WO1997040165B1 - Nouveaux produits de construction d'adn de cytomegalovirus humain, et leurs utilisations - Google Patents
Nouveaux produits de construction d'adn de cytomegalovirus humain, et leurs utilisationsInfo
- Publication number
- WO1997040165B1 WO1997040165B1 PCT/US1997/006866 US9706866W WO9740165B1 WO 1997040165 B1 WO1997040165 B1 WO 1997040165B1 US 9706866 W US9706866 W US 9706866W WO 9740165 B1 WO9740165 B1 WO 9740165B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- immunogenic composition
- pδrc
- group
- hcmv
- human cytomegalovirus
- Prior art date
Links
- 229920003013 deoxyribonucleic acid Polymers 0.000 title claims abstract 12
- 241000701024 Human betaherpesvirus 5 Species 0.000 title claims 12
- 230000028993 immune response Effects 0.000 claims abstract 4
- 102000004169 proteins and genes Human genes 0.000 claims abstract 3
- 108090000623 proteins and genes Proteins 0.000 claims abstract 3
- 230000002163 immunogen Effects 0.000 claims 20
- 239000000427 antigen Substances 0.000 claims 6
- 102000038129 antigens Human genes 0.000 claims 6
- 108091007172 antigens Proteins 0.000 claims 6
- 239000000969 carrier Substances 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 2
- 206010011831 Cytomegalovirus infection Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 210000002845 Virion Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000003362 replicative Effects 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 229960005486 vaccines Drugs 0.000 abstract 1
Abstract
L'invention concerne des molécules d'ADN nouvelles servant à exprimer in vitro et in vivo le complexe gB du cytomégalovirus humain et des dérivés du complexe gB dont la transmembrane a été supprimée, tels que les protéines pp65, pp150 et IE-exon-4. Ces molécules sont de préférence des plasmides. L'invention concerne également des procédés d'utilisation de ces molécules d'ADN de façon à induire des réponses immunitaires en réaction au cytomégalovirus humain, et l'utilisation d'un plasmide de la présente invention, qui sert à amorcer des réponses immunitaires lors de l'administration de vaccins contre le cytomégalovirus humain.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/171,699 US6448389B1 (en) | 1996-04-23 | 1997-04-22 | Human cytomegalovirus DNA constructs and uses therefor |
AU28098/97A AU2809897A (en) | 1996-04-23 | 1997-04-22 | Novel human cytomegalovirus dna constructs and uses therefor |
EP97922429A EP0914441A2 (fr) | 1996-04-23 | 1997-04-22 | Nouveaux produits de construction d'adn de cytomegalovirus humain, et leurs utilisations |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1571796P | 1996-04-23 | 1996-04-23 | |
US60/015,717 | 1996-04-23 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/171,699 A-371-Of-International US6448389B1 (en) | 1996-04-23 | 1997-04-22 | Human cytomegalovirus DNA constructs and uses therefor |
US10/223,538 Division US20030120060A1 (en) | 1996-04-23 | 2002-08-19 | Human cytomegalovirus DNA constructs and uses therefor |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1997040165A1 WO1997040165A1 (fr) | 1997-10-30 |
WO1997040165B1 true WO1997040165B1 (fr) | 1998-01-08 |
WO1997040165A9 WO1997040165A9 (fr) | 1998-02-12 |
Family
ID=21773167
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/006866 WO1997040165A1 (fr) | 1996-04-23 | 1997-04-22 | Nouveaux produits de construction d'adn de cytomegalovirus humain, et leurs utilisations |
Country Status (4)
Country | Link |
---|---|
US (2) | US6448389B1 (fr) |
EP (1) | EP0914441A2 (fr) |
AU (1) | AU2809897A (fr) |
WO (1) | WO1997040165A1 (fr) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997040165A1 (fr) | 1996-04-23 | 1997-10-30 | The Wistar Institute Of Anatomy And Biology | Nouveaux produits de construction d'adn de cytomegalovirus humain, et leurs utilisations |
JP2000516617A (ja) | 1996-08-14 | 2000-12-12 | ザ・ウイスター・インステイテユート・オブ・アナトミー・アンド・バイオロジー | アテローム性動脈硬化病変の出現を予防するか又は遅らせるための方法及び組成物 |
US6562345B1 (en) | 1996-11-12 | 2003-05-13 | City Of Hope | Immuno-reactive peptide CTL epitopes of human cytomegalovirus |
US20030039657A1 (en) * | 1999-04-15 | 2003-02-27 | Johnston Stephen Albert | Inducible vaccines |
EP1612217A3 (fr) * | 2000-03-27 | 2006-01-18 | City of Hope | Epitopes ctl peptidiques immunoréactifs du cytomégalovirus |
US6783939B2 (en) * | 2000-07-07 | 2004-08-31 | Alphavax, Inc. | Alphavirus vectors and virosomes with modified HIV genes for use in vaccines |
AU2001271998A1 (en) | 2000-07-13 | 2002-01-30 | The Johns Hopkins University School Of Medicine | Detection and treatment of polycystic kidney disease |
WO2002020811A2 (fr) * | 2000-09-09 | 2002-03-14 | Basf Plant Science Gmbh | Systeme inductible tet modifie permettant la regulation de l'expression genique dans des plantes |
CA2425202C (fr) | 2000-10-20 | 2012-01-03 | City Of Hope | Epitopes ctl peptidiques immunoreactifs du cytomegalovirus pp150 |
CA2460269C (fr) * | 2001-09-06 | 2013-01-15 | Alphavax, Inc. | Systemes de vecteurs a base de replicons alphaviraux |
SI2311848T1 (sl) | 2002-12-23 | 2013-11-29 | Vical Incorporated | Cepiva proti okuĹľbi humanega citomegalovirusa z optimizacijo kodona, ki temeljijo na polinukleotidu |
US7494805B2 (en) * | 2003-02-14 | 2009-02-24 | Biogen Idec Ma Inc. | Expression cassette and vector for transient or stable expression of exogenous molecules |
US20040228842A1 (en) * | 2003-02-27 | 2004-11-18 | Shan Lu | Compositions and methods for cytomegalovirus treatment |
KR101518309B1 (ko) * | 2003-03-20 | 2015-05-08 | 알파벡스, 인크. | 개선된 알파바이러스 레플리콘 및 헬퍼 구축물 |
AU2004257214B2 (en) * | 2003-07-11 | 2010-04-22 | Alphavax, Inc. | Alphavirus-based cytomegalovirus vaccines |
US20080044384A1 (en) * | 2004-06-25 | 2008-02-21 | Medlmmune Vaccines, Inc. | Recombinant Human Cytomegalovirus And Vaccines Comprising Heterologous Antigens |
US7850977B2 (en) * | 2007-06-21 | 2010-12-14 | Alphavax, Inc. | Promoterless cassettes for expression of alphavirus structural proteins |
CN102123732A (zh) | 2008-06-20 | 2011-07-13 | 杜克大学 | 用于引发免疫应答的组合物,方法及试剂盒 |
US8812387B1 (en) | 2013-03-14 | 2014-08-19 | Csidentity Corporation | System and method for identifying related credit inquiries |
WO2015048744A2 (fr) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucléotides codant des polypeptides de modulation immunitaire |
JP6679484B2 (ja) * | 2013-12-11 | 2020-04-15 | ザ ヘンリー エム. ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド | ヒトヘルペスウイルス三量体糖タンパク質B、三量体gBを含むタンパク質複合体、及びワクチンとしてのそれらの使用 |
WO2017070613A1 (fr) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Vaccin contre le cytomégalovirus humain |
RU2616245C2 (ru) * | 2015-12-29 | 2017-04-13 | Сейфаддин Гашим Оглы Марданлы | Композиция для профилактики заболеваний, вызываемых цитомегаловирусной инфекцией |
US10611800B2 (en) | 2016-03-11 | 2020-04-07 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
JP6980780B2 (ja) | 2016-10-21 | 2021-12-15 | モデルナティーエックス, インコーポレイテッド | ヒトサイトメガロウイルスワクチン |
US11629172B2 (en) | 2018-12-21 | 2023-04-18 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
US11857622B2 (en) | 2020-06-21 | 2024-01-02 | Pfizer Inc. | Human cytomegalovirus GB polypeptide |
US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
Family Cites Families (26)
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US3959466A (en) | 1974-04-15 | 1976-05-25 | The Wistar Institute | Highly attenuated cytomegalovirus vaccine and production thereof |
ZA858044B (en) | 1984-11-01 | 1987-05-27 | American Home Prod | Oral vaccines |
US4689225A (en) | 1984-11-02 | 1987-08-25 | Institut Merieux | Vaccine for cytomegalovirus |
CA1335429C (fr) | 1986-03-07 | 1995-05-02 | Geoffrey L. Smith | Procedes de fabrication de glycoproteines hcmv, les anticorps et les vaccins diriges contre ces glycoproteines hcmv, et leurs vecteurs recombinants |
DE3619720A1 (de) | 1986-06-12 | 1987-12-17 | Behringwerke Ag | Hauptglykoprotein des menschlichen cytomegalovirus, seine herstellung und verwendung |
ES2044881T3 (es) * | 1986-06-12 | 1994-01-16 | Behringwerke Ag | Procedimiento para la preparacion de una fosfoproteina estructural (pp 150) del citomegalovirus humano. |
DE3619902A1 (de) | 1986-06-13 | 1988-03-03 | Biotechnolog Forschung Gmbh | Cmv-dna-strukturen, expressionsvektor dafuer, cmv-proteinstrukturen und deren verwendung |
ZA878031B (en) | 1986-11-04 | 1988-04-28 | Scripps Clinic And Research Foundation | Nucleic acid probes for the detection of latent human cytomegalovirus in blood products |
US5153311A (en) | 1986-11-24 | 1992-10-06 | The Children's Hospital, Incorporated | Immunogenic glycoproteins of human cytomegalovirus gCII |
US5124440A (en) | 1986-11-24 | 1992-06-23 | The Childrens Hospital, Inc. | Antibody and T cell recognition sites on glycoproteins comprising the GCI complex of human cytomegalovirus |
EP0277773A1 (fr) | 1987-01-30 | 1988-08-10 | The Board Of Trustees Of The Leland Stanford Junior University | Cytomégalovirus hybride et vaccin |
AU641121B2 (en) | 1988-01-29 | 1993-09-16 | Chiron Corporation | Recombinant CMV neutralizing proteins |
WO1990000062A1 (fr) | 1988-07-01 | 1990-01-11 | The Children's Hospital, Incorporated | Reconnaissance de fragments provenant de cytomegalovirus a l'aide d'anticorps |
WO1990006771A1 (fr) | 1988-12-12 | 1990-06-28 | The Children's Hospital, Incorporated | Fragments proteolytiques obtenus a partir du complexe i de glycoproteines de cytomegalovirus humain |
US5552143A (en) | 1989-03-24 | 1996-09-03 | The Wistar Institute Of Anatomy & Biology | Recombinant cytomegalovirus vaccine |
US5591439A (en) | 1989-03-24 | 1997-01-07 | The Wistar Institute Of Anatomy And Biology | Recombinant cytomegalovirus vaccine |
EP0389286B1 (fr) | 1989-03-24 | 1996-07-10 | The Wistar Institute Of Anatomy And Biology | Vaccin recombinant contre le virus cytomégalo |
WO1991002004A1 (fr) | 1989-08-07 | 1991-02-21 | Children's Biomedical Research Center | GLYCOPROTEINES IMMUNOGENIQUES DU CYTOMEGALOVIRUS HUMAIN gCII |
AU7906691A (en) | 1990-05-23 | 1991-12-10 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Adeno-associated virus (aav)-based eucaryotic vectors |
GB9014652D0 (en) | 1990-07-02 | 1990-08-22 | Wellcome Found | Antigen |
WO1992002628A1 (fr) | 1990-08-02 | 1992-02-20 | Chiron Corporation | Expression de glycoproteine-h de cytomegalovirus humain utilisant le systeme d'expression cellulaire de baculovirus-insectes |
FR2688514A1 (fr) | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
WO1994017810A1 (fr) | 1993-02-12 | 1994-08-18 | The Wistar Institute Of Anatomy And Biology | Vaccin recombine contre le cytomegalovirus |
CA2160583A1 (fr) | 1993-04-16 | 1994-10-27 | Stanley A. Plotkin | Vaccin de type cytomegalovirus recombinant |
IT1266740B1 (it) | 1994-07-01 | 1997-01-14 | Maria Paola Landini | Materiale proteico ricombinante legante anticorpi contro il citomegalovirus umano, reagenti diagnostici derivati da tale |
WO1997040165A1 (fr) | 1996-04-23 | 1997-10-30 | The Wistar Institute Of Anatomy And Biology | Nouveaux produits de construction d'adn de cytomegalovirus humain, et leurs utilisations |
-
1997
- 1997-04-22 WO PCT/US1997/006866 patent/WO1997040165A1/fr not_active Application Discontinuation
- 1997-04-22 US US09/171,699 patent/US6448389B1/en not_active Expired - Lifetime
- 1997-04-22 EP EP97922429A patent/EP0914441A2/fr not_active Withdrawn
- 1997-04-22 AU AU28098/97A patent/AU2809897A/en not_active Abandoned
-
2002
- 2002-08-19 US US10/223,538 patent/US20030120060A1/en not_active Abandoned
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