WO1999004857A1 - Dispositif et procede pour l'irradiation oculaire d'un patient dans le cadre d'une therapie photodynamique - Google Patents

Dispositif et procede pour l'irradiation oculaire d'un patient dans le cadre d'une therapie photodynamique Download PDF

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Publication number
WO1999004857A1
WO1999004857A1 PCT/EP1998/004642 EP9804642W WO9904857A1 WO 1999004857 A1 WO1999004857 A1 WO 1999004857A1 EP 9804642 W EP9804642 W EP 9804642W WO 9904857 A1 WO9904857 A1 WO 9904857A1
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WO
WIPO (PCT)
Prior art keywords
optical fiber
light
hemispheres
disc
radiation
Prior art date
Application number
PCT/EP1998/004642
Other languages
German (de)
English (en)
Inventor
Hubert Van Den Bergh
Boris Karamata
Michel Sickenberg
Original Assignee
Novartis Ag
Novartis-Erfindungen Verwaltungsgesellschaft Mbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Novartis-Erfindungen Verwaltungsgesellschaft Mbh filed Critical Novartis Ag
Priority to AU87325/98A priority Critical patent/AU8732598A/en
Publication of WO1999004857A1 publication Critical patent/WO1999004857A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/067—Radiation therapy using light using laser light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A61B2018/2255—Optical elements at the distal end of probe tips
    • A61B2018/2261—Optical elements at the distal end of probe tips with scattering, diffusion or dispersion of light

Definitions

  • the invention relates to a device for irradiating an eye of a patient in training in accordance with the preamble of claim 1 and a method for photodynamic therapy for preventing a secondary cataract.
  • Photodynamic therapy has been known since the 1970s and is primarily used in medicine to treat cancer.
  • the basic concept of the PDT is relatively simple: It is the use of light-absorbing molecules that are supplied to the tissue to be treated and of light of the appropriate wavelength. When the tissue is irradiated with the light, the light-absorbing molecules are selectively excited. This excitation energy is then released to the surrounding tissue, causing it to be destroyed by increased local energy supply.
  • EP-A-0437 181 describes a device for irradiating the bronchial tubes of a patient which has an optical fiber, the end of which opens into a tube filled with silicone compound and TiO 2 , as a result of which the light propagating in the direction of the longitudinal axis of the optical fiber is thus so is scattered that it spreads radially in all spatial directions and that the tissue previously treated with a dye is now evenly irradiated.
  • An irradiation device is known from US-A-4,660,925, in which the end of an optical fiber opens into a tube which is filled with a light-scattering material and produces a cylindrical beam profile.
  • a spatially uniform beam profile is thus achieved with both devices.
  • this is not desirable for certain applications in medicine because, due to the geometrical circumstances, spatially adapted radiation is required, such as for the photodynamic therapy of the secondary cataract.
  • a person has a 50% chance of developing a primary cataract (cataract) during their lifetime. This is a change in the eye lens that can lead to blindness without surgical treatment. There are various therapeutic options for treating cataracts. However, more than 40% of patients develop secondary cataract after this treatment, also known as night star or capsule opacification, which is a direct result of treatment for primary cataract.
  • the crystalline lens of the eye becomes cloudy in both primary and secondary cataracts.
  • the lens is made of an intracellular material that is encased in a relatively strong, elastic capsule made of glycoproteins. There is a single-layer epithelium in the front area. The epithelial cells that were on the back surface during the embryonic period were shifted towards the equator with the formation of lens fibers. Clinically, the lens is divided into the anterior and posterior poles, the equator and the various bowl-shaped zones. The innermost part is formed by the lens nucleus. It is not only the oldest, but also the hardest part of the lens.
  • the primary cataract corresponds to a clouding of the crystalline nucleus, which is caused by a number of factors, such as genetic disposition, aging processes and possibly the extent of the absorbed UV light.
  • the most frequently used therapy for cataract treatment is extracapsular lens removal, in which a 3 mm incision is made in the equatorial zone of the cornea. This opening allows a special suction-rinsing device, the tip of which vibrates with a high ultrasound frequency, to enter the eye. As a result, the lens core is smashed like with a gouge and then suctioned off. This procedure bites after removal of all lens opacities the posterior capsule as a fine clear cuticle that prevents the vitreous from stepping forward.
  • An artificial lens implant called an intraocular lens (IOL)
  • IOL intraocular lens
  • a disadvantage of extracapsular surgery is that after 3 months to 4 years, secondary cataracts (night star) occur in approximately 40% of patients.
  • This is a clouding of the posterior capsule, which is caused by the migration and proliferation of reproductive epithelial cells to the inside of the posterior capsule.
  • This is a direct result of extracapsular extraction, since cutting a circular opening into the capsule and extracting the core disrupts the epithelial cells and therefore forms fibrous and / or pearls during the healing process that migrate to the inside of the posterior capsule.
  • These new cell structures are cloudy and gradually reduce vision to blindness.
  • Epithelial cells which are located in the equatorial zone, show a strong cell division activity and are mainly responsible for the night star.
  • proliferation can lead to further complications, such as a shift in the intraocular lens.
  • the clouded structures are generally destroyed by irradiation with the light of a pulsed neodymium YAG (Nd-YAG) laser, which can be handled quite reliably.
  • Nd-YAG pulsed neodymium YAG
  • destruction of the posterior capsule occurs in 4% of cases, which can lead to various complications and even damage to the intraocular lens (IOL).
  • IOL intraocular lens
  • the additional treatment costs caused by a second procedure and the inconvenience for the patient should not be neglected. In developing countries in particular, the additional costs are so high that they cannot be met by most patients who suffer from a night star.
  • Another possibility of preventing the capsule from clouding is to destroy the capsule's epithelial cells during the extracapsular extraction, since these have lost their biological function after the extraction of the lens nucleus.
  • Another important reason for avoiding the appearance of a night star is the prospect of replacing the worn lens material with a transparent, biocompatible, visco-elastic material in order to restore the ability of the eye to accommodate those who do not suffer from primary cataracts .
  • Such a therapy is currently not feasible, especially since the posterior capsule becomes cloudy after the capsule has been refilled with the replacement material.
  • the epithelial cells should be irradiated as homogeneously as possible.
  • the typical irradiation should be in the range of 1 to 10 J / cm 2 and the irradiation time in the range of one minute in order to rule out damage to the adjacent tissue.
  • the wavelength of the light should be easy to handle and should preferably be in the visible range.
  • the maximum diameter of the device to be inserted should not exceed 2.5 mm so that it can be inserted into the eye relatively easily. Furthermore, the radiation device should not have any sharp edges so that it can be inserted into the lens area through the incision in the cornea, the device not coming into contact with the cornea or with the front capsule during insertion.
  • the radiation head must withstand mechanical loads when it is introduced into the eye and when it is removed.
  • the invention is concerned with the problem of developing a device for irradiating the eye with which photodynamic therapy for preventing secondary cataract can be carried out. Furthermore, it is an object of the invention to develop a method for preventing a secondary cataract.
  • the device according to the invention makes it possible, by scattering the light in an integrating sphere, to provide a toroidal beam profile which is matched to the geometry of the eye and thus allows selective irradiation of the desired eye area. Due to the spatially limited irradiation of the equatorial zone of the lens capsule, photodynamic therapy of the epithelial cells can thus be carried out, since it can be prevented that the surrounding tissue, such as the retina, is damaged by the combination of dye and light in areas where the dye molecules have inadvertently entered.
  • the device according to the invention achieves homogeneous irradiation of the epithelial cells, since the irradiance is almost constant in the area of the equatorial zone.
  • Figure 1 is an illustration of a device according to the invention.
  • Fig. 2 is an enlarged view of an embodiment of the
  • FIG. 3 shows an illustration of the exemplary embodiment of the radiation head from FIG. 2 with a partial illustration of a section through the irradiance profile of the emerging light;
  • Fig. 4 shows the course of the irradiance at
  • Fig. 5 shows the course of the irradiance at
  • Fig. 6 is a schematic representation of the extracapsular
  • Fig. 7 is a schematic representation of the onset of
  • the device for irradiating the eye for photodynamic therapy consists of a laser 2 which emits light of the desired wavelength, an optical light guide 3, a handle 4 and the irradiation head 5.
  • a laser 2 is preferably a Laser with a wavelength of 690 nm selected. The light emitted by the laser 2 is coupled into the optical fiber 3, passed on there and exits again in the region of the radiation head 5.
  • the head 5 of the device shown in more detail in FIG. 2 is designed as an integrating ball, which consists of two hemispheres 6, which are separated from one another by a gap 7.
  • a disc 8 is preferably made of transparent silicone, which preferably has a diameter of 2 mm and is 0.27 mm wide.
  • the silicone advantageously contains TiO 2 particles as the scattering material, the grain size of which is expediently 200 nm and which are distributed in the silicone disk with a density of 4 mg / g.
  • the base of the two hemispheres 6, which surround the disk 8 on both sides also has a diameter of 2 mm. They are preferably made of BK7 glass.
  • the outer surface of the hemispheres 6 is expediently coated with a 200 nm thick copper layer 9, which enables a reflection of the light of over 95% at a wavelength of 690 nm.
  • a thin layer of silica is advantageously applied to the copper layer in order to protect the copper layer 9 from mechanical influences and oxidation.
  • the optical fiber 3 is preferably cut at an angle of 40 °, polished and coated with a 200 nm thick copper layer 11, which enables a reflection of the light of 95% at a wavelength of the light of 690 nm.
  • the hemisphere 6 has a bore 12 into which the end 10 of the optical fiber 3 is inserted during the manufacture of the radiation head 5.
  • the bore 12 preferably has a diameter of 0.35 mm and is offset by 0.7 mm from the plane of the disc (8).
  • the optical fiber is inserted into the bore such that it is preferably inclined at an angle of 5 ° to 20 °, in particular 10 °, with respect to the plane of the disk 8.
  • the optical fiber 3 is glued into the bore 12 with a transparent, flexible epoxy resin 13.
  • a multimode fiber with a core diameter in the range of 200 ⁇ m is preferably used as the optical fiber 3, which preferably has a refractive index of 1.51. Since the refractive index of silicone is 1.40 and that of BK7 glass is 1.52, losses due to refraction are largely avoided.
  • the fiber 3 is expediently surrounded by a jacket 14 made of stainless steel with an outer diameter of 0.7 mm, the tip of which is advantageously cut at an angle of 40 °, since the jacket 14 can thus be better glued to the surface of the ball 6 .
  • the steel jacket 14 preferably has a bending radius of 11 mm and is connected to the handle 4. From the handle 4 to the laser 2, the optical fiber is guided in an outer tube made of PTFE (Teflon).
  • the fiber 3 preferably has a numerical aperture of 0.21, so that the device can be connected to a suitable laser.
  • a diode laser with an output of 500 mW, for example, is suitable for this.
  • An integrating sphere is a hollow backscattering sphere. After entering the integrating sphere, the light is reflected several times on the inner surface of the sphere. Multiple reflections are achieved by a highly backscattering coating that behaves locally like a Lambertian in which the luminance is independent of the direction of observation, i.e. the luminous surface looks equally bright from all directions.
  • a hole in the wall of the integrating sphere now behaves like an ideal Lambertian light source, i.e. the light intensity is directly dependent on the cosine of the angle ⁇ in relation to the surface normal of the emission surface:
  • the laser light is guided through the optical fiber 3 into the interior of the integrating ball 6 made of glass, in which the light is scattered several times.
  • the light can escape through the narrow equatorial gap 7.
  • the beam profile of the emerging light should be very similar to that of an ideal Lambertian lamp. In three dimensions, this corresponds to a toroidal distribution.
  • the backscattering coating normally consists of a very sensitive layer, such as barium sulfate or magnesium oxide, which is very difficult to adhere and must have a thickness of 1 mm in order to have good scattering properties. Therefore, a copper coating 9 with good reflection properties at 690 nm was used for the present invention. Due to the roughness of the spherical surface, the extent of the scatter is limited.
  • the radiation head 5 of the device according to the invention has an additional “scattering volume” 8 in order to scatter the light sufficiently.
  • This "scattering volume” 8 is arranged in the equatorial splitting plane 7 of the ball 6, i.e. the light leaves the sphere 6 after passing through this "scattering volume” 8.
  • the light intensity of the emitted light has the profile 15 of a "Lambert" -shaped steel, such as this is shown in Fig. 3.
  • the equatorial scattering volume 8 also has a smoothing effect on the profile of the luminous intensity, so that there is a maximum and constant profile in the equatorial plane of the sphere.
  • the fiber end 11 should be arranged perpendicular to the gap plane 7. In practice, however, this would mean that a very small radius of curvature of the optical fiber of about 2 mm would be required if the surgical incision was made in the peripheral zone of the cornea. However, such a geometry cannot be realized due to the physical properties of the optical fiber used.
  • the fiber 3 is therefore introduced into the ball 6 almost parallel (approximately at an angle of 10 °) and the light is reflected on the metal coating 11 at the fiber end 10, so that the light beam is now aligned perpendicular to the splitting plane 7.
  • the fiber 3 is also arranged in the steel jacket 14 in a slightly curved manner.
  • a beam profile is achieved in a good approximation to the specified geometric conditions of the eye.
  • the radiation head consists of a few components. This is important for the manufacture of the device, since the components are relatively small.
  • the shape of the radiation head is ideal for insertion and removal from the eye.
  • the radiation yield of the radiation head should be quite high.
  • a high radiation yield also makes it possible to reduce either the irradiation time or the required input power of the laser.
  • the profile of the irradiance was measured at a distance of 60 mm from the center of the irradiation head.
  • the radiation head was rotated about two axes of rotation, namely about axes A and B illustrated in FIG. 3.
  • the detector had a light-sensitive area of approximately 2 mm 2 and was arranged in the slit plane.
  • the irradiance profile When measuring the beam profile by rotating the device around the A axis in the range from 0 ° to 360 °, the irradiance profile should be constant. 4 shows the measured irradiance profile as a function of the rotation angle. The relative error of the irradiance was typically +/- 11% in the measurements, which is primarily due to geometrical inaccuracies in the irradiation head of the device and variations in the local concentration of TiO 2 .
  • the radiation head rotates at an angle of -90 ° to + 90 ° around the B axis, which extends at an angle of 90 ° to the A axis, into the paper plane and represents a tangent to the surface of the sphere.
  • the measurements showed that the profile is approximately symmetrical with a maximum at 0 ° and minima at + 90 ° and -90 °, whereby the minima are somewhat higher than the 0 value, which is due to the cos law for an ideal integrating Bullet would be reached.
  • a higher transmission through the copper coating than assumed, small holes in the coating and possibly a too large scattering volume can explain the values by + 90 ° and - 90 °.
  • the irradiance on the surface of the ellipse can be calculated between + 90 ° and -90 °, based on the B axis.
  • the irradiance on the model surface is calculated by dividing the measured irradiance when rotating around the B axis by the square of the distance between the ellipse and the gap.
  • the angle of the incident light beam was taken into account by inserting the cosine between the ellipse gap vector and the ellipse vector.
  • the profile of the irradiance should be constant between + 45 ° and -45 ° and zero for higher angles.
  • the irradiance for angles greater than + 45 ° and angles less than - 45 ° is still significantly higher than zero, because due to the short distance between the capsule and the radiation head, the radiation intensity in the area of the minima is greater Dimension contributes to radiation.
  • the radiation H of the equatorial zone of the lens can be determined according to the following equation:
  • t (s) is the irradiation time
  • K is a constant and ⁇ LaSer is the laser beam power that is fed into the fiber optics, taking into account coupling losses of about 20%.
  • K depends on the radiation yield of the radiation head, the optical coupling of the laser beam into the fiber and the distance between the equatorial surface of the model lens and the device.
  • a K value of 0.15 is typically obtained, a value that can be assumed to be constant for the entire equatorial zone of the lens. This means that with an input power of 300 mW and an irradiation time of 1 minute, an irradiation dose of 2.7 J / cm 2 for the epithelium is achieved. Because in practice the big one and the shape of the lens varies and the beam profile is not constant in the area to be treated, it is difficult to accurately determine the relative error of the radiation.
  • the present device according to the invention has no effect in the depth of the tissue, since the irradiance decreases inversely to the square of the distance. This means that the area behind the capsule is irradiated to a much lesser extent. The photo destruction is thus caused by an even distribution of the dye molecules in the epithelial cells.
  • the light ring of the radiation head serves as an orientation for the surgeon for the correct positioning of the device.
  • a holding device for example an XYZ table, can be provided, which fixes the irradiation head in the centered position during the irradiation.
  • All materials used for the device should be selected so that both gas phase sterilization with ethylene oxide and autoclaving at 135 ° C in a water vapor atmosphere is possible for one hour. It is also important that all materials used are non-toxic.
  • the maximum force that is exerted on the device during insertion and removal from the cornea is 0.1 N. Measurements have shown that the device according to the invention can also withstand a force of 0.5 N.
  • a new type of light emitter was created with the device according to the invention, which is based on the principle of the integrating sphere and produces a “toroidal” beam profile.
  • a beam profile enables the specific destruction of epithelial cells and reduces the risk of potentially dangerous radiation exposure from other parts of the Eye, like the retina.
  • the profile can be varied to a certain extent by the width of the gap and the concentration of TiO 2 particles. If a different wavelength range is to be used, the coating can be replaced by a different material, such as silver.
  • a relatively homogeneous radiation of up to 2.7 J / cm 2 can be applied in one minute without heating the tissue significantly above 37 ° C. Higher radiation can be achieved by increasing the laser power or by increasing the radiation time.
  • the device according to the invention is used in the context of photodynamic therapy (PDT).
  • PDT photodynamic therapy
  • the cells are made to take up a certain amount of a non-toxic dye. Then they are irradiated at a relatively low light intensity with the wavelength at which the dyes absorb, thereby creating metastable excited states. From the excited states, the energy is transferred to oxygen, which is very reactive and diffuses into the surrounding tissue. The excited oxygen and other excited particles then initiate chemical reactions that lead to tissue destruction.
  • the basic idea of the therapy is to try to use this principle for the destruction of essentially all epithelial cells.
  • the method according to the invention for preventing secondary cataract by means of photodynamic therapy preferably comprises the following steps:
  • BPD-MA monocarboxylic acid of the benzporphyrin derivative
  • the epithelial cells should be essentially destroyed, thus preventing secondary cataracts.
  • the success of the PDT step will depend, among other factors, above all on the fact that the radiation head according to the invention emits the light in the region in which the epithelial cells are arranged.

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  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

L'invention concerne un dispositif et un procédé pour l'irradiation oculaire lors d'une thérapie photodynamique. Le dispositif comporte une fibre optique dans laquelle on injecte la lumière d'un laser et dont une surface terminale de sortie lumineuse débouche dans une tête d'irradiation. Pour pouvoir adapter le profil de rayonnement à la géométrie de l'oeil, on réalise la tête d'irradiation sous forme de sphère d'intégration; la lumière sort de la sphère, au moins par zones, le long de la périphérie d'un plan cyclique équatorial.
PCT/EP1998/004642 1997-07-28 1998-07-24 Dispositif et procede pour l'irradiation oculaire d'un patient dans le cadre d'une therapie photodynamique WO1999004857A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU87325/98A AU8732598A (en) 1997-07-28 1998-07-24 Device and method for irradiating a patient's eye for photodynamic therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97112934.1 1997-07-28
EP97112934 1997-07-28

Publications (1)

Publication Number Publication Date
WO1999004857A1 true WO1999004857A1 (fr) 1999-02-04

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PCT/EP1998/004642 WO1999004857A1 (fr) 1997-07-28 1998-07-24 Dispositif et procede pour l'irradiation oculaire d'un patient dans le cadre d'une therapie photodynamique

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1225465A1 (fr) * 2001-01-19 2002-07-24 Optosys SA Dispositif optique
US7070554B2 (en) 2003-01-15 2006-07-04 Theragenics Corporation Brachytherapy devices and methods of using them
WO2007127894A3 (fr) * 2006-04-28 2008-07-03 Ondine Int Ltd dispositifs et procédés d'administration de photodésinfection
DE102011011192A1 (de) * 2011-02-14 2012-08-16 Geuder Ag Vorrichtung zum Einleiten von Licht in ein menschliches oder tierisches Auge
US9067059B2 (en) 2008-02-13 2015-06-30 Alois Bissig Light delivery device

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US4660925A (en) 1985-04-29 1987-04-28 Laser Therapeutics, Inc. Apparatus for producing a cylindrical pattern of light and method of manufacture
US4920143A (en) 1987-04-23 1990-04-24 University Of British Columbia Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents
EP0411132A1 (fr) * 1988-10-05 1991-02-06 S.L.T. Japan Co, Ltd. Equipement chauffant utilisant un faisceau laser
EP0437181A1 (fr) 1990-01-09 1991-07-17 Ciba-Geigy Ag Appareil pour irradier les bronches d'un patient pour une thérapie photodynamique
EP0441974A1 (fr) * 1989-09-05 1991-08-21 S.L.T. Japan Co, Ltd. Dispositif d'irradiation par faisceaux laser
WO1995032441A1 (fr) * 1994-05-25 1995-11-30 The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services Accessoire de rayonnement pour une fibre optique permettant d'obtenir un niveau uniforme d'illumination sur un plan
EP0743029A2 (fr) * 1995-04-26 1996-11-20 CeramOptec GmbH Dispositif laser de nettoyage et de traitement dentaire
EP0755697A2 (fr) * 1995-07-28 1997-01-29 Yasuo Hashimoto Instruments thérapeutiques destinés à traiter des cancers

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4660925A (en) 1985-04-29 1987-04-28 Laser Therapeutics, Inc. Apparatus for producing a cylindrical pattern of light and method of manufacture
US4920143A (en) 1987-04-23 1990-04-24 University Of British Columbia Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents
EP0411132A1 (fr) * 1988-10-05 1991-02-06 S.L.T. Japan Co, Ltd. Equipement chauffant utilisant un faisceau laser
EP0441974A1 (fr) * 1989-09-05 1991-08-21 S.L.T. Japan Co, Ltd. Dispositif d'irradiation par faisceaux laser
EP0437181A1 (fr) 1990-01-09 1991-07-17 Ciba-Geigy Ag Appareil pour irradier les bronches d'un patient pour une thérapie photodynamique
WO1995032441A1 (fr) * 1994-05-25 1995-11-30 The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services Accessoire de rayonnement pour une fibre optique permettant d'obtenir un niveau uniforme d'illumination sur un plan
EP0743029A2 (fr) * 1995-04-26 1996-11-20 CeramOptec GmbH Dispositif laser de nettoyage et de traitement dentaire
EP0755697A2 (fr) * 1995-07-28 1997-01-29 Yasuo Hashimoto Instruments thérapeutiques destinés à traiter des cancers

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1225465A1 (fr) * 2001-01-19 2002-07-24 Optosys SA Dispositif optique
US7070554B2 (en) 2003-01-15 2006-07-04 Theragenics Corporation Brachytherapy devices and methods of using them
WO2007127894A3 (fr) * 2006-04-28 2008-07-03 Ondine Int Ltd dispositifs et procédés d'administration de photodésinfection
KR101373506B1 (ko) 2006-04-28 2014-03-27 온딘 인터내셔널 리미티드. 광소독 전달 장치 및 방법
US9067059B2 (en) 2008-02-13 2015-06-30 Alois Bissig Light delivery device
DE102011011192A1 (de) * 2011-02-14 2012-08-16 Geuder Ag Vorrichtung zum Einleiten von Licht in ein menschliches oder tierisches Auge
DE102011011192B4 (de) * 2011-02-14 2019-06-13 Geuder Aktiengesellschaft Vorrichtung zum Einleiten von Licht in ein menschliches oder tierisches Auge

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