WO1997004748A3 - Enveloppes virales artificielles renforcees pour l'apport de substances therapeutiques dans les cellules - Google Patents
Enveloppes virales artificielles renforcees pour l'apport de substances therapeutiques dans les cellules Download PDFInfo
- Publication number
- WO1997004748A3 WO1997004748A3 PCT/US1996/012750 US9612750W WO9704748A3 WO 1997004748 A3 WO1997004748 A3 WO 1997004748A3 US 9612750 W US9612750 W US 9612750W WO 9704748 A3 WO9704748 A3 WO 9704748A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- vesicles
- therapeutic substances
- artificial viral
- envelopes
- nucleic acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU66914/96A AU6691496A (en) | 1995-08-01 | 1996-08-01 | Enhanced artificial viral envelopes for cellular delivery of therapeutic substances |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US173895P | 1995-08-01 | 1995-08-01 | |
US60/001,738 | 1995-08-01 | ||
US258095P | 1995-08-21 | 1995-08-21 | |
US60/002,580 | 1995-08-21 | ||
US69061396A | 1996-07-31 | 1996-07-31 | |
US60/690,613 | 1996-07-31 |
Publications (4)
Publication Number | Publication Date |
---|---|
WO1997004748A2 WO1997004748A2 (fr) | 1997-02-13 |
WO1997004748A3 true WO1997004748A3 (fr) | 1997-05-29 |
WO1997004748B1 WO1997004748B1 (fr) | 1997-07-17 |
WO1997004748A9 WO1997004748A9 (fr) | 1997-10-09 |
Family
ID=27356985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/012750 WO1997004748A2 (fr) | 1995-08-01 | 1996-08-01 | Enveloppes virales artificielles renforcees pour l'apport de substances therapeutiques dans les cellules |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU6691496A (fr) |
WO (1) | WO1997004748A2 (fr) |
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US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
US8871444B2 (en) | 2004-10-08 | 2014-10-28 | Medical Research Council | In vitro evolution in microfluidic systems |
US9012390B2 (en) | 2006-08-07 | 2015-04-21 | Raindance Technologies, Inc. | Fluorocarbon emulsion stabilizing surfactants |
US9228229B2 (en) | 2010-02-12 | 2016-01-05 | Raindance Technologies, Inc. | Digital analyte analysis |
US9273308B2 (en) | 2006-05-11 | 2016-03-01 | Raindance Technologies, Inc. | Selection of compartmentalized screening method |
US9328344B2 (en) | 2006-01-11 | 2016-05-03 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
US9448172B2 (en) | 2003-03-31 | 2016-09-20 | Medical Research Council | Selection by compartmentalised screening |
US9498759B2 (en) | 2004-10-12 | 2016-11-22 | President And Fellows Of Harvard College | Compartmentalized screening by microfluidic control |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
US9562897B2 (en) | 2010-09-30 | 2017-02-07 | Raindance Technologies, Inc. | Sandwich assays in droplets |
US11965877B2 (en) | 2011-02-18 | 2024-04-23 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
Families Citing this family (38)
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CA2251543A1 (fr) | 1996-04-12 | 1997-10-23 | University Of Pittsburgh | Nouveaux derives de cholesteryle cationiques contenant des groupes polaires cycliques |
US6258792B1 (en) | 1996-04-12 | 2001-07-10 | University Of Pittsburgh | Cationic cholesteryl derivatives containing cyclic polar groups |
FR2751222B1 (fr) | 1996-07-16 | 1998-10-09 | Capsulis | Compositions contenant au moins un acide nucleique et leurs applications dans le domaine biomedical, en particulier en therapie genique |
EP1017365B1 (fr) * | 1997-06-23 | 2003-12-10 | Sequus Pharmaceuticals, Inc. | Composition contenant un polynucleotidique piege dans des liposomes et procede correspondant |
DK1019496T3 (da) | 1997-07-07 | 2005-01-10 | Medical Res Council | In vitro-sorteringsmetode |
FR2766705B1 (fr) * | 1997-07-30 | 2001-05-25 | Biovector Therapeutics | Complexe particulaire de charge globale neutre ou negative forme d'une vesicule cationique ou neutre et d'une substance biologiquement active anionique, leur preparation et leur utilisation |
FR2766706B1 (fr) * | 1997-07-30 | 2001-05-25 | Biovector Therapeutics Sa | Complexes particulaires stables de charge globale neutre ou negative de structure multilamellaire composes par au moins une substance biologiquement active globalement anionique et un constituant cationique, leur preparation et utilisation |
US6372720B1 (en) * | 1998-02-05 | 2002-04-16 | Kenneth J. Longmuir | Liposome fusion and delivery vehicle |
US6903196B1 (en) | 1999-06-17 | 2005-06-07 | Utah Ventures Ii, L.P. | Methods for identifying and isolating tissue-specific lumen-exposed molecules |
GB0015624D0 (en) * | 2000-06-26 | 2000-08-16 | Nat Cancer Centre | Materials and methods relating to improved gene delivery |
AU2002231637A1 (en) * | 2000-11-22 | 2002-06-03 | Vectron Therapeutics Ag | Production and use of a targeted diagnostic system |
WO2002042468A2 (fr) | 2000-11-27 | 2002-05-30 | Geron Corporation | Vecteurs de glycosyltransferase pour traitement du cancer |
CA2444530A1 (fr) * | 2001-04-18 | 2002-10-24 | The Open University | Polypeptides, leurs derives et leurs utilisations |
US7622446B2 (en) | 2001-04-18 | 2009-11-24 | The Open University | Polypeptides, derivatives and uses thereof |
US7491702B2 (en) | 2001-04-18 | 2009-02-17 | The Open University | Polypeptides related to amyloid precursor protein, pharmaceutical compositions thereof, and methods of treatment using the same |
US20030203865A1 (en) * | 2001-04-30 | 2003-10-30 | Pierrot Harvie | Lipid-comprising drug delivery complexes and methods for their production |
JP2005501011A (ja) * | 2001-06-08 | 2005-01-13 | ユタ ベンチャー ザ セカンド リミテッド パートナーシップ | 組織特異的内皮膜タンパク質 |
EP1568379A1 (fr) | 2002-11-01 | 2005-08-31 | Genomidea Inc | Preparation medicinale comprenant un agent chimiotherapeutique encapsule |
US10533998B2 (en) | 2008-07-18 | 2020-01-14 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
SG10201912554TA (en) | 2005-03-23 | 2020-02-27 | Genmab As | Antibodies against cd38 for treatment of multiple myeloma |
US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
PL2612868T3 (pl) | 2007-11-01 | 2018-12-31 | Astellas Pharma Inc. | Immunosupresyjne polipeptydy i kwasy nukleinowe |
WO2010009365A1 (fr) | 2008-07-18 | 2010-01-21 | Raindance Technologies, Inc. | Bibliothèque de gouttelettes |
US8528589B2 (en) | 2009-03-23 | 2013-09-10 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
EP2486409A1 (fr) | 2009-10-09 | 2012-08-15 | Universite De Strasbourg | Nanomatériau marqué à base de silice à propriétés améliorées et ses utilisations |
US10837883B2 (en) | 2009-12-23 | 2020-11-17 | Bio-Rad Laboratories, Inc. | Microfluidic systems and methods for reducing the exchange of molecules between droplets |
US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
WO2012109600A2 (fr) | 2011-02-11 | 2012-08-16 | Raindance Technologies, Inc. | Procédés de formation de gouttelettes mélangées |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
WO2013142514A1 (fr) * | 2012-03-19 | 2013-09-26 | Isis Pharmaceuticals, Inc. | Procédés et compositions destinés à la modulation de l'expression de l'alpha-1-antitrypsine |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
EP3090063B1 (fr) | 2013-12-31 | 2019-11-06 | Bio-Rad Laboratories, Inc. | Procédé de détection de rétrovirus latent |
US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
EP3793570A2 (fr) * | 2018-05-15 | 2021-03-24 | Flagship Pioneering Innovations V, Inc. | Compositions de fusosome et leurs utilisations |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0475178A1 (fr) * | 1990-08-27 | 1992-03-18 | Kabushiki Kaisha Vitamin Kenkyusyo | Liposome pour envelopper un gène, préparation liposomale et procédé de manufacture de la préparation |
EP0497997A1 (fr) * | 1991-02-02 | 1992-08-12 | Nika Health Products Limited | Vésicules membranaires synthétiques contenant des peptides de fusion fonctionellement actifs comme systèmes de délivrance d'un médicament |
EP0544292A2 (fr) * | 1991-11-27 | 1993-06-02 | Roche Diagnostics GmbH | Méthode d'introduction d'acides nucléiques dans des cellules |
WO1994018947A1 (fr) * | 1993-02-16 | 1994-09-01 | Sharifa Karali | Complexe protamine-adn de haute purete et son utilisation |
WO1996040964A2 (fr) * | 1995-06-07 | 1996-12-19 | Inex Pharmaceuticals Corporation | Particules d'acides nucleiques et de lipides preparees au moyen d'un intermediaire de complexe hydrophobe d'acides nucleiques et de lipides et utilisation pour transferer des genes |
-
1996
- 1996-08-01 AU AU66914/96A patent/AU6691496A/en not_active Abandoned
- 1996-08-01 WO PCT/US1996/012750 patent/WO1997004748A2/fr active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0475178A1 (fr) * | 1990-08-27 | 1992-03-18 | Kabushiki Kaisha Vitamin Kenkyusyo | Liposome pour envelopper un gène, préparation liposomale et procédé de manufacture de la préparation |
EP0497997A1 (fr) * | 1991-02-02 | 1992-08-12 | Nika Health Products Limited | Vésicules membranaires synthétiques contenant des peptides de fusion fonctionellement actifs comme systèmes de délivrance d'un médicament |
EP0544292A2 (fr) * | 1991-11-27 | 1993-06-02 | Roche Diagnostics GmbH | Méthode d'introduction d'acides nucléiques dans des cellules |
WO1994018947A1 (fr) * | 1993-02-16 | 1994-09-01 | Sharifa Karali | Complexe protamine-adn de haute purete et son utilisation |
WO1996040964A2 (fr) * | 1995-06-07 | 1996-12-19 | Inex Pharmaceuticals Corporation | Particules d'acides nucleiques et de lipides preparees au moyen d'un intermediaire de complexe hydrophobe d'acides nucleiques et de lipides et utilisation pour transferer des genes |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9448172B2 (en) | 2003-03-31 | 2016-09-20 | Medical Research Council | Selection by compartmentalised screening |
US8871444B2 (en) | 2004-10-08 | 2014-10-28 | Medical Research Council | In vitro evolution in microfluidic systems |
US9186643B2 (en) | 2004-10-08 | 2015-11-17 | Medical Research Council | In vitro evolution in microfluidic systems |
US9498759B2 (en) | 2004-10-12 | 2016-11-22 | President And Fellows Of Harvard College | Compartmentalized screening by microfluidic control |
US9328344B2 (en) | 2006-01-11 | 2016-05-03 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
US9534216B2 (en) | 2006-01-11 | 2017-01-03 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
US9410151B2 (en) | 2006-01-11 | 2016-08-09 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
US9273308B2 (en) | 2006-05-11 | 2016-03-01 | Raindance Technologies, Inc. | Selection of compartmentalized screening method |
US9498761B2 (en) | 2006-08-07 | 2016-11-22 | Raindance Technologies, Inc. | Fluorocarbon emulsion stabilizing surfactants |
US9012390B2 (en) | 2006-08-07 | 2015-04-21 | Raindance Technologies, Inc. | Fluorocarbon emulsion stabilizing surfactants |
US9228229B2 (en) | 2010-02-12 | 2016-01-05 | Raindance Technologies, Inc. | Digital analyte analysis |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
US9562897B2 (en) | 2010-09-30 | 2017-02-07 | Raindance Technologies, Inc. | Sandwich assays in droplets |
US11965877B2 (en) | 2011-02-18 | 2024-04-23 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
Also Published As
Publication number | Publication date |
---|---|
AU6691496A (en) | 1997-02-26 |
WO1997004748A2 (fr) | 1997-02-13 |
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