B2
AU665648B2 AU49135/93A AU4913593A AU665648B2 AU 665648 B2 AU665648 B2 AU 665648B2 AU 49135/93 A AU49135/93 A AU 49135/93A AU 4913593 A AU4913593 A AU 4913593A AU 665648 B2 AU665648 B2 AU 665648B2
Authority
AU
Australia
Prior art keywords
azacycloalkanes
azacycloalkane derivatives
azacycloalkane
derivatives
arylidene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU49135/93A
Other versions
AU4913593A (en
Inventor
Ralph-Michael Budzinski
Bernhard Eisele
Gerhard Hallermeyer
Rudolf Hurnaus
Roland Maier
Michael Mark
Peter Muller
Eberhard Woitun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4235590A external-priority patent/DE4235590A1/en
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of AU4913593A publication Critical patent/AU4913593A/en
Application granted granted Critical
Publication of AU665648B2 publication Critical patent/AU665648B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Ink Jet (AREA)
  • Developing Agents For Electrophotography (AREA)

Abstract

The invention relates to arylidene-1-azacycloalkanes and arylalkyl-1-azacycloalkanes of the general formula <IMAGE> in which n, m, p, A, W<1>, W<2>, X, Y and R<1> to R<11> are defined as in Claim 1, their isomers and isomer mixtures and their salts, which have useful properties and in particular exert an inhibitory action on cholesterol biosynthesis.
AU49135/93A 1992-10-22 1993-10-21 Azacycloalkane derivatives Ceased AU665648B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4235590 1992-10-22
DE4235590A DE4235590A1 (en) 1992-10-22 1992-10-22 Arylidene-1-aza:cycloalkane derivs. - are inhibitors of cholesterol biosynthesis and hence useful in treating hyper-cholesterolaemia and atherosclerosis.
DE4303840A DE4303840A1 (en) 1992-10-22 1993-02-10 Arylidene-1-azacycloalkanes and arylalkyl-1-azacycloalkanes, their salts, pharmaceutical compositions containing them and their use, and processes for their preparation
DE4303840 1993-02-10

Publications (2)

Publication Number Publication Date
AU4913593A AU4913593A (en) 1994-05-05
AU665648B2 true AU665648B2 (en) 1996-01-11

Family

ID=25919689

Family Applications (1)

Application Number Title Priority Date Filing Date
AU49135/93A Ceased AU665648B2 (en) 1992-10-22 1993-10-21 Azacycloalkane derivatives

Country Status (21)

Country Link
EP (1) EP0596326B1 (en)
JP (1) JP3396517B2 (en)
KR (1) KR100306520B1 (en)
CN (1) CN1040873C (en)
AT (1) ATE126797T1 (en)
AU (1) AU665648B2 (en)
CA (1) CA2108817C (en)
CZ (1) CZ286025B6 (en)
DE (2) DE4303840A1 (en)
DK (1) DK0596326T3 (en)
ES (1) ES2078787T3 (en)
FI (1) FI934665A (en)
GR (1) GR3017692T3 (en)
HK (1) HK1000285A1 (en)
HU (1) HU221630B1 (en)
IL (1) IL107342A (en)
NO (1) NO300843B1 (en)
NZ (1) NZ250018A (en)
PL (1) PL173775B1 (en)
RU (1) RU2126400C1 (en)
SK (1) SK281222B6 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4234295A1 (en) * 1992-10-12 1994-04-14 Thomae Gmbh Dr K Carboxylic acid derivatives, medicaments containing these compounds and process for their preparation
IL110943A (en) * 1994-09-13 1997-02-18 Univ Ramot Compositions comprising an inhibitor of cholesterol synthesis for the treatment of skin disorders
DE19754795A1 (en) * 1997-12-10 1999-06-17 Boehringer Ingelheim Pharma New urethanes, their thio and dithio analogues, their salts, medicines containing them and their use, and processes for their preparation
AU5227999A (en) * 1998-07-27 2000-02-21 Abbott Laboratories Substituted oxazolines as antiproliferative agents
US6228868B1 (en) 1998-07-27 2001-05-08 Abbott Laboratories Oxazoline antiproliferative agents
US7667053B2 (en) 2002-04-12 2010-02-23 Merck & Co., Inc. Bicyclic amides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0420116A2 (en) * 1989-09-22 1991-04-03 Merrell Pharmaceuticals Inc. Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis
EP0468434A1 (en) * 1990-07-25 1992-01-29 Merrell Pharmaceuticals Inc. Novel piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis
EP0506072A1 (en) * 1991-03-27 1992-09-30 Merrell Pharmaceuticals Inc. Novel azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863932A (en) * 1988-03-11 1989-09-05 Somatogenetics International, Inc. Squalene oxide cyclase inhibitors and therapeutic use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0420116A2 (en) * 1989-09-22 1991-04-03 Merrell Pharmaceuticals Inc. Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis
EP0468434A1 (en) * 1990-07-25 1992-01-29 Merrell Pharmaceuticals Inc. Novel piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis
EP0506072A1 (en) * 1991-03-27 1992-09-30 Merrell Pharmaceuticals Inc. Novel azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis

Also Published As

Publication number Publication date
EP0596326A1 (en) 1994-05-11
HK1000285A1 (en) 1998-02-20
DE4303840A1 (en) 1994-08-11
CZ286025B6 (en) 1999-12-15
HU221630B1 (en) 2002-12-28
PL300834A1 (en) 1994-05-16
CA2108817C (en) 2004-12-07
RU2126400C1 (en) 1999-02-20
ATE126797T1 (en) 1995-09-15
DE59300507D1 (en) 1995-09-28
NO933790L (en) 1994-04-25
HU9302986D0 (en) 1994-01-28
GR3017692T3 (en) 1996-01-31
NO933790D0 (en) 1993-10-21
FI934665A (en) 1994-04-23
FI934665A0 (en) 1993-10-22
SK281222B6 (en) 2001-01-18
CN1040873C (en) 1998-11-25
JP3396517B2 (en) 2003-04-14
DK0596326T3 (en) 1996-01-15
CA2108817A1 (en) 1994-04-23
KR940009181A (en) 1994-05-20
JPH06192256A (en) 1994-07-12
IL107342A0 (en) 1994-01-25
AU4913593A (en) 1994-05-05
SK107393A3 (en) 1994-09-07
ES2078787T3 (en) 1995-12-16
IL107342A (en) 1997-07-13
NO300843B1 (en) 1997-08-04
HUT68958A (en) 1995-08-28
CZ223693A3 (en) 1994-05-18
EP0596326B1 (en) 1995-08-23
PL173775B1 (en) 1998-04-30
KR100306520B1 (en) 2001-11-30
CN1090849A (en) 1994-08-17
NZ250018A (en) 1995-07-26

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired