WO1997048813B1 - Gene i activant le recepteur du facteur de croissance des fibroblastes, compositions et procedes connexes - Google Patents
Gene i activant le recepteur du facteur de croissance des fibroblastes, compositions et procedes connexesInfo
- Publication number
- WO1997048813B1 WO1997048813B1 PCT/US1997/010660 US9710660W WO9748813B1 WO 1997048813 B1 WO1997048813 B1 WO 1997048813B1 US 9710660 W US9710660 W US 9710660W WO 9748813 B1 WO9748813 B1 WO 9748813B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nucleic acid
- fragl
- polypeptide
- native
- human
- Prior art date
Links
- 230000004927 fusion Effects 0.000 title claims 8
- 108060006056 PGAP2 Proteins 0.000 title abstract 5
- 102000027757 FGF receptors Human genes 0.000 title 1
- 108091008101 FGF receptors Proteins 0.000 title 1
- 230000003213 activating Effects 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 claims abstract 35
- 150000007523 nucleic acids Chemical class 0.000 claims abstract 35
- 229920001184 polypeptide Polymers 0.000 claims abstract 27
- 241000700159 Rattus Species 0.000 claims abstract 12
- 102000004965 antibodies Human genes 0.000 claims abstract 4
- 108090001123 antibodies Proteins 0.000 claims abstract 4
- 102000027765 FGFR2 Human genes 0.000 claims abstract 3
- 108010081268 Type 2 Fibroblast Growth Factor Receptor Proteins 0.000 claims abstract 3
- 230000002759 chromosomal Effects 0.000 claims abstract 3
- 102000004169 proteins and genes Human genes 0.000 claims abstract 2
- 108090000623 proteins and genes Proteins 0.000 claims abstract 2
- 210000000349 Chromosomes Anatomy 0.000 claims 6
- 102000009465 Growth Factor Receptors Human genes 0.000 claims 6
- 108010009202 Growth Factor Receptors Proteins 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 229920002760 Expressed sequence tag Polymers 0.000 claims 4
- 210000004027 cells Anatomy 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 229920001405 Coding region Polymers 0.000 claims 3
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 230000000295 complement Effects 0.000 claims 3
- 230000001131 transforming Effects 0.000 claims 3
- 238000009396 hybridization Methods 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000007901 in situ hybridization Methods 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 102100000068 PGAP2 Human genes 0.000 abstract 4
- 102000037240 fusion proteins Human genes 0.000 abstract 2
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
Abstract
La présente invention a trait à un nouveau gène appelé FRAG1 ainsi qu'à sa protéine codée. Elle a trait également à une protéine de fusion appelée FGFR2-ROS, formée par remaniement chromosomique du FRAG1 du rat avec le FGFR2. De plus, la présente invention a trait aux procédés de production de la proteine FRAG1, des protéines de fusion connexes, et des anticorps de lutte contre la protéine FRAG1, ainsi qu'aux médicaments et aux procédés connexes d'utilisation de tels acides nucléiques, polypeptides et anticorps.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU34943/97A AU3494397A (en) | 1996-06-18 | 1997-06-18 | Fibroblast growth factor receptor activating gene i and related compositions and methods |
| US09/202,548 US6323316B1 (en) | 1996-06-18 | 1997-06-18 | Fibroblast growth factor receptor activating gene 1 and related compositions and methods |
| US10/993,191 US7297493B2 (en) | 1996-06-18 | 2004-11-18 | Fibroblast growth factor receptor activating gene 1 and related compositions and methods |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2000996P | 1996-06-18 | 1996-06-18 | |
| US60/020,009 | 1996-06-18 |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US09/202,548 A-371-Of-International US6323316B1 (en) | 1996-06-18 | 1997-06-18 | Fibroblast growth factor receptor activating gene 1 and related compositions and methods |
| US09202548 A-371-Of-International | 1997-06-18 | ||
| US09/942,858 Division US6608181B2 (en) | 1996-06-18 | 2001-08-29 | Fibroblast growth factor receptor activating gene I and related compositions and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO1997048813A2 WO1997048813A2 (fr) | 1997-12-24 |
| WO1997048813A3 WO1997048813A3 (fr) | 1998-02-12 |
| WO1997048813B1 true WO1997048813B1 (fr) | 1998-04-30 |
Family
ID=21796262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/010660 WO1997048813A2 (fr) | 1996-06-18 | 1997-06-18 | Gene i activant le recepteur du facteur de croissance des fibroblastes, compositions et procedes connexes |
Country Status (3)
| Country | Link |
|---|---|
| US (4) | US6323316B1 (fr) |
| AU (1) | AU3494397A (fr) |
| WO (1) | WO1997048813A2 (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997048813A2 (fr) | 1996-06-18 | 1997-12-24 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Gene i activant le recepteur du facteur de croissance des fibroblastes, compositions et procedes connexes |
| US6451572B1 (en) | 1998-06-25 | 2002-09-17 | Cornell Research Foundation, Inc. | Overexpression of phytase genes in yeast systems |
| PT2335501T (pt) | 2001-10-31 | 2016-10-28 | Huvepharma Ad | Alimento animal contendo fitase e método |
| EP2083081A1 (fr) | 2005-07-22 | 2009-07-29 | Five Prime Therapeutics, Inc. | Compositions et procédés pour traiter une maladie avec des protéines de fusion FGFR |
| US20070144800A1 (en) * | 2005-11-30 | 2007-06-28 | Stone Kevin T | System and method for braking resistor supplemental heating |
| ES2683846T3 (es) * | 2006-01-20 | 2018-09-28 | Cell Signaling Technology, Inc. | ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano |
| EP2046384A4 (fr) * | 2006-06-15 | 2009-12-02 | Fibron Ltd | Anticorps bloquant l'activation du récepteur du facteur de croissance des fibroblastes et leurs procédés d'utilisation |
| WO2008017066A2 (fr) | 2006-08-03 | 2008-02-07 | Cornell Research Foundation, Inc. | Phytases présentant une stabilité thermique améliorée |
| BRPI0916904A2 (pt) | 2008-08-04 | 2016-10-11 | Fiveprime Therapeutics Inc | polipeptídeos, moléculares de fusão ecd fgfr4, composições farmacêuticas, polinucleotídio e métodos de tratamento de desordem angiogênica, câncer em paciente e degeneração macular em paciente e respectivos usos |
| DK2365828T3 (en) | 2008-11-07 | 2014-12-08 | Galaxy Biotech Llc | Monoclonal antibodies against fibroblast second |
| PL2498799T3 (pl) | 2009-11-13 | 2017-03-31 | Five Prime Therapeutics, Inc. | Zastosowanie białek domeny zewnątrzkomórkowej FGFR1 do leczenia nowotworów charakteryzujących się mutacjami aktywującymi zależnymi od ligandów w FGFR2 |
| US8685931B2 (en) | 2009-12-17 | 2014-04-01 | Five Prime Therapeutics, Inc. | Hair growth methods using FGFR3 extracellular domains |
| US8481038B2 (en) | 2010-11-15 | 2013-07-09 | Five Prime Therapeutics, Inc. | Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins |
| US10016484B2 (en) | 2011-11-14 | 2018-07-10 | Five Prime Therapeutics, Inc. | Methods of treating lung cancer |
| EP4036118A1 (fr) | 2013-08-01 | 2022-08-03 | Five Prime Therapeutics, Inc. | Anticorps anti-fgfr2iiib non fucosilés |
| CA3004794A1 (fr) | 2015-11-23 | 2017-06-01 | Five Prime Therapeutics, Inc. | Inhibiteurs de fgfr2 seuls ou en combinaison avec des agents de stimulation immunitaire dans le traitement du cancer |
| BR112019023898A2 (pt) | 2017-05-16 | 2020-06-09 | Five Prime Therapeutics Inc | método para tratamento de câncer gástrico, uso de um anticorpo e composição |
| CN108949768B (zh) * | 2018-04-28 | 2021-09-07 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 一种用于诊断和/或治疗骨肉瘤的RAB22A-NoeFs融合基因系及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0529076B1 (fr) | 1990-04-27 | 1995-12-06 | Takeda Chemical Industries, Ltd. | Proteines presentant une activite de recepteur de facteur de croissance de fibroblaste |
| WO1994000599A2 (fr) | 1992-06-18 | 1994-01-06 | Whittier Institute For Diabetes And Endocrinology | Procede de detection des maladies neoplasiques |
| WO1997048813A2 (fr) | 1996-06-18 | 1997-12-24 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Gene i activant le recepteur du facteur de croissance des fibroblastes, compositions et procedes connexes |
-
1997
- 1997-06-18 WO PCT/US1997/010660 patent/WO1997048813A2/fr active Application Filing
- 1997-06-18 AU AU34943/97A patent/AU3494397A/en not_active Abandoned
- 1997-06-18 US US09/202,548 patent/US6323316B1/en not_active Expired - Lifetime
-
2001
- 2001-08-29 US US09/942,858 patent/US6608181B2/en not_active Expired - Lifetime
-
2003
- 2003-06-12 US US10/461,180 patent/US6831170B2/en not_active Expired - Lifetime
-
2004
- 2004-11-18 US US10/993,191 patent/US7297493B2/en not_active Expired - Lifetime
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