WO1998002138A1 - Desiccant composition, in emulsion form, for the skin - Google Patents
Desiccant composition, in emulsion form, for the skin Download PDFInfo
- Publication number
- WO1998002138A1 WO1998002138A1 PCT/BR1997/000027 BR9700027W WO9802138A1 WO 1998002138 A1 WO1998002138 A1 WO 1998002138A1 BR 9700027 W BR9700027 W BR 9700027W WO 9802138 A1 WO9802138 A1 WO 9802138A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- skin
- agent
- weight
- composition
- desiccant
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
Definitions
- the present invention refers to a desiccant composition for the skin, to collaborate in skin reconstitution in event of lesions, for example, produced by acne, reducing the local inflammatory process, regulating vascularization, fighting against harmful microorganisms and accelerating the cicatrization with no antiaesthetic marks.
- This composition for skin treatment is presented in form of an oil-in- water emulsion, which acts as vehicle to the dissolution, respectively, dispersion of the composition's active principles, and also of complementary agents, which are adjuvants or additives, usually, of conventional use in these type of cosmetic compositions.
- the active principles of the present composition are the ones which are going to actuate over the skin, respectively with desiccation, renovating, moisturizing, anti-inflammatory, and antiseptic functions, and as permeability regulating agent of the capillary system responsible for permeability regulation.
- these agents and active principles comprise:
- Desiccant agents generally applied through the association of two mineral desiccants, chosen, by one side, among the absorbing clays group, specially kaolin, and, by the other side, an activated titanium dioxide (TiO 2 ) of fine granularity, which can be derived either from the rutile form or from the anatase form, which are crystallographic varieties of the Ti0 2 .
- These desiccants act through adsorption and absorption, removing the oiliness excess of the skin's sebaceous glands secretions in the affected area and, consequently, accelerating skin reconstitution in this same area.
- the added ratio corresponds to 5,000 to 20,000% of kaolin and 1 ,000 to 15,000%, by weight, of Ti0 2 .
- a renovating or restoring agent for the skin tissues, favoring cellular proliferation which is allantoin, a glyoxylic acid diureide. This specific agent also calms down irritations and equalizes skin's roughness and is added in a 0,050 to 0,500%, by weight, ratio.
- An agent with simultaneous moisturizing and anti-inflammatory actions which, by choice, is panthenol, or better, D-panthenol, which exerts a moisturizing action and stimulates epithelium restoration, acting as superficial skin cicatrizant. Its ratio is of 0,100 to 5,000, by weight, in relation to the global composition.
- a cooperative cicatrization agent natural, namely a calendula extract, which, besides being cicatrizant, has an invigorating and cellular stimulation action, acting specifically as protective and restoring agent for the tissues.
- the added ratio corresponds to 0,100 to 5,000%, by weight, in relation to the composition.
- a specific antiseptic agent which is benzalconial chloride, a well know quaternary ammonium compound, with local anti-microbial and antiseptic action and skin's surface preserver. Is added in a 0,050 to 0,300%, by weight, ratio.
- a cooperative anti-inflammatory agent constituted of bisabolol, which has an anti-phlogistic action, reducing dermal tumefactions and irritations, and is added in a 0,500 to 5,000%, by weight, ratio
- a capillary permeability regulation agent which is rutin, a vitamin P derivative. Rutin normalizes capillary permeability through vasoconstrictive action, inhibits the abnormal liquid accumulation in the derma and protects against skin lesions, produced due to allergic reactions. Is added in a 0,001 to 0,050%, by weight, ratio.
- the above mentioned active substances are formulated in form of an oil-in-water type formulation, which maintains the insoluble solids in suspension, particularly the desiccant agents, usually with the help of usual additives, conventional in this type of cosmetic compositions. These additives comprise:
- a vehicle whose base is water, in which lipophile components of the composition itself will be emulsified, eventually with the addition of a compatible oil, conventional in liquid cosmetic preparations.
- This vehicle constitutes composition's 30,00 to 60,00%, by weight, serving as dispersion and/or suspension medium for the other components.
- An usual preservative chosen among the group comprising parabens, thiazolidines, imidazolidinyl urea, diazolidinyl urea, formaldehyde and formaldehyde derivatives, benzoic acid and derivatives, specially the lower alkyl esters of para-oxybenzoic acids, quatemium 15, phenoxyethanol, 2-bromo-2-nitropropane, 1 ,3-diol, added in ratio varying between 0,10 and 1 ,00%, by weight, in relation to the global composition.
- An emollient chosen among the group comprising the fatty esters, specially isopropyl isostearate, isobutyl palmitate, isocetyl stearate, octyl palmitate, isopropyl laurate, cetyl lactate, isopropyl linoleate, the palmitic acid itself, oleic acid, octadecanol, behenyl alcohol, cetyl palmitate, octyl isostearate, isopropyl stearate, glyceryl stearates, ethylene glycol stearate, alkyl benzoates and oxybenzoates, white pure mineral oil, lanolin alcohols and their derivatives, either esterified or etherified, waxes and refined vegetable oils, silicones and their derivatives, as well as a mixture of the above mentioned substances, in a 1 ,00 to 20,00%, by weight, ratio.
- An emulgator with the function of helping the formation of an oil-in-water type emulsion, in which the solid insoluble components will remain dispersed, either as discrete particles or as droplets, in the event of hydrophobic substances, usually oily.
- the emulgators are added in a 0,10 to 5,00%, by weight, ratio, and are(is) chosen among the sorbitan, glycerol, waxes and phosphated fatty amines derivatives, acrylic polymers and their salts, polyoxiethylenes, polyethylene glycols and their derivatives, ethoxylated fatty alcohols, ethoxylated fatty acids, with or without neutralization with mineral or organic bases.
- a thickener is added in a 0,10 to 15,00%, by weight, ratio.
- the thickeners are, by themselves, well known, and can be organic, as gums, usually vegetable, starches and modified starches, cellulose derivatives, as cellulose esters or ethers, hydrophilic fatty alcohols, polyethylene glycol stearates, alkyl aryl ammonium compounds, and hydrophilic, vinyl and acrylic polymers, or be mineral, as modified aluminium and magnesium silicates, esmectites, hydrated aluminum silicates, and mixtures of two or more of the above mentioned substances.
- the pigments used in the present invention are inorganic, as iron oxides, titanium dioxide, or compatible organic pigments, according to the state of technique, being added in a 0,10 to 5,00%, by weight, ratio. Their use aims to provide a pleasant color to the composition, without interfering in the desiccant agents action, which do also cooperate with the pigments to promote the final cosmetic color.
- sequestering agents are added with the objective of substance fixation, which, in free state, could interfere in the active components and/or certain adjuvants actuation, or even in the components that can be found in the water used to prepare the formulation.
- the sequestering agents are added in a 0,05 to 0,50%, by weight, ratio in relation to the composition and, usually, comprise ethylene diamino tetraacetic acid (EDTA) and its salts, ethydronic acid, deferrioxamine, lactoferrine.
- EDTA ethylene diamino tetraacetic acid
- the composition can also comprise humectant agents, added to diminish the interfacial tension of the solid or hydrophobic components in contact with water or other aqueous medium. These can be glycerol, glycol, sorbitol derivatives, hydrosoluble silicones and other humectants having surfactant properties, in a ratio varying between 5,00 and 20,00%, by weight, in relation to the global composition. Manufacturing Process
- the present desiccant emulsion, pigmented is manufactures through usual cosmetic processing techniques. Some special care should be taken to obtain a good disposition of the components insoluble in water or in the aqueous medium.
- the solid desiccant components and the pigments should be previously wetted and very well disposed in an adequate liquid, compatible with the emulsion, prepared separately.
- the dispersion of these insoluble components is done in an adequate equipment, in other words, in a micronizer, colloid mills and others, already conventional.
- the emulsion constituted of an aqueous phase, dispersant, and an oily phase, dispersed, should be previously homogenized and heated at 80°C. After that, it is possible to perform the final emulsification, and stabilization, through the action of the emulsifying additive. Then, the dispersion containing the solid components and, eventually, the other thermostable components, are added. The product is then cooled down to 45°C, or room temperature, for the incorporation of the thermosensitive components, followed by final mechanical homogenization. Examples
- the first step is the solids wetting, comprising 10,50% of kaolin, 7,50% of titanium dioxide and 0,5% of micronized basic iron oxide, in an adequate water quantity, containing 3,00% of usual emulsifying agent, as ethoxylated cetyl alcohol with 10-15 EO/mol.
- aqueous vehicle which totalizes 60,00%
- the other components are dissolved/dispersed, namely, 0,28% of allantoin, 1 ,00% of panthenol, 1 ,00% of calendula extract, 0,10% of benzalconial chloride, 0,60% of bisabolol and 0,02% of rutin, as well as 0,30% of methyl/isopropyl paraben, as preservative, 3,20% of an emollient, isopropyl linoleate, and 12,00% of an humectant, hydrosoluble silicone.
- the last mentioned components can only be added to a fraction of the aqueous vehicle, first adding the humectant and then the other complements through stirring and, at last, the remaining quantity of vehicle, performing, at last, the incorporation of the solids dispersion, previously prepared, through homogenization.
- Example 3 The example 1 is repeated, but half of the quantity of humectant is added in the previous solids dispersion and the other half quantity of humectant is added in the remaining aqueous vehicle and complements.
- Example 3 The example 1 is repeated, but half of the quantity of humectant is added in the previous solids dispersion and the other half quantity of humectant is added in the remaining aqueous vehicle and complements.
- the example 1 is repeated, adding the complete quantity, 12,00%, of humectant agent in the previous solids dispersion and using the total quantity of emulsifying agent, 3,00%, to emulsify the non-solid portion of the complementary components in the remaining vehicle.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI9603084-4 | 1996-07-12 | ||
BR9603084A BR9603084A (pt) | 1996-07-12 | 1996-07-12 | Composição secativa em forma de emulsão para a pele |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998002138A1 true WO1998002138A1 (en) | 1998-01-22 |
Family
ID=4064624
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/BR1997/000027 WO1998002138A1 (en) | 1996-07-12 | 1997-07-10 | Desiccant composition, in emulsion form, for the skin |
Country Status (4)
Country | Link |
---|---|
BR (1) | BR9603084A (pt) |
CO (1) | CO5261511A1 (pt) |
PE (1) | PE89598A1 (pt) |
WO (1) | WO1998002138A1 (pt) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000010513A1 (en) * | 1998-08-18 | 2000-03-02 | The Procter & Gamble Company | Cosmetic compositions containing rutile and anatase titanium oxide and emollients |
DE10050155A1 (de) * | 2000-10-11 | 2002-04-18 | Beiersdorf Ag | Kosemtische und dermatologische Zubereitungen mit einem Gehalt an Desferrioxamin |
EP1284601A2 (en) * | 2000-05-12 | 2003-02-26 | Alwyn Company, Inc. | Allantoin-containing skin cream |
FR2844716A1 (fr) * | 2002-09-23 | 2004-03-26 | Marcel Jacques Chicouri | Nouvelles compositions pharmaceutiques destinees notamment a l'hygiene des pieds des diabetiques |
WO2004032963A2 (en) * | 2002-10-04 | 2004-04-22 | Photokinetix Inc. | Photokinetic delivery of biologically active substances using pulsed incoherent light |
EP2172106A1 (en) * | 2000-05-12 | 2010-04-07 | Alwyn Company, Inc. | Allantoin-containing skin cream |
ITMI20091075A1 (it) * | 2009-06-17 | 2010-12-17 | Valetudo Srl | Composizioni farmaceutiche e cosmetiche comprendenti lactoferrina ciclopirox acido etidronico |
US7897144B2 (en) | 2001-02-28 | 2011-03-01 | Johnson & Johnson Comsumer Companies, Inc. | Compositions containing legume products |
US7985404B1 (en) | 1999-07-27 | 2011-07-26 | Johnson & Johnson Consumer Companies, Inc. | Reducing hair growth, hair follicle and hair shaft size and hair pigmentation |
US8039026B1 (en) | 1997-07-28 | 2011-10-18 | Johnson & Johnson Consumer Companies, Inc | Methods for treating skin pigmentation |
US8093293B2 (en) | 1998-07-06 | 2012-01-10 | Johnson & Johnson Consumer Companies, Inc. | Methods for treating skin conditions |
US8106094B2 (en) | 1998-07-06 | 2012-01-31 | Johnson & Johnson Consumer Companies, Inc. | Compositions and methods for treating skin conditions |
US8431550B2 (en) | 2000-10-27 | 2013-04-30 | Johnson & Johnson Consumer Companies, Inc. | Topical anti-cancer compositions and methods of use thereof |
US8877790B2 (en) | 1999-07-23 | 2014-11-04 | Scioderm, Inc. | Allantoin-containing skin cream |
US9095574B2 (en) | 2010-02-02 | 2015-08-04 | Scioderm, Inc. | Methods of treating psoriasis using allantoin |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3330628A1 (de) * | 1983-08-25 | 1985-03-07 | Schülke & Mayr GmbH, 2000 Norderstedt | Hautschutz- und -pflegelotion |
US4749563A (en) * | 1986-12-08 | 1988-06-07 | Charles Of The Ritz Group Ltd. | Moisture-resistant skin treatment compositions |
WO1993008793A1 (en) * | 1991-10-30 | 1993-05-13 | The Boots Company Plc | Toiletries composition |
WO1996017588A1 (de) * | 1994-12-07 | 1996-06-13 | Lancaster Group Gmbh | Kosmetische kaolinhaltige zubereitung |
-
1996
- 1996-07-12 BR BR9603084A patent/BR9603084A/pt unknown
-
1997
- 1997-07-10 CO CO97038625A patent/CO5261511A1/es unknown
- 1997-07-10 WO PCT/BR1997/000027 patent/WO1998002138A1/en active Application Filing
- 1997-07-11 PE PE1997000615A patent/PE89598A1/es not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3330628A1 (de) * | 1983-08-25 | 1985-03-07 | Schülke & Mayr GmbH, 2000 Norderstedt | Hautschutz- und -pflegelotion |
US4749563A (en) * | 1986-12-08 | 1988-06-07 | Charles Of The Ritz Group Ltd. | Moisture-resistant skin treatment compositions |
WO1993008793A1 (en) * | 1991-10-30 | 1993-05-13 | The Boots Company Plc | Toiletries composition |
WO1996017588A1 (de) * | 1994-12-07 | 1996-06-13 | Lancaster Group Gmbh | Kosmetische kaolinhaltige zubereitung |
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8039026B1 (en) | 1997-07-28 | 2011-10-18 | Johnson & Johnson Consumer Companies, Inc | Methods for treating skin pigmentation |
US8106094B2 (en) | 1998-07-06 | 2012-01-31 | Johnson & Johnson Consumer Companies, Inc. | Compositions and methods for treating skin conditions |
US8093293B2 (en) | 1998-07-06 | 2012-01-10 | Johnson & Johnson Consumer Companies, Inc. | Methods for treating skin conditions |
WO2000010513A1 (en) * | 1998-08-18 | 2000-03-02 | The Procter & Gamble Company | Cosmetic compositions containing rutile and anatase titanium oxide and emollients |
US9084780B2 (en) | 1999-07-23 | 2015-07-21 | Scioderm, Inc. | Allantoin-containing skin cream |
US8877788B2 (en) | 1999-07-23 | 2014-11-04 | Scioderm, Inc. | Allantoin-containing skin cream |
US8877790B2 (en) | 1999-07-23 | 2014-11-04 | Scioderm, Inc. | Allantoin-containing skin cream |
US8877789B2 (en) | 1999-07-23 | 2014-11-04 | Scioderm, Inc. | Allantoin-containing skin cream |
US7985404B1 (en) | 1999-07-27 | 2011-07-26 | Johnson & Johnson Consumer Companies, Inc. | Reducing hair growth, hair follicle and hair shaft size and hair pigmentation |
EP1284601A4 (en) * | 2000-05-12 | 2005-02-09 | Alwyn Co Inc | SKIN PROTECTION CREAM CONTAINING ALLANTOIN |
EP2172106A1 (en) * | 2000-05-12 | 2010-04-07 | Alwyn Company, Inc. | Allantoin-containing skin cream |
EP1284601A2 (en) * | 2000-05-12 | 2003-02-26 | Alwyn Company, Inc. | Allantoin-containing skin cream |
DE10050155A1 (de) * | 2000-10-11 | 2002-04-18 | Beiersdorf Ag | Kosemtische und dermatologische Zubereitungen mit einem Gehalt an Desferrioxamin |
US8431550B2 (en) | 2000-10-27 | 2013-04-30 | Johnson & Johnson Consumer Companies, Inc. | Topical anti-cancer compositions and methods of use thereof |
US7897144B2 (en) | 2001-02-28 | 2011-03-01 | Johnson & Johnson Comsumer Companies, Inc. | Compositions containing legume products |
FR2844716A1 (fr) * | 2002-09-23 | 2004-03-26 | Marcel Jacques Chicouri | Nouvelles compositions pharmaceutiques destinees notamment a l'hygiene des pieds des diabetiques |
WO2004032963A3 (en) * | 2002-10-04 | 2004-12-16 | Photokinetix Inc | Photokinetic delivery of biologically active substances using pulsed incoherent light |
WO2004032963A2 (en) * | 2002-10-04 | 2004-04-22 | Photokinetix Inc. | Photokinetic delivery of biologically active substances using pulsed incoherent light |
EP2275104A3 (en) * | 2009-06-17 | 2011-12-21 | Valetudo S.r.l. | Pharmaceutical and cosmetic composition including lactoferrin, ciclopirox and etidronic acid |
ITMI20091075A1 (it) * | 2009-06-17 | 2010-12-17 | Valetudo Srl | Composizioni farmaceutiche e cosmetiche comprendenti lactoferrina ciclopirox acido etidronico |
US9095574B2 (en) | 2010-02-02 | 2015-08-04 | Scioderm, Inc. | Methods of treating psoriasis using allantoin |
US9339492B1 (en) | 2010-02-02 | 2016-05-17 | Scioderm, Inc. | Methods of treating psoriasis using allantoin |
Also Published As
Publication number | Publication date |
---|---|
BR9603084A (pt) | 1998-05-05 |
CO5261511A1 (es) | 2003-03-31 |
PE89598A1 (es) | 1998-12-16 |
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