WO1998008885A1 - Combinatorial method of forming cascade polymer surfaces - Google Patents

Combinatorial method of forming cascade polymer surfaces Download PDF

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Publication number
WO1998008885A1
WO1998008885A1 PCT/US1997/014914 US9714914W WO9808885A1 WO 1998008885 A1 WO1998008885 A1 WO 1998008885A1 US 9714914 W US9714914 W US 9714914W WO 9808885 A1 WO9808885 A1 WO 9808885A1
Authority
WO
WIPO (PCT)
Prior art keywords
monomers
substrate
set forth
mixture
layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/014914
Other languages
English (en)
French (fr)
Inventor
George R. Newkome
Charles N. Moorefield
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of South Florida
University of South Florida St Petersburg
Original Assignee
University of South Florida
University of South Florida St Petersburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of South Florida, University of South Florida St Petersburg filed Critical University of South Florida
Priority to CA002264035A priority Critical patent/CA2264035C/en
Priority to JP10511785A priority patent/JP2000516985A/ja
Priority to AU42354/97A priority patent/AU4235497A/en
Priority to EP97940611A priority patent/EP0922062B1/en
Priority to AT97940611T priority patent/ATE283301T1/de
Priority to DE69731752T priority patent/DE69731752T2/de
Publication of WO1998008885A1 publication Critical patent/WO1998008885A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/14—Libraries containing macromolecular compounds and not covered by groups C40B40/06 - C40B40/12
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/71—Monoisocyanates or monoisothiocyanates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/71—Monoisocyanates or monoisothiocyanates
    • C08G18/718—Monoisocyanates or monoisothiocyanates containing silicon
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/754—Dendrimer, i.e. serially branching or "tree-like" structure

Definitions

  • the present invention relates to highly repetitive structural analysis.
  • cascade polymers as molecules per se or as
  • the isocyanate monomers are excellent
  • the isocyanate based monomers also provide for rapid,
  • cascade polymer can be performed relatively rapidly
  • Such substrates include silica based substances,
  • films are application-oriented with respect to
  • the present invention relates to the further
  • the present invention further provides a
  • a substrate including a surface and at least one
  • dendrimerized surface layer consisting of
  • Figure 1 is a schematic representation of
  • the present invention provides a cascade
  • the method generally includes the steps of
  • substrate is defined more
  • substrate can be a core molecule, such as carbon or
  • Examples of such substrates are silica
  • microgels spherical polymers, as well as
  • the present invention can be employed to "dendrimerize” any common material (s) possessing an
  • present invention can have a wide range of
  • the present invention can have a
  • R' being selected from the group consisting of
  • alkyl cycloalkyl, aryl, heteroaryl- polycycloalkyl ,
  • R being selected from the group consisting of
  • alkyl (c-1 to C(20), cycloalkyl (C-3 to C-10), aryl
  • heteroaryl polycycloalkyl, adamantyl
  • R" being selected from the group consisting of
  • R' ' ' being alkyl (C-1 to C-20) cycloalkyl
  • isocyanates and is not intended limit the broad scope of multifunctionalize isocyanates capable of use in
  • the present invention is characterized by
  • Some of the monomers may have carboxyl termini, some of the monomers may have carboxyl termini, some of the monomers may have carboxyl termini, some of the monomers may have carboxyl termini, some of the monomers may have carboxyl termini, some of the monomers may have carboxyl termini, some of the monomers may have carboxyl termini, some of the monomers may have carboxyl termini, some of the monomers may have carboxyl termini, some
  • the branches may have alcohol termini, some of the branches may have ester termini, etc.
  • the present invention can be termed "combinatorial
  • composition can be used at each tier or the
  • composition can be varied. Also, combinatorial tier
  • the dendrimerized surface is formed and includes a layer
  • the dendrimerizing step More specifically, the dendrimerizing step
  • -f " 1 is a mixture of protected functionalities, at least some of the protected functionalities possessing
  • the present invention derives from tier
  • branches are then deprotected by means
  • the protected groups can be deprotected.
  • FIG. 1 illustrates one permutation
  • dendrimer(l) is affected by treatment with a
  • dendrimer 4 multicomponent dendrimers such as dendrimer 4 in
  • coated molecule can be constructed consisting of
  • a substrate including a surface and at
  • the surface layer being
  • the substrate surface can include functional
  • the groups can consist of
  • the present invention possesses utility in
  • hydrophilic coatings for fabrics such as hydrophilic coatings for fabrics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Structural Engineering (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Polymerisation Methods In General (AREA)
  • Medicinal Preparation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
PCT/US1997/014914 1996-08-28 1997-08-25 Combinatorial method of forming cascade polymer surfaces Ceased WO1998008885A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002264035A CA2264035C (en) 1996-08-28 1997-08-25 Combinatorial method of forming cascade polymer surfaces
JP10511785A JP2000516985A (ja) 1996-08-28 1997-08-25 カスケードポリマー表面形成コンビナトリアル法
AU42354/97A AU4235497A (en) 1996-08-28 1997-08-25 Combinatorial method of forming cascade polymer surfaces
EP97940611A EP0922062B1 (en) 1996-08-28 1997-08-25 Combinatorial method of forming cascade polymer surfaces
AT97940611T ATE283301T1 (de) 1996-08-28 1997-08-25 Kombinatorisches verfahren zur herstellung von kaskadenpolymeroberflächen
DE69731752T DE69731752T2 (de) 1996-08-28 1997-08-25 Kombinatorisches verfahren zur herstellung von kaskadenpolymeroberflächen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/705,905 US5886126A (en) 1996-08-28 1996-08-28 Combinatorial method of forming cascade polymer surfaces
US08/705,905 1996-08-28

Publications (1)

Publication Number Publication Date
WO1998008885A1 true WO1998008885A1 (en) 1998-03-05

Family

ID=24835434

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/014914 Ceased WO1998008885A1 (en) 1996-08-28 1997-08-25 Combinatorial method of forming cascade polymer surfaces

Country Status (8)

Country Link
US (1) US5886126A (enExample)
EP (1) EP0922062B1 (enExample)
JP (2) JP2000516985A (enExample)
AT (1) ATE283301T1 (enExample)
AU (1) AU4235497A (enExample)
CA (1) CA2264035C (enExample)
DE (1) DE69731752T2 (enExample)
WO (1) WO1998008885A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1316594A1 (de) * 2001-11-28 2003-06-04 Bayer Aktiengesellschaft Silangruppen enthaltende Polymere
US7468206B1 (en) * 1996-12-19 2008-12-23 Panasonic Corporation Organic ultra-thin film

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US7250534B1 (en) 1999-07-27 2007-07-31 University Of South Florida Performance of energy storage devices: potential areas for dendritic chemistry involvement
US7448258B2 (en) * 1999-10-29 2008-11-11 Avery Dennison Corporation High throughput screening for moisture barrier characteristics of materials
WO2002030465A2 (en) 2000-10-12 2002-04-18 University Of Rochester Compositions that inhibit proliferation of cancer cells
US20020146684A1 (en) * 2001-04-09 2002-10-10 Meldal Morten Peter One dimensional unichemo protection (UCP) in organic synthesis
DE60332756D1 (de) 2002-02-06 2010-07-08 Vicor Technologies Inc Anti-infarkt-moleküle
WO2003093452A2 (en) * 2002-02-26 2003-11-13 University Of Utah Research Foundation Variants of nedd4l associated with hypertension and viral budding
US20050287648A1 (en) 2002-08-05 2005-12-29 University Of Rochester Protein Transducing Domain/Deaminase Chimeric Proteins, Related Compounds, and Uses Thereof
US20050106068A1 (en) * 2003-11-18 2005-05-19 Abdul Malik Sol-gel dendron separation and extraction capillary column
EP2631652A1 (en) 2005-04-05 2013-08-28 Corning Incorporated Label free biosensor
EP2371843B1 (en) 2005-05-19 2014-09-17 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services Functional epitopes of streptococcus pneumoniae psaA antigen and uses thereof
US8080534B2 (en) * 2005-10-14 2011-12-20 Phigenix, Inc Targeting PAX2 for the treatment of breast cancer
EP2392646A1 (en) 2005-10-14 2011-12-07 MUSC Foundation For Research Development Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy
US8258259B2 (en) * 2005-10-25 2012-09-04 Starpharma Pty Limited Macromolecular compounds having controlled stoichiometry
JP5926475B2 (ja) 2006-09-21 2016-05-25 ユニバーシティー オブ ロチェスター 筋緊張性ジストロフィーのためのタンパク質置換治療に関する組成物および方法
WO2008136852A2 (en) 2006-11-01 2008-11-13 University Of Rochester Methods and compositions related to the structure and function of apobec3g
US9381226B2 (en) 2007-02-08 2016-07-05 University Of Utah Research Foundation Methods and compositions related to inhibition of viral entry
US8816095B2 (en) * 2008-08-15 2014-08-26 Georgetown University Na channels, disease, and related assays and compositions
US20120070443A1 (en) 2008-12-02 2012-03-22 University Of Utah Research Foundation Pde1 as a target therapeutic in heart disease
WO2011022502A1 (en) 2009-08-18 2011-02-24 Georgetown University Boronic acid compositions and methods related to cancer
JP2013507365A (ja) 2009-10-07 2013-03-04 サンフォード−バーナム メディカル リサーチ インスティテュート 血餅結合脂質化合物に関する方法および組成物
JP2013515008A (ja) 2009-12-18 2013-05-02 サンフォード−バーナム メディカル リサーチ インスティテュート 凝血塊結合化合物に関連する方法および組成物
US20140323392A1 (en) 2011-03-28 2014-10-30 University Of Utah Research Foundation Methods and compositions related to inhibition of viral entry
WO2019055618A1 (en) 2017-09-15 2019-03-21 Arizona Board Of Regents On Behalf Of Arizona State University METHODS OF CLASSIFYING RESPONSES TO ANTICANCER IMMUNOTHERAPY
WO2021067550A1 (en) 2019-10-02 2021-04-08 Arizona Board Of Regents On Behalf Of Arizona State University Methods and compositions for identifying neoantigens for use in treating and preventing cancer

Citations (1)

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Publication number Priority date Publication date Assignee Title
US5414075A (en) * 1992-11-06 1995-05-09 Bsi Corporation Restrained multifunctional reagent for surface modification

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610268A (en) * 1992-01-13 1997-03-11 Dsm N.V. Dendritic macromolecule and the preparation thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5414075A (en) * 1992-11-06 1995-05-09 Bsi Corporation Restrained multifunctional reagent for surface modification

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7468206B1 (en) * 1996-12-19 2008-12-23 Panasonic Corporation Organic ultra-thin film
EP1316594A1 (de) * 2001-11-28 2003-06-04 Bayer Aktiengesellschaft Silangruppen enthaltende Polymere

Also Published As

Publication number Publication date
EP0922062A1 (en) 1999-06-16
CA2264035A1 (en) 1998-03-05
EP0922062A4 (en) 1999-11-10
JP2006188717A (ja) 2006-07-20
EP0922062B1 (en) 2004-11-24
ATE283301T1 (de) 2004-12-15
DE69731752D1 (de) 2004-12-30
AU4235497A (en) 1998-03-19
US5886126A (en) 1999-03-23
JP2000516985A (ja) 2000-12-19
CA2264035C (en) 2007-10-23
DE69731752T2 (de) 2005-12-22

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