WO1999000494A3 - Procede d'activation de cellule et reactifs a cet effet - Google Patents
Procede d'activation de cellule et reactifs a cet effet Download PDFInfo
- Publication number
- WO1999000494A3 WO1999000494A3 PCT/GB1998/001842 GB9801842W WO9900494A3 WO 1999000494 A3 WO1999000494 A3 WO 1999000494A3 GB 9801842 W GB9801842 W GB 9801842W WO 9900494 A3 WO9900494 A3 WO 9900494A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- activation process
- cell activation
- reagents therefor
- cell
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70507—CD2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU81210/98A AU8121098A (en) | 1997-06-25 | 1998-06-24 | Cell activation process and reagents therefor |
JP50537099A JP2002511757A (ja) | 1997-06-25 | 1998-06-24 | 細胞活性化プロセスおよびそのための試薬 |
EP98930934A EP1002073A2 (fr) | 1997-06-25 | 1998-06-24 | Procede d'activation de cellule et reactifs a cet effet |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9713473.8 | 1997-06-25 | ||
GBGB9713473.8A GB9713473D0 (en) | 1997-06-25 | 1997-06-25 | Biological products |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09446529 A-371-Of-International | 2000-05-19 | ||
US10/280,596 Continuation US20030060444A1 (en) | 1997-06-25 | 2002-10-24 | Cell activation process and reagents therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999000494A2 WO1999000494A2 (fr) | 1999-01-07 |
WO1999000494A3 true WO1999000494A3 (fr) | 1999-03-25 |
Family
ID=10814935
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1998/001842 WO1999000494A2 (fr) | 1997-06-25 | 1998-06-24 | Procede d'activation de cellule et reactifs a cet effet |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1002073A2 (fr) |
JP (1) | JP2002511757A (fr) |
AU (1) | AU8121098A (fr) |
GB (1) | GB9713473D0 (fr) |
WO (1) | WO1999000494A2 (fr) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9809658D0 (en) * | 1998-05-06 | 1998-07-01 | Celltech Therapeutics Ltd | Biological products |
GB9908816D0 (en) * | 1999-04-16 | 1999-06-09 | Celltech Therapeutics Ltd | Biological product |
GB9908814D0 (en) | 1999-04-16 | 1999-06-09 | Celltech Therapeutics Ltd | Process |
GB9908807D0 (en) * | 1999-04-16 | 1999-06-09 | Celltech Therapeutics Ltd | Synthetic signalling molecules |
GB9925848D0 (en) * | 1999-11-01 | 1999-12-29 | Celltech Therapeutics Ltd | Biological products |
US20030027763A1 (en) * | 2001-06-07 | 2003-02-06 | Rigel Pharmaceuticals, Incorporated | CD43: modulators of mast cell degranulation |
US20130266551A1 (en) | 2003-11-05 | 2013-10-10 | St. Jude Children's Research Hospital, Inc. | Chimeric receptors with 4-1bb stimulatory signaling domain |
US7435596B2 (en) | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
WO2007056812A1 (fr) * | 2005-11-16 | 2007-05-24 | Apollo Life Sciences Limited | Molecule et molecules chimeres de celle-ci |
GB0614780D0 (en) | 2006-07-25 | 2006-09-06 | Ucb Sa | Biological products |
BR122021026169B1 (pt) | 2010-12-09 | 2023-12-12 | The Trustees Of The University Of Pennsylvania | Uso de uma célula |
RU2708032C2 (ru) | 2013-02-20 | 2019-12-03 | Новартис Аг | ЛЕЧЕНИЕ РАКА С ИСПОЛЬЗОВАНИЕМ ХИМЕРНОГО АНТИГЕНСПЕЦИФИЧЕСКОГО РЕЦЕПТОРА НА ОСНОВЕ ГУМАНИЗИРОВАННОГО АНТИТЕЛА ПРОТИВ EGFRvIII |
WO2014130635A1 (fr) | 2013-02-20 | 2014-08-28 | Novartis Ag | Ciblage efficace de la leucémie primaire humaine au moyen de lymphocytes t génétiquement modifiés des récepteurs d'antigènes chimériques anti-cd123 |
EP2970426B1 (fr) | 2013-03-15 | 2019-08-28 | Michael C. Milone | Ciblage de cellules cytotoxiques par des récepteurs chimériques pour une immunothérapie adoptive |
UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
CA3225453A1 (fr) | 2013-12-19 | 2015-06-25 | Novartis Ag | Recepteurs antigeniques chimeriques de la mesotheline humaine et leurs utilisations |
EP3087101B1 (fr) | 2013-12-20 | 2024-06-05 | Novartis AG | Récepteur d'antigène chimérique régulable |
WO2015112626A1 (fr) | 2014-01-21 | 2015-07-30 | June Carl H | Capacité améliorée de présentation de l'antigène de lymphocytes t de récepteur d'antigène chimérique (car) par l'introduction conjointe de molécules de stimulation conjointe |
HUE054588T2 (hu) | 2014-04-07 | 2021-09-28 | Novartis Ag | Rák kezelése CD19 elleni, kiméra antigénreceptor alkalmazásával |
CN106459914B (zh) | 2014-05-15 | 2020-11-06 | 新加坡国立大学 | 经修饰的自然杀伤细胞及其用途 |
US11542488B2 (en) | 2014-07-21 | 2023-01-03 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
CA2955154C (fr) | 2014-07-21 | 2023-10-31 | Novartis Ag | Traitement du cancer a l'aide du recepteur antigenique chimerique anti-cd33 |
MY181834A (en) | 2014-07-21 | 2021-01-08 | Novartis Ag | Treatment of cancer using humanized anti-bcma chimeric antigen receptor |
PL3183268T3 (pl) | 2014-08-19 | 2020-09-07 | Novartis Ag | Chimeryczny receptor antygenowy (CAR) anty-CD123 do zastosowania w leczeniu nowotworu złośliwego |
WO2016044605A1 (fr) | 2014-09-17 | 2016-03-24 | Beatty, Gregory | Ciblage de cellules cytotoxiques avec des récepteurs chimériques pour l'immunothérapie adoptive |
KR20170068504A (ko) | 2014-10-08 | 2017-06-19 | 노파르티스 아게 | 키메라 항원 수용체 요법에 대한 치료 반응성을 예측하는 바이오마커 및 그의 용도 |
IL253149B2 (en) | 2014-12-29 | 2023-11-01 | Novartis Ag | Methods for preparing cells expressing a chimeric receptor antigen |
WO2016115482A1 (fr) | 2015-01-16 | 2016-07-21 | Novartis Pharma Ag | Promoteurs de phosphoglycérate kinase 1 (pgk) et procédés d'utilisation pour l'expression d'un récepteur antigénique chimérique |
WO2016126608A1 (fr) | 2015-02-02 | 2016-08-11 | Novartis Ag | Cellules exprimant car dirigées contre de multiples antigènes tumoraux et leurs utilisations |
EP4056588A1 (fr) | 2015-04-08 | 2022-09-14 | Novartis AG | Thérapies cd20, thérapies cd22 et thérapies combinées avec une cellule exprimant un récepteur d'antigène chimérique cd19 (car) |
CA2982996A1 (fr) | 2015-04-17 | 2016-10-20 | David Maxwell Barrett | Procedes pour ameliorer l'efficacite et l'expansion de cellules exprimant un recepteur antigenique chimerique |
AU2016297014B2 (en) | 2015-07-21 | 2021-06-17 | Novartis Ag | Methods for improving the efficacy and expansion of immune cells |
WO2017027392A1 (fr) | 2015-08-07 | 2017-02-16 | Novartis Ag | Traitement du cancer à l'aide des protéines de récepteur cd3 chimères |
CN108780084B (zh) | 2015-09-03 | 2022-07-22 | 诺华股份有限公司 | 预测细胞因子释放综合征的生物标志物 |
JP7082055B2 (ja) | 2015-12-22 | 2022-06-07 | ノバルティス アーゲー | 抗癌治療における組み合わせ使用のためのメソテリンキメラ抗原受容体(car)およびpd-l1阻害剤に対する抗体 |
WO2017165683A1 (fr) | 2016-03-23 | 2017-09-28 | Novartis Ag | Mini-corps sécrétés par des cellules et leurs usages |
CN117866991A (zh) | 2016-10-07 | 2024-04-12 | 诺华股份有限公司 | 用于治疗癌症的嵌合抗原受体 |
EP4043485A1 (fr) | 2017-01-26 | 2022-08-17 | Novartis AG | Compositions de cd28 et procédés pour une thérapie à base de récepteur antigénique chimérique |
RU2019133280A (ru) | 2017-03-22 | 2021-04-22 | Новартис Аг | Композиции и способы для иммуноонкологии |
MX2019011514A (es) | 2017-03-27 | 2020-01-27 | Nat Univ Singapore | Receptores quimericos nkg2d truncados y usos de los mismos en inmunoterapia con celulas asesinas naturales. |
KR20200086278A (ko) | 2017-10-18 | 2020-07-16 | 노파르티스 아게 | 선택적 단백질 분해를 위한 조성물 및 방법 |
AU2019284911A1 (en) | 2018-06-13 | 2020-12-17 | Novartis Ag | BCMA chimeric antigen receptors and uses thereof |
WO2020180882A1 (fr) | 2019-03-05 | 2020-09-10 | Nkarta, Inc. | Récepteurs d'antigènes chimériques anti-cd19 et leurs utilisations en immunothérapie |
CN114945382A (zh) | 2019-11-26 | 2022-08-26 | 诺华股份有限公司 | Cd19和cd22嵌合抗原受体及其用途 |
WO2023081878A2 (fr) * | 2021-11-08 | 2023-05-11 | Baylor College Of Medicine | Cellules immunitaires modifiées et leurs procédés d'utilisation |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996023814A1 (fr) * | 1995-02-03 | 1996-08-08 | Cell Genesys, Inc. | Molecules chimeres recepteur utilisees pour l'emission de signaux co-stimulateurs |
WO1996024671A1 (fr) * | 1995-02-06 | 1996-08-15 | Cell Genesys, Inc. | Recepteurs chimeres a specificites multiples |
WO1997023613A2 (fr) * | 1995-12-21 | 1997-07-03 | Celltech Therapeutics Ltd. | Procede d'activation de cellules et ses reactifs |
-
1997
- 1997-06-25 GB GBGB9713473.8A patent/GB9713473D0/en active Pending
-
1998
- 1998-06-24 AU AU81210/98A patent/AU8121098A/en not_active Abandoned
- 1998-06-24 EP EP98930934A patent/EP1002073A2/fr not_active Withdrawn
- 1998-06-24 JP JP50537099A patent/JP2002511757A/ja active Pending
- 1998-06-24 WO PCT/GB1998/001842 patent/WO1999000494A2/fr not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996023814A1 (fr) * | 1995-02-03 | 1996-08-08 | Cell Genesys, Inc. | Molecules chimeres recepteur utilisees pour l'emission de signaux co-stimulateurs |
WO1996024671A1 (fr) * | 1995-02-06 | 1996-08-15 | Cell Genesys, Inc. | Recepteurs chimeres a specificites multiples |
WO1997023613A2 (fr) * | 1995-12-21 | 1997-07-03 | Celltech Therapeutics Ltd. | Procede d'activation de cellules et ses reactifs |
Non-Patent Citations (5)
Title |
---|
MAECKER H.T. ET AL.: "The tetraspanin superfamily: molecular facilitators", THE FASEB JOURNAL, vol. 11, no. 6, May 1997 (1997-05-01), pages 428 - 442, XP002037857 * |
OZAKI Y. ET AL.: "Anti-CD-9 monoclonal antibody activates p72syk in human platelets", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 25, 23 June 1995 (1995-06-23), pages 15119 - 15124, XP002079592 * |
ROMEO C. ET AL.: "Activation of immune system effector function by T-cell or Fc receptor intracellular domains", COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, vol. 57, 1992, pages 117 - 125, XP000647674 * |
SHAW A.R.E. ET AL.: "Ectopic expression of human and feline CD9 in a human B cell line confers beta-1 Integrin-dependent motility on Fibronectin and Laminin substrates and enhanced tyrosine phosphorylation", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 41, 13 October 1995 (1995-10-13), pages 24092 - 24099, XP002079591 * |
TOYO-OKA K. ET AL.: "Synergy between CD28 and CD9 costimulation for naive T-cell activation", IMMUNOLOGY LETTERS, vol. 58, no. 1, 1997, pages 19 - 23, XP002079593 * |
Also Published As
Publication number | Publication date |
---|---|
GB9713473D0 (en) | 1997-09-03 |
AU8121098A (en) | 1999-01-19 |
WO1999000494A2 (fr) | 1999-01-07 |
JP2002511757A (ja) | 2002-04-16 |
EP1002073A2 (fr) | 2000-05-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1999000494A3 (fr) | Procede d'activation de cellule et reactifs a cet effet | |
WO1997023613A3 (fr) | Procede d'activation de cellules et ses reactifs | |
WO1994011503A3 (fr) | Facteur viii chimere | |
AU4512193A (en) | Human nucleic acid fragments, isolated from brain adrenal tissue, placenta or bone narrow | |
WO1998025965A3 (fr) | Peptides et composes qui se lient a un recepteur | |
MXPA02011656A (es) | Moleculas de acido nucleico nrg-2, polipeptidos, y metodos de diagnostico y terapeuticos. | |
WO1999053061A3 (fr) | Acides nucleiques associes a des tumeurs et leur emploi | |
DE69736840D1 (de) | Synthese von nukleosiden und polynukleotiden | |
AU8881201A (en) | Tnf receptor-like molecules and uses thereof | |
WO1999051727A3 (fr) | Sequences d'acides nucleiques humaines extraites des tissus sains d'ovaires | |
WO1998059040A3 (fr) | Sous-unite de telomerase catalytique humaine et son utilisation therapeutique et diagnostique | |
WO2000029623A3 (fr) | Acides nucleiques contenant des polymorphismes d'un seul nucleotide et utilisations de ces acides nucleiques | |
EP0642798A3 (fr) | Molécules "platform" définis et de valence non-polymérique et leur conjugés | |
DE3576361D1 (de) | Rekombinante dna, damit transformierter mikroorganismus, und verfahren zur herstellung von menschlicher cu-zn superoxiddismutase unter verwendung des transformierten mikroorganismus. | |
EP0910396A4 (fr) | Molecules d'acide nucleique isolees codant pour un antigene gage de rejet tumoral, antigene de rejet tumoral et leurs utilisations | |
EP0749312A4 (fr) | PROTEINES Gp29 DE -i(DIROFILARIA IMMITIS), MOLECULES D'ACIDE NUCLEIQUE ET LEURS UTILISATIONS | |
MXPA03000979A (es) | Moleculas tipo receptor de complemento c3b/c4b y usos de las mismas. | |
EP1019092A4 (fr) | Outils therapeutiques et diagnostiques pour desordres lies a une mauvaise tolerance glucidique | |
AU7508694A (en) | Novel tyrosine kinase | |
WO1998051782A3 (fr) | 3-hydroxyisobutyryl-coenzyme a hydrolase humaine | |
AU2347501A (en) | Trp-protein-related mtr1 protein and dna sequence coding therefor | |
WO1998041538A3 (fr) | Nouvelle proteine receptrice des cytokines/steroides humaine | |
WO1996038556A3 (fr) | Deltap62, ses variants, sequences d'acides nucleiques les codant, et leurs utilisations en therapie genique anti-cancereuse | |
WO1999000408A3 (fr) | Nouvelle proteine transmembranaire humaine | |
ITTO940379A1 (it) | Sequenze specifiche per il dna umano. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 1998930934 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 09446529 Country of ref document: US |
|
WWP | Wipo information: published in national office |
Ref document number: 1998930934 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: CA |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1998930934 Country of ref document: EP |