WO1997040073A3 - BIOLOGISCH AKTIVER EIWEISSSTOFF - KOLLAGENFRAGMENT HF-COLL-18/514cf - ZUR HEMMUNG DES WACHSTUMS VON TUMOREN UND VON GEFÄSSWUCHERUNGEN - Google Patents

BIOLOGISCH AKTIVER EIWEISSSTOFF - KOLLAGENFRAGMENT HF-COLL-18/514cf - ZUR HEMMUNG DES WACHSTUMS VON TUMOREN UND VON GEFÄSSWUCHERUNGEN Download PDF

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Publication number
WO1997040073A3
WO1997040073A3 PCT/EP1997/002012 EP9702012W WO9740073A3 WO 1997040073 A3 WO1997040073 A3 WO 1997040073A3 EP 9702012 W EP9702012 W EP 9702012W WO 9740073 A3 WO9740073 A3 WO 9740073A3
Authority
WO
WIPO (PCT)
Prior art keywords
coll
peptide
profilerations
tumours
capillary
Prior art date
Application number
PCT/EP1997/002012
Other languages
English (en)
French (fr)
Other versions
WO1997040073A2 (de
Inventor
Wolf-Georg Forssmann
Michael Schrader
Ludger Staendker
Manfred Raida
Peter Schulz-Knappe
Original Assignee
Haemopep Pharma Gmbh
Forssmann Wolf Georg
Michael Schrader
Ludger Staendker
Manfred Raida
Schulz Knappe Peter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haemopep Pharma Gmbh, Forssmann Wolf Georg, Michael Schrader, Ludger Staendker, Manfred Raida, Schulz Knappe Peter filed Critical Haemopep Pharma Gmbh
Priority to JP09537737A priority Critical patent/JP2000511511A/ja
Priority to AU27665/97A priority patent/AU2766597A/en
Priority to EP97921682A priority patent/EP0896584A2/de
Publication of WO1997040073A2 publication Critical patent/WO1997040073A2/de
Publication of WO1997040073A3 publication Critical patent/WO1997040073A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Die Erfindung betrifft ein Peptid aus menschlichem Blut, das HF-COLL-18/514cf, das zum Zwecke der diagnostischen, medizinischen und gewerblichen Verwendung als Arzneimittel in seiner Struktur aufgeklärt wurde. Die Isolierung dieses neuartigen Peptides HF-COLL-18/514cf beweist die Existenz des HF-COLL-18/514cf. Die Molekülform des HF-COLL-18/514cf wurde durch Massenspektrometrie und aminoterminale Sequenzierung bewiesen, und daß HF-COLL-18/514cf ein natürliches Peptid darstellt, welches zur Behandlung von zahlreichen Erkrankungen, die mit Störungen des Wachstums von Zellen, insbesondere von Endothelzellen und Gefäßen einhergehen und z.B. bei Krebs benutzt werden sollte. Weiter kann das HF-COLL-18/514cf in reiner Form oder als natürliches Rohextrakt für gewerbliche Zwecke in der Erforschung neuer Zellfunktionen benutzt werden.
PCT/EP1997/002012 1996-04-22 1997-04-22 BIOLOGISCH AKTIVER EIWEISSSTOFF - KOLLAGENFRAGMENT HF-COLL-18/514cf - ZUR HEMMUNG DES WACHSTUMS VON TUMOREN UND VON GEFÄSSWUCHERUNGEN WO1997040073A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP09537737A JP2000511511A (ja) 1996-04-22 1997-04-22 腫瘍成長阻害及び毛細管増殖のための生物学的活性タンパク質、コラーゲンフラグメントＨＦ―ＣＯＬＬ―１８／５１４ｃｆ
AU27665/97A AU2766597A (en) 1996-04-22 1997-04-22 Biologically active protein (collagen fragment hf-coll-18/514cf) for inhibiting the growth of tumours and capillary profilerations
EP97921682A EP0896584A2 (de) 1996-04-22 1997-04-22 BIOLOGISCH AKTIVER EIWEISSSTOFF - KOLLAGENFRAGMENT HF-COLL-18/514cf - ZUR HEMMUNG DES WACHSTUMS VON TUMOREN UND VON GEFÄSSWUCHERUNGEN

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19615710A DE19615710A1 (de) 1996-04-22 1996-04-22 Verfahren zur Gewinnung und Anwendung eines biologisch aktiven Eiweisstoffes - Kollagenfragment HF-COLL-18/514cf - in partiell aufgereinigter und synthetischer Form aus Körperflüssigkeiten zur Beeinflussung des Zellwachstums und der Diagnose von Kollagenerkrankungen sowie der Osteoporose
DE19615710.2 1996-04-22

Publications (2)

Publication Number Publication Date
WO1997040073A2 WO1997040073A2 (de) 1997-10-30
WO1997040073A3 true WO1997040073A3 (de) 1997-12-24

Family

ID=7791888

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/002012 WO1997040073A2 (de) 1996-04-22 1997-04-22 BIOLOGISCH AKTIVER EIWEISSSTOFF - KOLLAGENFRAGMENT HF-COLL-18/514cf - ZUR HEMMUNG DES WACHSTUMS VON TUMOREN UND VON GEFÄSSWUCHERUNGEN

Country Status (5)

Country Link
EP (1) EP0896584A2 (de)
JP (1) JP2000511511A (de)
AU (1) AU2766597A (de)
DE (1) DE19615710A1 (de)
WO (1) WO1997040073A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999048924A1 (en) * 1998-03-24 1999-09-30 The Children's Medical Center Corporation Endostatin derived peptides with anti-angiogenic and anti-cancer activity
WO2000017240A1 (de) * 1998-09-21 2000-03-30 Haemopep Pharma Gmbh Hmw-endostatin zur hemmung des wachstums von tumoren und von gefässwucherungen und zur diagnose von gefäss- und tumorerkrankungen
ITMI20010394A1 (it) * 2001-02-27 2002-08-27 Univ Degli Studi Milano Peptidi ad attivita' antiangiogenica
GB0114419D0 (en) * 2001-06-13 2001-08-08 Mars Uk Ltd Health food
JPWO2004050125A1 (ja) * 2002-12-03 2006-03-30 株式会社高研 腫瘍細胞の増殖及び／又は浸潤の抑制剤

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3633797A1 (de) * 1986-10-03 1988-04-07 Forssmann Wolf Georg Verfahren zur gewinnung von biologisch aktiven eiweissen (peptiden) aus menschlichem und tierischem blut (bzw. anderen koerperfluessigkeiten)
WO1993016716A1 (en) * 1992-02-24 1993-09-02 Northwestern University Method and composition for inhibiting angiogenesis
WO1997015666A1 (en) * 1995-10-23 1997-05-01 The Children's Medical Center Corporation Therapeutic antiangiogenic compositions and methods

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3633797A1 (de) * 1986-10-03 1988-04-07 Forssmann Wolf Georg Verfahren zur gewinnung von biologisch aktiven eiweissen (peptiden) aus menschlichem und tierischem blut (bzw. anderen koerperfluessigkeiten)
WO1993016716A1 (en) * 1992-02-24 1993-09-02 Northwestern University Method and composition for inhibiting angiogenesis
WO1997015666A1 (en) * 1995-10-23 1997-05-01 The Children's Medical Center Corporation Therapeutic antiangiogenic compositions and methods

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
M.S. O'REILLY ET AL.: "Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth", CELL, vol. 88, no. 2, 24 January 1997 (1997-01-24), NA US, pages 277 - 285, XP002044657 *
OH S P ET AL: "CLONING OF CDNA AND GENOMIC DNA ENCODING HUMAN TYPE XVIII COLLAGEN AND LOCALIZATION OF THE ALPHA1(XVIII) COLLAGEN GENE TO MOUSE CHROMOSOME 10 AND HUMAN CHROMOSOME 21", GENOMICS, vol. 19, no. 3, February 1994 (1994-02-01), pages 494 - 499, XP000615991 *
O'REILLY M S ET AL: "Endogenous inhibitors of angiogenesis.", 87TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, WASHINGTON, D.C., USA, APRIL 20-24, 1996. PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING 37 (0). 1996. 669. ISSN: 0197-016X, March 1996 (1996-03-01), XP002022627 *

Also Published As

Publication number Publication date
AU2766597A (en) 1997-11-12
DE19615710A1 (de) 1997-10-23
WO1997040073A2 (de) 1997-10-30
EP0896584A2 (de) 1999-02-17
JP2000511511A (ja) 2000-09-05

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