WO1997029682A1 - Aiguille de biopsie localisable - Google Patents
Aiguille de biopsie localisable Download PDFInfo
- Publication number
- WO1997029682A1 WO1997029682A1 PCT/IL1997/000058 IL9700058W WO9729682A1 WO 1997029682 A1 WO1997029682 A1 WO 1997029682A1 IL 9700058 W IL9700058 W IL 9700058W WO 9729682 A1 WO9729682 A1 WO 9729682A1
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- WIPO (PCT)
- Prior art keywords
- image
- needle
- position sensor
- tool
- ofthe
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Definitions
- This invention relates to guidance of biopsy needles and, more particularly, to guidance of biopsy needles using ultrasonic imaging and position sensors.
- a sample of tissue must be extracted from a target area in a body and examined in a laboratory. This procedure, called a biopsy, is typically performed using a biopsy needle, which is a long slender needle with a tissue receptacle at its end.
- the needle is inserted into the body until it enters the suspected tissue.
- the tissue receptacle is opened and a tissue sample is forced into the receptacle by internal tissue pressure.
- the receptacle is closed, the sample of tissue is caught within. Thereafter, the biopsy needle is removed and the tissue sample is sent to the laboratory.
- Inserting a long needle into the body is a dangerous and difficult procedure.
- a major blood vessel may be punctured or a vital organ may be injured during the biopsy procedure.
- correctly aiming the biopsy needle towards the target tissue is extremely important so that the tissue sample comes from the suspected tissue and not from some nearby, healthy, tissue.
- Two needle guidance methods are common in the art.
- a desired path of the needle is planned on a medical image of the body.
- the biopsy needle is then guided into the body along the calculated path.
- One limitation of this method is that the structure of the human body is plastic, so the medical image taken at some previous time might not represent the body as it is during the biopsy procedure.
- Another limitation of this method is that there is no feedback to the operator regarding the actual position ofthe needle nor is there feedback regarding any errors which the operator might have made in guiding the needle.
- the biopsy procedure is performed with a real-time or near real time image of the target tissue and/or the needle.
- a real-time ultrasound image is used to view both the needle and the target tissue.
- Ultrasound is preferred since it does not expose the patient or the operator to ionizing radiation.
- ultrasonic imagers are hand-held devices which are very maneuverable.
- the needle is preferably inserted through the front of the neck, through the trachea. It is not possible to image through the trachea with ultrasound, since the trachea is full of air.
- the preferred location for ultrasonic imaging is from the side of the neck, through the carotid artery. It is clearly not desirable to insert the needle through the carotid artery. Thus, in this procedure, it is not possible to image the needle along most of its path to the target tissue, using ultrasound.
- An advanced method of biopsy needle guiding uses a position sensor mounted on the proximal end of the needle. The position of the distal end of the needle is calculated and displayed as an overlay on the ultrasound image.
- U.S. Patent 5,251,635 to Dumoulin et al. discloses attaching an RF transmitter near the tip of a surgical instrument, determining the position of the transmitter and overlaying it on an image acquired by an X-ray imager.
- a biopsy needle is offered as one preferred type of surgical instrument.
- no method of attachment which is suitable for biopsy needles is disclosed.
- an ultrasound imager is suggested by Dumoulin et al., it is suggested as an alternative to the X-ray imager. Nowhere in this patent is it suggested that the imager have a position sensor mounted thereon or that both the ultrasonic imager and the biopsy needle may have unrestricted movement relative to each other.
- EP 94308176 published as EP 654244, the disclosure of which is inco ⁇ orated herein by reference, describes a biopsy guiding system having two articulated arms.
- An ultrasonic imager is mounted on a first arm and a needle holder is mounted on a second arm.
- a computer connected to both arms, to determine their locations in space, and connected to the ultrasonic imager, controls the positioning and the rotation of the second arm so that the needle is in an optimal position for insertion and biopsy taking.
- PCT application PCT/GB93/01736 describes an endoscope having a plurality of coils disposed therein for determining the layout ofthe endoscope when it is in a body.
- a biopsy needle has a position sensor mounted at its distal end (the tip).
- the position sensor in encapsulated in the tip of the needle.
- the position sensor includes an orientation sensor.
- the location of the needle tip is determined using the position sensor.
- the tip location is overlaid on a real-time ultrasound image.
- the needle position is non-cop lanar with the ultrasound image plane, so the three dimensional location ofthe needle tip relative to the target tissue can be seen on the image.
- the planned and/or the actual paths of the needle are also overlaid on the image, so errors in the needle path can be determined and are evident to the operator.
- the image plane of the ultrasonic imager is guided along the planned and/or the actual trajectories of the needle, to determine if any vital organs are likely to be unintentionally pierced by the needle. Such guiding is facilitated by a second position sensor mounted on the ultrasonic imager.
- a previously acquired image of the needle path is registered in real-time to the ultrasound image.
- detection of obstacles in the portion of the needle path outside the ultrasound image may be determined using the image acquired off-line, while ensuring that the biopsy is actually taken from the target tissue may be based on the real-time image.
- fiduciary markers on the body surface or implanted inside the body are used to register the needle and the ultrasonic imager to each other.
- fiduciary markers may be used to register the ultrasound image to a previously acquired image.
- the position sensor is mounted on an existing biopsy needle using a slip cover.
- the slip cover is a thin sheath having a position sensor mounted thereon.
- the biopsy needle is inserted into the slip cover, resulting in a position sensing biopsy needle.
- the slip cover has a lumen substantially greater than the diameter of the needle, to facilitate insertion of the needle.
- the slip cover is then shrunk so that it snugly engages the needle.
- the slip-cover is mounted with an adhesive.
- the position sensor may be mounted at the side of the needle or at its tip.
- the needle comprises a hollow guide and an internal needle portion. When taking the biopsy, the internal portion is pushed forward beyond the end ofthe guide. It should be appreciated that the position sensor may be damaged or misaligned by this action in some embodiments of the invention. However, once a biopsy is taken, the needle is promptly removed from the body along the insertion path, so the loss of the position sensor is not very important.
- the position sensor is encapsulated in the needle itself, either proximal to or distal to the tissue receptacle.
- the position sensor may be encapsulated in the guide.
- the position sensor is typically required to communicate the sensed position to a location external to the body, such as a computer coupled to a display on which the location is shown.
- position information is transmitted along electrically conducting wires.
- detected position information is transmitted using a fiber optic cable to the computer.
- the detected position is transmitted using radio waves, ultrasound waves or infra-red radiation from inside the body. It should be appreciated that, the ultrasound waves may travel along the biopsy needle itself to a receiver coupled to the proximal end of the needle or they may be received by the ultrasound imager or by other, additional, ultrasound receivers.
- the position sensor is a magnetic field position sensor, such as those well known in the art.
- other types of position sensors such as RF position sensors or ultrasound position sensors may be used.
- a coil based position sensor is used.
- the position sensor is a single coil sensor used to determine five of the position and orientation coordinates ofthe sensor.
- a relatively long, thin coil is used for the position sensor.
- This type of sensor is especially suitable for attachment as part of a slip cover.
- the biopsy needle or the needle guide may be formed of such a long coil embedded in a plastic matrix.
- the needle (or the slip cover) is formed of a plurality of distinct and collinear coils. The exact shape of the needle can then be determined, even when deformed, from the relative locations ofthe various coils.
- radiators are mounted on the needle or the ultrasonic imager, while a detector is mounted on the other one of the needle and imager.
- both the needle and the imager radiate or detect radiation to an eternal detector or from an external radiator.
- the external detector or radiator is preferably pre-registered to a fixed frame of reference.
- fiduciary markers are provided on the frame so that the needle and or the ultrasonic imager may be registered to the frame of reference.
- the needle has two configurations, a first configuration in which the needle has a constant diameter and where the position sensor is in a position which blocks the tissue receptacle and a second configuration in which the position sensor protrudes from the profile of the needle and does not block the tissue receptacle.
- the needle portion surrounding the position sensor expands, to make room for both the tissue receptacle and the position sensor.
- the biopsy needle is inserted into the body using a rigid sheath which constrains the needle to the first configuration.
- the sheath is retracted so that the tissue receptacle is unblocked.
- a flexible biopsy probe or catheter is used.
- the catheter is guided through physiological lumens ofthe body, such as the Gl tract and then pushed through the wall of a physiological lumen to reach the target tissue.
- physiological lumens ofthe body such as the Gl tract
- the catheter is guided between portions ofthe brain, such that substantially no brain damage is caused by the probe.
- a minimally damaging path is used from the lumen to the target tissue.
- a first such example is a shunt, particularly for the brain, but also for drainage of internal abscesses.
- a shunt can be placed with minimum damage to healthy tissue.
- Shunts are typically inserted using a rigid guide inserted in a lumen ofthe shunt.
- a shunt is inserted using a flexible guide/catheter. Since the shunt is inserted using a flexible catheter, the point of entry may be chosen to simplify the drainage of the shunt. For example, the shunt may be inserted through the nasal passages, with the drainage occurring directly into the digestive tract.
- a shunt is usually placed into the body for a long period of time, unlike a biopsy needle, which is usually inserted and retracted within 15 minutes.
- a position sensor mounted on the shunt (instead of on the guide to the shunt) can be used for long term monitoring of the shunt location.
- Another example of an invasive procedure wherein a needle is inserted into the body is the long term placement of catheters for injecting pharmaceutical agents into the blood stream or directly into diseased tissue.
- catheters for injecting pharmaceutical agents into the blood stream or directly into diseased tissue.
- a position sensor during the insertion of such a catheter ensures that the agent will be correctly injected.
- This may include injections into a vascular bed of a tumor, or in the case of a body-wide pharmaceutical agent, the right atrium of the heart, wherein the agent is mixed well with the blood.
- the placement of the catheter is non-invasively checked, such as by using an internal position sensor, before injecting the agent to ensure that the catheter did not move from its proper location since the previous injection.
- apparatus for mounting a position sensor on a surgical tool including: a thin sleeve adapted to snugly engage a portion of the tool; and a position sensor mounted on the sleeve.
- the sleeve is shrinkable to snugly engage the portion.
- the position sensor includes a lithographicly produced sensor.
- the position sensor includes at least one coil.
- the sleeve includes proximal, central and distal portions and the position sensor is mounted on the central portion.
- the tool is a biopsy needle.
- the position sensor is mounted at a distal end of the needle.
- the distal tip ofthe needle is hollow and an extension ofthe position sensor is inserted into the hollow tip.
- a biopsy system including: a biopsy needle, having a body and a window in the side of the body; and an orientation sensor mounted on the needle, where the orientation sensor provides an indication of the orientation of the window relative to an external reference frame.
- the orientation sensor is mounted adjacent the window. Additionally or alternatively, the orientation sensor also senses three-dimensional position.
- a biopsy needle including: an elongate body having an axis; an axial lumen formed in the body; an insert axially movable within the lumen; and a position sensor which blocks the pathway of the insert in the lumen in a first operational configuration ofthe needle and does not block the pathway in a second operational configuration ofthe needle, wherein, advancing the insert toward the position sensor changes the operational configuration ofthe needle from the first configuration to the second configuration.
- advancing the insert pushes the position sensor axially forward, out of the lumen.
- advancing the insert pushes the position sensor pe ⁇ endicular to the path of the insert.
- the position sensor is pierced by the insert.
- a biopsy needle including: a body having a lumen formed therein; l o a window in the side of the body; and an insert in the lumen having a tissue receptacle formed therein, whereby aligning the tissue receptacle with the window allows tissue from outside the needle to enter the receptacle, the needle having two operational configurations, a first configuration in which the position sensor is situated within the tissue receptacle and a second configuration in which the 15 tissue receptacle is aligned with the window and the position sensor is not situated within the tissue receptacle.
- rotating the insert in the lumen removes the position sensor from the tissue receptacle.
- the insert urges the position sensor sideways, through the body of the needle.
- the tissue receptacle has a sloped edge which engages the position sensor when the insert is rotated. 20
- a method of ultrasonic biopsy needle guiding including: imaging a suspected tissue using an ultrasonic imager having a field-of-view; determining a trajectory of a biopsy needle using a position sensor mounted on the needle; and 25 guiding the field-of-view of the imager along the trajectory using a position sensor mounted on the imager.
- the position sensor includes an orientation sensor.
- a method of medical tube implantation including: acquiring an image of a target tissue in a brain; 30 inserting a medical tube having a position sensor mounted at a distal end thereof into a cavity in the brain; determining the position ofthe medical tube; registering the position of the medical tube on the image; and guiding the tube through the cavity, to a location adjacent the target tissue, using the 35 image.
- the method includes guiding the tube from the location adjacent the target tissue, through the brain to the target tissue.
- the medical tube includes a shunt, alternatively or additionally, the medical tube includes a chemotherapy providing catheter.
- an integrated biopsy needle and position sensor including: a coil having a central axis and an outer diameter; and a cylindrical body encapsulating the coil and having an outer diameter, where the body is coaxial with the coil and where the body and the coil have substantially similar outer diameters.
- the body is defines an axial lumen. Additionally or alternatively, the body encapsulates a plurality of collinear coils.
- the needle is flexible. Additionally or alternatively, the needle is retractably mounted on an endoscope.
- a method of mounting a position sensor on a surgical tool having a reference location thereon including: determining an unmarked location on the tool which is a predetermined distance from the reference location; and mounting the position sensor at the determined location.
- determining a location includes, attaching a positioning jig to the surgical tool, where the positioning jig has a portion for receiving the reference location and a portion for receiving the position sensor.
- the surgical tool has a preferred orientation and including aligning the position sensor with the preferred orientation.
- a method of image acquisition including: determining a position of a probe in the body, utilizing a position sensor mounted thereon; determining at least one viewing parameter of an image acquisition device; adjusting the at least one viewing parameter using the determined position; and acquiring an image of the probe.
- the at least one viewing parameter includes the direction of a field of view of the image acquisition device.
- the at least one viewing parameter includes a magnification of the image.
- a method of selecting a reference image of a rhythmically moving body portion, which motion has a plurality of phases including: determining a position of a probe in the body portion, utilizing a position sensor mounted thereon; determining a current phase of the motion; obtaining a reference image having a motion phase substantially corresponding to the motion phase of the rhythmic motion; and displaying the reference image overlaid with a symbol marking the position of the probe.
- obtaining a reference image includes, selecting a given reference image from a plurality of reference images. Alternatively or additionally, obtaining includes forming an inte ⁇ olation from a plurality of images. Alternatively or additionally, determining a current phase includes determining the phase ofthe motion using a physiological motion monitor. Alternatively, determining a current phase includes: determining a profile of the probe motion which motions result from the rhythmic motion; and correlating the determined position ofthe probe with the determined profile.
- a method of image guiding including: determining the position of a portion of an unconstrained tool; determining the position and at least the direction of view of an unconstrained real-time medical imaging device; acquiring an image using the imaging device; and overlaying a symbol indicative of the position of the tool on the image.
- the tool is a biopsy needle, additionally or alternatively, the symbol is a trajectory of the tool.
- a biopsy taking tool having a position sensor mounted on a needle portion of the biopsy taking tool.
- the position sensor is mounted near a proximal end of the needle.
- a position sensor adapted to be mounted on a biopsy needle including: a position sensing portion; a body encapsulating the position sensing portion; and a needle engaging portion.
- at least a part of the needle engaging portion includes a flexible, high friction material.
- a positioning device for mounting a position sensor on a tool having a tip including: a base for receiving the tip; a tool gripper associated with the position sensor; and a positioning member which interconnects and positions the base and the tool gripper at a fixed distance from each other.
- the tool is a needle.
- the tool gripper includes two interlocking arms. Additionally or alternatively, a weak spot is formed in the distancing member, near the tool gripper. Additionally or alternatively, the position sensor is mounted on the tool gripper.
- the position sensor is radially spaced from the tool to reduce interactions between the position sensor and the tool.
- a method of image acquisition including, determining a position of a probe in the body, which probe has a position sensor mounted thereon; acquiring an image of a portion ofthe body related to the determined position; and modifying the image based on the determined position.
- modifying includes displaying only a portion of the image.
- modifying includes combining at least a portion of a reference image with the image.
- modifying includes overlaying a graphic on the image.
- a method of image guiding including: determining the position and at least the direction of view of a hand-held medical imaging device; acquiring an image using the imaging device; determining the position of a portion of a hand-held tool other than on the basis of the image; and modifying the image based on the determined position.
- the tool is a biopsy needle.
- modifying the image includes adding information related to the determined position to the image.
- the infoimation includes a symbol indicative of the determined position.
- the information includes a trajectory ofthe tool.
- the information includes an expected operation area of the tool.
- the information includes at least a portion of a reference image.
- the medical imaging device is a substantially real-time imaging device.
- a bendable rigid endoscope including, a rigid portion, a bendable portion and means for determining a degree of bend of the bendable portion.
- the means includes a bend controller which effects the bend.
- the means includes a bend sensor which measures the degree of bend ofthe bendable portion.
- apparatus for acquiring an image responsive to a determined position of a probe having a position sensor including an image acquisition device and a controller which determines at least one viewing parameter of the image acquisition device, adjusts the at least one viewing parameter responsive to a position of said probe determined utilizing said position sensor and controls the image acquisition device to acquire an image.
- the at least one viewing parameter includes the direction of a field of view of the image acquisition device.
- the at least one viewing parameter includes a magnification of the image.
- the controller adjusts the viewing parameter responsive to a future position ofthe probe.
- apparatus for acquiring an image responsive to a determined position of a probe having a position sensor including an image acquisition device and a controller which controls the image acquisition device to acquire an image responsive to a position determined utilizing the position sensor and which modifies the image responsive to the determined position.
- the apparatus includes a display on which said controller displays only a portion ofthe image. Additionally or alternatively, the controller combines at least a portion of a reference image with the acquired image and displays the combination image on the display. Alternatively or additionally, the controller overlays a graphic on the image, prior to a display on the display thereof.
- apparatus for selecting a reference image for a probe having a position sensor, of a rhythmically moving body portion, which motion has a plurality of phases including an image store having at least one image stored therein, means for determining a current phase of the motion and a controller which obtains a reference image from the image store, which image has a motion a motion phase substantially corresponding to current motion phase of the rhythmic motion and which controller marks the reference image with a symbol associated with a position ofthe probe determined utilizing the position sensor.
- the controller selects the reference image from the at least one image stored in the image store.
- the image store has a plurality of images stored therein and the controller forms the reference image by inte ⁇ olation from the plurality of images.
- the means for determining a current phase comprises a physiological motion monitor.
- the controller determines a profile of the probe motion, which motions results from the rhythmic motion and which controller correlates the determined position of the probe with the determined profile.
- apparatus for image guiding of a hand-held tool including a hand-held medical imaging device, which acquires an image, means for determining the position and the direction of view of the hand-held medical imaging device and a controller which determines the position of a portion of a hand-held tool other than on the basis of the image and which controller modifies the image based on the determined position.
- the controller adds information, related to the determined position, to the image.
- the information includes a symbol indicative of said determined position.
- the controller determines a projected trajectory of the tool and wherein said information includes the projected trajectory.
- controller determines a projected operational area of the tool and the information includes the projected operational area.
- the controller adds at least a portion of a reference image to the acquired image responsive to the determined position.
- the medical imaging device is a substantially real-time imaging device.
- Fig. IA is a schematic cutaway side view of a prior art sheath type biopsy needle in a closed position
- Fig. IB is a schematic side view ofthe biopsy needle of Fig. 1 A in an open position
- Fig. IC is a schematic side view of a prior art window type biopsy needle
- Figs. ID and IE are schematic cross-sectional views of the biopsy needle of Fig. IC along line LA-LA in respective open and closed configurations;
- Fig. 2 is a perspective view of relative positions of a biopsy needle and an ultrasound image plane during a biopsy procedure
- Fig. 3A is a schematic cross-sectional side view of a biopsy needle having a position sensor situated on the axis of the needle, according to a preferred embodiment of the invention
- Fig. 3B is a schematic cross-sectional side view of a biopsy needle having a position sensor mounted along the needle axis using a slip cover, according to another preferred embodiment ofthe invention
- Fig. 3C is a schematic cross-sectional side view of a biopsy needle having a position sensor mounted near the tip of the needle, according to yet another preferred embodiment of the invention.
- Fig. 4A is a schematic cross-sectional side view of an expandable biopsy needle, according to a preferred embodiment of the invention, in a closed configuration
- Fig. 4B is a schematic cross-sectional side view of the biopsy needle of Fig. 4A in an open configuration
- Figs. 5A and 5B are schematic cross-sectional front views of an expandable biopsy needle in open and closed configurations respectively, according to another preferred embodiment ofthe invention
- Fig. 6 is a schematic cross-sectional side view of a biopsy needle which is formed around a coil position sensor, according to yet another preferred embodiment ofthe invention
- Fig. 7 is a schematic cross-sectional side view of a flexible biopsy needle according to still another preferred embodiment ofthe invention.
- Fig. 8A is a schematic cross-sectional drawing of a spearable position sensor for a biopsy needle, in accordance with a preferred embodiment of the invention.
- Fig. 8B shows the position sensor of Fig. 8A mounted on a biopsy needle in accordance with a preferred embodiment ofthe invention
- Fig. 8C shows a mounting device for mounting a position sensor on a biopsy needle in accordance with a preferred embodiment ofthe invention
- Fig. 8D is a top view of an alternative embodiment of Fig. 8C, in accordance with another preferred embodiment of the invention.
- Fig. 8E shows another mounting device for mounting a position sensor on a biopsy needle in accordance with a preferred embodiment ofthe invention;
- FIG. 8F illustrates a preferred profile for the embodiment of Fig. 8E
- FIG. 9A is a schematic, partially phantom, view of the placement of a brain shunt according to a preferred embodiment ofthe invention
- Fig. 9B is a side view of a bendable, rigid endoscope in accordance with another preferred embodiment ofthe invention.
- Fig. 10 is a schematic, partially cut-away, view of a placement of a chemotherapy catheter in accordance with a preferred embodiment ofthe invention
- Fig. 11 is a block diagram of an image guided probe system in accordance with a preferred embodiment ofthe present invention.
- Biopsy needles are used in many medical applications to remove a sample of tissue from a target area in a body.
- the sample is usually analyzed in a laboratory to determine pathologies in the target area.
- Figs. IA and IB are schematic cross-sectional side views of a sheath-type biopsy needle 20, as known in the art.
- a needle 20 has an outside sheath 22 and an inner needle portion 24.
- a tissue receptacle 26 is formed in inner needle 24.
- Figs. IA and IB show, respectively, needle 20 in open and closed configurations. Needle 20 is inserted into the body to the target tissue while in the closed configuration, as shown in Fig. IA. Once at the target tissue, inner needle 24 is pushed forward relative to sheath 22. This exposes tissue receptacle 26, as shown in Fig. IB. Tissue from the target tissue area is forced into receptacle 26, due to the internal body pressure. When inner needle 24 is retracted (relative to sheath 22), an edge 30 of tissue receptacle 26 and a leading edge 28 of sheath 22 shear the target tissue so that a tissue sample is retained in tissue receptacle 26.
- Figs. IC, ID and IE shown another type of biopsy needle, utilizing a moving window.
- Fig. IC shows a window-type needle 32 comprising an outer body/sheath 34 having a window 40 formed therein and an inner portion 36 having a tissue receptacle 38 formed therein.
- Figs. ID and IE show a cross-sectional view of Fig. IC along line IA-IA, showing the interaction between window 40 and tissue receptacle 38.
- window 40 opens into receptacle 38, so that a tissue sample from adjacent target tissue may be forced into tissue receptacle 38.
- inner portion 36 is rotated relative to sheath 34, so that any tissue in tissue receptacle 38 is shorn from the target tissue.
- small tumors deep in the body may be detected using advanced imaging techniques, such as x-ray computerized tomography and magnetic resonance imaging.
- advanced imaging techniques such as x-ray computerized tomography and magnetic resonance imaging.
- the biopsy needle To excise a biopsy from such a small, deep seated tumor, the biopsy needle must be guided very precisely towards the tumor and the tissue receptacle in the needle must be positioned so that only suspected tissue and not healthy tissue is forced into the receptacle. Precise positioning of a biopsy needle is not generally possible without an external imaging aid which views the tissue-receptacle portion of the needle and the target tissue.
- ultrasonic imaging is used to determine the position of the needle and the target tissue. Ultrasonic imaging is preferred since it is non-ionizing and since an ultrasonic transducer can be hand-held and easily manipulated.
- Fig. 2 is a perspective view of relative positions of a biopsy needle 50 and an ultrasound image plane 56 during a biopsy procedure.
- An ultrasonic imager 54 is oriented so that its image plane 56, bisects a target tissue 52. Needle 50 is inserted into a body 62 along a trajectory 58 so that needle 50 will enter tissue 52 without causing significant damage to intervening tissues.
- trajectory 58 of needle 50 is generally not on image plane 56 which views target tissue 52. As a result, it may be difficult to detect errors in the actual trajectory 58 until the tip of needle 50 enters image plane 56. A correction of trajectory
- a position sensor 64 is mounted at or near the distal end of needle 50.
- the position of sensor 64 relative to image plane 56 may be dynamically determined by mounting another position sensor 60 on ultrasonic imager 54.
- the actual trajectory over which needle 50 advances can be determined by storing positions of the needle during its movement.
- the expected trajectory of needle 50 may be estimated from the current position and pointing direction of the needle.
- position sensor 60 also senses orientation information, which is useful for determining the plane of image plane 56.
- Position sensor 64 preferably includes an orientation sensor which senses at least the rotation of needle 50, to determine the position of the window of a tissue receptacle in needle 50 relative to the tissue.
- position sensor 64 may be mounted on the proximal end of biopsy needle 50, if the needle is rigid.
- planned and/or anticipated trajectory 58 is projected on image plane 56, for example, by using computer graphics, and displayed to an operator.
- a synthetic three dimensional display is generated, showing image plane 56, target tissue 52 and needle 50.
- the projected trajectory 58 is shown overlaid on the display, so that errors in positioning the needle may be determined.
- such a display includes the planned biopsy location and/or vital organs situated along trajectory 58 and/or the current position of the biopsy needle tip.
- the image is overlaid with a portion of a reference image at the position of the needle tip or along the expected trajectory. Further alternatively or additionally, the image may be limited to the area surrounding the needle tip and or the trajectory to help focus the attention of the operator.
- the acquired image is modified based on the determined position.
- a three dimensional tomographic image set such as an x-ray CT image set is registered to and displayed. This allows for alternative trajectories 58 to be planned in real time.
- the image set is mo ⁇ hed to account for tissue motility. Tissue motility may be determined using additional position sensors attached to the body and whose motion is monitored. Alternatively or additionally to displaying a tomographic image set, ultrasonic imager
- image plane 56 may be scanned along trajectory 58 to acquire a plurality of (semi- parallel) images and to determine the location of any intervening vital tissues.
- the images acquired by imager 54 are acquired and combined to form a three dimensional image set.
- the individual image planes 56 may be registered to each other using position sensor 60, particularly if sensor 60 also senses orientation information.
- imager 54 may be a 3D ultrasound scanner.
- the display may be used to assist an operator in reorienting image plane 56 so that imaging needle 50, target tissue 52 and/or trajectory 58 are viewed.
- changing points of view in an ultrasonic imaging procedure is time consuming and disorienting.
- the location of image plane 56 relative to any objects of interest may be directly determined by the operator, facilitating changing ofthe viewpoints.
- Another aspect of the invention relates to controlling the imager using the position of the needle.
- This control may be automatic or manual.
- the field-of-view of the imager is narrowed to magnify an image of a portion of tissue surrounding the needle or along the trajectory thereof.
- the direction of view of the imager is automatically adjusted to follow the needle tip.
- the imager has an electronic scanning capability so that the direction of view may be changed without moving the imager.
- the direction of view is set to a predetermined offset position from the position of the needle tip.
- any tool not just a biopsy needle, may be used in accordance with the above procedure.
- the tool is a laser tipped endoscope
- a symbol which indicates the location of interaction between the laser beam and the body tissue may be overlaid on the image instead of or in addition to the trajectory or the position of the endoscope itself.
- position sensor 64 is coupled to a sheath portion of needle 50, in other preferred embodiments of the invention, position sensor 64 is coupled to an inner portion of needle 50.
- Fig. 3A is a schematic side view of a biopsy needle 70 having a position sensor 72 situated along the axis of the needle, according to a preferred embodiment of the invention. Position sensor 72 may be located distal to or proximal to a tissue receptacle 76.
- FIG. 3 A shows needle 70 having an inner portion 74 having both a position sensor and a tissue receptacle formed therein, it should be appreciated that two individual inner portions 74 may be used: a first inner portion having only a position sensor 72 may be used for inserting needle 70, whereupon the first inner portion is removed and replaced with a second inner portion 74 having tissue receptacle 76 formed therein.
- Fig. 3B is a schematic side view of a biopsy needle 80 having a position sensor 82 mounted along the needle axis using a slip cover sleeve 86, according to another preferred embodiment of the invention.
- position sensor 82 is mounted unto slip cover sleeve 86.
- the slip-cover sleeve may be glued to the biopsy needle or heat- or chemical- shrinked to engage the tip of needle 80.
- an extension 83 of sensor 82 is inserted in the lumen of needle 80 to enhance the structural integrity of combined sensor/needle. Further alternatively, the body of sensor 82 is inserted into the lumen of needle 80.
- slip-cover sleeve 86 preferably terminates before the window of a tissue receptacle 87.
- a window is formed in the slip-cover adjacent the window in an outer sheath 88 of needle 80.
- an inner portion 84 of needle 80 may be advanced during operation through position sensor 82.
- position sensor 82 is hollow, to accommodate inner portion 84.
- position sensor 82 is misaligned, damaged or destroyed by the advancement of inner portion 84.
- position sensor 82 may be pushed out of needle 80.
- position sensor 82 stays connected to needle 80 by way of slip-cover 86.
- Fig. 3C is a schematic side view of a biopsy needle 90 having a position sensor 92 mounted near the tip of the needle, according to yet another preferred embodiment of the invention.
- position sensor 92 protrudes from the profile of needle 90, however, the protrusion is preferably small and streamlined.
- the advantage of this embodiment is that the tip of the needle is free of any additions.
- a slip cover may be advantageously used to mount a position sensor on a variety of surgical tools and probes.
- a biopsy may be performed with a minimum of radiological imaging, using a technique called "proximity,” which is further described in U.S. Provisional Application 60/012,275, titled “Lesion Location Method", and filed on February 26, 1996, the disclosure of which is inco ⁇ orated herein by reference.
- proximity a position sensor is implanted in the suspected tissue and the biopsy needle is guided until the distance between the two position sensors is minimal. This technique is useful where repeated biopsies must be taken of a single body portion. The position of the implanted position sensor may be determined to ensure that the implanted sensor did not move relative to the target tissue.
- the position sensor may be one of many types of miniature position sensors.
- PCT application US95/01103 titled “Medical Diagnosis, Treatment and Imaging Systems", filed January 24, 1995 and published as PCT publication, WO96/05768, the disclosure of which is inco ⁇ orated herein by reference, describes a low-frequency magnetic position sensor suitable for biopsy needle applications.
- ultrasonic or other types of positioning sensors may be used.
- the biopsy needle When using a magnetic field sensor, care must be taken that the biopsy needle does not distort the magnetic field used for sensing.
- the needle is made of a suitable hard plastic material, which is non-conducting and has a magnetic permeability similar to that of air.
- the biopsy needle may be formed of a non-metallic composite material.
- a stainless steel needle When a stainless steel needle is used, it is preferably heat-relaxed to reduce its permeability as much as possible. Steels having one of the following SAE numbers, which are non-magnetic when annealed (but slightly magnetic when cold-worked), may be used: 30210, 30202, 30301 , 30302, 30303F, 30304, 30305, 30309, 30310 and 30316.
- the sensing means are preferably lithographically formed magnetic sensors, for example, lithographically printed coils.
- This embodiment is particularly useful where the sensor is mounted on the needle using a slip cover, since lithographic sensor coils may be made very thin.
- a preferred lithographic sensor has a size of 0.8 mm wide by 3 mm long, a thickness of 0.3 mm and includes a rectangular coil having the following characteristics: a line width of 6 ⁇ , a line spacing of 6 ⁇ and a line thickness of 2 ⁇ .
- the number of windings is preferably the maximum number which fit in the available area.
- a thin (0.3 mm) ferrite layer may be provided adjacent the coil to increase its sensitivity.
- the coil may be formed on a silicon substrate, or preferably, on a flexible polyimide substrate which can conform to the needle.
- a magnetic position system uses a magnetic field radiator.
- the field radiator is a local radiation generator, for example, as disclosed in US Provisional application No. 60/012,241, titled “Moveable Transmit or Receive Arrangement for Locating Systems", filed February 26, 1996, the disclosure of which is inco ⁇ orated herein by reference.
- Most position sensors measure values of a field, generate signals responsive to these values and convey the signals to a central computer or processor.
- the position sensor transmits such information outside the body using RF radiation and/or ultrasonic waves.
- Ultrasonic waves may travel along the biopsy needle to a receiver coupled to the needle.
- the ultrasonic imager itself is used to receive the position information carrying ultrasonic waves.
- at least one additional ultrasonic receiver receives waves transmitted from the position sensor.
- the position sensor conveys information via an optical fiber or insulated electrical wires. The optical fiber and/or electrical wires may be embedded in the sleeve of the slip-cover in the embodiments described in conjunction with Figs. 3B and 3C.
- the biopsy needle has two configurations.
- a position sensor does not protrude from the biopsy needle, but may obstruct the action of the tissue receptacle.
- the position sensor is moved by the operation so it protrudes from the biopsy needle.
- Fig. 4A is a schematic side view of an expandable biopsy needle 100, according to a preferred embodiment of the invention, in a blocked configuration and Fig. 4B is a schematic side view of biopsy needle 100 in an unblocked configuration.
- a position sensor 102 resides in the lumen of needle 100, where it blocks the advance of an inner needle
- position sensor 102 when inner needle 104 is advanced, position sensor 102 is urged through a sheath 108 of needle 100. When inner needle 104 is retracted, position sensor 10 may retract or not, depending on whether sheath 108 is elastically or plastically deformed. A portion of sheath 108 adjacent to position sensor
- sheath 108 is formed of a rigid material having a window of elastic material adjacent to position sensor 102.
- position sensor 102 is mounted to naturally assume a position protruding from needle 100. Needle 100 in inserted into the body encased in an external guide sheathing, which does not allow sensor 102 to protrude from needle 100. When the sheath is retracted, position sensor 102 is allowed to resume its natural position, protruding from needle 100, thereby, unobstructing the lumen.
- This type of needle may be constructed by making sheath 108 from a shape-memory alloy. Additional embodiments of an expandable probe are described in Israeli application 117,148, titled “Catheter with Lumen", filed February 15, 1996, the disclosure of which is inco ⁇ orated herein by reference. Additional non-obstructing configurations for position sensors are described in
- FIGs. 5A and 5B are schematic cut-away front views of an expandable biopsy needle 110, according to another preferred embodiment of the invention.
- a position sensor 112 is mounted on the inside surface of an outer sheath 118 of needle 110, inside a tissue receptacle 116 formed in an inner portion 114 of needle 110.
- Tissue receptacle 116 preferably has a sloped edge, so when inner portion 114 is rotated to align tissue receptacle 116 is with a window 119 in sheath 118, the inclined slope of tissue receptacle 116 forces position sensor 112 to protrude from outer sheath 118, as shown in Fig. 5B.
- a single coil position sensor is used, for example, as disclosed in PCT publication WO94/04938, the disclosure of which is inco ⁇ orated herein by reference.
- Fig. 6 is a schematic side view of a single coil sensor embodiment, where needle 120 is formed around the coil, such as by embedding a coil 122 and its associated wiring in a plastic matrix, resulting in a biopsy needle having an embedded position sensor which does not protrude.
- a coil sensor is mounted on the outside of the needle, such as by using a slip-cover.
- such a coil is inserted inside the needle instead of or as part ofthe inner portion ofthe biopsy needle.
- Fig. 7 is a schematic side view of a preferred embodiment of a flexible biopsy needle
- the instantaneous spatial shape of the biopsy needle may be determined and displayed to the operator by determining the positions of all the coils.
- the biopsy needle is curved and/or shaped and/or stiffed by a stylet which may be inserted into its lumen.
- a stylet which may be inserted into its lumen.
- Figs. 8A-8F illustrate methods of mounting a position sensor on a substantially rigid biopsy needle, typically, near its proximal end.
- Fig. 8A shows an encapsulated position sensing device 200 adapted to be mounted on a biopsy needle.
- Device 200 includes a position sensor 202.
- the body of device 200 has a lumen 204 formed therein, in which lumen the biopsy needle is inserted.
- the lumen is flanked by at least one O-ring 206 which is adapted to grip the biopsy needle when it is inserted in lumen 204.
- the body of device 200 is made of a hard rubber-like material which grips the needle when the needle is inserted therein.
- device 200 is bonded to the needle using an adhesive.
- Fig. 8B shows device 200 mounted on a biopsy needle 210.
- Position sensor 202 may be wireless. If position sensor 202 is not wireless, wires 208 carry data and/or power to and/or from position sensor 202.
- Device 200 is typically mounted on needle 210 by spearing the device with the needle. Preferably, device 200 is speared while in a sterile wrapping, to reduce the possibility of contamination of the biopsy needle.
- Device 200 is preferably pushed up needle 210 until a stop 212 mounted on the needle is reached, thus, ensuring that the position sensor is at a known location relative to the tissue receptacle. Stop 212 may be part of needle 210 or it may be a separate gauge tool.
- the position sensor is preferably aligned with the window while mounting.
- the position sensor In many uses of a biopsy needle it is desirable to know the location in space of the tip of the biopsy needle. If the position sensor is not mounted at the tip, it is necessary to determine exactly the distance between the tip of the needle and the position sensor. In addition, it is desirable to mount the position sensor on the needle in such a way that the position sensor will not move during the procedure. In a preferred embodiment of the invention, the distance of the position sensor from the needle tip is measured before the position sensor is fixed on the needle.
- Fig. 8C shows a device 220 for attaching a position sensor at a predetermined distance from the tip of biopsy needle 210.
- Device 220 has a base 222 for accommodating the tip of needle 210 at a distal portion of device 200, a body 223 connected to base 222 and two arms 224 and 226 at a proximal end of device 220, also attached to body 223.
- a position sensor 230 is mounted to one of arms 224 and 226.
- position sensor 230 is mounted at a radial distance from needle 210, to reduce any effects that needle 210 might have on the accuracy of position sensor 230.
- Arms 224 and 226 have jaws 232 and 234 formed thereon to engage needle 210.
- arms 224 and 226 may be closed so that jaws 232 and 234 firmly engage needle 210.
- Base 222 and body 223 may be removed at this point.
- a weak spot such as a grove 235, is formed in body 223, slightly distal to arms 224 and 226, so that body 223 is easily snapped off.
- arms 224 and 226 may be joined using a contact adhesive or using a snap-lock 228, as well known in the art of plastic attachments.
- a thin position sensor such as a lithographic- type sensor, is attached directly to needle 210.
- the position sensor is placed between arm 224 and arm 226, such that the position sensor is in contact with at least one of jaws 232 and 234.
- the jaws urge the position sensor against needle 210.
- the position sensor is coated with a contact cement, so that a strong bond between the position sensor and needle 210 is formed substantially instantly. After the bond is formed, device 223 may be removed.
- Fig. 8D is a top view of an alternative embodiment of the device shown in Fig. 8C, wherein needle 210 is gripped by triangular grooves formed in jaws 232 and 234.
- the use of triangular grooves ensures that the relative positions of the needle axis and position sensor 230 are not dependent on the needle diameter, for a substantial range of needle diameters.
- Arms 224 and 226 are preferably slightly flexible so that needle 210, body 223 and position sensor 230 are coplanar if a needle having a diameter within the centered range is used.
- Fig. 8E shows a device 240 for attaching a position sensor to a needle.
- Device 240 is especially useful for a reusable position sensor.
- Device 240 includes a first plate 246 having formed therein a grove 242 for receiving the needle and a cavity 244 for receiving a position sensor, groove 242 is preferably V-shaped so that it may receive many sizes of biopsy needles.
- a second plate 248 may be urged against first plate 246, such as by a screw 250, so that at least a needle placed in groove 242 is snugly engaged by plates 246 and 248.
- the position sensor in cavity 244 may also be engaged by the two plates. Alternatively, the position sensor may be glued to plate 246.
- FIG. 8F shows an alternative profile of plate 246 of device 240, wherein groove 242 is asymmetric.
- groove 242 is asymmetric.
- the relative positions of the needle axis and the position sensor depends on the diameter of the needle.
- an asymmetric groove is used with two different diameter needles, such as needles 210 and 210', the difference between the relative positions is smaller than when a symmetric groove is used.
- an endoscope may be more suitable than a biopsy needle in some applications, due to the greater maneuverability of the endoscope.
- a position sensor on needle 130 is desirable regardless of the existence of a position sensor in the endoscope, since needle 130 may be extended a considerable distance from the endoscope.
- needle 130 may be guided along the shortest path to the target tissue or along the path which causes the least damage to the body.
- One example where such maneuvering is important is in biopsies of the liver.
- a liver biopsy is performed by guiding a biopsy-taking catheter through the venous system after insertion into the jugular vein and then into the liver to take a biopsy.
- FIG. 9A is a schematic partial phantom view of the placement of a probe 140 according to a preferred embodiment of the invention.
- a target tissue 142 in the brain, may be unreachable along a straight trajectory without damaging important brain structures.
- a flexible probe such as probe 140
- Damage to important brain structures can be kept to a minimum.
- Probe 140 may be inserted into fluid filled cavities 144 of the brain through a nasal sinus. Probe 140 is then guided in cavities 144 until it has a relatively clear trajectory to target tissue 142.
- the trajectory of probe 140 through the brain tissue itself may be curved to avoid important brain structures.
- a medical probe can be inserted into the brain at a location which is best suited for insertion, such as a location where less damage is caused to the skull by insertion, and the probe can be navigated through the brain in a manner which does not substantially damage the brain, to reach its target tissue.
- This methodology stands in stark contrast to stereotaxic techniques, where the target tissues in the brain are practically always accessed through the cortex, which is an important brain structure.
- probe 140 is a shunt useful for relieving pressure in the brain.
- the distal end of the shunt is inserted through the skull and into a particular fluid filled cavity.
- the proximal end of the shunt is inserted under the skin, so that it vents inside the body, for example, into the esophagus.
- the distal end of the shunt is inserted into the brain from via an internal body cavity, such as through a nasal sinus.
- the proximal end of the shunt is also left inside the body, for example, in the nasal sinus, so that there is less danger of damage to the shunt by trauma. It should be appreciated that a shunt for any portion of the brain may be inserted through the nasal passages, if it is guided through the natural lumens of the brain.
- Fig. 9B shows a bendable, rigid endoscope 145 in accordance with a preferred embodiment of the invention.
- Endoscope 145 has a rigid portion 149 and a bendable portion 146, which bend is controlled by a bend controller 147.
- the degree of bending may be difficult to determine from the bend controller, since the flexibility of the catheter may affect the degree of bending.
- a position sensor 148 is mounted on the rigid portion
- the location of the tip of endoscope 145 is determined based on the position sensor and on the amount of bend in the catheter.
- the amount of bend may be determined from bend controller 147.
- a torque sensor is mounted in the bendable portion 146 and it measures the amount of bending of portion 146. Further methods of determining and controlling such a bend are described in "Bend Responsive Catheter” and “Conformal Catheter” filed as U.S. provisional applications on January 3, 1997, the disclosures of which are inco ⁇ orated herein by reference.
- Fig. 10 is a schematic partial cut-away view of the placement of a chemotherapy catheter 150 in accordance with a preferred embodiment of the invention.
- a chemotherapy catheter 150 is usually inserted into the right atria, where the blood flow is very turbulent and rapidly dilutes the pharmaceuticals.
- catheter 150 is usually inserted into the right atria, where the blood flow is very turbulent and rapidly dilutes the pharmaceuticals.
- catheter 150 is usually inserted into the right atria, where the blood flow is very turbulent and rapidly dilutes the pharmaceuticals.
- catheter 150 is usually inserted into the right atria, where the blood flow is very turbulent and rapidly dilutes the pharmaceuticals.
- catheter 150 is usually inserted into the right atria, where the blood flow is very turbulent and rapidly dilutes the pharmaceuticals.
- catheter 150 is usually inserted into the right atria, where the blood flow is very turbulent and rapidly dilutes the pharmaceuticals.
- catheter 150 is usually inserted into the right atria, where the blood flow is very turbulent and rapidly
- the catheter 150 may migrate from its proper location in the right atria to an improper location, such as the carotid veins. If a dose of pharmaceutical is injected when catheter 150 is in the carotid veins, the vein may be severely inflamed and damaged.
- the location of the catheter is verified using a position sensor 152 mounted at its distal end.
- the determined location of the probe tip may be used to optimize image acquisition.
- such optimization may include increasing the magnification of the ultrasonic image and/or automatically aiming the field-of-view of the ultrasonic imager so that the probe tip is in a predetermined portion of the image, such as the middle.
- the ultrasonic imager is mounted on a robotic arm which is articulated to align the field-of-view ofthe imager.
- the motion of the probe may be determined relative to the motion ofthe ultrasonic imager and/or the radiator (if one is needed). A profile of the motion of the probe, thus obtained, reflects the physiological motion of the portion of the body in which it is situated.
- the motion of the probe may be correlated with a measure of physiological motion such as an ECG (for cardiac motion), a belly strap (for breathing) and/or EMG (for other muscular motion).
- ECG for cardiac motion
- a belly strap for breathing
- EMG for other muscular motion
- a composite reference image may be generated for each instant by inte ⁇ olating between existing images or by mo ⁇ hing an existing image.
- Other methods of determining physiological motion of a probe are described in Israeli application number 119,137, titled “Intrabody Energy Focusing", filed on August 26, 1996 by applicant Biosense LTD., the disclosure of which is inco ⁇ orated herein by reference.
- Fig. 11 is a block diagram of a image guided probe system 300, in accordance with a preferred embodiment of the invention and suitable for applying the above describe guidance methods.
- System 300 includes a processor 302 which can determine the position of a probe 308 using position sensor 310.
- processor 302 displays an indication of the position of probe 308 on a display 304.
- the indication may be overlaid on an image retrieved from an image store 316.
- the indication may overlaid with an image from an imager 312.
- the relative positions and or orientations of imager 312 and probe 308 are preferably determined using a position sensor 314 mounted on imager 312.
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Abstract
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11926296A IL119262A0 (en) | 1996-02-15 | 1996-09-17 | Locatable biopsy needle |
AU16168/97A AU1616897A (en) | 1996-02-15 | 1997-02-14 | Locatable biopsy needle |
DE69731644T DE69731644T2 (de) | 1996-09-17 | 1997-09-15 | Positionsbestätigungsvorrichtung mit lern und testfunktionen |
AU42183/97A AU714071B2 (en) | 1996-09-17 | 1997-09-15 | Position confirmation with learn and test functions |
SI9730695T SI0926997T1 (en) | 1996-09-17 | 1997-09-15 | Position confirmation with learn and test functions |
ES97940317T ES2231887T3 (es) | 1996-09-17 | 1997-09-15 | Sistema para confirmar la posicion con funciones de aprendizaje y prueba. |
DK97940317T DK0926997T3 (da) | 1996-09-17 | 1997-09-15 | Positionsbekræftelsesindretning med lære- og prövefunktioner |
PCT/IL1997/000308 WO1998011840A1 (fr) | 1996-09-17 | 1997-09-15 | Dispositif de verification du positionnement a fonctions de detection et de confirmation |
IL12433297A IL124332A (en) | 1996-09-17 | 1997-09-15 | Position confirmation with learn and test functions |
AT97940317T ATE282370T1 (de) | 1996-09-17 | 1997-09-15 | Positionsbestätigungsvorrichtung mit lern und testfunktionen |
CA002237992A CA2237992C (fr) | 1996-09-17 | 1997-09-15 | Dispositif de verification du positionnement a fonctions de detection et de confirmation |
JP51445898A JP3934159B2 (ja) | 1996-09-17 | 1997-09-15 | 学習および試験機能を有する位置確認 |
EP97940317A EP0926997B1 (fr) | 1996-09-17 | 1997-09-15 | Dispositif de verification du positionnement a fonctions de detection et de confirmation |
Applications Claiming Priority (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1174396P | 1996-02-15 | 1996-02-15 | |
US1172196P | 1996-02-15 | 1996-02-15 | |
US60/011,743 | 1996-02-15 | ||
IL117148 | 1996-02-15 | ||
IL11714896A IL117148A (en) | 1996-02-15 | 1996-02-15 | Catheter with lumen |
US60/011,721 | 1996-02-15 | ||
US1227596P | 1996-02-26 | 1996-02-26 | |
US1224296P | 1996-02-26 | 1996-02-26 | |
US60/012,275 | 1996-02-26 | ||
US60/012,242 | 1996-02-26 | ||
IL119137 | 1996-08-26 | ||
IL11913796A IL119137A0 (en) | 1996-02-15 | 1996-08-26 | Intrabody energy focusing |
IL119262 | 1996-09-17 | ||
IL11926296A IL119262A0 (en) | 1996-02-15 | 1996-09-17 | Locatable biopsy needle |
US3470497P | 1997-01-03 | 1997-01-03 | |
US3470397P | 1997-01-03 | 1997-01-03 | |
US60/034,703 | 1997-01-03 | ||
US60/034,704 | 1997-01-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997029682A1 true WO1997029682A1 (fr) | 1997-08-21 |
Family
ID=27576389
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IL1997/000058 WO1997029682A1 (fr) | 1996-02-15 | 1997-02-14 | Aiguille de biopsie localisable |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU1616897A (fr) |
IL (1) | IL119262A0 (fr) |
WO (1) | WO1997029682A1 (fr) |
Cited By (119)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0794346A1 (fr) | 1996-03-04 | 1997-09-10 | GKN Automotive AG | Joint homocinétique fixe à billes |
WO1998025159A1 (fr) * | 1996-12-03 | 1998-06-11 | I.S.G. Technologies, Inc. | Procede et appareil pour visualiser des images ultrasonores |
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