WO1997030719A1 - Preparations for use in cosmetics and dermatology - Google Patents
Preparations for use in cosmetics and dermatology Download PDFInfo
- Publication number
- WO1997030719A1 WO1997030719A1 PCT/HU1997/000007 HU9700007W WO9730719A1 WO 1997030719 A1 WO1997030719 A1 WO 1997030719A1 HU 9700007 W HU9700007 W HU 9700007W WO 9730719 A1 WO9730719 A1 WO 9730719A1
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- WO
- WIPO (PCT)
- Prior art keywords
- seed
- preparation
- seeds
- treatment
- dry
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 61
- 239000002537 cosmetic Substances 0.000 title claims abstract description 22
- 239000000203 mixture Substances 0.000 claims abstract description 69
- 238000011282 treatment Methods 0.000 claims abstract description 59
- 241000196324 Embryophyta Species 0.000 claims abstract description 38
- 206010000496 acne Diseases 0.000 claims abstract description 37
- 208000002874 Acne Vulgaris Diseases 0.000 claims abstract description 25
- 208000024891 symptom Diseases 0.000 claims abstract description 21
- 235000014647 Lens culinaris subsp culinaris Nutrition 0.000 claims abstract description 18
- 150000002500 ions Chemical class 0.000 claims abstract description 18
- 239000002245 particle Substances 0.000 claims abstract description 18
- 206010039792 Seborrhoea Diseases 0.000 claims abstract description 14
- 230000002265 prevention Effects 0.000 claims abstract description 14
- 239000011148 porous material Substances 0.000 claims abstract description 12
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000006185 dispersion Substances 0.000 claims abstract description 10
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 9
- 239000000194 fatty acid Substances 0.000 claims abstract description 9
- 229930195729 fatty acid Natural products 0.000 claims abstract description 9
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 9
- 239000007788 liquid Substances 0.000 claims abstract description 9
- 238000000746 purification Methods 0.000 claims abstract description 7
- 239000011734 sodium Substances 0.000 claims abstract description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 6
- 235000010666 Lens esculenta Nutrition 0.000 claims abstract description 6
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims abstract description 6
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- 230000002757 inflammatory effect Effects 0.000 claims abstract description 6
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- 229910052742 iron Inorganic materials 0.000 claims abstract description 5
- 230000003902 lesion Effects 0.000 claims abstract description 5
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- 229910052700 potassium Inorganic materials 0.000 claims abstract description 5
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- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims abstract description 4
- 230000008030 elimination Effects 0.000 claims abstract description 4
- 238000003379 elimination reaction Methods 0.000 claims abstract description 4
- 235000021317 phosphate Nutrition 0.000 claims abstract description 4
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- 229910052698 phosphorus Inorganic materials 0.000 claims abstract description 4
- 229910001414 potassium ion Inorganic materials 0.000 claims abstract description 4
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- 238000009472 formulation Methods 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 22
- 239000000654 additive Substances 0.000 claims description 19
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- 208000003251 Pruritus Diseases 0.000 claims description 2
- 235000017276 Salvia Nutrition 0.000 claims description 2
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- 238000009738 saturating Methods 0.000 claims description 2
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- 239000007787 solid Substances 0.000 claims 1
- 241000219739 Lens Species 0.000 abstract description 15
- 240000004322 Lens culinaris Species 0.000 abstract description 7
- 210000003491 skin Anatomy 0.000 description 21
- 239000006071 cream Substances 0.000 description 12
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- 239000004615 ingredient Substances 0.000 description 7
- 210000001732 sebaceous gland Anatomy 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000003086 colorant Substances 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- 239000003921 oil Substances 0.000 description 6
- 235000019198 oils Nutrition 0.000 description 6
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 5
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 5
- 210000004907 gland Anatomy 0.000 description 5
- 238000001802 infusion Methods 0.000 description 5
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- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 5
- 206010037888 Rash pustular Diseases 0.000 description 4
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 4
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
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- AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 description 2
- 235000003880 Calendula Nutrition 0.000 description 2
- 240000001432 Calendula officinalis Species 0.000 description 2
- 229940124091 Keratolytic Drugs 0.000 description 2
- 206010033733 Papule Diseases 0.000 description 2
- 229930046231 Phaseol Natural products 0.000 description 2
- 244000046052 Phaseolus vulgaris Species 0.000 description 2
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 2
- 230000009471 action Effects 0.000 description 2
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- 239000003242 anti bacterial agent Substances 0.000 description 2
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- 238000009835 boiling Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
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- 238000004519 manufacturing process Methods 0.000 description 2
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- 150000003839 salts Chemical class 0.000 description 2
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- 235000011121 sodium hydroxide Nutrition 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 235000007173 Abies balsamea Nutrition 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 241000602336 Anthemis arvensis Species 0.000 description 1
- 240000005528 Arctium lappa Species 0.000 description 1
- 239000004857 Balsam Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- 241000195950 Equisetum arvense Species 0.000 description 1
- 239000005768 Equisetum arvense L. Substances 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 244000044980 Fumaria officinalis Species 0.000 description 1
- 235000006961 Fumaria officinalis Nutrition 0.000 description 1
- 101001091385 Homo sapiens Kallikrein-6 Proteins 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- 244000018716 Impatiens biflora Species 0.000 description 1
- 102100034866 Kallikrein-6 Human genes 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
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- 239000005864 Sulphur Substances 0.000 description 1
- 235000019486 Sunflower oil Nutrition 0.000 description 1
- 244000274883 Urtica dioica Species 0.000 description 1
- 235000009108 Urtica dioica Nutrition 0.000 description 1
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- 150000003841 chloride salts Chemical class 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
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- 208000037893 chronic inflammatory disorder Diseases 0.000 description 1
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- 150000002148 esters Chemical class 0.000 description 1
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- 239000003517 fume Substances 0.000 description 1
- 150000002314 glycerols Chemical class 0.000 description 1
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- 239000011707 mineral Substances 0.000 description 1
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- 230000000116 mitigating effect Effects 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000010461 other edible oil Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- HCTVWSOKIJULET-LQDWTQKMSA-M phenoxymethylpenicillin potassium Chemical compound [K+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)COC1=CC=CC=C1 HCTVWSOKIJULET-LQDWTQKMSA-M 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 229940058287 salicylic acid derivative anticestodals Drugs 0.000 description 1
- 150000003872 salicylic acid derivatives Chemical class 0.000 description 1
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- 239000012266 salt solution Substances 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
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- 150000003456 sulfonamides Chemical class 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
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- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/52—Juglandaceae (Walnut family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
Definitions
- the invention is related to cosmetic and dermatological preparations, to processes for their preparation and to their method of use. These preparations are specifically useful in treatment of cutaneous lesions attributable to seborrhoea, in purification of pustulous, fatty skin, treatment of acne, symp ⁇ toms of seborrhoea, comedo, psoriasis, in prevention of related inflammatory and other symptoms.
- the sebaceous gland is placed in the up ⁇ per third part of the co ⁇ um, in the corner limited by the pilo- rum (muscle) and the hair follicle.
- the basal cells there are cells producing sebum formed which are situated in the connective tissue surrounding the gland. Following cell division the new cells are moved deeper whilst they are progressively undergoing fatty degeneration.
- Within the sebaceous gland there are cells present which are filled with sebum. It takes about a week after division until the cell ar ⁇ rives into the interior of gland and discharge appears.
- sebum comprises a mixture of cell fragments and cytoplasm which underwent fatty degeneration containing numerous glycerol esters, some fatty alcohols, free fatty acids and cholesterol (see Dr. Hajdu I: Cosmetic Manual, edited by M ⁇ szaki Konyvkiado, Budapest 1990, pages 56 - 60) .
- Seborrhoea is a functional disturbance of the sebaceous glands marked by the occurrence of excessive dis ⁇ charge of sebum from the glands forming white or yellowish greasy scales or cheesy plugs on the body. The irregularities based on seborrhoea are the consequences of the above.
- the comedo represents a staphylome or retention blocking the exit opening of the sebaceous gland. It is caused by increased production of suet and increased keratmization and other fac- tors. Once the comedo is already present the acne is formed.
- the acne vulgaris is a chronic inflammatory disease of the sebaceous glands, occurring most frequently on the face, back and chest.
- the inflamed glands form either small, pink papules, which some ⁇ times surround comedones so as to have black centers, or else pustules or hypertrophied nodes.
- ester cleaving en ⁇ zyme of the Propionibactenum acne is cleaving the suet within the gland and on the course of hydrolysis fatty acids are formed together with glycerol.
- the fatty acids are irritating the ambi ⁇ ent conum. Inflammations appear around the sebaceous gland, painful nods of violet to red colour are formed, a sanguineous or seropuruient discharge appears. In serious cases (and when there is an inclination for celoid formation) deforming scars remain on the skin after healing.
- compositions were completed with various plant ex ⁇ tracts e.g. with extracts of nettle and Grammeae or extracts of ground camomile and peppermint (e.g. Hungarian Patent specifica ⁇ tions N° 210708 and N° 209484) .
- Synthetic ingredients or anti ⁇ biotics were also proposed for use e.g. for treatment of acne gel preparations containing tetracyclme or keratolytic products e.g.
- fat plugs are blocking the pores and the hair follicles thereby limiting the activity of the ac ⁇ tive ingredients specifically in the fatty, inflamed skin.
- skin erasers and desquamative products are only serving elimina ⁇ tion of the surface horny layer of the skin - they do not treat the deeper inflamed regions.
- the basis of the present invention is the experience that in treatment of fatty skin with the dry or water-saturated powder of ground lentil seeds - optionally peeled - m the form of a pulp or after addition with a (preferably natural) carrier in the form of a creamy substance - it was found that within short this product shows a "sucking action" on the treated skin binding thereby the fat blocking the pores and hair follicles of the skin. It is possible that the salts of the fatty acids present are formed which are dissolved in the preparation and are thus eliminated from the ambience of the sebaceous gland.
- the product liberates the territory from the irritating fatty acids whereby free respiration of the sk n is achieved and besides - if still necessary - it also gives free entrance for different ac ⁇ tive ingredients into the deeper regions of the skin whereby me ⁇ tabolism of the skin is already improved.
- the dry ground lentil see ⁇ s show also a water-absorbing activity and thus perform - besides of treating the deeper regions of the skin - also a peel ⁇ ing effect.
- the object of the invention is a cosmetic or dermatology preparation specifically for the treatment of cutaneous lesions attributable to seborrhoea, for purification of pores of pustu ⁇ lous, fatty skin, for elimination of excess fatty acids, for treatment and prevention of acne, symptoms of seborrhoea, comedo, psoriasis, in prevention of inflammatory symptoms
- said preparation comprising a finely dispergated plant seed and op ⁇ tionally a carrier and whereby the plant seed may be dry or satu ⁇ rated with a liquid carrier the seeds being present as a fine dispersion of small particles having preferably a particle size ⁇ 500 ⁇ preferably ⁇ 50 ⁇ of a papilinaceous plant seed comprising a total of about 1000 mg of potassium and sodium (mostly m the form of ions) in 100 g of the dry seed mass while the mass ratio of potassium ions to sodium ions preferably amounts to 1 : 2.5 - 1 : 5 most preferably to 1 : 3 -
- the finely dispersed seed is the seed of the lentil (Lens culi nari s) which normally contains the necessary ions in a natural manner.
- compositions for use in cosmetics and dermatology characterized by containing seeds of lentil in finely dispergated form optionally with or without the chopped peelings of the seed.
- the ions can be introduced into the preparation on the course of the process by way of addition into the seed mass, or into the composition on the course of its admixture or finishing.
- vetch types Vi cia ; V. vill osa ; V. sati va ; sweat pea, hairy vetch
- pea Pi sum sativum
- beans ⁇ Pha seol us vul ga ⁇ s , Faba alba
- compositions according to the invention carriers are comprised which are acceptable in preparations for cosmetics and dermatology and in which the finely chopped seeds are readily disperged.
- the papilmaceous plant seeds present in the compositions are in a state of saturation (swelling) of the seeds - carried out before or after chopping or grinding.
- Suitable saturating agents include water, aqueous solutions, distilled water, solu ⁇ tions containing dissolved active ingredients or salt-solutions.
- ground and optionally saturated seeds and optionally disperged in a carrier are already considered to represent a composition of the invention and they might be used in the sense of the treatments according to the invention.
- compositions according to the invention preferably may contain additional products along with the ground and optionally saturated seeds and disperged seeds, which additives are promot ⁇ ing application, spreading and acceptability of the preparation.
- composition might comprise further active ingredients and in these cases it is made possible to introduce into the deeper regions of the skin further active ingredients - in addition of and favoured by the seed preparation - namely active ingredients in addition to those which are naturally pres ⁇ ent in the papilionaceous plant seeds or which are added therein on the course of production of the composition.
- Additive ingredients optionally present in the preparation according to the invention include cosmetically and dermatologi- cally acceptable carriers, hydrat g agents, gel forming addi- tives, diluting agents, stabilisers, colorants, essences of per ⁇ fume or other usual additives of skin preparations.
- a preferable carrier is water (which also might serve as swelling material of the seeds before or after chopping) along with oils and fats mainly of plant origin.
- the composition may contain sunflower oil, soy bean oil, olive oil, rape-seed oil, or other edible oils or other oils acceptable for use cosmetics or dermatoligy.
- oil as a carrier also the presence of a stabiliser against rancidity is advisable.
- Stabilising agents such as antioxidants - possibly of natu ⁇ ral origin - may be incorporated into the compositions.
- Colorants - preferably of natural origin - are optionally comprised into the preparation according to the invention. Such colorants have to meet the cosmetic and dermatological measures of the country of use of the product.
- composition according to the invention it is possible to bring further active ingredients on the surface of treatment and into the treated or already puri ⁇ fied pores.
- compositions which include additional biologically preferable active ingredients above the finely dispersed seeds disclosed above.
- the prepara ⁇ tion contains merely active ingredients used m the cosmetic or dermatological treatments which are of purely natural origin and which are suitable for mitigation, prevention or treatment of inflammation symptoms of the skm.
- plants or parts of plants of the following group might be used as additional active ingre ⁇ washer: wild camomile, Galli um verum, Vi ol a tri col or, Fumaria of ⁇ ficmali s , Achill ea millefoli um, Equi setum arvense L . , Sal vi a officmalis L . , Sal vi a sclarea L . , Cal endula offi cmalis L .
- the pH value of the composition according to the invention is within the range of 6 to 7.3 preferably around 6.4.
- the products according to the invention may appear any known form acceptable for cosmetic or dermatological use: suspen ⁇ sions, gels, creams, foaming products, powders, compressions, cosmetic sticks, plasters etc.
- the composition according to the invention appears in at least two formulation forms which are physically separated from each other (e.g. two ars, two tubes, two bottles etc.)
- one formulation the examples the one marked "A"
- the formulation only contains the mixture containing the milled seeds.
- the second and optionally further formulation comprise (s) the additional active ingredients, plant extracts or suspensions, antipru ⁇ tics etc.
- the preparations comprising two or more formulations are preferably marketed together (e.g. packed into one common box etc.) .
- the invention also comprises the combination of such physically separated formulations.
- a further object of the invention is the process for the preparation of the cosmetic and dermatological preparations ac ⁇ cording to the invention.
- seeds of the selected plants milled to an average particle size of ⁇ 500 ⁇ preferably ⁇ 50 ⁇ are mixed together optionally with further additives whereby the ground seeds are in dry state or in a swollen state using a liq ⁇ uid carrier.
- the process may be brought about by soaking the seeds of a papilionaceous plant (preferably lentils) water or water containing additives.
- additives are e.g. stabilisers, other water soluble additives, vitamins, trace elements and the like.
- Further additives can be given to the mixture and thereafter the mass containing the soaked seed grains is subjected to chopping until a suspension is obtained the average particle size of which does not exceed 50 ⁇ . Practically the product appears m this stage in the form of a light, easily applicable, soft cream.
- the preparations are filled into physically separated at least two distinct formulations.
- the formulation (suspension, gel, cream) containing the seed preparation is separated from the for ⁇ mulation (suspension, gel, cream) containing other ingredients the application of which might be preferable or necessary for further treatment of the clean pores and sk .
- the additives may be applied directly on the ground and/or swollen and chopped seeds or they can be added successively to the formulation on the course of its admixture.
- Additives which are soluble in the carrier fluid - e.g. water, oil - can be pref ⁇ erably dissolved in the carrier or in the soaking water to ensure maximal uniform distribution.
- plant ex ⁇ tracts e.g. aqueous extracts, teas
- a further object of the invention consist the applica ⁇ tion of cosmetic or dermatologic preparations for the treatment of patients need of such treatment in cases of cutaneous le ⁇ sions attributable to seborrhoea, for purification of pores of pustulous, fatty skm, for elimination of excess fatty acids, for treatment and prevention of acne, symptoms of seborrhoea, come ⁇ o, psoriasis, in prevention of inflammatory symptoms
- said preparation comprising a finely dispergated plant seed and op ⁇ tionally a carrier and whereby the plant seed may be dry or satu ⁇ rated with a liquid carrier, ground into small particles of fine dispersion and preferably of a particle size ⁇ 500 ⁇ preferably ⁇ 50 ⁇ of a papilmaceous plant seed comprising a total of about 1000 mg of potassium and sodium (mostly in the form of ions) m 10 g of the dry seed mass while the mass ratio of potassium ions to sodium ions preferably amounts to 1 : 2.5 -
- the method of treatment can be applied specifically well for regular treatment of fatty sk and to prevent and solve problems of acne of teenagers and those who are facing this prob ⁇ lem practically through their lifetime.
- the method of treatment may be carried out m the following way:
- the composition is adapted on the territory to be treated of the skm a uniform manner so that the formulation (balsam, cream, liquid etc.) totally covers the territory where symptoms are to be seen or where the patient observes irregular symptoms (e.g. itching, pain) .
- a preparation which comprises two or more separate formulations the first administration is accomplished with the formula containing the seed mixture (formula "A" of the examples below) .
- the preparation should be left on the skm until dry which takes about 10 to 30 minutes depending on the layer applied. Thereafter the surface is washed preferably with clean or distilled water or an aqueous solution which might already contain water soluble additives which are taken up by the freshly cleaned pores.
- the second formulation e.g. formula "B" of the examples
- This layer can be dried and washed away or - depending on the additives and carriers used - it can be absorbed by the skin. If several formulae are used, the fol ⁇ lowing layers can be applied thereafter.
- compositions according to the invention can be applied the form of masks. This method is highly advantageous when preventive treatments are applied e.g. on fatty skm which is susceptible for acne formation.
- the full skm surface to be treated is covered with the composition according to the invention - such as the face, neck, shoulders etc. Creams, gels, liquids, pastes etc. can be used for this purpose.
- the composition is used in the form of at least two distinct formulations the formulation containing the seeds is used first
- the preparations can be used for prevention.
- double formula ⁇ tions are applied then it is only the first formulation which is used for this treatment.
- the cream is left on the skm until dry which takes about 15 - 30 minutes. Thereafter the dry composition is eliminated by washing with water and the skm is dried. Treat ⁇ ments twice a week are advisable and there is no need to use the second formulation.
- preferred treatments are those where only natural active ingredients, originating from plants are used for the treatments.
- 1 kG of dried lentil (Lens culinaris) seeds milled to an average particle size of ⁇ 50 ⁇ are mixed with 2 1 of distilled water and soaked for 12 hours.
- the pulp obtained can be used for treatment of the skm optionally after addition of a stabiliser.
- 1 kG of dried lentil (Lens culinaris) seeds are mixed with 3 1 of distilled water and soaked for 24 hours. After separating the peels of the seeds from the surface layer the mixture is de ⁇ canted leaving the swollen, wet seeds behind. Boric acid is added to the mixture obtained and the mixture is subjected to turbomix g technology until a uniform average particle size of ⁇ 50 ⁇ is reached.
- the pulp obtained is mixed with 0.5 kG of sun ⁇ flower oil containing a minimum 70 mg/100 ml natural tocopherol using a mixer equipment.
- the cream obtained is filled into tubes or jars.
- a cream of slight menthol odour is obtained which is filled into 60 ml tubes in a tube-filler apparatus.
- the tubes are closed by weldmg.
- the ground lentil seed comprises tne following:
- 100 g of the milled lentil product comprises the following elements (mainly in the form of ions)
- the used quantity of the dry plants (whole or parts) is added to the boiling water. After boiling for about 1 minute the infusion is left alone for 5 minutes and is then filtered. Calcu ⁇ lated on 100 g of the infusion 10 g of every plant is used with the exception of Galium verum which is used m a 50 g quantity.
- the infusion is poured into a vessel and the compounds 2. - 6. of the composition are added while stirring.
- the dispersion obtained is stirred until no foam or lumps are present whereupon the sodium hydroxide is added while stirring is continued.
- BUD- bles of air are eliminated under vacuum.
- Example 1 The process according to Example 1. is used however instead of lentil seeds the seeds of peas ( Pusum sa ti vum) or beans ( Phaseol us vulgari s) are used.
- the seeds are treated as disclosed in Example II.1. with the difference that the soaking water is completed with the quantity of additional sodium and iron salts which are missing to achieve the ion relation according to the prescription of the invention.
- the objective of the experiment was to determine the effi ⁇ cacy of the preparation according to Example II.1 in the treat ⁇ ment of m ld to moderately severe cases of Acne vulgaris.
- Age of patients 15 to 40 years; average age 27.3 years.
- Patient gender 14 women and 6 men.
- the acne patients selected for the tests have received treatment for years and presented a great number of clinical symptoms. As a rule, they were tired of the various treatments and had a negative opinion of themselves
- the method of treatment was explained to each patient who was provided with components "A" and "B” of the product.
- the control examinations took place on the 4th, 7th, 14th and 21st days of treatment.
- the acne load value was as ⁇ sessed.
- the medical evaluation of the tests was carried out on the basis of the acne load value as follows:
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Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97903528A EP0886523A1 (en) | 1996-02-20 | 1997-02-17 | Preparations for use in cosmetics and dermatology |
AU18066/97A AU711191B2 (en) | 1996-02-20 | 1997-02-17 | Preparations for use in cosmetics and dermatology |
NO983792A NO983792L (en) | 1996-02-20 | 1998-08-19 | Preparations for use in cosmetics and dermatology |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HUP9600379 | 1996-02-20 | ||
HU9600379A HU9600379D0 (en) | 1996-02-20 | 1996-02-20 | Cosmetic composition, especially for treating of acne |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997030719A1 true WO1997030719A1 (en) | 1997-08-28 |
Family
ID=89993733
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/HU1997/000007 WO1997030719A1 (en) | 1996-02-20 | 1997-02-17 | Preparations for use in cosmetics and dermatology |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0886523A1 (en) |
AU (1) | AU711191B2 (en) |
HU (1) | HU9600379D0 (en) |
NO (1) | NO983792L (en) |
WO (1) | WO1997030719A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1707213A1 (en) * | 2005-03-17 | 2006-10-04 | Elisabeth Kern | Herbal composition for the treatment of cutaneous Erythema |
FR2945209A1 (en) * | 2009-05-07 | 2010-11-12 | Limousine D Applic Biolog Dite | Cosmetic use of an active ingredient from Lens culinaris or Lens esculenta in a cosmetic composition to prevent or mitigate the unsightly aspect of dilated pores on the skin, and to limit the expansion of pores of the skin |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU210708B (en) * | 1992-01-02 | 1995-06-28 | Chempro Vegyipari Kutato Fejle | Face-treating alcoholic composition containing herb extract |
-
1996
- 1996-02-20 HU HU9600379A patent/HU9600379D0/en unknown
-
1997
- 1997-02-17 WO PCT/HU1997/000007 patent/WO1997030719A1/en not_active Application Discontinuation
- 1997-02-17 AU AU18066/97A patent/AU711191B2/en not_active Ceased
- 1997-02-17 EP EP97903528A patent/EP0886523A1/en not_active Withdrawn
-
1998
- 1998-08-19 NO NO983792A patent/NO983792L/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU210708B (en) * | 1992-01-02 | 1995-06-28 | Chempro Vegyipari Kutato Fejle | Face-treating alcoholic composition containing herb extract |
Non-Patent Citations (1)
Title |
---|
DATABASE WPI Section Ch Week 9532, Derwent World Patents Index; Class D21, AN 93-314081, XP002033162 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1707213A1 (en) * | 2005-03-17 | 2006-10-04 | Elisabeth Kern | Herbal composition for the treatment of cutaneous Erythema |
FR2945209A1 (en) * | 2009-05-07 | 2010-11-12 | Limousine D Applic Biolog Dite | Cosmetic use of an active ingredient from Lens culinaris or Lens esculenta in a cosmetic composition to prevent or mitigate the unsightly aspect of dilated pores on the skin, and to limit the expansion of pores of the skin |
Also Published As
Publication number | Publication date |
---|---|
AU711191B2 (en) | 1999-10-07 |
NO983792D0 (en) | 1998-08-19 |
AU1806697A (en) | 1997-09-10 |
EP0886523A1 (en) | 1998-12-30 |
HU9600379D0 (en) | 1996-04-29 |
NO983792L (en) | 1998-10-15 |
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