EP1019092A4 - Outils therapeutiques et diagnostiques pour desordres lies a une mauvaise tolerance glucidique - Google Patents

Outils therapeutiques et diagnostiques pour desordres lies a une mauvaise tolerance glucidique

Info

Publication number
EP1019092A4
EP1019092A4 EP98922382A EP98922382A EP1019092A4 EP 1019092 A4 EP1019092 A4 EP 1019092A4 EP 98922382 A EP98922382 A EP 98922382A EP 98922382 A EP98922382 A EP 98922382A EP 1019092 A4 EP1019092 A4 EP 1019092A4
Authority
EP
European Patent Office
Prior art keywords
glucose tolerance
impaired glucose
therapeutic
diagnostic tools
tolerance conditions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98922382A
Other languages
German (de)
English (en)
Other versions
EP1019092A1 (fr
Inventor
Gary Ruvkun
Koutarou Kimura
Garth Patterson
Scott Ogg
Suzanne Paradis
Heidi Tissenbaum
Jason Morris
Allison Koweek
Sarah Pierce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/857,076 external-priority patent/US6225120B1/en
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of EP1019092A1 publication Critical patent/EP1019092A1/fr
Publication of EP1019092A4 publication Critical patent/EP1019092A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/033Rearing or breeding invertebrates; New breeds of invertebrates
    • A01K67/0333Genetically modified invertebrates, e.g. transgenic, polyploid
    • A01K67/0335Genetically modified worms
    • A01K67/0336Genetically modified Nematodes, e.g. Caenorhabditis elegans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596Molecules with a "CD"-designation not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082Supracellular entities, e.g. tissue, organisms
    • G01N33/5085Supracellular entities, e.g. tissue, organisms of invertebrates
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00Modified animals
    • A01K2207/15Humanized animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/075Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/0306Animal model for genetic diseases
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/035Animal model for multifactorial diseases
    • A01K2267/0362Animal model for lipid/glucose metabolism, e.g. obesity, type-2 diabetes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G01N2333/43526Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms
    • G01N2333/4353Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms from nematodes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Environmental Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Food Science & Technology (AREA)

Abstract

L'invention concerne de nouveaux gènes et de nouveaux procédés de criblage d'outils thérapeutiques, utiles au traitement des désordres liés à une mauvaise tolérance glucidique, ainsi que des compositions diagnostiques et thérapeutiques permettant d'identifier ou de traiter des désordres similaires.
EP98922382A 1997-05-15 1998-05-15 Outils therapeutiques et diagnostiques pour desordres lies a une mauvaise tolerance glucidique Withdrawn EP1019092A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US888534 1986-07-22
US857076 1997-05-15
US08/857,076 US6225120B1 (en) 1997-05-15 1997-05-15 Therapeutic and diagnostic tools for impaired glucose tolerance conditions
US88853497A 1997-07-07 1997-07-07
PCT/US1998/010080 WO1998051351A1 (fr) 1997-05-15 1998-05-15 Outils therapeutiques et diagnostiques pour desordres lies a une mauvaise tolerance glucidique

Publications (2)

Publication Number Publication Date
EP1019092A1 EP1019092A1 (fr) 2000-07-19
EP1019092A4 true EP1019092A4 (fr) 2004-12-15

Family

ID=27127391

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98922382A Withdrawn EP1019092A4 (fr) 1997-05-15 1998-05-15 Outils therapeutiques et diagnostiques pour desordres lies a une mauvaise tolerance glucidique

Country Status (6)

Country Link
EP (1) EP1019092A4 (fr)
JP (1) JP2002511747A (fr)
AU (1) AU752962B2 (fr)
CA (1) CA2287839A1 (fr)
PL (1) PL336858A1 (fr)
WO (1) WO1998051351A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225120B1 (en) 1997-05-15 2001-05-01 The General Hospital Corporation Therapeutic and diagnostic tools for impaired glucose tolerance conditions
US6861256B2 (en) 1997-05-15 2005-03-01 The General Hospital Corporation Therapeutic and diagnostic tools for impaired glucose tolerance conditions
WO2000055318A2 (fr) 1999-03-15 2000-09-21 University Of British Columbia Methodes et reactifs permettant de moduler les taux de cholesterol
US6787125B1 (en) 1999-04-15 2004-09-07 Devgen Nv Compound screening method
HUP0201142A2 (en) * 1999-04-15 2002-08-28 Devgen Nv Compound screening method
GB9908676D0 (en) * 1999-04-15 1999-06-09 Devgen Nv Method for screening compounds
GB2349217B (en) * 1999-04-15 2001-04-04 Devgen Nv Compound screening methods
AU7353700A (en) * 1999-09-07 2001-04-10 Neurogenetics, Inc. Therapies and reagents for increasing stress resistance and life span
US7083947B2 (en) 2000-05-19 2006-08-01 Devgen Nv Assay techniques using nematode worms
GB0014009D0 (en) * 2000-06-08 2000-08-02 Devgen Nv Compound screens relating to insulin deficiency or insulin resistance

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196333A (en) * 1990-05-30 1993-03-23 The Trustees Of Columbia University DNA sequences involved in neuronal degeneration, multicellular organisms containing same and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LEVITAN D ET AL: "Assessment of normal and mutant human presenilin function in Caenorhabditis elegans", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 93, December 1996 (1996-12-01), pages 14940 - 14944, XP002097562, ISSN: 0027-8424 *
See also references of WO9851351A1 *
STERN ET AL: "The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5", MOLECULAR BIOLOGY OF THE CELL, BETHESDA, MD, US, vol. 4, no. 11, 1 November 1993 (1993-11-01), pages 1175 - 1188, XP002079466, ISSN: 1059-1524 *

Also Published As

Publication number Publication date
JP2002511747A (ja) 2002-04-16
CA2287839A1 (fr) 1998-11-19
EP1019092A1 (fr) 2000-07-19
AU752962B2 (en) 2002-10-03
AU7494198A (en) 1998-12-08
PL336858A1 (en) 2000-07-17
WO1998051351A1 (fr) 1998-11-19

Similar Documents

Publication Publication Date Title
EP1163515A4 (fr) Outils diagnostiques et therapeutiques permettant de traiter les troubles de la tolerance glucidique
CA2359116A1 (fr) Porphyrines substituees
IL135949A0 (en) Substituted porphyrins
MX9709240A (es) Fenilpiridazinonas.
WO2001079459A3 (fr) Polypeptides ayant une activite d'haloperoxydase et acides nucleiques qui les codent
WO2000040525A3 (fr) Ensembles de polymeres et techniques de production et d'utilisation
EP2011499A3 (fr) Compositions de pyrrolo(2,3d)-pyrimidine et leur utilisation
ZA993364B (en) Novel 4-phenylpiperidines for the treatment of pruritic dermatoses.
WO2000028090A3 (fr) Essais diagnostiques du cancer
AU1367095A (en) Effector proteins of rapamycin
CA2381770A1 (fr) Anticorps contre l'antigene ctla-4 humain et utilisation
IL143748A0 (en) Substituted aryl or heteroarylamides having retinoid-like biological activity
AU2002366641A1 (en) Methods for inhibiting ocular processes
WO2001036487A3 (fr) Fragments de liaison a l'antigene specifiques aux cellules dendritiques, compositions et methodes d'utilisation, antigenes ainsi reconnus et cellules ainsi obtenues
WO2000018899A3 (fr) Homologue d'enzyme de conversion d'angiotensine et son utilisation
BG102016A (en) Method for the diagnostics of schizophrenia
WO1998028317A3 (fr) Synthese chimique d'analogues de nucleosides et leur incorporation dans des polynucleotides
WO1998021239A3 (fr) Compositions et procedes therapeuthiques et dosages diagnostiques permettant de traiter des diabetes de type ii impliquant hnf-1
EP1019092A4 (fr) Outils therapeutiques et diagnostiques pour desordres lies a une mauvaise tolerance glucidique
WO2000029623A3 (fr) Acides nucleiques contenant des polymorphismes d'un seul nucleotide et utilisations de ces acides nucleiques
AU5596998A (en) Pyk2 related products and methods
CA2363503A1 (fr) Procedes de diagnostic et de therapie des maladies des yeux associees aux drusen
WO2000021513A3 (fr) Procedes pour traiter la sclerose en plaques
WO2000050565A3 (fr) Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs
WO1999051779A3 (fr) Traitement et diagnostic du glaucome

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19991215

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RIN1 Information on inventor provided before grant (corrected)

Inventor name: KOWEEK, ALLISON

Inventor name: MORRIS, JASON

Inventor name: TISSENBAUM, HEIDI

Inventor name: PARADIS, SUZANNE

Inventor name: OGG, SCOTT

Inventor name: PATTERSON, GARTH

Inventor name: KIMURA, KOUTAROU

Inventor name: RUVKUN, GARY

A4 Supplementary search report drawn up and despatched

Effective date: 20041102

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1029741

Country of ref document: HK

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20061206