WO1999000494A3 - Procede d'activation de cellule et reactifs a cet effet - Google Patents

Procede d'activation de cellule et reactifs a cet effet Download PDF

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Publication number
WO1999000494A3
WO1999000494A3 PCT/GB1998/001842 GB9801842W WO9900494A3 WO 1999000494 A3 WO1999000494 A3 WO 1999000494A3 GB 9801842 W GB9801842 W GB 9801842W WO 9900494 A3 WO9900494 A3 WO 9900494A3
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WO
WIPO (PCT)
Prior art keywords
activation process
cell activation
reagents therefor
cell
receptor
Prior art date
Application number
PCT/GB1998/001842
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English (en)
Other versions
WO1999000494A2 (fr
Inventor
Helene Margaret Finney
Alastair David Griffith Lawson
Andrew Neil Charles Weir
Original Assignee
Celltech Therapeutics Ltd
Helene Margaret Finney
Alastair David Griffith Lawson
Andrew Neil Charles Weir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celltech Therapeutics Ltd, Helene Margaret Finney, Alastair David Griffith Lawson, Andrew Neil Charles Weir filed Critical Celltech Therapeutics Ltd
Priority to AU81210/98A priority Critical patent/AU8121098A/en
Priority to JP50537099A priority patent/JP2002511757A/ja
Priority to EP98930934A priority patent/EP1002073A2/fr
Publication of WO1999000494A2 publication Critical patent/WO1999000494A2/fr
Publication of WO1999000494A3 publication Critical patent/WO1999000494A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70507—CD2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé d'activation de cellule dans lequel une cellule effectrice est transformée avec un ADN codant un récepteur chimère contenant deux ou plusieurs composants de signalisation cytoplasmiques différents. Au moins un des composants de signalisation cytoplasmiques est dérivé de tout ou d'une partie d'une protéine transmembranaire à tétra couverture, CD43, CD6, d'un mannose, IL-7, IL-12 ou d'un récepteur du complément, d'une protéine associée à l'intégrine, ou d'une chaîne η associée à un récepteur de cytokine. La cellule activée peut s'utiliser dans le domaine médical, par exemple dans le traitement de maladies telles que le cancer.
PCT/GB1998/001842 1997-06-25 1998-06-24 Procede d'activation de cellule et reactifs a cet effet WO1999000494A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU81210/98A AU8121098A (en) 1997-06-25 1998-06-24 Cell activation process and reagents therefor
JP50537099A JP2002511757A (ja) 1997-06-25 1998-06-24 細胞活性化プロセスおよびそのための試薬
EP98930934A EP1002073A2 (fr) 1997-06-25 1998-06-24 Procede d'activation de cellule et reactifs a cet effet

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9713473.8A GB9713473D0 (en) 1997-06-25 1997-06-25 Biological products
GB9713473.8 1997-06-25

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09446529 A-371-Of-International 2000-05-19
US10/280,596 Continuation US20030060444A1 (en) 1997-06-25 2002-10-24 Cell activation process and reagents therefor

Publications (2)

Publication Number Publication Date
WO1999000494A2 WO1999000494A2 (fr) 1999-01-07
WO1999000494A3 true WO1999000494A3 (fr) 1999-03-25

Family

ID=10814935

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/001842 WO1999000494A2 (fr) 1997-06-25 1998-06-24 Procede d'activation de cellule et reactifs a cet effet

Country Status (5)

Country Link
EP (1) EP1002073A2 (fr)
JP (1) JP2002511757A (fr)
AU (1) AU8121098A (fr)
GB (1) GB9713473D0 (fr)
WO (1) WO1999000494A2 (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
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GB9809658D0 (en) * 1998-05-06 1998-07-01 Celltech Therapeutics Ltd Biological products
GB9908814D0 (en) * 1999-04-16 1999-06-09 Celltech Therapeutics Ltd Process
GB9908816D0 (en) * 1999-04-16 1999-06-09 Celltech Therapeutics Ltd Biological product
GB9908807D0 (en) * 1999-04-16 1999-06-09 Celltech Therapeutics Ltd Synthetic signalling molecules
GB9925848D0 (en) * 1999-11-01 1999-12-29 Celltech Therapeutics Ltd Biological products
US20030027763A1 (en) * 2001-06-07 2003-02-06 Rigel Pharmaceuticals, Incorporated CD43: modulators of mast cell degranulation
US20130266551A1 (en) 2003-11-05 2013-10-10 St. Jude Children's Research Hospital, Inc. Chimeric receptors with 4-1bb stimulatory signaling domain
US7435596B2 (en) 2004-11-04 2008-10-14 St. Jude Children's Research Hospital, Inc. Modified cell line and method for expansion of NK cell
WO2007056812A1 (fr) * 2005-11-16 2007-05-24 Apollo Life Sciences Limited Molecule et molecules chimeres de celle-ci
GB0614780D0 (en) 2006-07-25 2006-09-06 Ucb Sa Biological products
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WO2014145252A2 (fr) 2013-03-15 2014-09-18 Milone Michael C Ciblage de cellules cytotoxiques par des récepteurs chimériques pour une immunothérapie adoptive
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EP3697436A1 (fr) 2017-10-18 2020-08-26 Novartis AG Compositions et méthodes pour la dégradation sélective d'une protéine
SG11202011830SA (en) 2018-06-13 2020-12-30 Novartis Ag Bcma chimeric antigen receptors and uses thereof
CN113766956B (zh) 2019-03-05 2024-05-07 恩卡尔塔公司 Cd19定向性嵌合抗原受体及其在免疫疗法中的用途
US11975026B2 (en) 2019-11-26 2024-05-07 Novartis Ag CD19 and CD22 chimeric antigen receptors and uses thereof
WO2023081878A2 (fr) * 2021-11-08 2023-05-11 Baylor College Of Medicine Cellules immunitaires modifiées et leurs procédés d'utilisation

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WO1996023814A1 (fr) * 1995-02-03 1996-08-08 Cell Genesys, Inc. Molecules chimeres recepteur utilisees pour l'emission de signaux co-stimulateurs
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WO1997023613A2 (fr) * 1995-12-21 1997-07-03 Celltech Therapeutics Ltd. Procede d'activation de cellules et ses reactifs

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
WO1996023814A1 (fr) * 1995-02-03 1996-08-08 Cell Genesys, Inc. Molecules chimeres recepteur utilisees pour l'emission de signaux co-stimulateurs
WO1996024671A1 (fr) * 1995-02-06 1996-08-15 Cell Genesys, Inc. Recepteurs chimeres a specificites multiples
WO1997023613A2 (fr) * 1995-12-21 1997-07-03 Celltech Therapeutics Ltd. Procede d'activation de cellules et ses reactifs

Non-Patent Citations (5)

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Title
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ROMEO C. ET AL.: "Activation of immune system effector function by T-cell or Fc receptor intracellular domains", COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, vol. 57, 1992, pages 117 - 125, XP000647674 *
SHAW A.R.E. ET AL.: "Ectopic expression of human and feline CD9 in a human B cell line confers beta-1 Integrin-dependent motility on Fibronectin and Laminin substrates and enhanced tyrosine phosphorylation", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 41, 13 October 1995 (1995-10-13), pages 24092 - 24099, XP002079591 *
TOYO-OKA K. ET AL.: "Synergy between CD28 and CD9 costimulation for naive T-cell activation", IMMUNOLOGY LETTERS, vol. 58, no. 1, 1997, pages 19 - 23, XP002079593 *

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Publication number Publication date
JP2002511757A (ja) 2002-04-16
EP1002073A2 (fr) 2000-05-24
WO1999000494A2 (fr) 1999-01-07
GB9713473D0 (en) 1997-09-03
AU8121098A (en) 1999-01-19

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