DK0596326T3 - Arylidene-1-azacycloalkanes and arylalkyl-1-azacycloalkanes and their salts, drugs containing the compounds and the use of the compounds, and process for the preparation of the compounds - Google Patents

Arylidene-1-azacycloalkanes and arylalkyl-1-azacycloalkanes and their salts, drugs containing the compounds and the use of the compounds, and process for the preparation of the compounds

Info

Publication number
DK0596326T3
DK0596326T3 DK93116959.3T DK93116959T DK0596326T3 DK 0596326 T3 DK0596326 T3 DK 0596326T3 DK 93116959 T DK93116959 T DK 93116959T DK 0596326 T3 DK0596326 T3 DK 0596326T3
Authority
DK
Denmark
Prior art keywords
compounds
azacycloalkanes
arylidene
arylalkyl
salts
Prior art date
Application number
DK93116959.3T
Other languages
Danish (da)
Inventor
Roland Dr Dipl-Chem Maier
Peter Dr Dipl-Chem Mueller
Eberhard Dr Dipl-Chem Woitun
Rudolf Dr Dipl-Chem Hurnaus
Michael Dr Mark
Bernhard Dr Dipl-Chem Eisele
Ralph-Michael Dr Dip Budzinski
Gerhard Dr Dipl-Ch Hallermayer
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4235590A external-priority patent/DE4235590A1/en
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Application granted granted Critical
Publication of DK0596326T3 publication Critical patent/DK0596326T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Ink Jet (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to arylidene-1-azacycloalkanes and arylalkyl-1-azacycloalkanes of the general formula <IMAGE> in which n, m, p, A, W<1>, W<2>, X, Y and R<1> to R<11> are defined as in Claim 1, their isomers and isomer mixtures and their salts, which have useful properties and in particular exert an inhibitory action on cholesterol biosynthesis.
DK93116959.3T 1992-10-22 1993-10-20 Arylidene-1-azacycloalkanes and arylalkyl-1-azacycloalkanes and their salts, drugs containing the compounds and the use of the compounds, and process for the preparation of the compounds DK0596326T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4235590A DE4235590A1 (en) 1992-10-22 1992-10-22 Arylidene-1-aza:cycloalkane derivs. - are inhibitors of cholesterol biosynthesis and hence useful in treating hyper-cholesterolaemia and atherosclerosis.
DE4303840A DE4303840A1 (en) 1992-10-22 1993-02-10 Arylidene-1-azacycloalkanes and arylalkyl-1-azacycloalkanes, their salts, pharmaceutical compositions containing them and their use, and processes for their preparation

Publications (1)

Publication Number Publication Date
DK0596326T3 true DK0596326T3 (en) 1996-01-15

Family

ID=25919689

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93116959.3T DK0596326T3 (en) 1992-10-22 1993-10-20 Arylidene-1-azacycloalkanes and arylalkyl-1-azacycloalkanes and their salts, drugs containing the compounds and the use of the compounds, and process for the preparation of the compounds

Country Status (21)

Country Link
EP (1) EP0596326B1 (en)
JP (1) JP3396517B2 (en)
KR (1) KR100306520B1 (en)
CN (1) CN1040873C (en)
AT (1) ATE126797T1 (en)
AU (1) AU665648B2 (en)
CA (1) CA2108817C (en)
CZ (1) CZ286025B6 (en)
DE (2) DE4303840A1 (en)
DK (1) DK0596326T3 (en)
ES (1) ES2078787T3 (en)
FI (1) FI934665A (en)
GR (1) GR3017692T3 (en)
HK (1) HK1000285A1 (en)
HU (1) HU221630B1 (en)
IL (1) IL107342A (en)
NO (1) NO300843B1 (en)
NZ (1) NZ250018A (en)
PL (1) PL173775B1 (en)
RU (1) RU2126400C1 (en)
SK (1) SK281222B6 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4234295A1 (en) * 1992-10-12 1994-04-14 Thomae Gmbh Dr K Carboxylic acid derivatives, medicaments containing these compounds and process for their preparation
IL110943A (en) * 1994-09-13 1997-02-18 Univ Ramot Compositions comprising an inhibitor of cholesterol synthesis for the treatment of skin disorders
DE19754795A1 (en) * 1997-12-10 1999-06-17 Boehringer Ingelheim Pharma New urethanes, their thio and dithio analogues, their salts, medicines containing them and their use, and processes for their preparation
US6228868B1 (en) 1998-07-27 2001-05-08 Abbott Laboratories Oxazoline antiproliferative agents
WO2000006556A1 (en) * 1998-07-27 2000-02-10 Abbott Laboratories Substituted oxazolines as antiproliferative agents
AU2003223510B2 (en) 2002-04-12 2008-05-08 Merck Sharp & Dohme Corp. Bicyclic amides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863932A (en) * 1988-03-11 1989-09-05 Somatogenetics International, Inc. Squalene oxide cyclase inhibitors and therapeutic use thereof
CA2025490C (en) * 1989-09-22 2003-09-16 James R. Mccarthy Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis
CA2047375C (en) * 1990-07-25 2003-04-15 Charlotte L. Barney Piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis
US5084461A (en) * 1991-03-27 1992-01-28 Merrell Dow Pharmaceuticals Inc. Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis

Also Published As

Publication number Publication date
ATE126797T1 (en) 1995-09-15
CA2108817A1 (en) 1994-04-23
PL300834A1 (en) 1994-05-16
IL107342A (en) 1997-07-13
HU9302986D0 (en) 1994-01-28
FI934665A (en) 1994-04-23
HU221630B1 (en) 2002-12-28
SK281222B6 (en) 2001-01-18
CZ286025B6 (en) 1999-12-15
GR3017692T3 (en) 1996-01-31
IL107342A0 (en) 1994-01-25
AU4913593A (en) 1994-05-05
HUT68958A (en) 1995-08-28
KR100306520B1 (en) 2001-11-30
JPH06192256A (en) 1994-07-12
ES2078787T3 (en) 1995-12-16
AU665648B2 (en) 1996-01-11
CN1090849A (en) 1994-08-17
CZ223693A3 (en) 1994-05-18
DE59300507D1 (en) 1995-09-28
HK1000285A1 (en) 1998-02-20
NO933790D0 (en) 1993-10-21
EP0596326B1 (en) 1995-08-23
EP0596326A1 (en) 1994-05-11
CN1040873C (en) 1998-11-25
FI934665A0 (en) 1993-10-22
NO300843B1 (en) 1997-08-04
CA2108817C (en) 2004-12-07
DE4303840A1 (en) 1994-08-11
PL173775B1 (en) 1998-04-30
KR940009181A (en) 1994-05-20
NZ250018A (en) 1995-07-26
RU2126400C1 (en) 1999-02-20
SK107393A3 (en) 1994-09-07
JP3396517B2 (en) 2003-04-14
NO933790L (en) 1994-04-25

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