WO1998028075A1 - Plaque a micro-puits pour imagerie d'essais en fluorescence, chimiluminescence, bioluminescence et colorimetrie - Google Patents

Plaque a micro-puits pour imagerie d'essais en fluorescence, chimiluminescence, bioluminescence et colorimetrie Download PDF

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Publication number
WO1998028075A1
WO1998028075A1 PCT/IB1997/001585 IB9701585W WO9828075A1 WO 1998028075 A1 WO1998028075 A1 WO 1998028075A1 IB 9701585 W IB9701585 W IB 9701585W WO 9828075 A1 WO9828075 A1 WO 9828075A1
Authority
WO
WIPO (PCT)
Prior art keywords
well
micro
well plate
wells
plate
Prior art date
Application number
PCT/IB1997/001585
Other languages
English (en)
Inventor
Peter Ramm
Original Assignee
Imaging Research Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imaging Research Inc. filed Critical Imaging Research Inc.
Priority to AU52335/98A priority Critical patent/AU5233598A/en
Publication of WO1998028075A1 publication Critical patent/WO1998028075A1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0378—Shapes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence

Definitions

  • the invention resides in a fluid containment system
  • the present invention comprises a family of well plates. All of the plates have the inherent properties of: i) minimizing reflections from an excitation source into an imaging detector; ii) minimizing the concentration of excitation into intense and localized sources (lensing) ; and iii) allowing an epi-illuminating excitation beam to penetrate both central and lateral wells effectively.
  • Figure 4 is a schematic illustration of the present invention, as used with an imaging system designed for analysis of assays within wells.

Abstract

Système de maintien d'échantillons optimisant les propriétés optiques des dispositifs de maintien (puits) aux fins d'imagerie, de manière à augmenter le signal pertinent, par rapport à l'environnement. Dans un ensemble de plaques à puits, où les puits forment série, on a toujours les propriétés intrinsèques suivantes: i) réduction au minimum des réflexions produites par une source d'excitation dans un détecteur d'imagerie; ii) réduction au minimum de la concentration de l'excitation dans des sources intenses et localisées (diffusion par lentille); et iii) structure laissant pénétrer efficacement un faisceau d'excitation par illumination verticale dans les puits centraux et latéraux. Les plaques sont en matériau conçu ou traité pour avoir une fluorescence et des propriétés de réflexion minimes. Les chambres de puits sont asymétriques en profondeur (par exemple, surfaces de puits en pente) et sont irrégulières en section transversale. Le fonds de puits peut également comporter une crête ou être transparent pour réduire au minimum la réflexion de la lumière incidente qui en émane.
PCT/IB1997/001585 1996-12-20 1997-12-18 Plaque a micro-puits pour imagerie d'essais en fluorescence, chimiluminescence, bioluminescence et colorimetrie WO1998028075A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU52335/98A AU5233598A (en) 1996-12-20 1997-12-18 A micro-well plate for imaging of fluorescent, chemiluminescent, bioluminescent,and colorimetric assays

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3364696P 1996-12-20 1996-12-20
US60/033,646 1996-12-20
US5169197P 1997-07-03 1997-07-03
US60/051,691 1997-07-03

Publications (1)

Publication Number Publication Date
WO1998028075A1 true WO1998028075A1 (fr) 1998-07-02

Family

ID=26709957

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1997/001585 WO1998028075A1 (fr) 1996-12-20 1997-12-18 Plaque a micro-puits pour imagerie d'essais en fluorescence, chimiluminescence, bioluminescence et colorimetrie

Country Status (2)

Country Link
AU (1) AU5233598A (fr)
WO (1) WO1998028075A1 (fr)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999049974A1 (fr) * 1998-04-01 1999-10-07 The Du Pont Merck Pharmaceutical Company Dispositif sous forme de plaque servant a contenir de petits volumes de liquide
US6027695A (en) * 1998-04-01 2000-02-22 Dupont Pharmaceuticals Company Apparatus for holding small volumes of liquids
EP1019705A1 (fr) * 1996-08-16 2000-07-19 Imaging Research, Inc. Systeme numerique d'imagerie pour des plaques de puits, des gels et taches
WO2001003833A1 (fr) * 1999-07-13 2001-01-18 Commissariat A L'energie Atomique Support d'analyse a transmission de lumiere de fluorescence
WO2001006932A1 (fr) * 1999-07-27 2001-02-01 Sigma-Tau Healthscience S.P.A. Dispositif pour controler la fertilite chez la femme par une observation des changements physiques dans des fluides corporels
WO2001038583A2 (fr) * 1999-11-22 2001-05-31 Diversa Corporation Criblage de prelevement a l'aide d'un systeme en rangees de capillaires
EP1122576A2 (fr) * 2000-01-28 2001-08-08 Werner Dipl.-Ing. Freber Système optique
WO2004014554A1 (fr) * 2002-08-07 2004-02-19 International Business Machines Corporation Structures discretes nano-texturees de reseaux biomoleculaires, et leur procede d'utilisation
US6721053B1 (en) 1999-05-19 2004-04-13 Corning Intellisense Corporation System for high resolution chemical and biological sensing
US6794127B1 (en) 1997-06-16 2004-09-21 Diversa Corporation Capillary array-based sample screening
US6800491B2 (en) 2001-06-08 2004-10-05 Nalge Nunc International Corporation Robotic reservoir without liquid hangup
WO2005108955A1 (fr) * 2004-04-29 2005-11-17 Applera Corporation Procede permettant de reduire au minimum l'effet de menisque
US6972183B1 (en) 1997-06-16 2005-12-06 Diversa Corporation Capillary array-based enzyme screening
US6998270B2 (en) 2001-11-26 2006-02-14 Lab Vision Corporation Automated tissue staining system and reagent container
EP1862542A1 (fr) * 2005-03-18 2007-12-05 Toppan Printing Co., Ltd. Puce de détection et procédé de détection de substances utilisant celle-ci
GB2472321A (en) * 2009-07-31 2011-02-02 Simon Stafford A microplate and microplate holder
GB2472384A (en) * 2009-07-31 2011-02-09 Simon Stafford Modified microplate
WO2014137722A2 (fr) * 2013-03-07 2014-09-12 Hologic, Inc. Plaque à puits multiples et procédé d'utilisation
EP3093649A3 (fr) * 1998-05-16 2017-04-26 Life Technologies Corporation Un instrument optique servant à surveiller des réactions de polymérase en chaîne d'adn
CN107340555A (zh) * 2017-08-16 2017-11-10 西安应用光学研究所 大发散角光吸收阱
US9823195B2 (en) 1998-05-16 2017-11-21 Life Technologies Corporation Optical instrument comprising multi-notch beam splitter

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4240751A (en) * 1978-11-09 1980-12-23 Akzona Incorporated Method and apparatus for specific binding substances
EP0106662A2 (fr) * 1982-10-12 1984-04-25 Dynatech Laboratories, Incorporated Récipients non-fluorescents pour contenir des échantillons dans un test par fluorescence
WO1991004482A1 (fr) * 1989-09-19 1991-04-04 Park Pharmaceuticals Inc. Luminometre
EP0571661A1 (fr) * 1992-05-28 1993-12-01 Packard Instrument Company, Inc. Plaque d'essais à puits multiples utilisant des mesures de lumière
JPH0720037A (ja) * 1993-07-01 1995-01-24 J T Sci:Kk タイタプレート
WO1997012678A1 (fr) * 1995-10-05 1997-04-10 Corning Costar Corporation Plaques a microtitration permettant d'eviter un couplage parasite optique entre des cupules

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4240751A (en) * 1978-11-09 1980-12-23 Akzona Incorporated Method and apparatus for specific binding substances
EP0106662A2 (fr) * 1982-10-12 1984-04-25 Dynatech Laboratories, Incorporated Récipients non-fluorescents pour contenir des échantillons dans un test par fluorescence
WO1991004482A1 (fr) * 1989-09-19 1991-04-04 Park Pharmaceuticals Inc. Luminometre
EP0571661A1 (fr) * 1992-05-28 1993-12-01 Packard Instrument Company, Inc. Plaque d'essais à puits multiples utilisant des mesures de lumière
JPH0720037A (ja) * 1993-07-01 1995-01-24 J T Sci:Kk タイタプレート
WO1997012678A1 (fr) * 1995-10-05 1997-04-10 Corning Costar Corporation Plaques a microtitration permettant d'eviter un couplage parasite optique entre des cupules

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 095, no. 004 31 May 1995 (1995-05-31) *

Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1019705A1 (fr) * 1996-08-16 2000-07-19 Imaging Research, Inc. Systeme numerique d'imagerie pour des plaques de puits, des gels et taches
EP1019705A4 (fr) * 1996-08-16 2001-02-28 Imaging Res Inc Systeme numerique d'imagerie pour des plaques de puits, des gels et taches
US6794127B1 (en) 1997-06-16 2004-09-21 Diversa Corporation Capillary array-based sample screening
US6972183B1 (en) 1997-06-16 2005-12-06 Diversa Corporation Capillary array-based enzyme screening
US6866824B2 (en) 1997-06-16 2005-03-15 Diversa Corporation Capillary array-based sample screening
US6027695A (en) * 1998-04-01 2000-02-22 Dupont Pharmaceuticals Company Apparatus for holding small volumes of liquids
WO1999049974A1 (fr) * 1998-04-01 1999-10-07 The Du Pont Merck Pharmaceutical Company Dispositif sous forme de plaque servant a contenir de petits volumes de liquide
US9823195B2 (en) 1998-05-16 2017-11-21 Life Technologies Corporation Optical instrument comprising multi-notch beam splitter
EP3093649A3 (fr) * 1998-05-16 2017-04-26 Life Technologies Corporation Un instrument optique servant à surveiller des réactions de polymérase en chaîne d'adn
US9671342B2 (en) 1998-05-16 2017-06-06 Life Technologies Corporation Instrument for monitoring polymerase chain reaction of DNA
US6721053B1 (en) 1999-05-19 2004-04-13 Corning Intellisense Corporation System for high resolution chemical and biological sensing
FR2797053A1 (fr) * 1999-07-13 2001-02-02 Commissariat Energie Atomique Support d'analyse a transmission de lumiere de fluorescence
WO2001003833A1 (fr) * 1999-07-13 2001-01-18 Commissariat A L'energie Atomique Support d'analyse a transmission de lumiere de fluorescence
WO2001006932A1 (fr) * 1999-07-27 2001-02-01 Sigma-Tau Healthscience S.P.A. Dispositif pour controler la fertilite chez la femme par une observation des changements physiques dans des fluides corporels
US6793886B1 (en) 1999-07-27 2004-09-21 Kemifar S.R.L. Device for monitoring fertility in women by observing physical changes in body fluids
WO2001038583A2 (fr) * 1999-11-22 2001-05-31 Diversa Corporation Criblage de prelevement a l'aide d'un systeme en rangees de capillaires
WO2001038583A3 (fr) * 1999-11-22 2001-10-11 Diversa Corp Criblage de prelevement a l'aide d'un systeme en rangees de capillaires
EP1122576A2 (fr) * 2000-01-28 2001-08-08 Werner Dipl.-Ing. Freber Système optique
EP1122576A3 (fr) * 2000-01-28 2004-01-14 Werner Dipl.-Ing. Freber Système optique
US6800491B2 (en) 2001-06-08 2004-10-05 Nalge Nunc International Corporation Robotic reservoir without liquid hangup
US7435383B2 (en) 2001-11-26 2008-10-14 Lab Vision Corporation Automated tissue staining system and reagent container
US8142739B2 (en) 2001-11-26 2012-03-27 Lab Vision Corporation Automated tissue staining system and reagent container
US6998270B2 (en) 2001-11-26 2006-02-14 Lab Vision Corporation Automated tissue staining system and reagent container
US7642093B2 (en) 2001-11-26 2010-01-05 Lab Vision Corporation Automated tissue staining system and reagent container
US8585987B2 (en) 2001-11-26 2013-11-19 Lab Vision Corporation Automated tissue staining system and reagent container
US7901941B2 (en) 2001-11-26 2011-03-08 Lab Vision Corporation Automated tissue staining system and reagent container
US7354777B2 (en) 2002-08-07 2008-04-08 International Business Machines Corporation Discrete nano-textured structures in biomolecular arrays, and method of use
WO2004014554A1 (fr) * 2002-08-07 2004-02-19 International Business Machines Corporation Structures discretes nano-texturees de reseaux biomoleculaires, et leur procede d'utilisation
US6962822B2 (en) 2002-08-07 2005-11-08 International Business Machines Corporation Discrete nano-textured structures in biomolecular arrays, and method of use
WO2005108955A1 (fr) * 2004-04-29 2005-11-17 Applera Corporation Procede permettant de reduire au minimum l'effet de menisque
EP1862542A4 (fr) * 2005-03-18 2009-09-09 Toppan Printing Co Ltd Puce de détection et procédé de détection de substances utilisant celle-ci
EP1862542A1 (fr) * 2005-03-18 2007-12-05 Toppan Printing Co., Ltd. Puce de détection et procédé de détection de substances utilisant celle-ci
GB2472384A (en) * 2009-07-31 2011-02-09 Simon Stafford Modified microplate
GB2472321B (en) * 2009-07-31 2014-03-05 Oxley Hughes Ltd Means for improved liquid handling in a microplate
GB2472321A (en) * 2009-07-31 2011-02-02 Simon Stafford A microplate and microplate holder
WO2014137722A2 (fr) * 2013-03-07 2014-09-12 Hologic, Inc. Plaque à puits multiples et procédé d'utilisation
WO2014137722A3 (fr) * 2013-03-07 2014-10-30 Hologic, Inc. Plaque à puits multiples et procédé d'utilisation
CN107340555A (zh) * 2017-08-16 2017-11-10 西安应用光学研究所 大发散角光吸收阱
CN107340555B (zh) * 2017-08-16 2019-07-02 西安应用光学研究所 大发散角光吸收阱

Also Published As

Publication number Publication date
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