WO2005058251A3 - Anticorps specifiques de hla-dr, compositions et methodes associees - Google Patents

Anticorps specifiques de hla-dr, compositions et methodes associees Download PDF

Info

Publication number
WO2005058251A3
WO2005058251A3 PCT/US2004/042312 US2004042312W WO2005058251A3 WO 2005058251 A3 WO2005058251 A3 WO 2005058251A3 US 2004042312 W US2004042312 W US 2004042312W WO 2005058251 A3 WO2005058251 A3 WO 2005058251A3
Authority
WO
WIPO (PCT)
Prior art keywords
hla
methods
compositions
specific antibodies
antibodies
Prior art date
Application number
PCT/US2004/042312
Other languages
English (en)
Other versions
WO2005058251A2 (fr
Inventor
Catherine J Mcmahan
Lara Porter Stepan
Reiner Laus
Damir Vidovic
Original Assignee
Dendreon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dendreon Corp filed Critical Dendreon Corp
Priority to JP2006544134A priority Critical patent/JP2007513976A/ja
Priority to EP04814490A priority patent/EP1711527A4/fr
Priority to CA2550155A priority patent/CA2550155C/fr
Publication of WO2005058251A2 publication Critical patent/WO2005058251A2/fr
Publication of WO2005058251A3 publication Critical patent/WO2005058251A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des anticorps monoclonaux spécifiques de HLA-DR capables d'induire une apoptose dans des cellules tumorales exprimant HLA-DR. Certains anticorps spécifiques de HLA-DR exemplaires présentent des niveaux réduits de l'activité immunosuppresseur. Les anticorps de ladite invention trouvent leur utilisation dans des méthodes diagnostiques, ainsi que dans des compositions et des méthodes destinées au traitement de cancers liés aux cellules tumorales exprimant HLA-DR.
PCT/US2004/042312 2003-12-15 2004-12-15 Anticorps specifiques de hla-dr, compositions et methodes associees WO2005058251A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2006544134A JP2007513976A (ja) 2003-12-15 2004-12-15 Ｈｌａ−ｄｒ特異的抗体、組成物、および方法
EP04814490A EP1711527A4 (fr) 2003-12-15 2004-12-15 Anticorps specifiques de hla-dr, compositions et methodes associees
CA2550155A CA2550155C (fr) 2003-12-15 2004-12-15 Anticorps specifiques de hla-dr, compositions et methodes associees

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60894403P 2003-12-15 2003-12-15
US60/608,944 2003-12-15

Publications (2)

Publication Number Publication Date
WO2005058251A2 WO2005058251A2 (fr) 2005-06-30
WO2005058251A3 true WO2005058251A3 (fr) 2005-11-17

Family

ID=34700255

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/042312 WO2005058251A2 (fr) 2003-12-15 2004-12-15 Anticorps specifiques de hla-dr, compositions et methodes associees

Country Status (5)

Country Link
US (1) US8354507B2 (fr)
EP (1) EP1711527A4 (fr)
JP (1) JP2007513976A (fr)
CA (1) CA2550155C (fr)
WO (1) WO2005058251A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2625222A1 (fr) * 2005-10-11 2007-04-19 Domantis Limited Criblage de bibliotheques de polypeptides d'anticorps et polypeptides d'anticorps selectionnes
GB0525214D0 (en) * 2005-12-12 2006-01-18 Bioinvent Int Ab Biological materials and uses thereof
US9085614B2 (en) * 2008-08-01 2015-07-21 Immunas Pharma, Inc. Antibodies that specifically bind to Aβ oligomers and uses thereof
CA2799540A1 (fr) * 2010-06-08 2011-12-15 Genentech, Inc. Anticorps et conjugues modifies par la cysteine
BR112014009925B1 (pt) 2011-10-28 2022-09-20 Teva Pharmaceuticals Australia Pty Ltd Construtores de polipeptídeos e seus usos
US20160130336A1 (en) * 2013-12-31 2016-05-12 Development Center For Biotechnology Anti-vegf antibodies and use thereof
CN107847601A (zh) 2015-06-04 2018-03-27 南加利福尼亚大学 Lym‑1和lym‑2靶向的car细胞免疫疗法
WO2017106684A2 (fr) * 2015-12-17 2017-06-22 Janssen Biotech, Inc. Anticorps se liant spécifiquement à hla-dr et leurs utilisations
BR112019005333A2 (pt) 2016-09-21 2019-06-11 Aptevo Research And Development Llc proteínas de ligação a cd123 e composições e métodos relacionados
US20200016201A1 (en) * 2016-09-23 2020-01-16 University Of Southern California Chimeric antigen receptors and compositions and methods of use thereof
US11161897B2 (en) 2017-07-17 2021-11-02 Janssen Biotech, Inc. Antigen binding regions against fibronectin type III domains and methods of using the same
KR20210118945A (ko) 2019-02-15 2021-10-01 유니버시티 오브 써던 캘리포니아 Lym-1 및 lym-2 항체 조성물 및 개선된 car 구성물
WO2020204054A1 (fr) * 2019-04-01 2020-10-08 Chugai Seiyaku Kabushiki Kaisha Anticorps anti-hla-dq2.5
CN115028730B (zh) * 2022-05-17 2022-11-08 诺赛联合(北京)生物医学科技有限公司 一种成体干细胞衍生的类器官制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012560A1 (fr) * 1998-08-28 2000-03-09 Dendreon Corporation Apoptose selective de cellules neoplasiques mise en oeuvre par un anticorps monoclonal specifique au hla-dr

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO873164L (no) 1986-07-30 1988-02-01 Teijin Ltd Muse-humane kimaere antistoffer.
JPH0698021B2 (ja) * 1986-08-01 1994-12-07 帝人株式会社 マウス−ヒトキメラ抗体、それをコ−ドする発現型キメラｄｎａ配列、プラスミド及び細胞
US6180377B1 (en) 1993-06-16 2001-01-30 Celltech Therapeutics Limited Humanized antibodies
DK0877626T3 (da) * 1996-01-23 2002-12-30 Univ Vermont Anti-CD18 antistoffer til anvendelse mod slagtilfælde
ATE357459T1 (de) * 1998-01-23 2007-04-15 Hoffmann La Roche Antikörper gegen mensliches il-12
PL350909A1 (en) * 1999-02-12 2003-02-10 Genetics Inst Humanized immunoglobulin reactive with b7 molecules and methods of treatment therewith
EP1156060B1 (fr) * 2000-05-12 2007-06-27 GPC Biotech AG Peptides/protéines humaines causant ou menant à la mort de cellules y compris de cellules lymphoides tumorales
KR20050036852A (ko) 2001-10-15 2005-04-20 기린 비루 가부시키가이샤 항-ｈｌａ-ｄｒ 항체
EP1461428B1 (fr) * 2001-12-03 2012-03-21 Alexion Pharmaceuticals, Inc. Méthode de production d'anticorps hybrides
US8450348B2 (en) * 2007-02-21 2013-05-28 Forma Tm, Llc Derivatives of squaric acid with anti-proliferative activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012560A1 (fr) * 1998-08-28 2000-03-09 Dendreon Corporation Apoptose selective de cellules neoplasiques mise en oeuvre par un anticorps monoclonal specifique au hla-dr

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Dendreon Grants Kirin HLA-DR Antibody License to Regain Asian Rights to Provenge Immunotherapy", BUSINESS WIRE, 14 November 2003 (2003-11-14), XP002987935, Retrieved from the Internet <URL:http://investor.dendreon.com.> *
"Dendreon to acquire Corvas", SCRIP., no. 2828, 2003, XP002987936 *

Also Published As

Publication number Publication date
US8354507B2 (en) 2013-01-15
US20050208048A1 (en) 2005-09-22
EP1711527A2 (fr) 2006-10-18
JP2007513976A (ja) 2007-05-31
CA2550155A1 (fr) 2005-06-30
CA2550155C (fr) 2015-03-17
EP1711527A4 (fr) 2008-09-03
WO2005058251A2 (fr) 2005-06-30

Similar Documents

Publication Publication Date Title
WO2006015263A3 (fr) Analogues de lonidamine
WO2004034990A3 (fr) Methodes et compositions a utiliser dans le traitement du cancer
EP2014669A3 (fr) Procédés et compositions de lutte contre le cancer
WO2007061874A3 (fr) Procedes et compositions utilises dans le traitement du cancer
WO2005039382A3 (fr) Prediction de probabilite de la recurrence d&#39;un cancer
WO2002080754A3 (fr) Methodes d&#39;utilisation d&#39;une annexine permettant de visualiser la mort cellulaire in vivo et de traiter des etats pathologiques
TW200732349A (en) Anti-OX40L antibodies and methods using same
WO2003008583A3 (fr) Nouvelles compositions et methodes relatives au cancer
WO2004063355A3 (fr) Nouveaux procedes de diagnostic d&#39;un cancer metastatique, compositions et procedes de depister des modulateurs du cancer metastatique
WO2006083971A3 (fr) Anticorps dr5 et utilisations de ceux-ci
WO2006029219A3 (fr) Anticorps monoclonaux humains anti-ctla4 dans le traitement du cancer
WO2004058171A3 (fr) Anticorps anti-gpr64 et utilisations
WO2000028090A3 (fr) Essais diagnostiques du cancer
WO2005058251A3 (fr) Anticorps specifiques de hla-dr, compositions et methodes associees
AU2003300368A1 (en) Methods and compositions for the diagnosis, prognosis, and treatment of cancer
WO2006060680A3 (fr) Variants de la proteine mda-7 presentant une activite antiproliferative
EP1742654A4 (fr) Anticorps anti-lfl2 pour le diagnostic, le pronostic et le traitement d&#39;un cancer
WO2006029220A3 (fr) Therapie combinee utilisant des anticorps anti-ctla4 et anti-4-1bb
WO2003045230A3 (fr) Compositions et procedes contre le cancer
WO2003057146A3 (fr) Compositions et procedes concernant le cancer
WO2006015191A3 (fr) Analogues de lonidamine multicycliques
WO2007076320A3 (fr) Composes
WO2007075706A3 (fr) Anticorps agonistes d&#39;epha2 a affinites optimisees et methodes d&#39;utilisation de ces anticorps
WO2004045545A3 (fr) Compositions et procedes destines au traitement du cancer, au criblage des composants anticancereux presumes et a l&#39;estimation de l&#39;evolution du cancer
WO2004047757A3 (fr) Diagnostic et traitement des cancers hematopoietiques

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2550155

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2006544134

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

WWE Wipo information: entry into national phase

Ref document number: 2004814490

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2004814490

Country of ref document: EP