WO1998004546A1 - Derives de benzimidazole, leurs preparations et leurs applications en therapeutique - Google Patents

Derives de benzimidazole, leurs preparations et leurs applications en therapeutique Download PDF

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Publication number
WO1998004546A1
WO1998004546A1 PCT/FR1997/001364 FR9701364W WO9804546A1 WO 1998004546 A1 WO1998004546 A1 WO 1998004546A1 FR 9701364 W FR9701364 W FR 9701364W WO 9804546 A1 WO9804546 A1 WO 9804546A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
formula
alkyl
general formula
compound
Prior art date
Application number
PCT/FR1997/001364
Other languages
English (en)
French (fr)
Inventor
Gilles Courtemanche
Luc Even
Gérard Defosse
Jean Bertin
Philippe Bovy
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Priority to AU38530/97A priority Critical patent/AU3853097A/en
Publication of WO1998004546A1 publication Critical patent/WO1998004546A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Definitions

  • the compounds of general formula (I) can be in the form of a free base, of N-oxide or of addition salts with pharmaceutically acceptable acids, which also form part of the invention.
  • the IC 50 values of the compounds of the invention vis-à-vis the M 3 receptors are between 1 and 800 nM.
  • the IC 50 values of the compounds of the invention vis-à-vis the M x and M 2 receptors are higher by a factor of 1 to 126.
  • the compounds of the invention have also been studied as to their antagonistic effects with respect to contractions of the female rabbit detrusor, mediated by the M 3 receptors.
  • Female rabbits New Zealanders, 3-4 kg; ESD supplier) aged about 20 weeks were sacrificed by cervical dislocation and then bloodless.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/FR1997/001364 1996-07-25 1997-07-23 Derives de benzimidazole, leurs preparations et leurs applications en therapeutique WO1998004546A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU38530/97A AU3853097A (en) 1996-07-25 1997-07-23 Benzimidazole derivatives, preparation thereof, and therapeutical uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR96/09360 1996-07-25
FR9609360A FR2751647B1 (fr) 1996-07-25 1996-07-25 Derives de benzimidazole, leurs preparations et leurs applications en therapeutique

Publications (1)

Publication Number Publication Date
WO1998004546A1 true WO1998004546A1 (fr) 1998-02-05

Family

ID=9494466

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1997/001364 WO1998004546A1 (fr) 1996-07-25 1997-07-23 Derives de benzimidazole, leurs preparations et leurs applications en therapeutique

Country Status (6)

Country Link
AR (1) AR007937A1 (es)
AU (1) AU3853097A (es)
CO (1) CO4890848A1 (es)
FR (1) FR2751647B1 (es)
WO (1) WO1998004546A1 (es)
ZA (1) ZA976619B (es)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999025710A1 (fr) * 1997-11-19 1999-05-27 Sanofi-Synthelabo Derives d'imidazole, leur preparation et leur application en therapeutique
WO2000006544A1 (fr) * 1998-07-31 2000-02-10 Kyorin Pharmaceuticals Co., Ltd. Derives amines cycliques et leur procede de preparation
FR2789077A1 (fr) * 1999-02-02 2000-08-04 Synthelabo Derives de perazole, leur preparation et leur application en therapeutique
WO2001064631A2 (fr) * 2000-03-01 2001-09-07 Sanofi-Synthelabo Derives de polyfluoroalkylimidazole, leur preparation et leur application en therapeutique
FR2805816A1 (fr) * 2000-03-01 2001-09-07 Sanofi Synthelabo Derives d'haloimidazole, leur preparation et leur application en therapeutique
EP1535912A1 (en) * 2000-04-28 2005-06-01 Arcadia Pharmaceuticals Inc. Muscarinic agonists
US7238713B2 (en) 2000-04-28 2007-07-03 Acadia Pharmaceuticals, Inc. Muscarinic agonists

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2811989A1 (fr) * 2000-07-18 2002-01-25 Sanofi Synthelabo Derives de polyfluoroalkytriazole, leur preparation et leur application en therapeutique

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009030A1 (en) * 1989-12-12 1991-06-27 Rhone-Poulenc Sante 2-substituted 4,5-diphenyl-imidazoles
WO1994008577A1 (en) * 1992-10-14 1994-04-28 Merck & Co., Inc. Fibrinogen receptor antagonists
DE4304650A1 (de) * 1993-02-16 1994-08-18 Thomae Gmbh Dr K Kondensierte 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
WO1996013262A1 (en) * 1994-10-27 1996-05-09 Merck & Co., Inc. Muscarine antagonists

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009030A1 (en) * 1989-12-12 1991-06-27 Rhone-Poulenc Sante 2-substituted 4,5-diphenyl-imidazoles
WO1994008577A1 (en) * 1992-10-14 1994-04-28 Merck & Co., Inc. Fibrinogen receptor antagonists
DE4304650A1 (de) * 1993-02-16 1994-08-18 Thomae Gmbh Dr K Kondensierte 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
WO1996013262A1 (en) * 1994-10-27 1996-05-09 Merck & Co., Inc. Muscarine antagonists

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999025710A1 (fr) * 1997-11-19 1999-05-27 Sanofi-Synthelabo Derives d'imidazole, leur preparation et leur application en therapeutique
US6200991B1 (en) 1997-11-19 2001-03-13 Sanofi-Synthelabo Imidazole derivatives, preparation and therapeutic application thereof
WO2000006544A1 (fr) * 1998-07-31 2000-02-10 Kyorin Pharmaceuticals Co., Ltd. Derives amines cycliques et leur procede de preparation
FR2789077A1 (fr) * 1999-02-02 2000-08-04 Synthelabo Derives de perazole, leur preparation et leur application en therapeutique
WO2000046220A1 (fr) * 1999-02-02 2000-08-10 Sanofi-Synthelabo Derives de triazoles et tetrazoles, et leur utilisation en therapeutique
FR2805816A1 (fr) * 2000-03-01 2001-09-07 Sanofi Synthelabo Derives d'haloimidazole, leur preparation et leur application en therapeutique
WO2001064631A2 (fr) * 2000-03-01 2001-09-07 Sanofi-Synthelabo Derives de polyfluoroalkylimidazole, leur preparation et leur application en therapeutique
FR2805815A1 (fr) * 2000-03-01 2001-09-07 Sanofi Synthelabo Derives de polyfluoroalkylimidazole, leur preparation et leur application en therapeutique
WO2001064671A2 (fr) * 2000-03-01 2001-09-07 Sanofi-Synthelabo Derives d'haloimidazole et leur utilisation en tant qu'antagonistes des recepteurs muscariniques m3 et serotoniques 5-ht4
WO2001064671A3 (fr) * 2000-03-01 2002-03-14 Sanofi Synthelabo Derives d'haloimidazole et leur utilisation en tant qu'antagonistes des recepteurs muscariniques m3 et serotoniques 5-ht4
WO2001064631A3 (fr) * 2000-03-01 2002-03-28 Sanofi Synthelabo Derives de polyfluoroalkylimidazole, leur preparation et leur application en therapeutique
EP1535912A1 (en) * 2000-04-28 2005-06-01 Arcadia Pharmaceuticals Inc. Muscarinic agonists
US7238713B2 (en) 2000-04-28 2007-07-03 Acadia Pharmaceuticals, Inc. Muscarinic agonists

Also Published As

Publication number Publication date
FR2751647B1 (fr) 1998-09-11
AU3853097A (en) 1998-02-20
FR2751647A1 (fr) 1998-01-30
CO4890848A1 (es) 2000-02-28
ZA976619B (en) 1998-02-10
AR007937A1 (es) 1999-11-24

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