WO1997020019A1 - Emballage de lentille de contact - Google Patents

Emballage de lentille de contact Download PDF

Info

Publication number
WO1997020019A1
WO1997020019A1 PCT/GB1996/002937 GB9602937W WO9720019A1 WO 1997020019 A1 WO1997020019 A1 WO 1997020019A1 GB 9602937 W GB9602937 W GB 9602937W WO 9720019 A1 WO9720019 A1 WO 9720019A1
Authority
WO
WIPO (PCT)
Prior art keywords
contact lens
surfactant
solution
container
packing solution
Prior art date
Application number
PCT/GB1996/002937
Other languages
English (en)
Inventor
Ronald Shade Hamilton
Original Assignee
Award Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Award Plc filed Critical Award Plc
Priority to EP96940011A priority Critical patent/EP0912672A1/fr
Priority to AU77019/96A priority patent/AU7701996A/en
Publication of WO1997020019A1 publication Critical patent/WO1997020019A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D11/00—Producing optical elements, e.g. lenses or prisms
    • B29D11/00009—Production of simple or compound lenses
    • B29D11/0048—Moulds for lenses
    • B29D11/00567—Moulds for lenses wherein the mould forms part of the final package for lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/88—Ampholytes; Electroneutral compounds
    • C11D1/90—Betaines
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses

Definitions

  • This invention relates to soft contact lenses and the initial packaging thereof.
  • the invention is concerned with the packaging of disposable contact lenses.
  • soft contact lenses are thus provided packaged in saline (having the advantage of low cost) which is of typically 0.5% to 0.9% w/v concentration, this corresponding approximately to the composition of the tear film (i.e. the mucus layer or lipid layer) found in the eye.
  • the composition of the saline is generally also chosen so as to have a target pH substantially equal to seven e.g. between pH 7.0 and 7.2. The reason for this is that some users may suffer some initial discomfort, commonly in the form of a brief stinging sensation, where the pH value of the lens packing solution is not substantially equal to seven.
  • the saline composition includes a buffer to maintain the pH value at substantially seven.
  • the lenses are normally individually packaged in sealed containers or packets containing the saline composition. When first used, each lens is removed from its packet and usually placed directly on the user's eye.
  • buffered saline One disadvantage of the use of buffered saline is that it can nevertheless also cause initial discomfort, for some wearers (in fact, approximately one in one thousand wearers) whose eye pH is not substantially equal to seven and thus does not match the pH of the buffered saline packing solution.
  • Such discomfort is commonly in the form of a stinging sensation of a more pronounced nature than that suffered by some wearers where no buffer is used, and can last for anything between a few minutes to an hour or more. While such discomfort may be endurable upon first use of a lens where that lens is intended for extended wear e.g. a lens designed for use over a one month or three month period, such discomfort is less acceptable where the lens is intended only for single use, one-day wear.
  • a known way of improving wearer comfort is to use eye drops of an ocular lubricant which may be applied directly into the wearer's eye, while the lens is being worn, in order to provide symptomatic relief, at least to some extent.
  • Such eye drops may be used to ease the initial discomfort of wearers using a new lens or lenses for the first time, or for providing relief to wearers suffering from dry-eye effects.
  • the disadvantage of such eye drops is that they require to be obtained separately and are administered following insertion of the contact lens i.e. when the user is already suffering discomfort, thus adding cost and inconvenience to the wearer. It may moreover be awkward or inconvenient for a wearer to always carry a supply of eye drops, and/or to apply the drops in a public place. Moreover, such eye drops tend to provide only rather short term relief.
  • the present invention comprises the use of a physiologically compatible surfactant, in solution, in a contact lens package, as an ocular lubricant.
  • a physiologically compatible surfactant in solution, in a contact lens package, as an ocular lubricant.
  • suitable surfactants include alkylaminocarboxyglycinate components.
  • One which may be mentioned by way of example is disodium cocoamphodiacetate.
  • said solution contains a surfactant which is a physiologically acceptable salt of a compound according to the general formula (I) :
  • R represents a C 8 -C 18 substituted or unsubstituted alkyl or alkenyl.
  • said salt is a physiologically acceptable alkali metal or alkaline earth metal salt.
  • the presence of the surfactant solution in the contact lens package ensures that any fluid transferred to the eye with a lens, when the lens is initially transferred from the packet to the eye, will include a quantity of the surfactant thereby substantially avoiding discomfort to the wearer.
  • the surfactant may be included in a packing solution in the contact lens package. It is believed that the use of the surfactant in the lens package may ease any initial discomfort suffered by wearers whose eye pH does not match the pH of the packing solution. It is further believed that where the pH of the packing solution is generally neutral and not less than six there is no need to include a buffer in the packing solution as the surfactant will act to ease any initial wearer discomfort.
  • the invention is particularly advantageous where the lens package contains a one-day wear lens for which the packing solution is the only solution which the lens will experience (since the lens will not be subject to any further cleaning or storing after it has been worn) .
  • the invention also includes use of an ocular lubricant as a packing solution in a contact lens packet containing a disposable contact lens.
  • ocular lubricants are known in the art. Suitable ocular lubricants generally comprise an effective lubricating amount of a lubricant compound such as a surfactant, for example, disodium cocoamphodiacetate, in aqueous solution.
  • a surfactant for example, disodium cocoamphodiacetate
  • An example of commercially available disodium cocoamphodiacetate is that sold under the MIRANOL (Trade Mark) brand name (grade C2M CONC NP) by Rhone-Poulenc Chemicals.
  • lubricant compound in the ocular lubricant solution, which may also, if desired, contain one or more other substances commonly used in packing solutions such as preservatives or bacteriostats.
  • a suitable preservative is borax.
  • the invention provides a contact lens package comprising a sealed container, containing a soft contact lens and a contact lens packing solution, the lens being immersed in the packing solution, wherein the packing solution comprises an ocular lubricant.
  • the ocular lubricant may be an aqueous solution of a surfactant, such as disodium cocoamphodiacetate.
  • the packing solution may further include physiologically compatible or isotonic saline.
  • the ocular lubricant comprises a surfactant dissolved in saline.
  • the packing solution may also include a buffer for maintaining the pH value of the packing solution substantially equal to seven.
  • An example of a buffer suitable for use with saline and which is physiologically compatible is sodium phosphate (or potassium phosphate) at a concentration of 0.01M. Potassium hydrogen phosphate and potassium dihydrogen phosphate may also be used.
  • the concentration of the surfactant in the packing solution may be in the range of 100 to 5000 ppm e.g.
  • the quantity of surfactant in the packing solution is chosen so as to provide effective ocular lubrication, a ⁇ well as minimising the propensity to froth which may be exhibited by the surfactant-containing packing solution when shaken.
  • the sealed container may be any suitable generally inert packaging material providing a reasonable degree of protection to the lens, such as glass or preferably a plastics material such as a polyalkene, PVC, polyamide etc.
  • the present invention provides a method of reducing contact lens insertion discomfort to a disposable lens wearer, comprising the steps of providing an ocular lubricant in a packing solution of a packaged un-used disposable contact lens, and inserting said disposable contact lens into the eye of the contact lens wearer.
  • any solution transferred to the eye with the lens when this is placed in the eye for the first time will contain a quantity of ocular lubricant.
  • additional quantities of ocular lubricant which may have been absorbed within the lens itself may be gradually released onto the eyeball in use of the lens.
  • the ocular lubricant is added to a conventional packing solution (e.g. physiologically compatible saline) and mixed therewith, prior to introduction thereof into a container holding a contact lens, and sealing of the container.
  • a conventional packing solution e.g. physiologically compatible saline
  • the ocular lubricant could be added directly to a conventional packing solution previously introduced into a container for a contact lens, prior to sealing of the container.
  • the contact lens may be present in the packing solution when the ocular lubricant i ⁇ added, or introduced subsequently before sealing of the container.
  • the invention also includes a method of manufacturing a contact lens package comprising a contact lens in a sealed container, and comprising the steps of: i) moulding a contact lens in a mould comprising at least first and second mould portions; ii) hydrating and cleaning said lens in a container comprising at least one of said mould portions; iii) introducing a packing solution with ocular lubricant to the container with said lens supported therein; and iv) sealing the container.
  • the method also includes the step of sterilising the contents of the container.
  • Sterilisation may take place prior to, or most conveniently after, sealing of the container and may be effected by any suitable method known in the art e.g. by balanced autoclaving of the sealed container at temperatures of approximately 120°C or above.
  • the invention provides in a particularly convenient and economic manner improved comfort for the contact lens wearer which is of particular benefit to the wearer of single use, one-day- wear lenses and avoids the inconvenience of purchasing and administering special ocular lubricants, for example, in the form of eye drops.
  • a mixture made up of 11-12% sodium chloride and 89-88% disodium cocoamphodiacetate (a coconut base surfactant) was added to a quantity of 0.9% w/v saline (aqueous sodium chloride) in a ratio of 0.05% "mixture” to 99.95% "saline", to produce a final packing solution in which the disodium cocoamphodiacetate was present in a concentration of substantially 450 ppm.
  • the final packing solution was introduced into individual lens packets, each containing a disposable soft contact lens, during the lens package manufacturing process, prior to sealing of the packet and sterilisation of the lens packet contents.
  • the lens packets may each comprise one half of a mould in which a lens i ⁇ manufactured, and in which mould portion the lens is hydrated and cleaned according to the method described in our International PCT patent application no. PCT/GB96/02467, prior to the introduction of the packing solution into the lens packets.
  • the method of moulding a contact lens and the packaging thereof is preferably that disclosed in United Kingdom Patent Publications No. GB 2237240 and GB 2237241 and European Patent Publication No. 367513 all in the name of British Technology Group and which are incorporated herein by reference thereto.

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Mechanical Engineering (AREA)
  • Ophthalmology & Optometry (AREA)
  • Manufacturing & Machinery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Eyeglasses (AREA)
  • Medicinal Preparation (AREA)

Abstract

Utilisation d'un tensioactif physiologiquement compatible, en solution, dans un emballage de lentilles de contact, comme lubrifiant oculaire. Ce tensioactif peut par exemple être du cocoamphodiacétate de disodium.
PCT/GB1996/002937 1995-11-30 1996-11-29 Emballage de lentille de contact WO1997020019A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP96940011A EP0912672A1 (fr) 1995-11-30 1996-11-29 Emballage de lentille de contact
AU77019/96A AU7701996A (en) 1995-11-30 1996-11-29 Contact lens packaging

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9524452.1A GB9524452D0 (en) 1995-11-30 1995-11-30 Contact lens packaging
GB9524452.1 1995-11-30

Publications (1)

Publication Number Publication Date
WO1997020019A1 true WO1997020019A1 (fr) 1997-06-05

Family

ID=10784662

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1996/002937 WO1997020019A1 (fr) 1995-11-30 1996-11-29 Emballage de lentille de contact

Country Status (4)

Country Link
EP (1) EP0912672A1 (fr)
AU (1) AU7701996A (fr)
GB (1) GB9524452D0 (fr)
WO (1) WO1997020019A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998055155A2 (fr) * 1997-06-06 1998-12-10 Bausch & Lomb Incorporated Solutions et procedes de conditionnement de lentilles de contact jetables pour en ameliorer le confort
US7410050B2 (en) 2005-03-24 2008-08-12 Medical Instill Technologies, Inc. Contact lens storage container with needle penetrable and laser resealable stopper, and related method
EP1976570A2 (fr) * 2006-01-18 2008-10-08 Menicon Co., Ltd. Procédés et systèmes pour la stérilisation de lentilles de contact
WO2009032122A1 (fr) 2007-08-31 2009-03-12 Novartis Ag Solutions de conditionnement de lentilles de contact
WO2009089207A1 (fr) * 2008-01-09 2009-07-16 Bausch & Lomb Incorporated Solutions de conditionnement
EP2147686A1 (fr) 2004-10-01 2010-01-27 Menicon Co., Ltd. Méthode d'emballage pour les lentilles de contact
US7722808B2 (en) 2003-09-12 2010-05-25 Novartis Ag Method and kits for sterilizing and storing soft contact lenses
EP2990837A1 (fr) 2007-08-31 2016-03-02 Novartis AG Produits de type lentilles de contact
WO2017093834A1 (fr) 2015-12-03 2017-06-08 Novartis Ag Solutions de conditionnement pour lentilles de contact

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013576A (en) * 1973-11-21 1977-03-22 Wesley-Jessen Inc. Contact lens treating composition
JPH01268667A (ja) * 1988-04-20 1989-10-26 Kao Corp 界面活性剤の製造方法
US4908147A (en) * 1986-02-19 1990-03-13 Ciba-Geigy Corporation Aqueous self preserving soft contact lens solution and method
JPH02218797A (ja) * 1989-02-20 1990-08-31 Kao Corp 低刺激性洗浄剤組成物
EP0392320A2 (fr) * 1989-04-14 1990-10-17 Kao Corporation Composition de shampooing
GB2237241A (en) * 1988-11-02 1991-05-01 Nat Res Dev Contact lens casting and packaging
DE4026340A1 (de) * 1989-08-05 1992-03-26 Bruno Koller Kontaktlinsen-pflegemittel-reinigungsmittel
EP0521799A1 (fr) * 1991-07-05 1993-01-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions ophtalmiques

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013576A (en) * 1973-11-21 1977-03-22 Wesley-Jessen Inc. Contact lens treating composition
US4908147A (en) * 1986-02-19 1990-03-13 Ciba-Geigy Corporation Aqueous self preserving soft contact lens solution and method
JPH01268667A (ja) * 1988-04-20 1989-10-26 Kao Corp 界面活性剤の製造方法
GB2237241A (en) * 1988-11-02 1991-05-01 Nat Res Dev Contact lens casting and packaging
JPH02218797A (ja) * 1989-02-20 1990-08-31 Kao Corp 低刺激性洗浄剤組成物
EP0392320A2 (fr) * 1989-04-14 1990-10-17 Kao Corporation Composition de shampooing
DE4026340A1 (de) * 1989-08-05 1992-03-26 Bruno Koller Kontaktlinsen-pflegemittel-reinigungsmittel
EP0521799A1 (fr) * 1991-07-05 1993-01-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions ophtalmiques

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 8949, Derwent World Patents Index; Class D21, AN 89-359891, XP002025726 *
DATABASE WPI Section Ch Week 9041, Derwent World Patents Index; Class D25, AN 90-309128, XP002025727 *

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998055155A3 (fr) * 1997-06-06 1999-03-11 Bausch & Lomb Solutions et procedes de conditionnement de lentilles de contact jetables pour en ameliorer le confort
US6699435B2 (en) 1997-06-06 2004-03-02 Bausch & Lomb Incorporated Contact lens packing solutions
WO1998055155A2 (fr) * 1997-06-06 1998-12-10 Bausch & Lomb Incorporated Solutions et procedes de conditionnement de lentilles de contact jetables pour en ameliorer le confort
US7722808B2 (en) 2003-09-12 2010-05-25 Novartis Ag Method and kits for sterilizing and storing soft contact lenses
EP2147686A1 (fr) 2004-10-01 2010-01-27 Menicon Co., Ltd. Méthode d'emballage pour les lentilles de contact
US7410050B2 (en) 2005-03-24 2008-08-12 Medical Instill Technologies, Inc. Contact lens storage container with needle penetrable and laser resealable stopper, and related method
EP1976570A4 (fr) * 2006-01-18 2010-11-03 Menicon Co Ltd Procédés et systèmes pour la stérilisation de lentilles de contact
EP1976570A2 (fr) * 2006-01-18 2008-10-08 Menicon Co., Ltd. Procédés et systèmes pour la stérilisation de lentilles de contact
US8109064B2 (en) 2006-01-18 2012-02-07 Menicon Signapore Pte Ltd. Methods and systems for contact lens sterilization
EP2990837A1 (fr) 2007-08-31 2016-03-02 Novartis AG Produits de type lentilles de contact
US8689971B2 (en) 2007-08-31 2014-04-08 Novartis Ag Contact lens packaging solutions
US9162784B2 (en) 2007-08-31 2015-10-20 Novartis Ag Contact lens packaging solutions
WO2009032122A1 (fr) 2007-08-31 2009-03-12 Novartis Ag Solutions de conditionnement de lentilles de contact
US9348061B2 (en) 2007-08-31 2016-05-24 Novartis Ag Contact lens products
US7837934B2 (en) 2008-01-09 2010-11-23 Bausch & Lomb Incorporated Packaging solutions
JP2011510693A (ja) * 2008-01-09 2011-04-07 ボーシュ アンド ローム インコーポレイティド パッケージ液
WO2009089207A1 (fr) * 2008-01-09 2009-07-16 Bausch & Lomb Incorporated Solutions de conditionnement
WO2017093834A1 (fr) 2015-12-03 2017-06-08 Novartis Ag Solutions de conditionnement pour lentilles de contact
US9829723B2 (en) 2015-12-03 2017-11-28 Novartis Ag Contact lens packaging solutions
EP3543004A1 (fr) 2015-12-03 2019-09-25 Novartis AG Solutions de conditionnement de lentilles de contact

Also Published As

Publication number Publication date
AU7701996A (en) 1997-06-19
EP0912672A1 (fr) 1999-05-06
GB9524452D0 (en) 1996-01-31

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