USRE36774E - Cylindrical blood heater/oxygenator - Google Patents

Cylindrical blood heater/oxygenator Download PDF

Info

Publication number
USRE36774E
USRE36774E US08/842,528 US84252897A USRE36774E US RE36774 E USRE36774 E US RE36774E US 84252897 A US84252897 A US 84252897A US RE36774 E USRE36774 E US RE36774E
Authority
US
United States
Prior art keywords
blood
compartment
heat exchange
housing
oxygenating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US08/842,528
Inventor
Louis C. Cosentino
Jeffrey A. Lee
Daniel A. Baker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Edwards Lifesciences Corp
Original Assignee
Baxter Healthcare Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to PCT/US1989/004314 priority Critical patent/WO1991004758A1/en
Priority to US07/844,620 priority patent/US5270004A/en
Priority to US11599693A priority
Priority to US26381794A priority
Priority to US08/511,287 priority patent/US5578267A/en
Priority to US08/842,528 priority patent/USRE36774E/en
Application filed by Baxter Healthcare Corp filed Critical Baxter Healthcare Corp
Assigned to BAXTER HEALTHCARE CORPORATION reassignment BAXTER HEALTHCARE CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MINNTECH CORPORATION
Application granted granted Critical
Publication of USRE36774E publication Critical patent/USRE36774E/en
Assigned to EDWARDS LIFESCIENCES CORPORATION reassignment EDWARDS LIFESCIENCES CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BAXTER HEALTHCARE CORPORATION
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

Links

Images

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D63/00Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02Hollow fibre modules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris with membranes
    • A61M1/1621Constructional aspects thereof
    • A61M1/1623Disposition of membranes
    • A61M1/1625Dialyser of the outside perfusion type, i.e. blood flow outside hollow membrane fibres or tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris with membranes
    • A61M1/1621Constructional aspects thereof
    • A61M1/1629Constructional aspects thereof with integral heat exchanger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris with membranes
    • A61M1/1698Blood oxygenators with or without heat-exchangers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D63/00Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02Hollow fibre modules
    • B01D63/025Bobbin units
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D63/00Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02Hollow fibre modules
    • B01D63/04Hollow fibre modules comprising multiple hollow fibre assemblies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00Characteristics of a physical parameter; associated device therefor
    • A61M2206/10Flow characteristics
    • A61M2206/16Rotating swirling helical flow, e.g. by tangential inflows
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2313/00Details relating to membrane modules or apparatus
    • B01D2313/38Heat exchangers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00Surgery
    • Y10S128/03Heart-lung
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S261/00Gas and liquid contact apparatus
    • Y10S261/28Blood oxygenators

Abstract

A combination heat exchanger and oxygenator device is provided. The device includes a generally cylindrical housing having first and second compartments with hollow heat exchange tubes and hollow gas exchange tubes disposed therein, a blood inlet, a blood outlet, a heat exchanges medium inlet, a heat exchange medium outlet, an oxygenating fluid inlet and an oxygenating fluid outlet. The housing has a central axis with the second compartment being concentric thereto. The blood flow passage is defined by blood entering the device generally axially through a path extending along the central axis of the housing and flows generally radially through the second, oxygenating compartment.

Description

This is a continuation of application Ser. No. 08/263,817, filed on Jun. 22, 1994, now abandoned which is a divisional of application Ser. No. 08/115,996, filed on Sep. 2, 1993, now abandoned, which is a continuation of application Ser. No. 07/844,620, now U.S. Pat. No. 5,270,004 filed on May 11, 1992, .[.which claims priority to PCT/US89/04314 filed Oct. 1, 1990.]. .Iadd.which is a national stage application under 35 U.S.C. 371 of PCT/US89/04314, filed Oct. 1, 1989, .Iaddend.the entireties of which are hereby incorporated by reference.

FIELD OF THE INVENTION

This invention relates to a blood oxygenator having an integral heat exchanging unit, the oxygenator being of the outside perfusion type.

BACKGROUND OF THE INVENTION Blood Oxygenators

In known blood oxygenators, hollow fibers are used as a means to bring blood into contact with oxygen and provide a means for removal of carbon dioxide from the blood. The fibers are typically made of a homogeneous membrane of gas-permeable material such as silicone or of hollow fibers made of a microporous membrane of hydrophobic polymeric material such as polyolefins.

There are two types of hollow fiber blood oxygenators: the inside perfusion type in which blood is passed through the bores of the hollow fibers while oxygen is passed on the outside of the hollow fibers, and the outside perfusion type. Blood oxygenators of the outside perfusion type pass oxygen through the bores of the hollow fibers while blood is flowed past the outside of the hollow fibers.

Examples of inside perfusion type hollow-fiber oxygenators are disclosed in U.S. Pat. Nos. 4,239,729 and 4,749,551.

In blood oxygenators of the outside perfusion type the oxygen can be distributed uniformly through the spaces between adjacent fibers and the blood can be expected to move with better mixing. However, outside perfusion has had the disadvantage of being subject to less than the desired oxygenation of the blood because of region channeling of the blood as it passes the outsides of the hollow fibers. Blood-side convective mixing is essential for efficient gas transfer in blood oxygenators. Without such mixing, sharply defined boundary layers of fully oxygenated blood develop near the exchange surfaces and the fluxes of oxygen and carbon dioxide tend to be low. Low transport efficiency results in bulky devices with undesirable high blood priming volumes.

Outside perfusion type blood oxygenators are known in which the hollow fibers are in perpendicular orientation to the direction of blood flow so as to produce more mixing of the blood as the blood flows than inside perfusion constructions. This arrangement can bring about an improvement in oxygenation rate. However, if the number of fibers used in such a blood oxygenator is large (as is desirable) and/or the flow rate of blood is increased in order to treat large volumes of blood, problems arise. For example, unacceptable pressure drop of the blood between inlet and outlets and/or channeling of the blood between groups of fibers may occur. By channeling it is to be understood that a significant flow of blood takes place through relatively large area voids between fibers so that there is little or no mixing. As the rate of oxygen transfer primarily takes place in a thin boundary layer adjacent the hollow fibers, the effectiveness of desired oxygenation is reduced.

Examples of blood oxygenators of the outside perfusion type are disclosed in copending application PCT/US89/00146 filed Jan. 13, 1989; WO 89/00864; and U.S. Pat. Nos. 3,794,468; 4,352,736; 4,622,206; 4,659,549; 4,639,353; 4,620,965; 4,791,054; and 4,808,378, all incorporated herein by reference.

Combined Oxygenator and Heat Exchanger Devices

In the prior art it has been recognized that there is considerable heat loss in all extracorporeal circuits and various devices have been introduced for the purpose of maintaining the temperature of blood within the normal physiological range. Devices which combine the function of blood heating and oxygenation are known. U.S. Pat. No. 4,111,659 describes an embossed film membrane heater/oxygenator. U.S. Pat. No. 4,138,288 describes a bubble-type oxygenator with an integral heater at the blood outlet side of the oxygenator. U.S. Pat. No. 4,620,965 describes an outside perfusion type hollow fiber blood oxygenator with an associated heat exchanger, also located on the blood outlet side of the device, in which the blood flows longitudinally through the oxygenator portion of the device and generally parallel to the hollow gas exchange fibers. U.S. Pat. Nos. 4,639,353, 4,659,549 and 4,791,054 also disclose outside perfusion type hollow-fiber oxygenators in which blood flowing longitudinally through a generally rectangular or cylindrical device passes through multiple hollow fiber exchange chambers separated by narrow channel baffles. In some embodiments of the latter device, separate heat and Oxygen exchange chambers are provided.

U.S. Pat. No. 4,645,645 describes a hollow-fiber blood oxygenator to which a helical heat exchanger may be attached. Heat exchange is accomplished by passing blood across the outside of a helical coated metal coil.

U.S. Pat. No. 4,424,910 describes another form of hollow-fiber oxygenator with an attached heater compartment displaced longitudinally on a generally cylindrical device.

A problem with prior blood oxygenator/heater combination devices which has been recognized in the prior art is the considerable bulk, with consequent large priming volume of the combined devices. A flat device is described in WO 89/00864 and co-pending application, PCT/US89/00146 filed Jan. 13, 1989, which locates heated exchange fibers and gas exchange fibers in adjacent compartments separated by a porous wall so as to eliminate collection and distribution manifolds between the devices. Such flat devices, however, are difficult to manufacture because of the difficulty of properly packing the gas exchange fibers for optimal efficiency.

SUMMARY OF THE INVENTION

The present invention pertains to a novel compact integrated blood heater/oxygenator in which the blood advantageously flows transversely to the axial direction of hollow heat exchange and oxygenation fibers, the device having a minimal priming volume and which is easily assembled using conventional fiber winding techniques for packing the gas exchange fibers.

The inventive blood heater oxygenator is a generally cylindrical device which is constructed so that the blood enters a central chamber extending longitudinally along the axis of the device and then moves radially through respective annular hollow heat exchange and oxygenation fiber bundles in a direction generally perpendicular to the axis of the device and generally transverse to the axial direction of the fibers toward the outer wall of the device where the temperature adjusted and oxygenated blood is collected and passed out of the device via an exit port.

DESCRIPTION OF THE FIGURES

FIG. 1 is a side perspective view of a blood heat exchanger/oxygenator of the invention.

FIG. 2 is a side plan view with parts cut away of the heat exchanger/oxygenator of FIG. 1.

FIG. 3 shows a sectional view of the heat exchanger/oxygenator of the invention taken along line 3--3 of FIG. 2.

FIG. 4 is a side view of a portion of the device as seen from line 4--4 of FIG. 3.

FIG. 5 is an enlarged perspective view of the portion of FIG. 2 indicated by the bold numeral 5.

DESCRIPTION OF THE PREFERRED EMBODIMENT

The invention is best described by reference to the preferred embodiment as illustrated in FIGS. 1-5.

The preferred heat exchanger/oxygenator device of the invention is generally designated in the figures by the numeral 10. The exterior of device 10 comprises a generally cylindrical exterior wall portion 12, proximal cover member 14 and distal cover member 20. The distal cover 20 includes a central blood inlet port 26, a heating fluid outlet port 28 and a gas outlet port 30.

The proximal cap 14 includes a blood outlet port 32, a heater exchange fluid inlet port 36 and a gas inlet port 38. Raised circular portions 40 and 42 define heat exchange fluid and gas distribution manifolds, respectively, which provide fluid communication between the respective inlet ports 36 and 38 and respective hollow bundles of heat exchange and gas exchange fibers, respectively, within the device. A raised circular portion 44 defines a blood collecting manifold which, as shown in FIG. 1, increases in dimension as it approaches the exit port 32.

On the distal cover 16 there are also included raised circular portions 46 and 48 which define manifolds for collecting and directing heat exchange fluid and oxygenation gas from the fiber bundles to their respective outlet ports.

The interior of the device includes a series of annular cylindrical chambers 50, 54, 58 and 62 separated by tubular porous wall members 52, 56 and 60.

The central chamber 50 communicates with blood inlet port 26. The next outward annular chamber 54 comprises the heat exchanger portion of the device and is filled with heat exchange tubes 70 of known type which extend generally in an axial direction. Annular chamber 58 comprises the oxygenator portion of the device and is filled with tubes 74 of a gas exchange membrane material, also of known type. The gas exchange tubes 74 are also preferably oriented generally in an axial direction. Between the porous wall 60 and the inner surface of the outer wall 12 of the device is a hollow cylindrical blood collection chamber 62.

The tubular porous walls 52, 56, 60, the heat exchange tubes 70, and gas exchange tubes 74 are all potted together with a conventional potting material 76 which holds the various interior components of the device together as a unit and isolates the open ends of the tubes 70 and 74 from the blood flow path.

The respective bundles of heat exchange and gas exchange fibers are desirably simultaneously end potted so as to produce a unitary assembly which can be readily sheared to produce open tube ends as best shown in FIG. 5. The covers 14 and 16 are aligned so that they sealingly engage the potted assembly between the respective fiber bundles. Suitably the porous tubular wall members 52, 56 and 60 are provided with continuous non-porous end portions 80 entrained in the potting material such that when the potted assembly is sheared the end portions 80 expose continuous annular rings which provide sealing surface to engage the covers and isolate the respective gas blood and heating fluid distribution and collection manifolds, as shown in FIGS. 2 and 5. Most preferably the cover assemblies are heat or sonically welded to the end portions 80 and to the ends of outer cylindrical wall 12.

The tubular porous wall members 52, 56 and 60 provide separation between the chambers while allowing blood to pass therethrough without offering substantial resistance or directional change. Any porous structure which allows the passage of blood without significant damage may be used. However, it is preferred that these wall members be constructed of a biocompatible plastic material containing a plurality of spaced orifices 82. The orifices 82 are preferably no greater than 1/2 inch (1.27 cm) and preferably 3/8 inches (0.95 cm) in diameter. Larger diameter orifices will allow the fibers to bulge into the orifices and thereby potentially create void spots in the fiber bundle therebelow. Another disadvantage in fibers bulging into the orifices is that pinching to close a fiber may occur. Smaller diameter orifices may be used, by spacing must be selected so that the total area of the orifices 82 is sufficient to assure that the respective porous tubular wall members do not themselves create significant resistance to blood flow or dead spots where blood may collect and coagulate.

Suitable gas exchange membrane material for fibers 74 may be made of polypropylene, polyethylene or other biocompatible material which provides gas exchange. The fibers are liquid impermeable. Suitable fibers for this purpose are well known and commercially available from a number of manufacturers including Mitsubishi Rayon Sale, Ltd. of Tokyo, Japan and Celanese Chemical Company of New York, N.Y., U.S.A.

The heat exchange tubes 70 are preferably formed from a polyurethane resin such as B. F. Goodrich Estane 58091. The tubes are much larger than the hollow fibers in the oxygenator, typically being about 0.033 inches (840 microns) in outside diameter with a wall thickness of about 0.004 inches (102 microns). In contrast, a typical oxygenator fiber has an outside diameter of about 200-450 microns and a wall thickness of less than 50 microns. The formation of heat exchanger tubes from polyurethane rather than the stainless steel, polyethylene, or polypropylene is preferred. While the efficiency of the heat exchange it an important design consideration, it is vital that there must be no leakage. The end seals where polyurethane potting compounds are used with stainless steel tubes represent potential leakage areas of the cooling fluid into the blood.

The use of polyurethane heat exchange tubes with the polyurethane end potting compounds provides a positive seal which ensures that no leakage will occur. This compatibility with the potting compound greatly increases the safety of the product.

The hollow heat exchange tubes are packed into chamber 70 such that channeling is minimized. However, performance of the heat exchanger is not greatly affected if some channeling is present. A pack density of between about 40% and 60% provides an efficient heat exchanger with an accept&hie pressure drop. It is preferred to pack the polyurethane tubes at about 45%-55% pack density which provides an efficient unit, low pressure drop and low blood priming volume. The thin walled polyurethane hollow tubes provide good heat transfer. The efficiency desired is in ensuring that all of the blood is heated or cooled as desired, not in how much heat exchange fluid is required. The temperature differential between the blood and heat exchange fluid should be low to provide better control.

In the preferred embodiment the overall size of the unit is approximately 5 inches (12.5 cm) in diameter by 7.5 inches (18.75 cm) long. The heat exchange tubes are polymeric tubes having an approximate diameter of 0.033 inches (0.83 mm or 830 μ), and the heat exchange chamber containing approximately 2750 tubes. The gas exchange fibers suitably are microporous hollow polypropylene membrane is sufficient quantity to provide a total blood contact surface area of approximately 3.8 square meters. The device permits an outlet blood oxygen tension of 150 torr or more, tested on bovine blood with a hemoglobin concentration of 12 gram-percent; with an inlet saturation of 55% a blood flow of 6 liters per minute and an oxygen flow of 6 liters per minute. The heat exchanger provides an effectiveness level of 45% as measured by the protocol of the American Association of Medical Instrumentation (AAMI).

The heat exchange tubes are preferably cut to length and then placed into the chamber 52. Winding the tubes about central core 52 is less preferable as it tends to cause the hollow tubes to bend and may cause cracks or breaks.

The gas exchange fiber bundle is most suitably prepared by spiral winding fibers 74 around the tubular wall member 56, successive layers being angled relative to each other to produce a crisscross pattern. The crossing fiber arrangement is preferred over parallel fiber packing since it forces the blood into effective but gentle transverse, mixing without traumatizing the blood. Winding techniques for producing cylindrical bundles of hollow fibers are well known and are described in such references as U.S. Pat. No. 3,755,034, 3,794,468, 4,224,094, 4,336,138, 4,368,124 and 4,430,219, all incorporated herein by reference. The preferred angle between the fibers of successive layers is in the range of between about 10° and 30°, more preferably between about 15° and 20°, most preferably 18°. The fibers run in a generally axial direction, so that an axial plane bisects the angle between the successive layers of the fibers. For instance, in the most preferred embodiment, one layer will deviate from the axial direction by +9° and the next layer will deviate from the axial direction by -9°. The pack density of the gas exchange fibers 74 should be between about 45% and 60%, most preferably about 50% and 55%. When the pack density is too high the resulting resistance to blood flow reduces oxygenation efficiency. Likewise, when the pack density is too low channeling and reduced turbulent flow of the blood also reduces oxygenation efficiency. Within the preferred range oxygenation efficiency is maximized.

For potting the ends of the assembly of fiber bundles and porous wall members 52, 56 and 60, a polyurethane potting compound is preferred. Suitable potting compounds are available from Caschem, Inc. of Bayonne, N.J., U.S.A. A polyurethane casting system of Caschem, Inc. is described in U.S. Pat. Reissue No. 31,389. After potting the hollow fibers are reopened by conventional techniques such as shearing the potting with a sharp knife so as to expose the interiors of the fibers.

After insertion of the potted and sheared assembly into cylinder 12 the cover members 14 and 20 are inserted in line so that they sealingly engage the potted assembly between the respective fiber bundles.

The covers 14 and 20, cylinder case 12 and the porous tubular wall members 52, 56 and 60 are all preferably made from nontoxic biocompatible plastic resins. Suitable resins are polycarbonate resins such as the Lexan brand resins of General Electric Company, Polymer Product Department, Pittsfield, Mass. Lexan 144 grade polycarbonate resins are currently preferred.

In operation, blood entering the device through the central inlet port 26, fills chamber 50 and then passes in a direction generally perpendicular to the axis through porous wall 52, around heat exchange fibers 70, through porous wall 56, around gas exchange fibers 74, through wall 60, into collection chamber 62 and then up into the blood collecting manifold 44 in cover 14, finally exiting the device via blood exit port 32.

An advantage provided by the compact structure of the device is a reduction in priming volume which results because blood is directly passed from the heat exchange chamber 54 to the oxygenation chamber 58 without passing through intermediate collection and distribution manifolds.

Yet another advantage of the invention compared to many of the prior art devices described in the Background section, above, is the location of the heat exchange chamber upstream from the gas exchange chamber. Since gas solubility varies significantly with temperature, it is important that the blood is oxygenated at the temperature it will enter the body. If the blood is heated after it is oxygenated, the oxygenation level may exceed the gas saturation point at the higher temperature, resulting in formation of dangerous emboli. If blood is cooled after oxygenation inefficient oxygenation can result.

Compared to the rectangular devices of WO 89/0864 and PCT/US89/00146, the device of the present invention also provides a significantly less complicated device to manufacture. In particular, to obtain the desired angular and Offset orientation of the gas exchange fibers in the prior art rectangular device it was necessary to employ a manufacturing technique which not only laid alternate layers in a crisscross pattern angled with respect to each other approximately 18', but also required offsetting each successive parallel layer to minimize channeling. In the cylindrical device of the invention the desired crisscrossing of successive layers can readily be performed by conventional spiral winding techniques and the increasing diameter of the winding naturally results in an offset of successive parallel layers without complex controls.

Claims (22)

What is claimed is:
1. A combination heat exchanger and oxygenator device comprising:
a housing including structure defining first and second compartments, a blood inlet, a blood outlet, a heat exchange medium inlet, a heat exchange medium outlet, an oxygenating fluid inlet and an oxygenating fluid outlet, said housing having a central axis, said second compartment being concentric to said axis;
structure defining a flow passage for blood through said housing from said blood inlet to said blood outlet;
structure defining a flow passage for heat exchange medium from said heat exchange medium inlet to said heat exchange medium outlet;
structure defining a flow passage for oxygenating fluid from said oxygenating fluid inlet to said oxygenating fluid outlet;
a plurality of hollow gas exchange tubes disposed in said second compartment;
said blood flow passage comprising a heat exchange path through said first compartment, said blood flow passage further comprising a central path extending along at least a portion of said central axis of said housing, said blood flow passage further comprising an oxygenating path extending generally radially through said second compartment, around said gas exchange tubes, said central path being upstream of said oxygenating path, whereby blood flows axially along at least a portion of the central axis of said housing and then generally radially through said second compartment.
2. The combination heat exchanger and oxygenator device of claim 1, wherein said blood outlet has a central fluid flow axis disposed in a plane substantially transverse to said central axis of said housing.
3. The combination heat exchanger and oxygenator device of claim 1, wherein said oxygenating fluid inlet and oxygenating fluid outlet respectively comprise a gas inlet and a gas outlet.
4. The combination heat exchanger and oxygenator device of claim 1, wherein said heat exchange path extends generally radially through said first compartment.
5. The combination heat exchanger and oxygenator device of claim 1, wherein said central path is upstream of said heat exchange path.
6. The combination heat exchanger and oxygenator device of claim 1, wherein said heat exchange path is upstream of said oxygenating path.
7. The combination heat exchanger and oxygenator device of claim 1, wherein said first and second compartments are concentric.
8. The combination heat exchanger and oxygenator device of claim 1 wherein said plurality of hollow gas exchange tubes disposed in said second compartment are comprised of hollow gas exchange tubes generally longitudinally disposed within said .[.first.]. .Iadd.second .Iaddend.compartment.
9. The combination heat exchanger and oxygenator device of claim 1 wherein said plurality of hollow gas exchange tubes disposed in said second compartment are comprised of hollow gas exchange tubes that are spirally wound in concentric layers extending generally longitudinally.
10. The combination heat exchanger and oxygenator device of claim 1 wherein said first compartment is upstream of said second compartment.
11. The combination heat exchanger and oxygenator device of claim 1 wherein said structure defining a flow passage for heat exchange medium from said heat exchange medium inlet to said heat exchange medium outlet includes a plurality of hollow heat exchange tubes disposed in said first compartment.
12. The combination heat exchanger and oxygenator device of claim 11, wherein said heat exchange path is defined around said heat exchange tubes and said heat exchange medium flows through said heat exchange tubes.
13. The combination heat exchanger and oxygenator device of claim 11, wherein said blood flow passage extends axially of said first compartment, via said central path, and then radially through said first compartment, around said heat exchange tubes, via said heat exchange path, and then radially through said second compartment, around said gas exchange tubes, via said oxygenating path.
14. The combination heat exchanger and oxygenator device of claim 11 wherein said plurality of hollow heat exchange tubes disposed in said first compartment are comprised of heat exchange tubes generally longitudinally disposed within said first compartment.
15. The combination heat exchanger and oxygenator device of claim 1, wherein said blood flow passage extends axially of said first compartment, via said central path, and then radially through said first compartment, via said heat exchange path, and then radially through said second compartment, via said oxygenating path. .Iadd.16. The combination heat exchanger and oxygenator device of claim 1, wherein said housing is constructed and arranged and said flow passage for blood is defined such that blood flows vertically upwardly along at least a portion of the central path. .Iaddend..Iadd.17. A combination heat exchange and oxygenator device comprising:
a housing including first and second compartments, a blood inlet, a blood outlet, a heat exchange medium inlet, a heat exchange medium outlet, an oxygenating fluid inlet, an oxygenating fluid outlet, said housing having a central axis, said second compartment being concentric to said axis, wherein the first and second compartments are concentric along at least a substantial portion of their length;
a flow passage for blood through said housing from said blood inlet to said blood outlet;
a flow passage for heat exchange medium from said heat exchange medium inlet to said heat exchange medium outlet;
a flow passage for oxygenating fluid from said oxygenating fluid inlet to said oxygenating fluid outlet;
a plurality of hollow gas exchange tubes disposed in said second compartment;
said blood flow passage comprising a heat exchange path through said first compartment and an oxygenating path extending generally radially through said second compartment, around said gas exchange tubes, at least a portion of said blood flow passage including a generally central path generally parallel to said central axis of said housing, said central path being upstream of said oxygenating path, whereby blood in said central path flows in a direction generally parallel to the central axis of the housing and then generally radially through said second compartment.
.Iaddend..Iadd.18. The combination heat exchanger and oxygenator device of claim 17, wherein said central path is upstream of said heat exchange path. .Iaddend..Iadd.19. The combination heat exchanger and oxygenator device of claim 17, comprising a tubular wall member defining said central path. .Iaddend..Iadd.20. The combination heat exchanger and oxygenator device of claim 19, wherein said tubular wall member is porous.
.Iaddend..Iadd.21. A blood heater and oxygenating device for heating and then oxygenating a patient's blood, and which is designed to reduce priming volume required by the device, comprising:
a housing including first and second compartments internal to the housing, a blood inlet, a blood outlet, a heat exchange medium inlet, a heat exchange medium outlet, an oxygenating fluid inlet and an oxygenating fluid outlet, said housing having a central axis, said second compartment being concentric to said axis and including a plurality of hollow gas exchange tubes contained therein;
said housing including a blood flow passage entirely internal to said housing and extending from said blood inlet to said blood outlet thereof;
a heat exchange medium flow passage internal to said housing, connected to and extending between said heat exchange medium inlet and said heat exchange medium outlet, whereby heat exchange medium may be introduced into said heat exchange medium flow passage through the heat exchange medium inlet and circulated out of said heat exchange medium flow passage through said heat exchange medium outlet;
an oxygenating fluid flow passage internal to said housing, connected to and extending between said oxygenation fluid inlet and said oxygenating fluid outlet, whereby an oxygenating fluid may be introduced into said hollow tubes through said oxygenating fluid inlet, and circulated out of and away from said hollow tubes through said oxygenating fluid outlet;
said blood inlet connected to said first compartment so that the blood diffuses directly from said blood inlet into said first compartment without significant collection of the blood between said blood inlet and said first compartment, and the blood being heated as it passes through said first compartment; and
said blood flow passage comprising a heat exchange path through said first compartment, said blood flow passage further comprising a central path extending along at least a portion of said central axis of said housing, said blood flow passage further comprising an oxygenating path extending generally radially through said second compartment, and around said hollow gas exchange tubes, and said central path being upstream of said oxygenating path, whereby blood flows axially along at least a portion of the central axis of said housing and then generally radially through said
second compartment. .Iaddend..Iadd.22. The device of claim 21, wherein said blood outlet has a central fluid flow axis disposed in a plane substantially transverse to said central axis of said housing. .Iaddend..Iadd.23. The device of claim 21, wherein said oxygenating fluid inlet and oxygenating fluid outlet respectively comprise a gas inlet and a gas outlet. .Iaddend..Iadd.24. The device of claim 21, wherein said first and second compartments are cylindrical. .Iaddend..Iadd.25. The device of claim 21 wherein said plurality of hollow gas exchange tubes disposed in said second compartment are comprised of hollow gas exchange tubes that are spirally wound around said central axis. .Iaddend..Iadd.26. The device of claims 21 or 24 wherein said first compartment is upstream of said second compartment. .Iaddend..Iadd.27. The device of claim 21 wherein said housing is constructed and arranged and said flow passage for blood is defined such that blood flows in a vertically upward direction along at
least a portion of said central path. .Iaddend..Iadd.28. A blood heater and oxygenating device for heating and then oxygenating a patient's blood, and which is designed to reduce priming volume required by the device, comprising:
a housing including first and second compartments internal to the housing, a blood inlet, a blood outlet, a heat exchange medium inlet, a heat exchange medium outlet, an oxygenating fluid inlet and an oxygenating fluid outlet, said housing having a central axis, said second compartment being concentric to said axis and including a plurality of hollow gas exchange tubes contained therein;
said housing including a blood flow passage entirely internal to said housing and extending from said blood inlet to said blood outlet thereof;
a heat exchange medium flow passage internal to said housing, connected to and extending between said heat exchange medium inlet and said heat exchange medium outlet, whereby heat exchange medium may be introduced into said heat exchange medium flow passage through the heat exchange medium inlet and circulated out of said heat exchange medium flow passage through said heat exchange medium outlet;
an oxygenating fluid flow passage internal to said housing, connected to and extending between said oxygenation fluid inlet and said oxygenating fluid outlet, whereby an oxygenating fluid may be introduced into said hollow tubes through said oxygenating fluid inlet, and circulated out of and away from said hollow tubes through said oxygenating fluid outlet;
said blood inlet connected to a chamber which is porous throughout so that the blood diffuses directly into said first compartment without significant collection of the blood in said chamber, and the blood being heated as it passes through said first compartment; and
said blood flow passage comprising a heat exchange path through said first compartment, said blood flow passage further comprising a central path extending along at least a portion of said central axis of said housing, said blood flow passage further comprising an oxygenating path extending generally radially through said second compartment, and around said hollow gas exchange tubes, and said central path being upstream of said oxygenating path, whereby blood flows axially along at least a portion of the central axis of said housing and then generally radially through said second compartment. .Iaddend..Iadd.29. The device of claim 28, wherein said blood outlet has a central fluid flow axis disposed in a plane substantially transverse to said central axis of said housing. .Iaddend..Iadd.30. The device of claim 28, wherein said oxygenating fluid inlet and oxygenating fluid outlet respectively comprise a gas inlet and a gas outlet. .Iaddend..Iadd.31. The device of claim 28, wherein said first and second compartments are cylindrical. .Iaddend..Iadd.32. The device of claim 28 wherein said plurality of hollow gas exchange tubes disposed in said second compartment are comprised of hollow gas exchange tubes that are spirally wound around said central axis. .Iaddend..Iadd.33. The device of claims 28 or 31 wherein said first compartment is upstream of said second compartment. .Iaddend..Iadd.34. The device of claim 28 wherein said housing is constructed and arranged and said flow passage for blood is defined such that blood flows in a vertically upward direction along at
least a portion of said central path. .Iaddend..Iadd.35. A blood heater and oxygenating device for heating and then oxygenating a patient's blood, and which is designed to reduce priming volume required by the device, comprising:
a housing including first and second compartments internal to the housing, a blood inlet, a blood outlet, a heat exchange medium inlet, a heat exchange medium outlet, an oxygenating fluid inlet and an oxygenating fluid outlet, said housing having a central axis, said second compartment being concentric to said axis and including a plurality of hollow gas exchange tubes contained therein;
said housing including a blood flow passage entirely internal to said housing and extending from said blood inlet to said blood outlet thereof;
a heat exchange medium flow passage internal to said housing, connected to and extending between said heat exchange medium inlet and said heat exchange medium outlet, whereby heat exchange medium may be introduced into said heat exchange medium flow passage through the heat exchange medium inlet and circulated out of said heat exchange medium flow passage through said heat exchange medium outlet;
an oxygenating fluid flow passage internal to said housing, connected to and extending between said oxygenation fluid inlet and said oxygenating fluid outlet, whereby an oxygenating fluid may be introduced into said hollow tubes through said oxygenating fluid inlet, and circulated out of and away from said hollow tubes through said oxygenating fluid outlet;
said blood inlet connected to a chamber and from which blood diffuses directly into said first compartment along substantially the entire length of said chamber without significant collection of the blood in said chamber, and the blood being heated as it passes through said first compartment; and
said blood flow passage comprising a heat exchange path through said first compartment, said blood flow passage further comprising a central path extending along at least a portion of said central axis of said housing, said blood flow passage further comprising an oxygenating path extending generally radially through said second compartment, and around said hollow gas exchange tubes, and said central path being upstream of said oxygenating path, whereby blood flows axially along at least a portion of the central axis of said housing and then generally radially through said second compartment. .Iaddend..Iadd.36. The device of claim 35, wherein said blood outlet has a central fluid flow axis disposed in a plane substantially transverse to said central axis of said housing. .Iaddend..Iadd.37. The device of claim 35, wherein said oxygenating fluid inlet and oxygenating fluid outlet respectively comprise a gas inlet and a gas outlet. .Iaddend..Iadd.38. The device of claim 35, wherein said first and second compartments are cylindrical. .Iaddend..Iadd.39. The device of claim 35, wherein said plurality of hollow gas exchange tubes disposed in said second compartment are comprised of hollow gas exchange tubes that are spirally wound around said central axis. .Iaddend..Iadd.40. The device of claims 35 or 38 wherein said first compartment is upstream of said second compartment. .Iaddend..Iadd.41. The device of claim 35 wherein said housing is constructed and arranged and said flow passage for blood is defined such that blood flows in a vertically upward direction along at
least a portion of said central path. .Iaddend..Iadd.42. A combination heat exchanger and oxygenator device comprising:
a housing including first and second compartments internal to the housing, a blood inlet, a blood outlet, a heat exchange medium inlet, a heat exchange medium outlet, an oxygenating fluid inlet and an oxygenating fluid outlet, said housing having a central axis, said second compartment being concentric to said axis;
a blood flow passage entirely internal to said housing extending through said housing from said blood inlet to said blood outlet;
a heat exchange medium flow passage connected to and extending from said heat exchange medium inlet to said heat exchange medium outlet;
an oxygenating fluid flow passage connected to and extending from said oxygenating fluid inlet to said oxygenating fluid outlet;
a plurality of hollow gas exchange tubes disposed in said second compartment; and
said blood flow passage comprising a heat exchange path through said first compartment, said blood flow passage further comprising a central path extending along at least a portion of said central axis of said housing, said blood flow passage further comprising an oxygenating path extending generally radially through said second compartment, and around said hollow gas exchange tubes, said central path being upstream of said oxygenating path, whereby blood flows axially along at least a portion of the central axis of said housing and then generally radially through said second compartment. .Iaddend..Iadd.43. The device of claim 42, wherein said blood outlet has a central fluid flow axis disposed in a plane substantially
transverse to said central axis of said housing. .Iaddend..Iadd.44. The device of claim 42, wherein said oxygenating fluid inlet and oxygenating fluid outlet respectively comprise a gas inlet and a gas outlet. .Iaddend..Iadd.45. The device of claim 42, wherein said first and second compartments are cylindrical. .Iaddend..Iadd.46. The device of claim 42 wherein said plurality of hollow gas exchange tubes disposed in said second compartment are comprised of hollow gas exchange tubes that are spirally wound around said central axis. .Iaddend..Iadd.47. The device of claims 42 or 45 wherein said first compartment is upstream of said second compartment. .Iaddend..Iadd.48. The device of claim 42 wherein said housing is constructed and arranged and said flow passage for blood is defined such that blood flows in a vertically upward direction along at least a portion of said central path. .Iaddend.
US08/842,528 1989-10-01 1997-04-24 Cylindrical blood heater/oxygenator Expired - Lifetime USRE36774E (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
PCT/US1989/004314 WO1991004758A1 (en) 1989-10-01 1989-10-01 Cylindrical blood heater/oxygenator
US07/844,620 US5270004A (en) 1989-10-01 1990-10-01 Cylindrical blood heater/oxygenator
US11599693A true 1993-09-02 1993-09-02
US26381794A true 1994-06-22 1994-06-22
US08/511,287 US5578267A (en) 1992-05-11 1995-08-04 Cylindrical blood heater/oxygenator
US08/842,528 USRE36774E (en) 1989-10-01 1997-04-24 Cylindrical blood heater/oxygenator

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/842,528 USRE36774E (en) 1989-10-01 1997-04-24 Cylindrical blood heater/oxygenator

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
US26381794A Continuation 1994-06-22 1994-06-22
US08/511,287 Reissue US5578267A (en) 1989-10-01 1995-08-04 Cylindrical blood heater/oxygenator

Publications (1)

Publication Number Publication Date
USRE36774E true USRE36774E (en) 2000-07-11

Family

ID=26780011

Family Applications (2)

Application Number Title Priority Date Filing Date
US07/844,620 Expired - Lifetime US5270004A (en) 1989-10-01 1990-10-01 Cylindrical blood heater/oxygenator
US08/842,528 Expired - Lifetime USRE36774E (en) 1989-10-01 1997-04-24 Cylindrical blood heater/oxygenator

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US07/844,620 Expired - Lifetime US5270004A (en) 1989-10-01 1990-10-01 Cylindrical blood heater/oxygenator

Country Status (1)

Country Link
US (2) US5270004A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6402967B1 (en) * 1997-05-01 2002-06-11 Eclipse Environmental Australia Pty Limited Grease separating device and method
US6682698B2 (en) 2001-08-23 2004-01-27 Michigan Critical Care Consultants, Inc. Apparatus for exchanging gases in a liquid
US20120018367A1 (en) * 2009-03-31 2012-01-26 Kubota Corporation Membrane separator
EP2524712A1 (en) * 2011-05-17 2012-11-21 Sorin Group Italia S.r.l. Blood processing unit with cross blood flow
US8388566B2 (en) 2010-04-29 2013-03-05 Sorin Group Italia, S.r.l. Oxygenator with integrated arterial filter including filter frame
US8394049B2 (en) 2010-08-19 2013-03-12 Sorin Group Italia S.R.L. Blood processing unit with modified flow path
US8545754B2 (en) 2009-04-23 2013-10-01 Medtronic, Inc. Radial design oxygenator with heat exchanger
US10098994B2 (en) 2014-01-09 2018-10-16 Sorin Group Italia S.R.L. Blood processing unit with heat exchanger core for providing modified flow path
US10369262B2 (en) 2014-02-28 2019-08-06 Sorin Group Italia S.R.L. System for providing an integrated arterial filter into an oxygenator, minimizing added priming volume

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578267A (en) * 1992-05-11 1996-11-26 Minntech Corporation Cylindrical blood heater/oxygenator
US5514335A (en) * 1993-10-25 1996-05-07 Minnesota Mining And Manufacturing Company Blood oxygenation system and reservoir and method of manufacture
EP0765683B1 (en) * 1995-09-25 1998-07-01 MEDOS Medizintechnik GmbH Device for treating liquids, in particular blood
US5762868A (en) * 1995-11-30 1998-06-09 Minnesota Mining And Manufacturing Company Blood oxygenator and heat exchanger
EP0876197A1 (en) * 1995-11-30 1998-11-11 Minnesota Mining And Manufacturing Company Multilayer hollow fiber body and method of making
US5922281A (en) * 1996-01-11 1999-07-13 Medtronic, Inc. Surface treatment for micro-conduits employed in blood heat exchange system
US5823987A (en) * 1996-01-11 1998-10-20 Medtronic, Inc. Compact membrane-type blood oxygenator with concentric heat exchanger
US5876667A (en) * 1996-01-11 1999-03-02 Medtronic, Inc. Blood heat exchange system employing micro-conduit
JP3803421B2 (en) * 1996-04-26 2006-08-02 富士システムズ株式会社 Gas exchange device
US6001306A (en) * 1996-11-07 1999-12-14 C. R. Bard, Inc. Integrated oxygenator and heat exchanger
US6497841B1 (en) 1997-07-22 2002-12-24 Medtronic, Inc. Prevention of electrical discharges in polymeric heat exchangers
US6508983B1 (en) 1999-07-19 2003-01-21 Cobe Cardiovascular Exchanger apparatus and method of manufacture
US6464666B1 (en) * 1999-10-08 2002-10-15 Augustine Medical, Inc. Intravenous fluid warming cassette with stiffening member and integral handle
US6638479B1 (en) 1999-10-11 2003-10-28 Medtronic, Inc. Variable packing density in hollow fiber device
EP2295133B8 (en) 2005-04-21 2014-07-30 University of Pittsburgh - Of The Commonwealth System of Higher Education Paracorporeal respiratory assist lung
US20100272604A1 (en) * 2009-04-23 2010-10-28 Medtronic, Inc. Radial Design Oxygenator with Heat Exchanger and Integrated Pump
US8518259B2 (en) 2011-01-27 2013-08-27 Medtronic, Inc. De-airing oxygenator for treating blood in an extracorporeal blood circuit
GB201108495D0 (en) 2011-05-20 2011-07-06 Haemair Ltd Gas/fluid exchange apparatus
US8906300B2 (en) 2011-08-11 2014-12-09 The University Of Kentucky Research Foundation Even perfusion pump-integrated blood oxygenator
US9034083B2 (en) * 2012-04-10 2015-05-19 Vivonics, Inc. Array of hollow fibers and a system and method of manufacturing same
US8777832B1 (en) 2013-03-14 2014-07-15 The University Of Kentucky Research Foundation Axial-centrifugal flow catheter pump for cavopulmonary assistance
US9431725B2 (en) * 2013-12-13 2016-08-30 Asia Connection LLC Water bonding fixture
JP6461975B2 (en) * 2013-12-23 2019-01-30 ユニバーシティ・オブ・メリーランド・ボルティモアUniversity Of Maryland, Baltimore Blood oxygenator
KR101762228B1 (en) 2015-11-27 2017-07-27 재단법인 아산사회복지재단 A blood oxygenator
CN105457118B (en) * 2015-12-17 2018-01-02 珠海健帆生物科技股份有限公司 And a system for blood purification apparatus

Citations (175)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US27100A (en) * 1860-02-14 Robert f
US32186A (en) * 1861-04-30 Improved telegraphic cable
US33932A (en) * 1861-12-17 Improvement in the base-pin and rammer of revolving pistols
US2659368A (en) * 1949-05-28 1953-11-17 Jefferson Medical College Of P Extracorporeal circulation device
US2684728A (en) * 1952-05-17 1954-07-27 Ind Rayon Corp Apparatus for removing air from viscose solution
US2937644A (en) * 1957-10-15 1960-05-24 Corco Inc Blood oxygenator for facilitating heart surgery
US3026871A (en) * 1958-01-30 1962-03-27 Const Mecaniques De Stains Soc Apparatus for oxygenating blood
US3058464A (en) * 1957-04-22 1962-10-16 Baxter Laboratories Inc Oxygenator
US3142296A (en) * 1962-05-31 1964-07-28 Jack W Love Blood oxygenator
US3171475A (en) * 1962-04-06 1965-03-02 Baxter Laboratories Inc Apparatus for blood handling
US3211148A (en) * 1962-05-25 1965-10-12 Jr John E Galajda Rotary disk oxygenator and heater
US3256883A (en) * 1963-08-08 1966-06-21 Wall Richard A De Oxygenator with heat exchanger
US3315740A (en) * 1965-01-14 1967-04-25 Du Pont Flexible plastic tube bundle and method of making
US3342729A (en) * 1964-12-09 1967-09-19 Dow Chemical Co Permeability separatory cell and apparatus and method of using the same
US3413095A (en) * 1965-06-14 1968-11-26 Mogens L. Bramson Membrane oxygenator
US3466148A (en) * 1966-02-15 1969-09-09 Hazen F Everett Blood oxygenator
US3484211A (en) * 1964-12-08 1969-12-16 Us Army Membrane oxygenator
US3492991A (en) * 1967-02-23 1970-02-03 Richard H Dyer Jr Autotransfusion apparatus
US3513845A (en) * 1966-09-15 1970-05-26 United Aircraft Corp Bypass heart pump and oxygenator system
US3527572A (en) * 1965-10-11 1970-09-08 A Edward Urkiewicz Apparatus for treating blood
US3547591A (en) * 1968-10-16 1970-12-15 Jose C Torres Bubble film oxygenator
US3557962A (en) * 1968-06-28 1971-01-26 North American Rockwell Reverse osmosis fabric
USRE27100E (en) 1968-06-20 1971-03-30 Oxygenator with heat exchanger
US3651616A (en) * 1968-02-14 1972-03-28 Rhone Poulenc Sa Process for effecting absorption or removal of gas from a liquid
US3691068A (en) * 1971-01-08 1972-09-12 Amicon Corp Dialysis membrane and its use
US3722694A (en) * 1970-06-10 1973-03-27 Romicon Inc Filtration device
US3755034A (en) * 1971-02-25 1973-08-28 Dow Chemical Co Method for making a hollow fiber separatory element
US3764271A (en) * 1972-01-10 1973-10-09 R Brumfield Blood oxygenator in combination with a low pressure heat exchanger
US3769162A (en) * 1971-08-26 1973-10-30 R Brumfield Blood oxygenator and thermoregulator apparatus
US3769163A (en) * 1971-11-08 1973-10-30 R Brumfield Blood oxygenator flow guide
US3768653A (en) * 1972-03-21 1973-10-30 R Brumfield Filtering cardiotomy reservoir
US3794468A (en) * 1972-01-10 1974-02-26 Baxter Laboratories Inc Mass transfer device having a wound tubular diffusion membrane
US3807958A (en) * 1972-06-05 1974-04-30 Harvey Res Corp William A bubble oxygenerator including a blood foam return exchanger device
US3848660A (en) * 1970-08-17 1974-11-19 Du Pont Plastic heat exchange apparatus and a method for making
US3853479A (en) * 1972-06-23 1974-12-10 Sherwood Medical Ind Inc Blood oxygenating device with heat exchanger
US3870470A (en) * 1970-07-24 1975-03-11 Fumitake Yoshida Bubble-type blood oxygenator with baffles
US3881483A (en) * 1972-09-12 1975-05-06 Rhone Poulenc Sa Extracorporeal blood circuit
US3884814A (en) * 1972-07-26 1975-05-20 Rhone Poulenc Sa Apparatus for fractionating fluids
US3890969A (en) * 1974-01-21 1975-06-24 Baxter Laboratories Inc Cardiopulmonary bypass system
US3918912A (en) * 1973-10-15 1975-11-11 Sherwood Medical Ind Inc Blood oxygenator
US3927981A (en) * 1972-08-30 1975-12-23 Rhone Poulenc Sa Membrane-type blood oxygenator with recycle of oxygen-containing gas
US3956112A (en) * 1973-01-02 1976-05-11 Allied Chemical Corporation Membrane solvent extraction
US3957504A (en) * 1974-11-11 1976-05-18 Allied Chemical Corporation Membrane hydro-metallurgical extraction process
DE2456932A1 (en) 1974-12-02 1976-06-10 Gebhard Roggors Magnetic field oxygenation enclosure - for gas exchange between blood and a gas atmosphere in a magnetic field
US3993816A (en) * 1973-07-11 1976-11-23 Rhone-Poulenc S.A. Hollow fiber assembly for use in fluid treatment apparatus
US3994689A (en) * 1971-09-08 1976-11-30 Dewall Richard A Metabolic bubble oxygenator
SU543400A1 (en) 1974-12-16 1977-01-25 Белорусский Филиал Всесоюзного Научно-Исследовательского Института Технической Эстетики Foam type oxygenator
SU554869A1 (en) 1975-06-30 1977-04-25 Предприятие П/Я А-1874 Cardiopulmonary bypass
US4022692A (en) * 1975-08-01 1977-05-10 Erika, Inc. Non-woven support screen for mass transfer devices
US4026669A (en) * 1975-07-14 1977-05-31 Baxter Laboratories, Inc. Variable capacity reservoir assembly
US4036231A (en) * 1975-11-20 1977-07-19 Sherwood Medical Industries Inc. Thoracic drainage unit with defoaming means
US4038190A (en) * 1973-05-30 1977-07-26 Rhone-Poulenc S.A. Fluid fractionation apparatus and method of manufacturing the same
US4065264A (en) * 1976-05-10 1977-12-27 Shiley Laboratories, Inc. Blood oxygenator with integral heat exchanger for regulating the temperature of blood in an extracorporeal circuit
US4077578A (en) * 1976-02-13 1978-03-07 Baxter Travenol Laboratories, Inc. Machine for winding hollow filaments
US4111659A (en) * 1974-09-25 1978-09-05 Graeme L. Hammond Mass and heat transfer exchange apparatus
US4140637A (en) * 1977-10-06 1979-02-20 Walter Carl W Permeability separatory method and apparatus
US4158693A (en) * 1977-12-29 1979-06-19 Texas Medical Products, Inc. Blood oxygenator
US4168293A (en) * 1977-03-07 1979-09-18 Bramson Mogens L Blood oxygenator
US4180896A (en) * 1977-12-29 1980-01-01 Texas Medical Products, Inc. Blood oxygenator assembly method
US4187180A (en) * 1976-10-18 1980-02-05 Nippon Zeon Co. Ltd. Hollow-fiber permeability apparatus
US4186713A (en) * 1976-10-28 1980-02-05 Lucas Industries Limited Ignition systems for internal combustion engine
US4188360A (en) * 1978-09-08 1980-02-12 Japan Medical Supply Co., Ltd. Artificial lung with a built-in heat exchanger
US4202776A (en) * 1975-07-28 1980-05-13 Nippon Zeon Co., Ltd. Hollow-fiber permeability apparatus
US4205042A (en) * 1978-06-23 1980-05-27 Cobe Laboratories, Inc. Blood oxygenator with a gas filter
US4213858A (en) * 1977-11-18 1980-07-22 Gambro Ab Supporting net
US4225439A (en) * 1977-10-17 1980-09-30 Gambro Dialysatoren Gmbh & Co. Kg Apparatus for selective separation of matter through semi-permeable membranes
US4239729A (en) * 1978-06-06 1980-12-16 Terumo Corporation Oxygenator
US4244094A (en) * 1978-11-28 1981-01-13 Fabryka Narzedzi Chirurgicznych Instrument for removing exchangeable blades from surgical scalpes
US4254081A (en) * 1979-09-21 1981-03-03 Research Partners Limited Blood oxygenator
US4256692A (en) * 1979-02-01 1981-03-17 C. R. Bard, Inc. Membrane oxygenator
US4268279A (en) * 1978-06-15 1981-05-19 Mitsubishi Rayon Co., Ltd. Gas transfer process with hollow fiber membrane
US4280981A (en) * 1979-11-06 1981-07-28 C. R. Bard, Inc. Blood oxygenator
US4282180A (en) * 1975-06-06 1981-08-04 Bentley Laboratories, Inc. Blood oxygenator
US4306018A (en) * 1980-06-26 1981-12-15 The Board Of Regents Of The University Of Nebraska Method of gas-heat exchange
US4308230A (en) * 1977-03-07 1981-12-29 Bramson Mogens L Blood oxygenator
US4315819A (en) * 1978-06-12 1982-02-16 Monsanto Company Hollow fiber permeator apparatus
US4346006A (en) * 1980-03-24 1982-08-24 Baxter Travenol Laboratories, Inc. Diffusion membrane units with adhered semipermeable capillaries
US4352736A (en) * 1980-12-08 1982-10-05 Toyo Boseki Kabushiki Kaisha Wound flattened hollow fiber assembly having plural spaced core sections
US4372914A (en) * 1975-06-06 1983-02-08 Bentley Laboratories, Inc. Blood oxygenator
US4374802A (en) * 1980-09-25 1983-02-22 Terumo Corporation Oxygenator
US4376095A (en) * 1980-08-25 1983-03-08 Terumo Corporation Hollow fiber-type artificial lung having enclosed heat exchanger
US4389363A (en) * 1980-11-03 1983-06-21 Baxter Travenol Laboratories, Inc. Method of potting microporous hollow fiber bundles
US4411872A (en) * 1977-03-07 1983-10-25 Bramson Mogens L Water unit for use with a membrane blood oxygenator
US4414110A (en) * 1979-05-14 1983-11-08 Cordis Dow Corp. Sealing for a hollow fiber separatory device
US4424190A (en) * 1982-02-22 1984-01-03 Cordis Dow Corp. Rigid shell expansible blood reservoir, heater and hollow fiber membrane oxygenator assembly
US4425234A (en) * 1979-07-30 1984-01-10 Hospal Ltd. Hollow fiber separatory device
US4428934A (en) * 1977-08-09 1984-01-31 Bentley Laboratories, Inc. Method for oxygenating blood
US4428403A (en) * 1980-12-19 1984-01-31 Extracorporeal Medical Specialties, Inc. Conduit having spirally wound monofilament material
US4440722A (en) * 1980-10-06 1984-04-03 Dideco S.P.A Device for oxygenating blood circulating in an extracorporeal circuit with a heat exchanger
US4440723A (en) * 1981-07-10 1984-04-03 Bentley Laboratories, Inc. Blood oxygenator
US4445500A (en) * 1982-03-03 1984-05-01 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4455230A (en) * 1982-04-26 1984-06-19 Cobe Laboratories, Inc. Pleated membrane transfer device utilizing potting and thixotropic adhesive
EP0114732A2 (en) 1983-01-14 1984-08-01 Baxter Travenol Laboratories, Inc. Blood oxygenator
US4466804A (en) * 1981-09-25 1984-08-21 Tsunekazu Hino Extracorporeal circulation of blood
US4493692A (en) * 1982-09-29 1985-01-15 Reed Charles C Blood gas concentration control apparatus and method
US4533516A (en) * 1981-07-07 1985-08-06 Gambro Cardio Ab Apparatus for the transfer of one or more substances between a gas and a liquid
US4540492A (en) * 1981-11-16 1985-09-10 Millipore Corporation Method and apparatus for treating whole blood
US4556489A (en) * 1983-03-09 1985-12-03 Shiley Incorporated Membrane oxygenator
US4559999A (en) * 1983-04-08 1985-12-24 Shiley, Inc. Heat exchanger for extracorporeal circuit
US4588026A (en) * 1979-06-11 1986-05-13 Raytheon Company Coiled heat exchanger
USRE32186E (en) 1976-07-23 1986-06-17 American Hospital Supply Corp. Fluid transfer apparatus and method of fluid transfer
US4599093A (en) * 1982-02-12 1986-07-08 Steg Jr Robert F Extracorporeal blood processing system
US4612170A (en) * 1983-06-13 1986-09-16 Luther Ronald B Blood oxygenator with dual sparger and reuseable heat exchanger
US4622140A (en) * 1974-03-19 1986-11-11 Extracorporeal Medical Specialties, Inc. Device useful in the treatment of blood
US4622206A (en) * 1983-11-21 1986-11-11 University Of Pittsburgh Membrane oxygenator and method and apparatus for making the same
US4637917A (en) 1983-10-14 1987-01-20 Reed Charles C Bubble oxygenator
US4639353A (en) 1984-04-24 1987-01-27 Mitsubishi Rayon Co., Ltd. Blood oxygenator using a hollow-fiber membrane
US4645645A (en) 1985-04-04 1987-02-24 Renal Systems, Inc. Oxygenator having an improved heat exchanger
US4650457A (en) 1985-08-16 1987-03-17 Kuraray Co., Ltd. Apparatus for extracorporeal lung assist
US4656004A (en) 1985-05-17 1987-04-07 Cobe Laboratories, Inc. Medical heat exchange
US4657743A (en) 1981-11-18 1987-04-14 Terumo Corporation Heat exchanger-incorporated hollow fiber type artifical lung
US4658367A (en) 1984-08-23 1987-04-14 Hewlett-Packard Company Noise corrected pole and zero analyzer
US4659549A (en) 1984-03-14 1987-04-21 Mitsubishi Rayon Co., Ltd. Blood oxygenator using a hollow fiber membrane
US4684508A (en) 1983-12-27 1987-08-04 American Hospital Supply Corp. Blood heat exchanger
US4686085A (en) 1980-04-14 1987-08-11 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4704203A (en) 1982-08-27 1987-11-03 Reed Charles C Cardiotomy reservoir apparatus and method
US4705508A (en) 1985-09-30 1987-11-10 Regents Of The University Of Minnesota Apparatus and method for rapid infusion of circulatory supportive fluids
US4707587A (en) 1986-01-27 1987-11-17 Greenblatt Gordon M Blood warming method and apparatus using gaseous heat exchange medium
US4717377A (en) 1981-11-13 1988-01-05 Terumo Kabushiki Kaisha Blood circulating circuit for membrane-type artificial lung, and reservoir for use in blood circulating circuit
US4722829A (en) 1986-03-24 1988-02-02 Giter Gregory D Blood oxygenator
US4734269A (en) 1985-06-11 1988-03-29 American Hospital Supply Corporation Venous reservoir bag with integral high-efficiency bubble removal system
US4735775A (en) 1984-02-27 1988-04-05 Baxter Travenol Laboratories, Inc. Mass transfer device having a heat-exchanger
US4756705A (en) 1985-12-19 1988-07-12 Gambro, Ab Heart-lung system using the lung as an oxygenator
US4769959A (en) 1983-07-08 1988-09-13 Lindsey Manufacturing Company Temporary power line tower assembly and method of installing same
US4772256A (en) 1986-11-07 1988-09-20 Lantech, Inc. Methods and apparatus for autotransfusion of blood
US4775360A (en) 1986-11-07 1988-10-04 Lantech, Inc. Autologus blood methods and apparatus
US4781889A (en) 1983-05-27 1988-11-01 Terumo Kabushiki Kaisha Hollow fiber membrane type artificial lung
US4791054A (en) 1984-10-01 1988-12-13 Mitsubishi Rayon Co., Ltd. Heat exchanger and blood oxygenating device furnished therewith
US4828543A (en) 1986-04-03 1989-05-09 Weiss Paul I Extracorporeal circulation apparatus
EP0217759B1 (en) 1985-09-24 1989-06-14 SORIN BIOMEDICA S.p.A. Improvements in hollow-fibre oxygenators for blood
US4857081A (en) 1987-10-15 1989-08-15 Separation Dynamics, Inc. Separation of water from hydrocarbons and halogenated hydrocarbons
US4863600A (en) 1984-11-05 1989-09-05 Baxter International Inc. Hollow fiber bundle having transverse binding means and method of making same
US4869822A (en) 1985-09-27 1989-09-26 Ube Industries, Ltd. Filter apparatus employing hollow fibers
US4874581A (en) 1986-06-13 1989-10-17 Baxter International Inc. O2 /CO2 control in blood oxygenators
US4876066A (en) 1986-07-14 1989-10-24 Baxter International Inc. Integrated membrane oxygenator, heat exchanger and reservoir
US4909989A (en) 1985-09-13 1990-03-20 Terumo Kabushiki Kaisha (Terumo Corporation) Gas-exchange membrane for an artificial lung
US4911846A (en) 1988-05-27 1990-03-27 Kuraray Co., Ltd. Fluid treating apparatus and method of using it
US4923679A (en) 1984-05-24 1990-05-08 Terumo Kabushiki Kaisha Hollow fiber membrane type oxygenator and method for manufacturing same
US4948560A (en) 1984-11-27 1990-08-14 Terumo Corporation Oxygenator
US4950391A (en) 1988-02-22 1990-08-21 Secon Gmbh Capillary dialyzer
US4954317A (en) 1975-06-06 1990-09-04 Baxter International, Inc. Blood oxygenator
US4976682A (en) 1987-11-23 1990-12-11 Lane Perry L Methods and apparatus for autologous blood recovery
US5011469A (en) 1988-08-29 1991-04-30 Shiley, Inc. Peripheral cardiopulmonary bypass and coronary reperfusion system
US5026525A (en) 1987-05-19 1991-06-25 Terumo Kabushiki Kaisha Extracorporeal blood circulating apparatus
US5034188A (en) 1987-02-09 1991-07-23 Senko Medical Instrument Mfg. Co., Ltd. Artificial lung
US5039482A (en) 1987-12-15 1991-08-13 Shiley Inc. Integrated unit for extracorporeal blood circuits
US5039486A (en) 1986-07-14 1991-08-13 Baxter Inrternational, Inc. Liquid and gas separation system
US5049146A (en) 1989-05-31 1991-09-17 Baxter International, Inc. Blood/gas separator and flow system
US5058661A (en) 1987-06-29 1991-10-22 Terumo Kabushiki Kaisha Heat exchanger with leakage collector
US5084244A (en) 1989-01-10 1992-01-28 Terumo Kabushiki Kaisha Artificial lung assembly
US5106579A (en) 1985-09-13 1992-04-21 Terumo Corporation Membrane type artificial lung and method for manufacture thereof
US5110549A (en) 1986-07-14 1992-05-05 Baxter International Inc. Liquid and gas separation system
US5110548A (en) 1987-03-25 1992-05-05 Montevecchi Franco M Apparatus for concurrently oxgenating and pumping blood circulated extra-corporeally in cardiovascular systems
US5112480A (en) 1987-07-07 1992-05-12 Terumo Kabushiki Kaisha Blood reservoir
USRE33932E (en) 1982-09-22 1992-05-19 Terumo Corporation Hollow fiber-type artificial lung
US5116308A (en) 1989-01-13 1992-05-26 Terumo Kabushiki Kaisha Apparatus for processing fluid and method of driving the same
US5117903A (en) 1987-07-13 1992-06-02 Terumo Kabushiki Kaisha Multitube heat exchanger with uniform-flow baffles in head chamber
US5120502A (en) 1988-04-11 1992-06-09 Baxter International Inc. Pressure relief valve for membrane oxygenator
US5120501A (en) 1988-10-20 1992-06-09 Baxter International Inc. Integrated membrane blood oxygenator/heat exchanger
US5120302A (en) 1989-07-31 1992-06-09 Dideco, S.P.A. Blood container for medical apparatus
US5124127A (en) 1989-01-26 1992-06-23 Shiley, Incorporated Hollow fiber blood oxygenator
US5151192A (en) 1990-07-13 1992-09-29 Pall Corporation Method for removing heparin from blood or plasma
US5158533A (en) 1991-03-26 1992-10-27 Gish Biomedical, Inc. Combined cardiotomy/venous/pleural drainage autotransfusion unit with filter and integral manometer and water seal
US5160615A (en) 1990-04-18 1992-11-03 Terumo Kabushiki Kaisha Hollow fiber type liquid processing apparatus
US5162102A (en) 1987-09-21 1992-11-10 Terumo Kabushiki Kaisha Medical instrument and production thereof
US5167921A (en) 1986-07-14 1992-12-01 Baxter International Inc. Liquid and gas separation system
US5225161A (en) 1988-10-20 1993-07-06 Baxter International Inc. Integrated membrane blood oxygenator/heat exchanger
US5234663A (en) 1989-01-26 1993-08-10 Shiley, Inc. Hollow fiber blood oxygenator
US5236665A (en) 1988-10-20 1993-08-17 Baxter International Inc. Hollow fiber treatment apparatus and membrane oxygenator
US5266265A (en) 1992-10-08 1993-11-30 Baxter International, Inc. Modular disposable blood oxygenator/heat exchanger with durable heat source component, selectively including rotary or ventricular blood pump, venous reservoir, and auxiliary heat exchange component
US5316724A (en) 1989-03-31 1994-05-31 Baxter International Inc. Multiple blood path membrane oxygenator
US5322500A (en) 1991-05-09 1994-06-21 Cardio Pulmonary Supplies, Inc. Variable ratio blood-additive solution device and delivery system
US5411706A (en) 1994-02-09 1995-05-02 Hubbard; Lloyd C. Pump/oxygenator with blood recirculation
US5489413A (en) 1992-11-03 1996-02-06 Cobe Laboratories, Inc. Hollow fiber blood oxygenator
US5489382A (en) 1987-10-29 1996-02-06 Terumo Kabushiki Kaisha Oxygenator using porous hollow fiber membrane

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963319B (en) * 1969-12-17 1970-12-03 Bio Cal Instr Gmbh artificial lung
GB1482405A (en) * 1973-05-29 1977-08-10 Bentley Lab Membrane transfer process and apparatus
US4818490A (en) * 1982-04-26 1989-04-04 Cobe Laboratories, Inc. Integral blood oxygenator
US4715953A (en) * 1983-04-01 1987-12-29 Baxter Travenol Laboratories, Inc. Hollow fiber separation device manifold
US4808378A (en) * 1985-11-11 1989-02-28 Senko Medical Instrument Mfg. Co., Ltd. Blood oxygenator
US4698207A (en) * 1986-07-14 1987-10-06 Baxter Travenol Laboratories, Inc. Integrated membrane oxygenator, heat exchanger and reservoir
EP0566114B1 (en) * 1987-07-28 1996-04-17 Minntech Corporation Outside perfusion type blood oxygenator
US4906581A (en) * 1988-10-20 1990-03-06 Minntech Corporation Method of quality control for hollow fiber gas transfer cells

Patent Citations (180)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US27100A (en) * 1860-02-14 Robert f
US32186A (en) * 1861-04-30 Improved telegraphic cable
US33932A (en) * 1861-12-17 Improvement in the base-pin and rammer of revolving pistols
US2659368A (en) * 1949-05-28 1953-11-17 Jefferson Medical College Of P Extracorporeal circulation device
US2684728A (en) * 1952-05-17 1954-07-27 Ind Rayon Corp Apparatus for removing air from viscose solution
US3058464A (en) * 1957-04-22 1962-10-16 Baxter Laboratories Inc Oxygenator
US2937644A (en) * 1957-10-15 1960-05-24 Corco Inc Blood oxygenator for facilitating heart surgery
US3026871A (en) * 1958-01-30 1962-03-27 Const Mecaniques De Stains Soc Apparatus for oxygenating blood
US3171475A (en) * 1962-04-06 1965-03-02 Baxter Laboratories Inc Apparatus for blood handling
US3211148A (en) * 1962-05-25 1965-10-12 Jr John E Galajda Rotary disk oxygenator and heater
US3142296A (en) * 1962-05-31 1964-07-28 Jack W Love Blood oxygenator
US3256883A (en) * 1963-08-08 1966-06-21 Wall Richard A De Oxygenator with heat exchanger
US3484211A (en) * 1964-12-08 1969-12-16 Us Army Membrane oxygenator
US3342729A (en) * 1964-12-09 1967-09-19 Dow Chemical Co Permeability separatory cell and apparatus and method of using the same
US3315740A (en) * 1965-01-14 1967-04-25 Du Pont Flexible plastic tube bundle and method of making
US3413095A (en) * 1965-06-14 1968-11-26 Mogens L. Bramson Membrane oxygenator
US3527572A (en) * 1965-10-11 1970-09-08 A Edward Urkiewicz Apparatus for treating blood
US3466148A (en) * 1966-02-15 1969-09-09 Hazen F Everett Blood oxygenator
US3513845A (en) * 1966-09-15 1970-05-26 United Aircraft Corp Bypass heart pump and oxygenator system
US3492991A (en) * 1967-02-23 1970-02-03 Richard H Dyer Jr Autotransfusion apparatus
US3651616A (en) * 1968-02-14 1972-03-28 Rhone Poulenc Sa Process for effecting absorption or removal of gas from a liquid
USRE27100E (en) 1968-06-20 1971-03-30 Oxygenator with heat exchanger
US3557962A (en) * 1968-06-28 1971-01-26 North American Rockwell Reverse osmosis fabric
US3547591A (en) * 1968-10-16 1970-12-15 Jose C Torres Bubble film oxygenator
US3722694A (en) * 1970-06-10 1973-03-27 Romicon Inc Filtration device
US3870470A (en) * 1970-07-24 1975-03-11 Fumitake Yoshida Bubble-type blood oxygenator with baffles
US3848660A (en) * 1970-08-17 1974-11-19 Du Pont Plastic heat exchange apparatus and a method for making
US3691068A (en) * 1971-01-08 1972-09-12 Amicon Corp Dialysis membrane and its use
US3755034A (en) * 1971-02-25 1973-08-28 Dow Chemical Co Method for making a hollow fiber separatory element
US3769162A (en) * 1971-08-26 1973-10-30 R Brumfield Blood oxygenator and thermoregulator apparatus
US3994689A (en) * 1971-09-08 1976-11-30 Dewall Richard A Metabolic bubble oxygenator
US3769163A (en) * 1971-11-08 1973-10-30 R Brumfield Blood oxygenator flow guide
US3794468A (en) * 1972-01-10 1974-02-26 Baxter Laboratories Inc Mass transfer device having a wound tubular diffusion membrane
US3764271A (en) * 1972-01-10 1973-10-09 R Brumfield Blood oxygenator in combination with a low pressure heat exchanger
US3768653A (en) * 1972-03-21 1973-10-30 R Brumfield Filtering cardiotomy reservoir
US3807958A (en) * 1972-06-05 1974-04-30 Harvey Res Corp William A bubble oxygenerator including a blood foam return exchanger device
US3853479A (en) * 1972-06-23 1974-12-10 Sherwood Medical Ind Inc Blood oxygenating device with heat exchanger
US3884814A (en) * 1972-07-26 1975-05-20 Rhone Poulenc Sa Apparatus for fractionating fluids
US3927981A (en) * 1972-08-30 1975-12-23 Rhone Poulenc Sa Membrane-type blood oxygenator with recycle of oxygen-containing gas
US3881483A (en) * 1972-09-12 1975-05-06 Rhone Poulenc Sa Extracorporeal blood circuit
US3956112A (en) * 1973-01-02 1976-05-11 Allied Chemical Corporation Membrane solvent extraction
US4038190A (en) * 1973-05-30 1977-07-26 Rhone-Poulenc S.A. Fluid fractionation apparatus and method of manufacturing the same
US3993816A (en) * 1973-07-11 1976-11-23 Rhone-Poulenc S.A. Hollow fiber assembly for use in fluid treatment apparatus
US3918912A (en) * 1973-10-15 1975-11-11 Sherwood Medical Ind Inc Blood oxygenator
US3890969A (en) * 1974-01-21 1975-06-24 Baxter Laboratories Inc Cardiopulmonary bypass system
US4622140A (en) * 1974-03-19 1986-11-11 Extracorporeal Medical Specialties, Inc. Device useful in the treatment of blood
US4111659A (en) * 1974-09-25 1978-09-05 Graeme L. Hammond Mass and heat transfer exchange apparatus
US3957504A (en) * 1974-11-11 1976-05-18 Allied Chemical Corporation Membrane hydro-metallurgical extraction process
DE2456932A1 (en) 1974-12-02 1976-06-10 Gebhard Roggors Magnetic field oxygenation enclosure - for gas exchange between blood and a gas atmosphere in a magnetic field
SU543400A1 (en) 1974-12-16 1977-01-25 Белорусский Филиал Всесоюзного Научно-Исследовательского Института Технической Эстетики Foam type oxygenator
US4372914A (en) * 1975-06-06 1983-02-08 Bentley Laboratories, Inc. Blood oxygenator
US4954317A (en) 1975-06-06 1990-09-04 Baxter International, Inc. Blood oxygenator
US4282180A (en) * 1975-06-06 1981-08-04 Bentley Laboratories, Inc. Blood oxygenator
SU554869A1 (en) 1975-06-30 1977-04-25 Предприятие П/Я А-1874 Cardiopulmonary bypass
US4026669A (en) * 1975-07-14 1977-05-31 Baxter Laboratories, Inc. Variable capacity reservoir assembly
US4202776A (en) * 1975-07-28 1980-05-13 Nippon Zeon Co., Ltd. Hollow-fiber permeability apparatus
US4022692A (en) * 1975-08-01 1977-05-10 Erika, Inc. Non-woven support screen for mass transfer devices
US4036231A (en) * 1975-11-20 1977-07-19 Sherwood Medical Industries Inc. Thoracic drainage unit with defoaming means
US4077578A (en) * 1976-02-13 1978-03-07 Baxter Travenol Laboratories, Inc. Machine for winding hollow filaments
US4065264A (en) * 1976-05-10 1977-12-27 Shiley Laboratories, Inc. Blood oxygenator with integral heat exchanger for regulating the temperature of blood in an extracorporeal circuit
USRE32186E (en) 1976-07-23 1986-06-17 American Hospital Supply Corp. Fluid transfer apparatus and method of fluid transfer
US4187180A (en) * 1976-10-18 1980-02-05 Nippon Zeon Co. Ltd. Hollow-fiber permeability apparatus
US4186713A (en) * 1976-10-28 1980-02-05 Lucas Industries Limited Ignition systems for internal combustion engine
US4168293A (en) * 1977-03-07 1979-09-18 Bramson Mogens L Blood oxygenator
US4308230A (en) * 1977-03-07 1981-12-29 Bramson Mogens L Blood oxygenator
US4411872A (en) * 1977-03-07 1983-10-25 Bramson Mogens L Water unit for use with a membrane blood oxygenator
US4428934A (en) * 1977-08-09 1984-01-31 Bentley Laboratories, Inc. Method for oxygenating blood
US4140637A (en) * 1977-10-06 1979-02-20 Walter Carl W Permeability separatory method and apparatus
US4225439A (en) * 1977-10-17 1980-09-30 Gambro Dialysatoren Gmbh & Co. Kg Apparatus for selective separation of matter through semi-permeable membranes
US4213858A (en) * 1977-11-18 1980-07-22 Gambro Ab Supporting net
US4158693A (en) * 1977-12-29 1979-06-19 Texas Medical Products, Inc. Blood oxygenator
US4180896A (en) * 1977-12-29 1980-01-01 Texas Medical Products, Inc. Blood oxygenator assembly method
US4239729A (en) * 1978-06-06 1980-12-16 Terumo Corporation Oxygenator
US4315819A (en) * 1978-06-12 1982-02-16 Monsanto Company Hollow fiber permeator apparatus
US4268279A (en) * 1978-06-15 1981-05-19 Mitsubishi Rayon Co., Ltd. Gas transfer process with hollow fiber membrane
US4205042A (en) * 1978-06-23 1980-05-27 Cobe Laboratories, Inc. Blood oxygenator with a gas filter
US4188360A (en) * 1978-09-08 1980-02-12 Japan Medical Supply Co., Ltd. Artificial lung with a built-in heat exchanger
US4244094A (en) * 1978-11-28 1981-01-13 Fabryka Narzedzi Chirurgicznych Instrument for removing exchangeable blades from surgical scalpes
US4256692A (en) * 1979-02-01 1981-03-17 C. R. Bard, Inc. Membrane oxygenator
US4414110A (en) * 1979-05-14 1983-11-08 Cordis Dow Corp. Sealing for a hollow fiber separatory device
US4588026A (en) * 1979-06-11 1986-05-13 Raytheon Company Coiled heat exchanger
US4425234A (en) * 1979-07-30 1984-01-10 Hospal Ltd. Hollow fiber separatory device
US4254081A (en) * 1979-09-21 1981-03-03 Research Partners Limited Blood oxygenator
US4280981A (en) * 1979-11-06 1981-07-28 C. R. Bard, Inc. Blood oxygenator
US4346006A (en) * 1980-03-24 1982-08-24 Baxter Travenol Laboratories, Inc. Diffusion membrane units with adhered semipermeable capillaries
US4686085A (en) 1980-04-14 1987-08-11 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4306018A (en) * 1980-06-26 1981-12-15 The Board Of Regents Of The University Of Nebraska Method of gas-heat exchange
US4376095A (en) * 1980-08-25 1983-03-08 Terumo Corporation Hollow fiber-type artificial lung having enclosed heat exchanger
US4374802A (en) * 1980-09-25 1983-02-22 Terumo Corporation Oxygenator
US4440722A (en) * 1980-10-06 1984-04-03 Dideco S.P.A Device for oxygenating blood circulating in an extracorporeal circuit with a heat exchanger
US4389363A (en) * 1980-11-03 1983-06-21 Baxter Travenol Laboratories, Inc. Method of potting microporous hollow fiber bundles
US4352736A (en) * 1980-12-08 1982-10-05 Toyo Boseki Kabushiki Kaisha Wound flattened hollow fiber assembly having plural spaced core sections
US4428403A (en) * 1980-12-19 1984-01-31 Extracorporeal Medical Specialties, Inc. Conduit having spirally wound monofilament material
US4533516A (en) * 1981-07-07 1985-08-06 Gambro Cardio Ab Apparatus for the transfer of one or more substances between a gas and a liquid
US4440723A (en) * 1981-07-10 1984-04-03 Bentley Laboratories, Inc. Blood oxygenator
US4466804A (en) * 1981-09-25 1984-08-21 Tsunekazu Hino Extracorporeal circulation of blood
US4717377A (en) 1981-11-13 1988-01-05 Terumo Kabushiki Kaisha Blood circulating circuit for membrane-type artificial lung, and reservoir for use in blood circulating circuit
US4540492A (en) * 1981-11-16 1985-09-10 Millipore Corporation Method and apparatus for treating whole blood
US4657743A (en) 1981-11-18 1987-04-14 Terumo Corporation Heat exchanger-incorporated hollow fiber type artifical lung
US4599093A (en) * 1982-02-12 1986-07-08 Steg Jr Robert F Extracorporeal blood processing system
US4424190A (en) * 1982-02-22 1984-01-03 Cordis Dow Corp. Rigid shell expansible blood reservoir, heater and hollow fiber membrane oxygenator assembly
US4445500A (en) * 1982-03-03 1984-05-01 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4455230A (en) * 1982-04-26 1984-06-19 Cobe Laboratories, Inc. Pleated membrane transfer device utilizing potting and thixotropic adhesive
US4704203A (en) 1982-08-27 1987-11-03 Reed Charles C Cardiotomy reservoir apparatus and method
USRE33932E (en) 1982-09-22 1992-05-19 Terumo Corporation Hollow fiber-type artificial lung
US4493692A (en) * 1982-09-29 1985-01-15 Reed Charles C Blood gas concentration control apparatus and method
EP0114732A2 (en) 1983-01-14 1984-08-01 Baxter Travenol Laboratories, Inc. Blood oxygenator
US4556489A (en) * 1983-03-09 1985-12-03 Shiley Incorporated Membrane oxygenator
US4559999A (en) * 1983-04-08 1985-12-24 Shiley, Inc. Heat exchanger for extracorporeal circuit
US4781889A (en) 1983-05-27 1988-11-01 Terumo Kabushiki Kaisha Hollow fiber membrane type artificial lung
US4971836A (en) 1983-05-27 1990-11-20 Terumo Kabushiki Kaisha Method for manufacture of hollow fiber membrane type artificial lung
US4612170A (en) * 1983-06-13 1986-09-16 Luther Ronald B Blood oxygenator with dual sparger and reuseable heat exchanger
US4769959A (en) 1983-07-08 1988-09-13 Lindsey Manufacturing Company Temporary power line tower assembly and method of installing same
US4637917A (en) 1983-10-14 1987-01-20 Reed Charles C Bubble oxygenator
US4622206A (en) * 1983-11-21 1986-11-11 University Of Pittsburgh Membrane oxygenator and method and apparatus for making the same
US4684508A (en) 1983-12-27 1987-08-04 American Hospital Supply Corp. Blood heat exchanger
US4735775A (en) 1984-02-27 1988-04-05 Baxter Travenol Laboratories, Inc. Mass transfer device having a heat-exchanger
US4659549A (en) 1984-03-14 1987-04-21 Mitsubishi Rayon Co., Ltd. Blood oxygenator using a hollow fiber membrane
US4639353A (en) 1984-04-24 1987-01-27 Mitsubishi Rayon Co., Ltd. Blood oxygenator using a hollow-fiber membrane
US4923679A (en) 1984-05-24 1990-05-08 Terumo Kabushiki Kaisha Hollow fiber membrane type oxygenator and method for manufacturing same
US5037610A (en) 1984-05-24 1991-08-06 Terumo Kabushiki Kaisha Method for manufacturing a hollow fiber membrane oxygenator
US4658367A (en) 1984-08-23 1987-04-14 Hewlett-Packard Company Noise corrected pole and zero analyzer
US4791054A (en) 1984-10-01 1988-12-13 Mitsubishi Rayon Co., Ltd. Heat exchanger and blood oxygenating device furnished therewith
US4863600A (en) 1984-11-05 1989-09-05 Baxter International Inc. Hollow fiber bundle having transverse binding means and method of making same
US4948560A (en) 1984-11-27 1990-08-14 Terumo Corporation Oxygenator
US4645645A (en) 1985-04-04 1987-02-24 Renal Systems, Inc. Oxygenator having an improved heat exchanger
US4656004A (en) 1985-05-17 1987-04-07 Cobe Laboratories, Inc. Medical heat exchange
US4734269A (en) 1985-06-11 1988-03-29 American Hospital Supply Corporation Venous reservoir bag with integral high-efficiency bubble removal system
US4650457A (en) 1985-08-16 1987-03-17 Kuraray Co., Ltd. Apparatus for extracorporeal lung assist
US4909989A (en) 1985-09-13 1990-03-20 Terumo Kabushiki Kaisha (Terumo Corporation) Gas-exchange membrane for an artificial lung
US5106579A (en) 1985-09-13 1992-04-21 Terumo Corporation Membrane type artificial lung and method for manufacture thereof
EP0217759B1 (en) 1985-09-24 1989-06-14 SORIN BIOMEDICA S.p.A. Improvements in hollow-fibre oxygenators for blood
US4869822A (en) 1985-09-27 1989-09-26 Ube Industries, Ltd. Filter apparatus employing hollow fibers
US4705508A (en) 1985-09-30 1987-11-10 Regents Of The University Of Minnesota Apparatus and method for rapid infusion of circulatory supportive fluids
US4756705A (en) 1985-12-19 1988-07-12 Gambro, Ab Heart-lung system using the lung as an oxygenator
US4707587A (en) 1986-01-27 1987-11-17 Greenblatt Gordon M Blood warming method and apparatus using gaseous heat exchange medium
US4722829A (en) 1986-03-24 1988-02-02 Giter Gregory D Blood oxygenator
US4828543A (en) 1986-04-03 1989-05-09 Weiss Paul I Extracorporeal circulation apparatus
US4874581A (en) 1986-06-13 1989-10-17 Baxter International Inc. O2 /CO2 control in blood oxygenators
US5110549A (en) 1986-07-14 1992-05-05 Baxter International Inc. Liquid and gas separation system
US4876066A (en) 1986-07-14 1989-10-24 Baxter International Inc. Integrated membrane oxygenator, heat exchanger and reservoir
US5039486A (en) 1986-07-14 1991-08-13 Baxter Inrternational, Inc. Liquid and gas separation system
US5167921A (en) 1986-07-14 1992-12-01 Baxter International Inc. Liquid and gas separation system
US4775360A (en) 1986-11-07 1988-10-04 Lantech, Inc. Autologus blood methods and apparatus
US4772256A (en) 1986-11-07 1988-09-20 Lantech, Inc. Methods and apparatus for autotransfusion of blood
US5034188A (en) 1987-02-09 1991-07-23 Senko Medical Instrument Mfg. Co., Ltd. Artificial lung
US5110548A (en) 1987-03-25 1992-05-05 Montevecchi Franco M Apparatus for concurrently oxgenating and pumping blood circulated extra-corporeally in cardiovascular systems
US5026525A (en) 1987-05-19 1991-06-25 Terumo Kabushiki Kaisha Extracorporeal blood circulating apparatus
US5102533A (en) 1987-06-29 1992-04-07 Terumo Kabushiki Kaisha Material exchangers
US5058661A (en) 1987-06-29 1991-10-22 Terumo Kabushiki Kaisha Heat exchanger with leakage collector
US5112480A (en) 1987-07-07 1992-05-12 Terumo Kabushiki Kaisha Blood reservoir
US5117903A (en) 1987-07-13 1992-06-02 Terumo Kabushiki Kaisha Multitube heat exchanger with uniform-flow baffles in head chamber
US5162102A (en) 1987-09-21 1992-11-10 Terumo Kabushiki Kaisha Medical instrument and production thereof
US4857081A (en) 1987-10-15 1989-08-15 Separation Dynamics, Inc. Separation of water from hydrocarbons and halogenated hydrocarbons
US5489382A (en) 1987-10-29 1996-02-06 Terumo Kabushiki Kaisha Oxygenator using porous hollow fiber membrane
US4976682A (en) 1987-11-23 1990-12-11 Lane Perry L Methods and apparatus for autologous blood recovery
US5039482A (en) 1987-12-15 1991-08-13 Shiley Inc. Integrated unit for extracorporeal blood circuits
US4950391A (en) 1988-02-22 1990-08-21 Secon Gmbh Capillary dialyzer
US5120502A (en) 1988-04-11 1992-06-09 Baxter International Inc. Pressure relief valve for membrane oxygenator
US4911846A (en) 1988-05-27 1990-03-27 Kuraray Co., Ltd. Fluid treating apparatus and method of using it
US5011469A (en) 1988-08-29 1991-04-30 Shiley, Inc. Peripheral cardiopulmonary bypass and coronary reperfusion system
US5120501A (en) 1988-10-20 1992-06-09 Baxter International Inc. Integrated membrane blood oxygenator/heat exchanger
US5338512A (en) 1988-10-20 1994-08-16 Baxter International Inc. Method for oxygenation of a patient's blood
US5236665A (en) 1988-10-20 1993-08-17 Baxter International Inc. Hollow fiber treatment apparatus and membrane oxygenator
US5225161A (en) 1988-10-20 1993-07-06 Baxter International Inc. Integrated membrane blood oxygenator/heat exchanger
US5084244A (en) 1989-01-10 1992-01-28 Terumo Kabushiki Kaisha Artificial lung assembly
US5116308A (en) 1989-01-13 1992-05-26 Terumo Kabushiki Kaisha Apparatus for processing fluid and method of driving the same
US5234663A (en) 1989-01-26 1993-08-10 Shiley, Inc. Hollow fiber blood oxygenator
US5358689A (en) 1989-01-26 1994-10-25 Shiley Incorporated Hollow fiber blood oxygenator
US5124127A (en) 1989-01-26 1992-06-23 Shiley, Incorporated Hollow fiber blood oxygenator
US5316724A (en) 1989-03-31 1994-05-31 Baxter International Inc. Multiple blood path membrane oxygenator
US5049146A (en) 1989-05-31 1991-09-17 Baxter International, Inc. Blood/gas separator and flow system
US5120302A (en) 1989-07-31 1992-06-09 Dideco, S.P.A. Blood container for medical apparatus
US5160615A (en) 1990-04-18 1992-11-03 Terumo Kabushiki Kaisha Hollow fiber type liquid processing apparatus
US5151192A (en) 1990-07-13 1992-09-29 Pall Corporation Method for removing heparin from blood or plasma
US5158533A (en) 1991-03-26 1992-10-27 Gish Biomedical, Inc. Combined cardiotomy/venous/pleural drainage autotransfusion unit with filter and integral manometer and water seal
US5322500A (en) 1991-05-09 1994-06-21 Cardio Pulmonary Supplies, Inc. Variable ratio blood-additive solution device and delivery system
US5266265A (en) 1992-10-08 1993-11-30 Baxter International, Inc. Modular disposable blood oxygenator/heat exchanger with durable heat source component, selectively including rotary or ventricular blood pump, venous reservoir, and auxiliary heat exchange component
US5489413A (en) 1992-11-03 1996-02-06 Cobe Laboratories, Inc. Hollow fiber blood oxygenator
US5411706A (en) 1994-02-09 1995-05-02 Hubbard; Lloyd C. Pump/oxygenator with blood recirculation

Non-Patent Citations (21)

* Cited by examiner, † Cited by third party
Title
Belter et al, "Bioseparations: Downstream Processing for Biotechnology", A Wiley-Interscience Publication, Chapter 9 (Ultrafiltration and Electrophoresis), (1986), pp. 237-270.
Belter et al, Bioseparations: Downstream Processing for Biotechnology , A Wiley Interscience Publication, Chapter 9 (Ultrafiltration and Electrophoresis), (1986), pp. 237 270. *
Bird et al, Transport Phenomena, Wiley, 1980, Sections 2.3,6.2, 6.4. *
Cussler, A Mass Transfer Tutorial, Chemtech, (Jul., 1986), pp. 422 425. *
Cussler, A Mass Transfer Tutorial, Chemtech, (Jul., 1986), pp. 422-425.
Cussler, Diffusion: Mass transfer in fluid systems, Cambridge University Press, 1984, Chapter 2,, pp. 15 54 and Chapter 9, pp. 215 248. *
Cussler, Diffusion: Mass transfer in fluid systems, Cambridge University Press, 1984, Chapter 2,, pp. 15-54 and Chapter 9, pp. 215-248.
Semmens et al, Ammonia Removal From Water Using Microporous Hollow Fibers, undated paper, pp. 1 21. *
Semmens et al, Ammonia Removal From Water Using Microporous Hollow Fibers, undated paper, pp. 1-21.
Treybal, Mass Transfer Operations, Third Edition, McGraw Hill Book Company, (1980), pp. 47 54, 74 75. *
Treybal, Mass-Transfer Operations, Third Edition, McGraw-Hill Book Company, (1980), pp. 47-54, 74-75.
Wickramasinghe et al, "Mass transfer in various hollow fiber geometrics", Journal of Membrane Science, 69 (1992) pp. 235-250.
Wickramasinghe et al, Mass transfer in various hollow fiber geometrics , Journal of Membrane Science, 69 (1992) pp. 235 250. *
Wickramasingle, et al, "Hollow Fiber Modules Made With Hollow Fiber Fabric", Undated Paper, pp. 1-21.
Wickramasingle, et al, Hollow Fiber Modules Made With Hollow Fiber Fabric , Undated Paper, pp. 1 21. *
Winston, et al, Membrane Handbook, Prasad et al, Membrane Based Solvent Extraction, (1992) Chapter 41, pp. 727 763. *
Winston, et al, Membrane Handbook, Prasad et al, Membrane-Based Solvent Extraction, (1992) Chapter 41, pp. 727-763.
Yang et al, "Artifical Gills", Journal of Membrane Science, 42 (1989) pp. 273-284.
Yang et al, Artifical Gills , Journal of Membrane Science, 42 (1989) pp. 273 284. *
Yang et al, Designing Hollow Fiber Contactors, AlChE. Journal, (Nov. 1986), vol. 32, No. 11, pp. 1910 1916. *
Yang et al, Designing Hollow-Fiber Contactors, AlChE. Journal, (Nov. 1986), vol. 32, No. 11, pp. 1910-1916.

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6402967B1 (en) * 1997-05-01 2002-06-11 Eclipse Environmental Australia Pty Limited Grease separating device and method
US6682698B2 (en) 2001-08-23 2004-01-27 Michigan Critical Care Consultants, Inc. Apparatus for exchanging gases in a liquid
US20120018367A1 (en) * 2009-03-31 2012-01-26 Kubota Corporation Membrane separator
US8545754B2 (en) 2009-04-23 2013-10-01 Medtronic, Inc. Radial design oxygenator with heat exchanger
US9162022B2 (en) 2010-04-29 2015-10-20 Politecnico Di Milano Oxygenator with integrated arterial filter including filter frame
US8388566B2 (en) 2010-04-29 2013-03-05 Sorin Group Italia, S.r.l. Oxygenator with integrated arterial filter including filter frame
US10159777B2 (en) 2010-08-19 2018-12-25 Sorin Group Italia S.R.L. Blood processing unit with modified flow path
US9402943B2 (en) 2010-08-19 2016-08-02 Sorin Group Italia S.R.L. Blood processing unit with modified flow path
US8394049B2 (en) 2010-08-19 2013-03-12 Sorin Group Italia S.R.L. Blood processing unit with modified flow path
US8795220B2 (en) 2010-08-19 2014-08-05 Politecnico Di Milano Blood processing unit with circumferential blood flow
US8652406B2 (en) 2010-08-19 2014-02-18 Sorin Group Italia S.R.L. Blood processing unit with modified flow path
US8980176B2 (en) 2010-08-20 2015-03-17 Sorin Group Italia S.R.L. Blood processing unit with cross blood flow
WO2012156907A1 (en) * 2011-05-17 2012-11-22 Sorin Group Italia S.R.L. Blood processing unit with cross blood flow
EP2524712A1 (en) * 2011-05-17 2012-11-21 Sorin Group Italia S.r.l. Blood processing unit with cross blood flow
US10098994B2 (en) 2014-01-09 2018-10-16 Sorin Group Italia S.R.L. Blood processing unit with heat exchanger core for providing modified flow path
US10369262B2 (en) 2014-02-28 2019-08-06 Sorin Group Italia S.R.L. System for providing an integrated arterial filter into an oxygenator, minimizing added priming volume

Also Published As

Publication number Publication date
US5270004A (en) 1993-12-14

Similar Documents

Publication Publication Date Title
US3505686A (en) Device for effecting blood interchange functions
US3794468A (en) Mass transfer device having a wound tubular diffusion membrane
CN1238096C (en) Fiber dialyser comprising curled hollow fibre
EP0048943B1 (en) Oxygenator
US6723283B2 (en) Device for oxygenating blood in an extracorporeal circuit
US5951863A (en) Water purification using reverse osmosis device for formulation of medical solution
JP4531091B2 (en) Pressure vessel for holding a cylindrical filter cartridge
US4559999A (en) Heat exchanger for extracorporeal circuit
US4231871A (en) Artificial kidney and method for making same
US4211597A (en) Method for making artificial kidney
US4138464A (en) Blood oxygenator with integral heat exchanger
EP0378168B1 (en) Artificial lung assembly
EP0652779B1 (en) Hollow fiber blood oxygenator
EP1418960B1 (en) Apparatus for exchanging gases in a liquid
JP3320778B2 (en) Apparatus for moving the mass and / or heat
EP0408000A1 (en) Fluid processing apparatus
US4239728A (en) Apparatus and method for the diffusion of substances between two fluids separated by a semipermeable membrane
CA1323582C (en) Fluid treating apparatus and method of using it
EP0217759B1 (en) Improvements in hollow-fibre oxygenators for blood
US4111659A (en) Mass and heat transfer exchange apparatus
US5037383A (en) Intravascular lung assist device and method
US4735775A (en) Mass transfer device having a heat-exchanger
EP0853951B1 (en) Inflatable percutaneous oxygenator with transverse hollow fibers
US4376095A (en) Hollow fiber-type artificial lung having enclosed heat exchanger
US4141836A (en) Dialyser cartridge and method for its manufacture

Legal Events

Date Code Title Description
AS Assignment

Owner name: BAXTER HEALTHCARE CORPORATION, CALIFORNIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MINNTECH CORPORATION;REEL/FRAME:010018/0314

Effective date: 19981123

AS Assignment

Owner name: EDWARDS LIFESCIENCES CORPORATION, CALIFORNIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BAXTER HEALTHCARE CORPORATION;REEL/FRAME:011979/0094

Effective date: 20010607

FPAY Fee payment

Year of fee payment: 8

FPAY Fee payment

Year of fee payment: 12

REMI Maintenance fee reminder mailed