WO1997008307A1 - Systeme de production de proteines heterologues au moyen de cellules aviaires - Google Patents

Systeme de production de proteines heterologues au moyen de cellules aviaires Download PDF

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Publication number
WO1997008307A1
WO1997008307A1 PCT/KR1996/000145 KR9600145W WO9708307A1 WO 1997008307 A1 WO1997008307 A1 WO 1997008307A1 KR 9600145 W KR9600145 W KR 9600145W WO 9708307 A1 WO9708307 A1 WO 9708307A1
Authority
WO
WIPO (PCT)
Prior art keywords
epo
cells
dna
group
vector
Prior art date
Application number
PCT/KR1996/000145
Other languages
English (en)
Inventor
Sun Young Kim
Kee Won Kim
Tae Han Kim
Jeong Ho Hwang
Seon Hee Kim
Sun Young Lee
Original Assignee
Il Dong Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Il Dong Pharmaceutical Co., Ltd. filed Critical Il Dong Pharmaceutical Co., Ltd.
Priority to EP96927924A priority Critical patent/EP0851917A1/fr
Priority to AU67563/96A priority patent/AU6756396A/en
Priority to JP9510142A priority patent/JPH11502719A/ja
Publication of WO1997008307A1 publication Critical patent/WO1997008307A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/30—Bird
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron

Abstract

Système d'expression de protéines hétérologues comprenant un ADN de gène hétérologue, tel qu'un ADN génomique d'érythropoïétine (EPO), un vecteur recevant l'ADN et une cellule aviaire, telle qu'une lignée cellulaire d'embryon de canard ou de fibrosarcome de caille, exprimant le gène dans le vecteur. On peut utiliser ce système afin de produire efficacement des protéines hétérologues, telles que EPO.
PCT/KR1996/000145 1995-08-24 1996-08-23 Systeme de production de proteines heterologues au moyen de cellules aviaires WO1997008307A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP96927924A EP0851917A1 (fr) 1995-08-24 1996-08-23 Systeme de production de proteines heterologues au moyen de cellules aviaires
AU67563/96A AU6756396A (en) 1995-08-24 1996-08-23 Heterologous protein production system using avian cells
JP9510142A JPH11502719A (ja) 1995-08-24 1996-08-23 鳥類細胞を用いた異種蛋白質の生産システム

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1995/26391 1995-08-24
KR1019950026391A KR970010968A (ko) 1995-08-24 1995-08-24 오리 배 세포를 이용한 에리스로포이틴의 발현 시스템

Publications (1)

Publication Number Publication Date
WO1997008307A1 true WO1997008307A1 (fr) 1997-03-06

Family

ID=19424385

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR1996/000145 WO1997008307A1 (fr) 1995-08-24 1996-08-23 Systeme de production de proteines heterologues au moyen de cellules aviaires

Country Status (5)

Country Link
EP (1) EP0851917A1 (fr)
JP (1) JPH11502719A (fr)
KR (2) KR970010968A (fr)
AU (1) AU6756396A (fr)
WO (1) WO1997008307A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999010505A2 (fr) * 1997-08-22 1999-03-04 University Of Guelph Production de proteines dans les oeufs
WO2003054172A3 (fr) * 2002-01-17 2004-02-19 Lonza Biologics Plc Cellules humaines auxotrophes pour la glutamine capables de produire des proteines et de se developper dans un milieu exempt de glutamine
US6861572B1 (en) 1997-11-14 2005-03-01 Origen Therapeutics, Inc. Production of proteins in eggs
GB2408980A (en) * 2003-12-09 2005-06-15 Nat Biolog Standards Board Genetic reference standard
EP1552298A2 (fr) * 2002-07-01 2005-07-13 The Kenneth S. Warren Institute, Inc. Cytokines protectrices des tissus recombinees et acides nucleiques codants associes pour la protection, la restauration et l'amelioration de cellules, de tissus et d'organes sensibles
EP1939281A1 (fr) 2003-11-03 2008-07-02 ProBioGen AG Lignées de cellules aviaires immortalisées pour la production de virus
WO2012095514A1 (fr) 2011-01-14 2012-07-19 Vivalis Système de production de protéines recombinantes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989003877A1 (fr) * 1987-10-21 1989-05-05 Institut National De La Recherche Agronomique (Inr Vecteurs viraux d'integration et d'expression

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989003877A1 (fr) * 1987-10-21 1989-05-05 Institut National De La Recherche Agronomique (Inr Vecteurs viraux d'integration et d'expression

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999010505A2 (fr) * 1997-08-22 1999-03-04 University Of Guelph Production de proteines dans les oeufs
WO1999010505A3 (fr) * 1997-08-22 1999-05-20 Univ Guelph Production de proteines dans les oeufs
AU750028B2 (en) * 1997-08-22 2002-07-11 Regents Of The University Of California, The Production of proteins in eggs
US6861572B1 (en) 1997-11-14 2005-03-01 Origen Therapeutics, Inc. Production of proteins in eggs
WO2003054172A3 (fr) * 2002-01-17 2004-02-19 Lonza Biologics Plc Cellules humaines auxotrophes pour la glutamine capables de produire des proteines et de se developper dans un milieu exempt de glutamine
EP1552298A2 (fr) * 2002-07-01 2005-07-13 The Kenneth S. Warren Institute, Inc. Cytokines protectrices des tissus recombinees et acides nucleiques codants associes pour la protection, la restauration et l'amelioration de cellules, de tissus et d'organes sensibles
EP1552298A4 (fr) * 2002-07-01 2006-11-08 Kenneth S Warren Inst Inc Cytokines protectrices des tissus recombinees et acides nucleiques codants associes pour la protection, la restauration et l'amelioration de cellules, de tissus et d'organes sensibles
EP1939281A1 (fr) 2003-11-03 2008-07-02 ProBioGen AG Lignées de cellules aviaires immortalisées pour la production de virus
EP2192173A1 (fr) 2003-11-03 2010-06-02 ProBioGen AG Lignées de cellules aviaires immortalisées pour la production de virus
US8940534B2 (en) 2003-11-03 2015-01-27 Probiogen Ag Immortalized avian cell lines for virus production
GB2408980A (en) * 2003-12-09 2005-06-15 Nat Biolog Standards Board Genetic reference standard
GB2408980B (en) * 2003-12-09 2006-06-07 Nat Biolog Standards Board Genetic reference materials
WO2012095514A1 (fr) 2011-01-14 2012-07-19 Vivalis Système de production de protéines recombinantes

Also Published As

Publication number Publication date
JPH11502719A (ja) 1999-03-09
AU6756396A (en) 1997-03-19
KR19990044135A (ko) 1999-06-25
KR100274225B1 (ko) 2000-12-15
EP0851917A1 (fr) 1998-07-08
KR970010968A (ko) 1997-03-27

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