WO1998003152A1 - Compositions for treating sunburn and oral hygiene problems - Google Patents
Compositions for treating sunburn and oral hygiene problems Download PDFInfo
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- WO1998003152A1 WO1998003152A1 PCT/FR1996/001198 FR9601198W WO9803152A1 WO 1998003152 A1 WO1998003152 A1 WO 1998003152A1 FR 9601198 W FR9601198 W FR 9601198W WO 9803152 A1 WO9803152 A1 WO 9803152A1
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- cosmetic
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- local application
- dermopharmaceutical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
Definitions
- Patent FR 2682296 proposes a method of non-chemical preservation of cosmetic or dermopharmaceutical products which is based on the use of gels of the glyceryl poly (meth) acrylate type, the property of which has a strong osmotic effect on its environment, which inactivates the microorganisms introduced into a cosmetic preparation by depriving them of water.
- Patent application 95-09512 of August 4, 1995 proposed improving the efficiency of the method by combining polyols and a fluidizing agent with poly (meth) acrylic gel!
- the discovery object of this patent is that these gels have antimicrobial properties, moisturizing, healing, anti-inflammatory such as their cosmetic, dermopharmaceutical or oral hygiene is particularly interesting, especially since these gels are non-toxic, non-irritant, colorless and odorless, soluble and miscible in water, pleasant to the touch and economical.
- the glyceryl poly (meth) acrylate gel is obtained by mixing water, glycerin, in a polyacrylic or polymethacrylic acid polymer in selected proportions (about 30-50% water, 30-60% glycerin and 0.1 to 5% of polymer) according to a particular manufacturing process which gives the gel physical activity (osmotic power and water absorption capacity).
- This physical activity is the important key of the compositions for carrying out the invention.
- This chlatrate gel is characterized by its strong water retention power. It does not dry, even exposed for months to ambient air or subjected to a vacuum for 48 hours. This property is essential, conventional hydrogels, alginate, polysaccharide, cellulose or its derivatives or silicate gels do not meet this criterion.
- the gel is particularly effective in inactivating the microorganisms with which it comes into contact, depriving germs by its osmotic effect of the water they need to survive.
- the gel is also characterized by its viscosity (50,000-2,000,000 centipoises; nevertheless with a non-Newtonian rheological behavior).
- the polymer is preferably chosen from sodium, potassium, triethylamine, triethanolamine, ammoniacal salts of acrylic acid and / or methacrylic acid, but also from the esters or amides of these acid polymers, or the crosslinked derivatives of carbomer type (crosslinking with allyl ethers of pentaerythritol, sucrose or propylene, for example).
- the polyol contained in the base gel is preferably glycerin, to which other polyols can be mixed in variable proportions: alkane-diols and their monoethers, polyalkylglycols, various sugars. These gels can then be used either in pure form or in diluted form, or incorporated into other gels or other dosage forms.
- Triethanolamine qs pH 5.
- the base vehicle can be prepared from the substances usually used to make hydrogels acceptable in the food industry or for topical application (carrageenans, xanthan gums and other polysaccharides, polyacrylates or polymethacrylates and their crosslinked derivatives such as carbomers, aluminum soda silicates etc.).
- Examples of cosmetic applications of these gels Example n ° 6: The gel of example n ° 5 was tested for its anti-solar erythema activity. Protocol:
- Oral treatment 30 people diagnosed with either gum hypersensitivity, a dry mouth or mouth ulcers or dental plates or loosening problems (mild periodontitis) participated in the study. They are divided into 2 groups of 15 people. After clinical examination by the stomatologist, the two groups receive a toothpaste specially formulated for the test; one containing 15% of the gel of Example No. 2, the other - without gel - being placebo. The panelists use the toothpaste twice a day, morning and evening, after the meal, for 4 weeks.
- the glyceryl poly (meth) acrylate gels which are the subject of this patent can be used in any dosage form used in cosmetics or dermopharmacy or dental hygiene for local application on the skin, mucous membranes, mouth: aqueous solutions, O / W and E emulsions / H, milks, lotions, gels, ointments, soaps, sticks, sprays, poultices, dressings, without this list being exhaustive.
- the concentration of use of these glycerylpoly (meth) acrylate type gels which are the subject of this patent can vary between 1 and 100% (w / w) depending on the application.
- a particularly interesting embodiment of the invention is the gel which is composed of glycerin (40-70% w / w), water (10-50% w / w), 1, 2-octanediol (0.1 to 10% w / w), polyethylene glycol (0.1 to 30% w / w) and neutralized polyacrylate or polymethacrylate (0.1 to 5%).
- glyceryl poly (meth) acrylate type gels which are the subject of this patent can be combined in cosmetic or dermopharmaceutical compositions with any other ingredient usually used in this field: extraction and / or synthetic lipids, gelling and viscosifying polymers, surfactants and emulsifiers, water- or fat-soluble active ingredients, vitamins, plant extracts, tissue extracts, marine extracts, alcohols and polyols, softeners, anti-microbial agents, etc.
- compositions containing the glyceryl poly (meth) acrylate type gels which are the subject of this patent can therefore be intended for the treatment and prevention of "sunburn” burns, erythemas and / or solar edemas, as well as for the prevention and the treatment of oral diseases (dryness, canker sores, dental plaques, mild periodontoses, irritations, swelling, loosening).
Abstract
The cosmetic use of topical glyceryl poly(meth)acrylate gels for treating various symptoms and preventing certain skin and mucosal disorders is disclosed. The discovery is useful for treating and preventing sunburn (solar erythema) and/or solar oedema, as well as treating and preventing oral hygiene problems such as dryness, mouth ulcers, dental plaque, periodontosis, irritation, and swelling. The gels consist of glyceryl poly(meth)acrylate, i.e. glycerine, water and polyacrylate, and may contain other polyols to reinforce the beneficial effect. Said gels may be used in sunscreen-type cosmetics and oral and dental hygiene products.
Description
COMPOSITIONS POUR LE TRAITEMENT DES ERYTHEMES SOLAIRES ET DES AFFECTIONS BUCCALESCOMPOSITIONS FOR THE TREATMENT OF SOLAR ERYTHEMS AND ORAL CONDITIONS
Ce brevet concerne les gels obtenus par le mélange des composants eau, glycérine et autres polyols, et de polyacrylate ou polymethacrylate et de leur utilisation dans le domaine pharmaceutique. Certaines activités, essentiellement cosmétiques, de ces gels ont été décrites avant. Le brevet FR 2682296 propose une méthode de conservation non- chimique de produits cosmétiques ou dermopharmaceutiques qui est basée sur l'utilisation de gels du type glyceryl poly(méth)acrylate, dont la propriété est d'exercer un fort effet osmotique sur son environnement, ce qui permet d'inactiver les microorganismes introduits dans une préparation cosmétique en les privant d'eau. La demande de brevet 95-09512 du 4 août 1995 a proposé une amélioration de l'efficacité de la méthode en associant des polyols et un agent fluidifiant au gel poly(méth)acry!ate. La découverte objet du présent brevet est que ces gels possèdent des propriétés antimicrobiennes, hydratantes, cicatrisantes, anti-inflammatoires telles que leur utilisation cosmétique, dermopharmaceutique ou d' hygiène buccale est particulièrement intéressante, d'autant plus que ces gels sont non-toxiques, non-irritants, incolores et inodores, solubles et miscibles dans l'eau, agréables au toucher et économiques.This patent relates to the gels obtained by the mixture of the water, glycerin and other polyol components, and of polyacrylate or polymethacrylate and of their use in the pharmaceutical field. Certain activities, essentially cosmetic, of these gels have been described before. Patent FR 2682296 proposes a method of non-chemical preservation of cosmetic or dermopharmaceutical products which is based on the use of gels of the glyceryl poly (meth) acrylate type, the property of which has a strong osmotic effect on its environment, which inactivates the microorganisms introduced into a cosmetic preparation by depriving them of water. Patent application 95-09512 of August 4, 1995 proposed improving the efficiency of the method by combining polyols and a fluidizing agent with poly (meth) acrylic gel! The discovery object of this patent is that these gels have antimicrobial properties, moisturizing, healing, anti-inflammatory such as their cosmetic, dermopharmaceutical or oral hygiene is particularly interesting, especially since these gels are non-toxic, non-irritant, colorless and odorless, soluble and miscible in water, pleasant to the touch and economical.
Quelques exemples vont illustrer le type de gel objet du brevet ainsi que les applications possibles :Some examples will illustrate the type of gel covered by the patent as well as the possible applications:
Le gel glyceryl poly(méth)acrylate est obtenu en mélangeant de l'eau, de la glycérine, en un polymère d'acide polyacrylique ou polyméthacrylique dans des proportions choisies (environ 30-50% d'eau, 30-60% de glycérine et 0.1 à 5% de polymère) selon un procédé de fabrication particulier qui confère au gel une activité physique (pouvoir osmotique et capacité d'absorption d'eau). Cette activité physique est la clef importante des compositions pour réaliser l'invention.
Ce gel chlatrate se caractérise par son fort pouvoir de rétention d'eau. Il ne sèche pas, même exposé pendant des mois à l'air ambiant ou soumis au vide d'air pendant 48 heures. Cette propriété est essentielle, les hydrogels classiques, les gels d'alginate, de polysaccharide, de cellulose ou ses dérivés ou de silicate ne satisfont pas ce critère.The glyceryl poly (meth) acrylate gel is obtained by mixing water, glycerin, in a polyacrylic or polymethacrylic acid polymer in selected proportions (about 30-50% water, 30-60% glycerin and 0.1 to 5% of polymer) according to a particular manufacturing process which gives the gel physical activity (osmotic power and water absorption capacity). This physical activity is the important key of the compositions for carrying out the invention. This chlatrate gel is characterized by its strong water retention power. It does not dry, even exposed for months to ambient air or subjected to a vacuum for 48 hours. This property is essential, conventional hydrogels, alginate, polysaccharide, cellulose or its derivatives or silicate gels do not meet this criterion.
Ce gel est particulièrement efficace à inactiver les microorganismes avec lesquels il entre en contact, privant les germes par son effet osmotique de l'eau dont ils ont besoin pour survivre. Le gel est aussi caractérisé par sa viscosité (50.000-2.000.000 centipoises; avec néanmoins un comportement rheologique non-newtonien). Le polymère est choisi de préférence parmi les sels sodiques, potassiques, triéthylaminiques, triéthanolaminiques, ammoniacaux de l'acide acrylique et/ou de l'acide méthacrylique, mais aussi parmi les esters ou les amides de ces polymères acides, ou les dérivés réticulés du type carbomère (réticulation par des éthers allyliques de pentaerythritol, de sucrose ou de propylene, par exemple).This gel is particularly effective in inactivating the microorganisms with which it comes into contact, depriving germs by its osmotic effect of the water they need to survive. The gel is also characterized by its viscosity (50,000-2,000,000 centipoises; nevertheless with a non-Newtonian rheological behavior). The polymer is preferably chosen from sodium, potassium, triethylamine, triethanolamine, ammoniacal salts of acrylic acid and / or methacrylic acid, but also from the esters or amides of these acid polymers, or the crosslinked derivatives of carbomer type (crosslinking with allyl ethers of pentaerythritol, sucrose or propylene, for example).
Le polyol contenu dans le gel de base est de préférence la glycérine, à laquelle d'autres polyols peuvent être mélangés en proportions variables: alcane-diols et leurs monoéthers, polyalkylglycols, sucres divers. Ces gels peuvent ensuite être utilisés soit sous forme pure, soit sous forme diluée, ou incorporés dans d'autres gels ou d'autres formes galéniques.The polyol contained in the base gel is preferably glycerin, to which other polyols can be mixed in variable proportions: alkane-diols and their monoethers, polyalkylglycols, various sugars. These gels can then be used either in pure form or in diluted form, or incorporated into other gels or other dosage forms.
Exemple n° 1 :Example 1:
Gel pur: % (P/P)Pure gel:% (W / W)
Glycérine 65Glycerin 65
Eau 34 polyacrylate de sodium 1.Water 34 sodium polyacrylate 1.
Ceci représente le type de gel poly(méth)acrylate de base. Il peut être reformulé pour des applications particulières, par exemple comme suit:
Exemple n° 2:This represents the type of basic poly (meth) acrylate gel. It can be reformulated for specific applications, for example as follows: Example 2:
Gel amélioré:Improved gel:
Glycérine 55Glycerin 55
1 ,2-Octanediol 31, 2-Octanediol 3
Ethoxydiglycol 20Ethoxydiglycol 20
Polyacrylate 1Polyacrylate 1
Eau qsp. 100Water qs. 100
Avec ces gels de base on peut formuler de;With these basic gels one can formulate;
Exemple n° 3:Example 3:
Gel formulé:Formulated gel:
CarbopolR 934 (Goodrich) 0.2Carbopol R 934 (Goodrich) 0.2
Glyceryl polyacrylate 5Glyceryl polyacrylate 5
Glyceryl polymethacrylate 5Glyceryl polymethacrylate 5
Butylène glycol 5Butylene glycol 5
Ethoxyéthanolacétate 4Ethoxyethanolacetate 4
Ethylhexylglycol 1Ethylhexylglycol 1
Eau qsp 100Water qs 100
Triéthanolamine qsp pH 5.Triethanolamine qs pH 5.
Exemple n° 4Example 4
Carboxy méthyl cellulose 0.5Carboxy methyl cellulose 0.5
Glyceryl polymethacrylate 20Glyceryl polymethacrylate 20
Polyethylene glycol PEG 400 5Polyethylene glycol PEG 400 5
1 ,2 Pentanediol 1.51, 2 Pentanediol 1.5
Sorbitol 10Sorbitol 10
Eau qsp 100Water qs 100
Exemple n° 5Example 5
Carbopol 940 (Goodrich) 0.2Carbopol 940 (Goodrich) 0.2
Glyceryl polyacrylate 15Glyceryl polyacrylate 15
Ethoxydiglycol 4Ethoxydiglycol 4
Octane 1 ,2 diol 1Octane 1, 2 diol 1
Eau qsp 100Water qs 100
Soude (30%) qsp pH 5.5
Ces exemples ne sont pas limitatifs. Le véhicule de base peut être préparé à partir des substances habituellement utilisées pour faire des hydrogels acceptables dans les domaines agro-alimentaires ou pour une application topique (carraghénanes, gommes de xanthane et autres polysaccharides, polyacrylates ou polyméthacrylates et leur dérivés réticulés comme les carbomères, aluminium silicates sodés etc.). Exemples d'applications cosmétiques de ces gels: Exemple n° 6: Le gel de l'exemple n° 5 a été testé pour son activité anti-érythème solaire. Protocole:Soda (30%) qs pH 5.5 These examples are not limitative. The base vehicle can be prepared from the substances usually used to make hydrogels acceptable in the food industry or for topical application (carrageenans, xanthan gums and other polysaccharides, polyacrylates or polymethacrylates and their crosslinked derivatives such as carbomers, aluminum soda silicates etc.). Examples of cosmetic applications of these gels: Example n ° 6: The gel of example n ° 5 was tested for its anti-solar erythema activity. Protocol:
10 personnes volontaires, 6 hommes et 4 femmes, âgées entre 25 et 47 ans, ont participé à l' étude. Ils subissent une irradiation UV simulant une partie du spectre solaire (lampe UVB de 40W ) qui provoque un érythème détectable (2 à 3 DEM). Deux sites choisis sur le dos des panelistes sont ainsi irradiés. Ensuite, un site est traité par I ' application du gel avec léger massage , I ' autre est laissé sans traitement. Un examen clinique (appréciation de la rougeur, sécheresse cutanée) et un examen chromamétrique (mesure chiffrée de la rougeur) sont effectués à différents temps après l ' irradiation. On obtient ainsi des valeurs maximales de notation et une estimation de la durée nécessaire à la disparition de l' érythème. Résultats:10 volunteers, 6 men and 4 women, aged between 25 and 47 years, participated in the study. They undergo UV irradiation simulating part of the solar spectrum (40W UVB lamp) which causes a detectable erythema (2 to 3 DEM). Two sites chosen on the back of the panelists are thus irradiated. Then a site is treated by I application of the gel with light massage, I the other is left untreated. Clinical examination (assessment of redness, dryness) and a chromametric examination (numerical measure of redness) are performed at different times after irradiation. This gives maximum rating values and an estimate of the time required for the disappearance of the rash. Results:
5 heures après l' irradiation, la notation de l ' érythème et la valeur chromamétrique sont à leur maximum. Les sites traités avec le gel sont notés en moyenne 45% moins rouge, moins desséchés que les sites non traités. La disparition de tout érythème visible est deux fois plus rapide sur les sites traités au gel de l' exemple n°5 que sur les sites non traités. Exemple n° 7:5 hours after the irradiation, the notation of the erythema and chromametric value are at their maximum. The sites treated with the gel are noted on average 45% less red, less dried out than the untreated sites. The disappearance of all visible rash is two times faster on treated sites in Gel Example No. 5 as the untreated sites. Example 7:
Traitement buccal 30 personnes diagnostiquées avec soit une hypersensibilité des gencives, soit une sécheresse de la bouche, soit des aphtes, soit des plaques dentaires, soit des problèmes de déchaussement (parodontose légère) ont participé à l' étude.
Elles sont réparties sur 2 groupes de 15 personnes. Après l' examen clinique par le stomatologue, les deux groupes reçoivent un dentifrice spécialement formulé pour le test; l' un contenant 15% du gel de l' exemple n° 2, l 'autre - sans gel - étant le placebo. Les panelistes utilisent le dentifrice deux fois par jour, matin et soir, après le repas, pendant 4 semaines.Oral treatment 30 people diagnosed with either gum hypersensitivity, a dry mouth or mouth ulcers or dental plates or loosening problems (mild periodontitis) participated in the study. They are divided into 2 groups of 15 people. After clinical examination by the stomatologist, the two groups receive a toothpaste specially formulated for the test; one containing 15% of the gel of Example No. 2, the other - without gel - being placebo. The panelists use the toothpaste twice a day, morning and evening, after the meal, for 4 weeks.
Après cette période, un nouvel examen clinique est effectué, les états des affections sont notés sur des échelles analogiques.After this period, a new clinical examination is carried out, the states of the affections are noted on analog scales.
Alors que dans le groupe recevant le dentifrice placebo, on ne constate que de légères améliorations (partiellement dues à une hygiène buccale plus régulière), les personnes ayant utilisé le dentifrice contenant le gel manifestent une amélioration très nette des symptômes: disparition de sécheresse, diminution des saignements lors du brossage, guérison rapide des aphtes. L'action bénéfique du gel (grâce à son pouvoir hydratant et antimicrobien) a été très fortement appréciée et confirmée par cette étude clinique. Ces exemples ne sont pas limitatifs. L'homme de l'art peut formuler des produits selon les besoins de l'application en incorporant le gel de type glyceryl poly(méth)acrylate dans toute forme galénique adaptée. Les applications possibles de ces gels incluent: les produits cosmétiques et dermopharmaceutiques dits " solaires " et " après solaires ", les pâtes et gels dentifrices, les bains de bouche sans que cette liste soit limitative.While in the group receiving the placebo toothpaste, there are only slight improvements (partially due to more regular oral hygiene), people who have used the toothpaste containing the gel show a very clear improvement in symptoms: disappearance of dryness, reduction bleeding when brushing, rapid healing of canker sores. The beneficial action of frost (due to its moisturizing and antimicrobial potency) was very much appreciated and confirmed by this clinical study. These examples are not limitative. Those skilled in the art can formulate products according to the needs of the application by incorporating the glyceryl poly (meth) acrylate type gel in any suitable dosage form. Possible applications of these gels include: cosmetic and dermopharmaceutical products called "sun" and "after sun", toothpaste pastes and gels, mouthwashes without this list being exhaustive.
Les gels glyceryl poly(méth)acrylates objets du présent brevet peuvent être utilisés dans toute forme galénique employée en cosmétique ou en dermopharmacie ou hygiène dentaire pour application locale sur la peau, les muqueuses, la bouche: solutions aqueuses, émulsions H/E et E/H, laits, lotions, gels, pommades, savons, sticks, sprays, cataplasmes, pansements, sans que cette liste soit limitative.The glyceryl poly (meth) acrylate gels which are the subject of this patent can be used in any dosage form used in cosmetics or dermopharmacy or dental hygiene for local application on the skin, mucous membranes, mouth: aqueous solutions, O / W and E emulsions / H, milks, lotions, gels, ointments, soaps, sticks, sprays, poultices, dressings, without this list being exhaustive.
La concentration d'utilisation de ces gels de type glycerylpoly(meth)acrylate objets du présent brevet peut varier entre 1 et 100% (p/p) selon l'application. Une réalisation particulièrement intéressante de l'invention est le gel qui est composé de glycérine (40-70% p/p), d'eau (10-50% p/p), de 1 ,2-octanediol (0.1 à 10% p/p), de polyéthylèneglycol (0.1 à 30% p/p) et de polyacrylate ou polymethacrylate neutralisé (0.1 à 5%).
Les gels de type glyceryl poly(méth)acrylate objets du présent brevet peuvent être combinés dans les compositions cosmétiques ou dermopharmaceutiques avec tout autre ingrédient habituellement utilisé dans ce domaine: lipides d'extraction et/ou de synthèse, polymères gélifiants et viscosants, tensioactifs et émulsifiants, principes actifs hydro- ou liposolubles, vitamines, extraits de plantes, extraits tissulaires, extraits marins, alcools et polyols, adoucissants, agents anti -microbiens..The concentration of use of these glycerylpoly (meth) acrylate type gels which are the subject of this patent can vary between 1 and 100% (w / w) depending on the application. A particularly interesting embodiment of the invention is the gel which is composed of glycerin (40-70% w / w), water (10-50% w / w), 1, 2-octanediol (0.1 to 10% w / w), polyethylene glycol (0.1 to 30% w / w) and neutralized polyacrylate or polymethacrylate (0.1 to 5%). The glyceryl poly (meth) acrylate type gels which are the subject of this patent can be combined in cosmetic or dermopharmaceutical compositions with any other ingredient usually used in this field: extraction and / or synthetic lipids, gelling and viscosifying polymers, surfactants and emulsifiers, water- or fat-soluble active ingredients, vitamins, plant extracts, tissue extracts, marine extracts, alcohols and polyols, softeners, anti-microbial agents, etc.
Ces compositions contenant les gels de type glyceryl poly(méth)acrylate objets du présent brevet peuvent donc être destinées aux traitements et à la prévention des brûlures " coup de soleil ", des érythèmes et/ou oedèmes solaires, ainsi qu' à la prévention et le traitement des affections buccales (sécheresse, aphtes, plaques dentaires, parodontoses légères, irritations, gonflements, déchaussements).
These compositions containing the glyceryl poly (meth) acrylate type gels which are the subject of this patent can therefore be intended for the treatment and prevention of "sunburn" burns, erythemas and / or solar edemas, as well as for the prevention and the treatment of oral diseases (dryness, canker sores, dental plaques, mild periodontoses, irritations, swelling, loosening).
Claims
1. Compositions à usage cosmétique ou dermopharmaceutique pour une application locale, caractérisées en ce qu'elles contiennent au moins un gel de type glyceryl poly(méth)acrylate hydratant et non séchant, composé de glycérine, d'eau et de poly(méth)acrylate et fabriqué de façon à conférer au gel une activité physique (pouvoir osmotique et capacité d'absorption d'eau).1. Compositions for cosmetic or dermopharmaceutical use for local application, characterized in that they contain at least one gel of the hydrating and non-drying glyceryl poly (meth) acrylate type, composed of glycerin, water and poly (meth) acrylate and manufactured in such a way as to give the gel physical activity (osmotic power and water absorption capacity).
2. Compositions à usage cosmétique ou dermopharmaceutique pour une application locale selon la revendication 1 , caractérisées en ce qu'elles contiennent en outre au moins un autre polyol choisi parmi les alcane- diols, les monoéthers des alcane-diols, les polyalkylglycols.2. Compositions for cosmetic or dermopharmaceutical use for local application according to claim 1, characterized in that they additionally contain at least one other polyol chosen from alkane diols, monoethers of alkane diols, polyalkylglycols.
3. Compositions à usage cosmétique ou dermopharmaceutique pour une application locale selon les revendications 1 ou 2, caractérisées en ce qu'elles contiennent le gel à une concentration qui varie entre 1 et 100%.3. Compositions for cosmetic or dermopharmaceutical use for local application according to claims 1 or 2, characterized in that they contain the gel at a concentration which varies between 1 and 100%.
4. Compositions à usage cosmétique ou dermopharmaceutique pour une application locale selon l'une quelconque des revendications de 1 à 3, caractérisées en ce que le gel est composé de glycérine (40-70% p/p), d'eau (10-50% p/p), de 1 ,2-octanediol (0.1 à 10% p/p), de polyéthylèneglycol (0.1 à 30% p/p) et de polyacrylate ou polymethacrylate neutralisé (0.1 à 5%).4. Compositions for cosmetic or dermopharmaceutical use for local application according to any one of claims 1 to 3, characterized in that the gel is composed of glycerin (40-70% w / w), water (10- 50% w / w), 1, 2-octanediol (0.1 to 10% w / w), polyethylene glycol (0.1 to 30% w / w) and neutralized polyacrylate or polymethacrylate (0.1 to 5%).
5. Compositions à usage cosmétique ou dermopharmaceutique pour une application locale selon l'une quelconque des revendications de 1 à 4, caractérisées en ce que le gel est utilisé dans toute forme galénique employée en cosmétique, dermopharmacie ou hygiène buccale pour application locale sur la peau, les muqueuses, la bouche: solutions aqueuses, émulsions H/E et E/H, laits, lotions, gels, pommades, savons, sticks, sprays, cataplasmes, pansements. 5. Compositions for cosmetic or dermopharmaceutical use for local application according to any one of claims 1 to 4, characterized in that the gel is used in any galenical form used in cosmetics, dermopharmacy or oral hygiene for local application on the skin , mucous membranes, mouth: aqueous solutions, O / W and W / O emulsions, milks, lotions, gels, ointments, soaps, sticks, sprays, poultices, dressings.
6. Compositions à usage cosmétique ou dermopharmaceutique pour une application locale selon l'une quelconque des revendications de 1 à 5, caractérisées en ce qu'elles contiennent en outre tout autre ingrédient habituellement utilisé dans ce domaine: lipides d'extraction et/ou de synthèse, polymères gélifiants et viscosants, tensioactifs et émulsifiants, principes actifs hydro- ou liposolubles, vitamines, extraits de plantes, extraits tissulaires, extraits marins, alcools et polyols, adoucissants, agents anti-microbiens.6. Compositions for cosmetic or dermopharmaceutical use for local application according to any one of claims 1 to 5, characterized in that they also contain any other ingredient usually used in this field: extraction lipids and / or synthesis, gelling and viscosifying polymers, surfactants and emulsifiers, water- or fat-soluble active ingredients, vitamins, plant extracts, tissue extracts, marine extracts, alcohols and polyols, softeners, anti-microbial agents.
7. Utilisation des compositions cosmétiques, dermopharmaceutiques ou d' hygiène buccale préparées selon l'une quelconque des revendications de 1 à 6 pour la prévention et le traitement des brûlures " coup de soleil ", des érythèmes et/ou oedèmes solaires, ainsi qu 'à la prévention et le traitement des affections buccales (sécheresse, aphtes, plaques dentaires, parodontoses légères, irritations, gonflements, déchaussements). 7. Use of the cosmetic, dermopharmaceutical or oral hygiene compositions prepared according to any one of claims 1 to 6 for the prevention and treatment of "sunburn" burns, erythemas and / or solar edemas, as well as prevention and treatment of oral diseases (dryness, canker sores, dental plaques, mild periodontoses, irritations, swelling, loosening).
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU67043/96A AU6704396A (en) | 1996-07-19 | 1996-07-19 | Compositions for treating sunburn and oral hygiene problems |
PCT/FR1996/001198 WO1998003152A1 (en) | 1996-07-19 | 1996-07-19 | Compositions for treating sunburn and oral hygiene problems |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/FR1996/001198 WO1998003152A1 (en) | 1996-07-19 | 1996-07-19 | Compositions for treating sunburn and oral hygiene problems |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998003152A1 true WO1998003152A1 (en) | 1998-01-29 |
Family
ID=9488714
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR1996/001198 WO1998003152A1 (en) | 1996-07-19 | 1996-07-19 | Compositions for treating sunburn and oral hygiene problems |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU6704396A (en) |
WO (1) | WO1998003152A1 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999011237A1 (en) * | 1997-09-01 | 1999-03-11 | The Boots Company Plc | Dermatological compositions |
WO2000074668A1 (en) * | 1999-06-08 | 2000-12-14 | Ravi Shrivastava | Non-solid composition for local application |
US6296858B1 (en) | 1998-02-12 | 2001-10-02 | L'oreal | Cosmetic composition comprising an aqueous dispersion of film-forming polymer particles containing 1,2-pentanediol |
WO2002062331A1 (en) * | 2001-01-16 | 2002-08-15 | Hans Brinch Lyster | Cyanoacrylate compositions for prophylactic or therapeutic treatment of diseases manifesting themselves in and/or damaging cutaneous tissue |
FR2981846A1 (en) * | 2011-10-28 | 2013-05-03 | Sensient Cosmetic Technologies | Aqueous pigment dispersion, useful as cosmetic composition including make-up foundation, mascara or eyeliner, comprises pigment comprising metallic oxide, suspending agent, dispersing agent e.g. citric acid, and water and glycerin |
WO2018212771A1 (en) * | 2017-05-17 | 2018-11-22 | Colgate-Palmolive Company | Oral care compositions and methods of use |
WO2020144380A1 (en) * | 2019-01-11 | 2020-07-16 | Biopass | Product for the treatment of dysbioses |
US11957778B2 (en) | 2017-05-17 | 2024-04-16 | Colgate-Palmolive Company | Oral care compositions and methods of use |
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US4837019A (en) * | 1986-08-11 | 1989-06-06 | Charles Of The Ritz Group Ltd. | Skin treatment composition and method for treating burned skin |
US4863725A (en) * | 1982-10-27 | 1989-09-05 | Deckner George E | Novel clear oil-free moisturizer composition |
EP0332501A1 (en) * | 1988-03-01 | 1989-09-13 | LABORATOIRES Dr. N.G. PAYOT | Use of polyacrylate polymers as stabilizing agents of dispersions constituted of a water-insoluble phase in an aqueous phase, dispersions obtained, and their preparation |
FR2694189A1 (en) * | 1992-07-30 | 1994-02-04 | Sederma Sa | A process for raising viscosity of cosmetic - by incorporating polyglyceryl methacrylate gel and soln. of polyacrylic-methacrylic acid, with synergistic effect |
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WO1996039118A1 (en) * | 1995-06-06 | 1996-12-12 | Sederma S.A. | Slimming cosmetic compositions |
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- 1996-07-19 AU AU67043/96A patent/AU6704396A/en not_active Abandoned
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US4863725A (en) * | 1982-10-27 | 1989-09-05 | Deckner George E | Novel clear oil-free moisturizer composition |
US4837019A (en) * | 1986-08-11 | 1989-06-06 | Charles Of The Ritz Group Ltd. | Skin treatment composition and method for treating burned skin |
EP0332501A1 (en) * | 1988-03-01 | 1989-09-13 | LABORATOIRES Dr. N.G. PAYOT | Use of polyacrylate polymers as stabilizing agents of dispersions constituted of a water-insoluble phase in an aqueous phase, dispersions obtained, and their preparation |
FR2694189A1 (en) * | 1992-07-30 | 1994-02-04 | Sederma Sa | A process for raising viscosity of cosmetic - by incorporating polyglyceryl methacrylate gel and soln. of polyacrylic-methacrylic acid, with synergistic effect |
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WO1996039118A1 (en) * | 1995-06-06 | 1996-12-12 | Sederma S.A. | Slimming cosmetic compositions |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999011237A1 (en) * | 1997-09-01 | 1999-03-11 | The Boots Company Plc | Dermatological compositions |
AU738015B2 (en) * | 1997-09-01 | 2001-09-06 | Reckitt & Colman (Overseas) Limited | Dermatological compositions |
US6296858B1 (en) | 1998-02-12 | 2001-10-02 | L'oreal | Cosmetic composition comprising an aqueous dispersion of film-forming polymer particles containing 1,2-pentanediol |
WO2000074668A1 (en) * | 1999-06-08 | 2000-12-14 | Ravi Shrivastava | Non-solid composition for local application |
US6964783B1 (en) | 1999-06-08 | 2005-11-15 | Naturveda | Non-solid composition for local application |
WO2002062331A1 (en) * | 2001-01-16 | 2002-08-15 | Hans Brinch Lyster | Cyanoacrylate compositions for prophylactic or therapeutic treatment of diseases manifesting themselves in and/or damaging cutaneous tissue |
FR2981846A1 (en) * | 2011-10-28 | 2013-05-03 | Sensient Cosmetic Technologies | Aqueous pigment dispersion, useful as cosmetic composition including make-up foundation, mascara or eyeliner, comprises pigment comprising metallic oxide, suspending agent, dispersing agent e.g. citric acid, and water and glycerin |
WO2018212771A1 (en) * | 2017-05-17 | 2018-11-22 | Colgate-Palmolive Company | Oral care compositions and methods of use |
CN110636887A (en) * | 2017-05-17 | 2019-12-31 | 高露洁-棕榄公司 | Oral care compositions and methods of use |
AU2017414704B2 (en) * | 2017-05-17 | 2020-12-10 | Colgate-Palmolive Company | Oral care compositions and methods of use |
RU2738847C1 (en) * | 2017-05-17 | 2020-12-17 | Колгейт-Палмолив Компани | Oral care compositions and methods for use thereof |
US11957778B2 (en) | 2017-05-17 | 2024-04-16 | Colgate-Palmolive Company | Oral care compositions and methods of use |
WO2020144380A1 (en) * | 2019-01-11 | 2020-07-16 | Biopass | Product for the treatment of dysbioses |
FR3091650A1 (en) * | 2019-01-11 | 2020-07-17 | Biopass | PRODUCT FOR THE TREATMENT OF DYSBIOSES |
Also Published As
Publication number | Publication date |
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AU6704396A (en) | 1998-02-10 |
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