WO1997026032A1 - Ecarteur a mailles pour echangeur thermique - Google Patents

Ecarteur a mailles pour echangeur thermique Download PDF

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Publication number
WO1997026032A1
WO1997026032A1 PCT/US1997/000480 US9700480W WO9726032A1 WO 1997026032 A1 WO1997026032 A1 WO 1997026032A1 US 9700480 W US9700480 W US 9700480W WO 9726032 A1 WO9726032 A1 WO 9726032A1
Authority
WO
WIPO (PCT)
Prior art keywords
blood
hollow conduits
mesh
heat
hollow
Prior art date
Application number
PCT/US1997/000480
Other languages
English (en)
Inventor
Henry W. Palermo
Peter J. Hier
Peter Z. Kubisa
Original Assignee
Medtronic, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic, Inc. filed Critical Medtronic, Inc.
Priority to AU15770/97A priority Critical patent/AU1577097A/en
Priority to JP52609997A priority patent/JP3609835B2/ja
Priority to EP97901998A priority patent/EP0876169A1/fr
Priority to CA002241844A priority patent/CA2241844C/fr
Publication of WO1997026032A1 publication Critical patent/WO1997026032A1/fr

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28—HEAT EXCHANGE IN GENERAL
    • F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
    • F28F1/00—Tubular elements; Assemblies of tubular elements
    • F28F1/10—Tubular elements and assemblies thereof with means for increasing heat-transfer area, e.g. with fins, with projections, with recesses
    • F28F1/12—Tubular elements and assemblies thereof with means for increasing heat-transfer area, e.g. with fins, with projections, with recesses the means being only outside the tubular element
    • F28F1/122—Tubular elements and assemblies thereof with means for increasing heat-transfer area, e.g. with fins, with projections, with recesses the means being only outside the tubular element and being formed of wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3623—Means for actively controlling temperature of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/369—Temperature treatment
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28—HEAT EXCHANGE IN GENERAL
    • F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
    • F28F21/00—Constructions of heat-exchange apparatus characterised by the selection of particular materials
    • F28F21/06—Constructions of heat-exchange apparatus characterised by the selection of particular materials of plastics material
    • F28F21/062—Constructions of heat-exchange apparatus characterised by the selection of particular materials of plastics material the heat-exchange apparatus employing tubular conduits
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28—HEAT EXCHANGE IN GENERAL
    • F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
    • F28F9/00—Casings; Header boxes; Auxiliary supports for elements; Auxiliary members within casings
    • F28F9/007—Auxiliary supports for elements
    • F28F9/013—Auxiliary supports for elements for tubes or tube-assemblies
    • F28F9/0137—Auxiliary supports for elements for tubes or tube-assemblies formed by wires, e.g. helically coiled
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28—HEAT EXCHANGE IN GENERAL
    • F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
    • F28F2240/00—Spacing means

Definitions

  • the present invention generally relates to heat exchangers for use in regulating the temperature of a patient's blood during surgery, and more particularly to a micro-conduit heat exchanger with enhanced flow of the heat transfer fluid around the micro-conduits.
  • Blood oxygenators are typically disposable and serve to infuse oxygen into a patient's blood during medical procedures such as heart surgery.
  • Most commercially available blood oxygenators employ a membrane-type oxygenator, which comprises thousands of tiny hollow fibers having microscopic pores. Inside the membrane oxygenator blood flows around the outside surfaces of these fibers while a controlled oxygen rich gas mixture is pumped through the fibers. Due to the relatively high concentration of carbon dioxide in the blood arriving from the patient, carbon dioxide from the blood diffuses through the fibers' microscopic pores and into the gas mixture. Due to the relatively low concentration of oxygen in the blood arriving from the patient, oxygen from the gas mixture diffuses into the blood through the fibers' microscopic pores.
  • Most blood oxygenators also employ a heat exchanger to precisely regulate the temperature of a patient's blood.
  • the heat exchanger usually includes one or more relatively large conduits housed in a vessel. The patient's blood is continuously pumped through the conduits while a heat transfer fluid such as water flows through the vessel around the conduits, or vice versa. The heat exchange medium is either heated or cooled to maintain the patient's blood at a desired temperature.
  • One example of a commercially successful blood oxygenator is sold under the designation MAXIMATM by Medtronic, Inc.
  • MAXIMATM the heat transfer fluid (water) flows inside relatively large diameter metal tubes while blood flows on the outside of the tubes within the vessel.
  • the TERUMO brand oxygenator uses a different configuration, where blood flows inside relatively large diameter metal tubes.
  • BARD WILLIAM HARVEY HF-5700 blood oxygenator the blood flows outside plastic tubes that contain a flow of temperature-regulated water.
  • Heat exchangers in blood oxygenators are subject to a number of design constraints.
  • the heat exchangers should be compact due to physical space limitations in the operating room environment. Also, small size is important in minimizing the internal priming volume of the blood oxygenator due to the high cost and limited supply of blood.
  • the heat exchanger must be large enough to provide an adequate volumetric flow rate of blood to allow proper temperature control and oxygenation.
  • blood flow rate or flow resistance inside the blood oxygenator and heat exchanger must not be excessive since the cells and platelets in the human blood are delicate and can be traumatized if subjected to excessive shear forces resulting from turbulent flow.
  • One way to meet the above requirements is to provide a heat exchanger with improved heat exchange efficiency.
  • a more efficient heat exchanger can provide adequate temperature control in a compact space with minimal priming volume.
  • a blood heat exchange system comprising a plurality of small polymeric hollow conduits for conveying blood.
  • the hollow conduits are formed in a flat or mat shape that are wrapped in layers around a spindle. Layers of the hollow conduits are spaced from each other by a mesh spacer.
  • the mesh spacer has holes through it so that a heat transfer fluid such as water may more efficiently flow over and around the outside of the hollow conduits.
  • the heat transfer fluid conveys heat from or to the outside surfaces of the hollow conduits which in turn transfer heat from or to the blood passing through the hollow conduits.
  • the invention provides a heat exchanger that is more efficient than previously known heat exchangers because the flow of the heat transfer fluid over and around the outer surface of the hollow conduits is more efficient. More efficient flow of the heat transfer fluid allows for more efficient heat transfer from or to the walls of the hollow conduits. More efficient heat transfer from the walls of the hollow conduits to the heat transfer fluid in turn produces a more efficient heat transfer from and to the blood passing through the hollow conduits.
  • the invention advantageously provides a blood heat exchanger with markedly improved heat exchange characteristics.
  • Another advantage of the invention includes its low cost, since the mesh can be made from inexpensive materials.
  • the mesh is also easy to make and assemble with the hollow conduits. It is therefore an object of the present invention to provide an improved blood heat exchanger.
  • FIG. 1 is a vertical sectional view of a blood heat exchanger apparatus in accordance with the invention
  • Figure 1 A is an enlarged vertical sectional view of a portion of the blood heat exchanger apparatus shown in Figure 1 ;
  • Figure 2 is a greatly enlarged plan view of a micro-conduit wrapping material in accordance with the invention.
  • Figure 3 is further enlarged perspective view of a section of micro-conduit wrapping material of Figure 2;
  • Figure 4 is a plan view of the mesh of the present invention.
  • Figure 5 is a flow chart of a sequence of steps used in fabricating a heat exchanger apparatus in accordance with the invention.
  • the present invention concerns a blood heat exchanger which employs a polymeric micro-conduit to carry blood while a heat transfer fluid passes around the micro-conduits to permit temperature control of the blood.
  • the invention provides a mesh like spacer that provides for more efficient flow of the heat transfer fluid around the micro-conduits.
  • the heat exchanger 10 includes a generally cylindrical heat exchange core 12 which is made from a mat of micro-conduit wrapping material 14 wound about a central spindle 16.
  • the spindle has first and second ends 18, 20.
  • the individual fibers of the wrapping material 14 (shown in more detail in Figures 2 and 3) are cut to provide substantially flat end surfaces proximate the first and second ends 18, 20 of the spindle 16.
  • the core 12 may include, for example, about five thousand four- hundred individual fibers.
  • FIG 2 depicts the micro-conduit wrapping material 14 prior to wrapping into the core 12 shown in Figure 1.
  • the micro conduit wrapping material 14 comprises a plurality of small fibers 32.
  • Each fiber 32 is hollow, with a cross- sectional shape preferably being rounded, or alternatively triangular, rectangular or other appropriate shape.
  • each fiber 32 has defined therein an inner channel 34 having an inner surface 36.
  • the fibers outer diameter is about five hundred and seventy- five microns, while the inner channel 34 has a diameter of about four-hundred and twenty-eight microns.
  • the fibers 32 may be about ten centimeters long. However, a wide range of fiber lengths may be used, depending upon the requirements of a particular application for the blood heat exchanger.
  • the fibers 32 are preferably made from a plastic material such as polypropylene, polyethylene, a different polymeric substance, or other material that is inexpensive, pharmacologically safe, lightweight, easily cut and flexible.
  • the material of the fibers 32 should also be easily formed into fibers with sufficiently small inner and outer dimensions.
  • the mat of micro-conduit wrapping material 14 includes a thin flexible interconnect 38 that maintains the fibers 32 at predetermined spacing in substantially parallel alignment with each other.
  • the interconnect In the illustrated embodiment, the interconnect
  • the wrapping material 14 aides in positioning the fibers 32 during surface treatment and construction of the blood heat exchanger as discussed in more detail below.
  • the wrapping material 14 is preferably made of a commercially available product from Mitsubishi Rayon Company Limited sold under the designation HFE430-1 Hollow Fiber.
  • the fibers of this product are made of polyethylene.
  • Similar wrapping material is also commercially available from Hoechst Celanese Corp. under the designation Heat Exchanger Fiber Mat, which uses polypropylene fibers.
  • FIG. 4 shows a mesh 40 that overlays the wrapping material 14 as wrapping material 14 is wrapped around spindle 16.
  • Mesh 40 comprises an open matrix 42 that produces a variety of holes 44. As wrapping material 14 and mesh 40 are wound around spindle 16, mesh 40 spaces layers of wrapping material 14 from each other.
  • Mesh 40 preferably has a width W approximately the same as the width W of wrapping material 14.
  • mesh 40 preferably has a thickness of about .030 " but could have a thickness considerably larger or smaller; the key being that opposed layers of wrapping material 14 are spaced apart from each other and that heat exchange fluid may pass through the holes 44 as will be described hereafter. This spacing combined with the holes 44 provides passages through holes 44 for the heat exchange fluid to more freely travel around the fibers 32 of wrapping material 14.
  • Mesh 40 is preferably made of a polyolifin material such as polyethylene or polypropylene but could be made of other materials. Whatever the material used for mesh 40, the material should be flexible enough to allow mesh 40 to be wrapped around spindle 16 with wrapping material 14 and should be rigid enough to prevent mesh 40 and holes 44 from collapsing so that heat exchange fluid can pass through and around mesh 40.
  • a rigid cylindrical shell 22 encloses the core 12 and spindle 16.
  • the shell 22 includes an inlet 24 and an outlet (not shown) to facilitate the flow of a heat transfer fluid through the shell 22 and around the micro-conduit wrapping material 14 inside the shell 22.
  • the heat exchange medium is water which has adequate heat exchange properties while also being relatively biocompatible as compared to other commonly used heat exchange mediums.
  • the core 12 includes an upper seal 26 and a lower seal 28.
  • the upper and lower seals 26, 28 comprise a layer of potting compound sealingly applied between the individual fibers of the micro-conduit wrapping material 14 approximate the spindles first and second ends 18,20.
  • the potting compound comprises a urethane material.
  • the upper and lower seals 26, 28 are applied in a manner described in more detail below. Importantly, the seals 26, 28 provide a tight and reliable isolation between the heat exchange medium entering inlet 24 and the blood passing through the individual fibers of the micro-conduit wrapping material 14.
  • the core 12 is enclosed within the shell 22 by an upper blood transition manifold 29, forming outlet chamber 33 and a lower blood inlet manifold 30 forming inlet chamber 31. Further details of the heat exchanger 10 are described in co-pending U.S. Patent Applications Serial No. filed on January 11, 1996 entitled Surface Treatment for Micro-conduits Employed in Blood Heat Exchange System, U.S. Patent Applications Serial No. filed on January 11, 1996 entitled Compact Membrane-Type Blood Oxygenator With
  • FIG. 5 a sequence 78 for manufacturing a blood heat exchanger in accordance with one example of the invention is illustrated.
  • the surface of the fibers 32 are treated in accordance with one of the surface treatment techniques such as is described in co-pending U.S. Patent Application Serial No. filed on January 11, 1996 entitled SURFACE TREATMENT FOR MICRO-CONDUITS EMPLOYED IN BLOOD HEAT EXCHANGE
  • the micro-conduit wrapping material 14 and mesh 40 are simultaneously wrapped around the spindle 16, preferably without any substantial tension on the wrapping material.
  • the shell 22 is installed over the core 12 in task 84.
  • the upper and lower seals 26, 28 are formed.
  • urethane potting compound is injected between the fibers 32 to substantially seal the spaces between the fibers. This is done by putting the ends of the fibers in potting cups and inserting the core 18 into a centrifuge and spinning it while urethane from a reservoir fills the cups. The high G forces of the spinning process forces the urethane around the exterior of the fibers.
  • the thickness of the upper and lower seals 26, 28 is determined by the amount of urethane which is used during the potting process.
  • the ends of the fibers may be sealed to prevent the potting compound from entering therein.
  • the potting material is a bio-compatible urethane commercially available under the name BIOTHANE from CasChem Corporation of Bayonne, New Jersey, U.S.A. This is a particular formulation of urethane which has as its primary components Polycin and Vorite. Other kinds of urethane may also be suitable in some applications, as well as non-urethane potting materials such as epoxy and silicone.
  • the fibers 32 are trimmed proximate the first and second ends 18, 20 of the spindle 16 as shown in task 88.
  • the trimmed fibers 32 form uniform flat upper and lower surfaces of the core 12.
  • This trimming is preferably a two-stage process in which a rough cut is initially made with a rotary blade and then the ends are trimmed with a microtome.
  • the manifolds such as are attached to the shell 22.
  • hoses and other plumbing lines are attached to the heat exchanger 10 as needed for transportation of heat exchange fluid, blood, priming solution, and other media as appropriate.
  • the heat exchanger 10 serves to regulate the temperature during a medical procedure such as open-heart surgery. Heat exchanger 10 also may be advantageously incorporated into a blood oxygenator such as disclosed in the aforementioned U.S. Patent Application entitled "Compact Membrane-Type Blood
  • a heat transfer fluid such as water flows into the shell 22 through the inlet 24 during the medical procedure. While in the shell 22, the heat transfer fluid passes between and around the exterior of the fibers 32 in the core 12, preferably flowing in a direction opposite to the of blood. This flow is improved considerably by the presence of mesh 40 which provides holes 44 through which the heat transfer fluid more easily flow. This counter-flow is achieved using a flow channel, (not illustrated) for the water which flows from inlet 24 to the top of the shell 22 where the water exists and flows downwardly. Due to the large number of fibers 32 and their small size and thin walls, there is substantial area of surface contact and heat exchange between the heat exchange fluid and the blood inside the fibers 32.
  • a patient's blood which flows into inlet manifold 30 and chamber 31 through the fibers 32 of the core 12 and exits through the upper end of the fibers past seal 26 through a transition manifold 29 and outlet chamber 33.
  • the temperature of the blood flowing through the core may be easily regulated by a heat exchange fluid temperature controlling unit (not shown) due to the high degree of thermal contact between the blood and the heat exchange medium as well as the relatively high thermal conductivity of the thin wall fibers.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Thermal Sciences (AREA)
  • Anesthesiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Geometry (AREA)
  • External Artificial Organs (AREA)
  • Heat-Exchange Devices With Radiators And Conduit Assemblies (AREA)

Abstract

Un dispositif d'échange thermique avec le sang (10) comporte généralement une pluralité de petits conduits creux (32) en matière polymère destinés au transport du sang. Ces conduits creux (32) sont fabriqués à partir d'une forme plate enroulée en couches autour d'un axe (16). Les couches des conduits creux (32) sont espacées les unes des autres par un écarteur à mailles (40). Cet écarteur à mailles (40) a des trous (44) à travers lesquels un fluide caloporteur tel que l'eau peut circuler de façon plus efficace au-dessus et autour de la surface externe desdits conduits creux (32). Ledit fluide caloporteur effectue un échange thermique avec les surfaces externes des conduits creux (32) qui à leur tour effectuent un échange thermique avec le sang traversant lesdits conduits creux (32). Cette invention concerne également un échangeur thermique (10) qui s'avère plus efficace que les échangeurs thermiques connus de l'état antérieur de la technique du fait que l'écoulement du fluide caloporteur au-dessus et autour de la surface externe des conduits creux (32) est plus efficace.
PCT/US1997/000480 1996-01-18 1997-01-10 Ecarteur a mailles pour echangeur thermique WO1997026032A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU15770/97A AU1577097A (en) 1996-01-18 1997-01-10 Mesh spacer for heat exchanger
JP52609997A JP3609835B2 (ja) 1996-01-18 1997-01-10 血液熱交換システム
EP97901998A EP0876169A1 (fr) 1996-01-18 1997-01-10 Ecarteur a mailles pour echangeur thermique
CA002241844A CA2241844C (fr) 1996-01-18 1997-01-10 Ecarteur a mailles pour echangeur thermique

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59124496A 1996-01-18 1996-01-18
US08/591,244 1996-01-18

Publications (1)

Publication Number Publication Date
WO1997026032A1 true WO1997026032A1 (fr) 1997-07-24

Family

ID=24365695

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/000480 WO1997026032A1 (fr) 1996-01-18 1997-01-10 Ecarteur a mailles pour echangeur thermique

Country Status (5)

Country Link
EP (1) EP0876169A1 (fr)
JP (1) JP3609835B2 (fr)
AU (1) AU1577097A (fr)
CA (1) CA2241844C (fr)
WO (1) WO1997026032A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5846224A (en) * 1996-10-01 1998-12-08 Baxter International Inc. Container for use with blood warming apparatus
US6047108A (en) * 1996-10-01 2000-04-04 Baxter International Inc. Blood warming apparatus
WO2000053992A1 (fr) * 1999-03-08 2000-09-14 E.I. Du Pont De Nemours And Company Echangeur thermique constitue de plaques tubulaires tissees
US6613279B1 (en) 1999-08-31 2003-09-02 Medtronic, Inc. Method and apparatus for improving blood mixing in oxygenators
NL2009330C2 (en) * 2012-08-16 2014-02-18 X Flow Bv Filter module and filter apparatus containing such filter module.
US9572695B2 (en) 2009-08-24 2017-02-21 New Phase Ltd Phase-change and shape-change materials
US9872902B2 (en) 2014-11-25 2018-01-23 New Phase Ltd. Phase-change nanoparticle
US10254017B2 (en) 2011-09-20 2019-04-09 Lockheed Martin Corporation Extended travel flexure bearing and micro check valve

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE654158C (de) * 1934-10-24 1937-12-14 Henry Dieterlen Waermeaustauscher
JPS5625696A (en) * 1979-08-07 1981-03-12 Toshimi Kuma Heat exchanging element
FR2555724A1 (fr) * 1983-11-24 1985-05-31 Ducol Jean Paul Materiau utilisable pour la realisation d'echangeurs calorifiques
US4770778A (en) * 1984-11-29 1988-09-13 Asahi Kasei Kogyo Kabushiki Kaisha Hollow fiber semipermeable membrane element and a method of producing the same
EP0299381A2 (fr) * 1987-07-11 1989-01-18 Dainippon Ink And Chemicals, Inc. Poumon artificiel du type à membrane et son procédé d'utilisation
EP0408000A1 (fr) * 1989-07-14 1991-01-16 Terumo Kabushiki Kaisha Dispositif pour le traitement de fluide

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE654158C (de) * 1934-10-24 1937-12-14 Henry Dieterlen Waermeaustauscher
JPS5625696A (en) * 1979-08-07 1981-03-12 Toshimi Kuma Heat exchanging element
FR2555724A1 (fr) * 1983-11-24 1985-05-31 Ducol Jean Paul Materiau utilisable pour la realisation d'echangeurs calorifiques
US4770778A (en) * 1984-11-29 1988-09-13 Asahi Kasei Kogyo Kabushiki Kaisha Hollow fiber semipermeable membrane element and a method of producing the same
EP0299381A2 (fr) * 1987-07-11 1989-01-18 Dainippon Ink And Chemicals, Inc. Poumon artificiel du type à membrane et son procédé d'utilisation
EP0408000A1 (fr) * 1989-07-14 1991-01-16 Terumo Kabushiki Kaisha Dispositif pour le traitement de fluide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 005, no. 076 (M - 069) 20 May 1981 (1981-05-20) *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5846224A (en) * 1996-10-01 1998-12-08 Baxter International Inc. Container for use with blood warming apparatus
US6047108A (en) * 1996-10-01 2000-04-04 Baxter International Inc. Blood warming apparatus
WO2000053992A1 (fr) * 1999-03-08 2000-09-14 E.I. Du Pont De Nemours And Company Echangeur thermique constitue de plaques tubulaires tissees
US6613279B1 (en) 1999-08-31 2003-09-02 Medtronic, Inc. Method and apparatus for improving blood mixing in oxygenators
US9572695B2 (en) 2009-08-24 2017-02-21 New Phase Ltd Phase-change and shape-change materials
US10492935B2 (en) 2009-08-24 2019-12-03 New Phase Ltd Phase-change materials
US10254017B2 (en) 2011-09-20 2019-04-09 Lockheed Martin Corporation Extended travel flexure bearing and micro check valve
NL2009330C2 (en) * 2012-08-16 2014-02-18 X Flow Bv Filter module and filter apparatus containing such filter module.
WO2014027889A1 (fr) * 2012-08-16 2014-02-20 X-Flow B.V. Membranes tubulaires parallèles présentant une structure de support métallique élastique
US9872902B2 (en) 2014-11-25 2018-01-23 New Phase Ltd. Phase-change nanoparticle
US10172939B2 (en) 2014-11-25 2019-01-08 New Phase Ltd. Phase-change nanoparticle

Also Published As

Publication number Publication date
CA2241844C (fr) 2001-08-14
CA2241844A1 (fr) 1997-07-24
JP3609835B2 (ja) 2005-01-12
EP0876169A1 (fr) 1998-11-11
JPH11509760A (ja) 1999-08-31
AU1577097A (en) 1997-08-11

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