WO2000050565A3 - Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs - Google Patents

Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs Download PDF

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Publication number
WO2000050565A3
WO2000050565A3 PCT/US2000/004950 US0004950W WO0050565A3 WO 2000050565 A3 WO2000050565 A3 WO 2000050565A3 US 0004950 W US0004950 W US 0004950W WO 0050565 A3 WO0050565 A3 WO 0050565A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
tumor suppressor
kits
compositions
methods relating
Prior art date
Application number
PCT/US2000/004950
Other languages
English (en)
Other versions
WO2000050565A2 (fr
Inventor
Carlo M Croce
Hideshi Ishii
Original Assignee
Univ Jefferson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Jefferson filed Critical Univ Jefferson
Priority to CA002361396A priority Critical patent/CA2361396A1/fr
Priority to JP2000601129A priority patent/JP2003508011A/ja
Priority to EP00912007A priority patent/EP1163252A4/fr
Publication of WO2000050565A2 publication Critical patent/WO2000050565A2/fr
Publication of WO2000050565A3 publication Critical patent/WO2000050565A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

L'invention concerne des homologues de polynucléotides isolés avec une partie d'un brin du gène suppresseur de tumeur de l'homme, le gène FEZ1. L'invention traite également de la protéine suppresseur de tumeur ainsi codée, Fezl. Ces polynucléotides présentent un grand intérêt, par exemple, comme sondes, comme amorces, comme parties de vecteurs d'expression et similaires. L'invention traite également de procédés de diagnostique, de thérapie, de prolifération cellulaire et de dosage utilisant ces polynucléotides et ces protéines. L'invention a également pour objet des kits permettant de mettre en oeuvre les procédés selon l'invention.
PCT/US2000/004950 1999-02-25 2000-02-25 Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs WO2000050565A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002361396A CA2361396A1 (fr) 1999-02-25 2000-02-25 Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs
JP2000601129A JP2003508011A (ja) 1999-02-25 2000-02-25 ヒトｆｅｚ１遺伝子である新規ガン抑制遺伝子に関する組成物、キットおよび方法
EP00912007A EP1163252A4 (fr) 1999-02-25 2000-02-25 Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12153799P 1999-02-25 1999-02-25
US60/121,537 1999-02-25

Publications (2)

Publication Number Publication Date
WO2000050565A2 WO2000050565A2 (fr) 2000-08-31
WO2000050565A3 true WO2000050565A3 (fr) 2000-12-07

Family

ID=22397335

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/004950 WO2000050565A2 (fr) 1999-02-25 2000-02-25 Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs

Country Status (4)

Country Link
EP (1) EP1163252A4 (fr)
JP (1) JP2003508011A (fr)
CA (1) CA2361396A1 (fr)
WO (1) WO2000050565A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911998B2 (en) 2007-10-26 2014-12-16 The Ohio State University Methods for identifying fragile histidine triad (FHIT) interaction and uses thereof
US9125923B2 (en) 2008-06-11 2015-09-08 The Ohio State University Use of MiR-26 family as a predictive marker for hepatocellular carcinoma and responsiveness to therapy

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7141417B1 (en) 1999-02-25 2006-11-28 Thomas Jefferson University Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene
EP2719773A3 (fr) 2007-06-15 2014-07-30 The Ohio State University Research Foundation Protéines de fusion all-1 oncogènes pour cibler le traitement de micro-arn régulé par drosha
US8465918B2 (en) 2007-08-03 2013-06-18 The Ohio State University Research Foundation Ultraconserved regions encoding ncRNAs
CA2781547A1 (fr) 2009-11-23 2011-05-26 The Ohio State University Substances et procedes pouvant s'utiliser pour agir sur la croissance, la migration, et l'invasion de cellules tumorales
WO2012065049A1 (fr) 2010-11-12 2012-05-18 The Ohio State University Research Foundation Matériaux et procédés relatifs aux microarn-21, réparation de désappariement et cancer colorectal
JP2014500258A (ja) 2010-11-15 2014-01-09 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 制御放出粘膜付着システム
CN103561750A (zh) 2011-03-07 2014-02-05 俄亥俄州立大学 通过microRNA-155(miR-155)诱导的增变活性使炎症与癌症关联
EP2766500A4 (fr) 2011-10-14 2015-10-14 Univ Ohio State Méthodes et matériaux relatifs au cancer des ovaires
US9481885B2 (en) 2011-12-13 2016-11-01 Ohio State Innovation Foundation Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis
JP2015511121A (ja) 2012-01-20 2015-04-16 ジ・オハイオ・ステート・ユニバーシティ 浸潤性および予後に関する乳がんバイオマーカーシグネチャー

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001055300A2 (fr) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Acides nucleiques, proteines et anticorps
CA2395872A1 (fr) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Acides nucleiques, proteines et anticorps

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK ISHII ET AL.: "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein and its expression is altered in multiple human tumors", XP002950674 *
DATABASE GENBANK ISHII ET AL.: "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein and its expression is altered in multiple human tumors", XP002950675 *
DATABASE GENBANK WANG ET AL.: "Large-scale indentification, mapping and genotyping of single-nucleotide polymorphiosms in the human genome", XP002950673 *
PROC. NATL. ACAD. SCI. USA, vol. 96, no. 7, 1999, pages 3928 - 3933 *
SCIENCE, vol. 280, no. 5366, 1998, pages 1077 - 1082 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911998B2 (en) 2007-10-26 2014-12-16 The Ohio State University Methods for identifying fragile histidine triad (FHIT) interaction and uses thereof
US9125923B2 (en) 2008-06-11 2015-09-08 The Ohio State University Use of MiR-26 family as a predictive marker for hepatocellular carcinoma and responsiveness to therapy

Also Published As

Publication number Publication date
CA2361396A1 (fr) 2000-08-31
WO2000050565A2 (fr) 2000-08-31
JP2003508011A (ja) 2003-03-04
EP1163252A2 (fr) 2001-12-19
EP1163252A4 (fr) 2004-04-07

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