WO1996039125A1 - Composition et procede d'administration de catalyseurs bio-influants - Google Patents

Composition et procede d'administration de catalyseurs bio-influants Download PDF

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Publication number
WO1996039125A1
WO1996039125A1 PCT/US1996/009262 US9609262W WO9639125A1 WO 1996039125 A1 WO1996039125 A1 WO 1996039125A1 US 9609262 W US9609262 W US 9609262W WO 9639125 A1 WO9639125 A1 WO 9639125A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
phase
bio
catalyst
matrix
Prior art date
Application number
PCT/US1996/009262
Other languages
English (en)
Inventor
Sandeep Kumar
Kenneth J. Himmelstein
Original Assignee
University Of Nebraska Board Of Regents
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Nebraska Board Of Regents filed Critical University Of Nebraska Board Of Regents
Priority to AU62577/96A priority Critical patent/AU6257796A/en
Publication of WO1996039125A1 publication Critical patent/WO1996039125A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des compositions et des procédés d'administration d'un catalyseur bio-influant, tel qu'une enzyme. Les compositions comprennent au moins une enzyme ou un autre catalyseur bio-influant, contenus à l'intérieur de la matrice. La matrice présente une barrière entre l'enzyme piégée et des enzymes de décompositions extérieures ou des systèmes de défenses cellulaires du corps d'un patient, et empêche également la libération de l'enzyme. La matrice comprend des pores ou des voies permettant l'entrée et la sortie de substrats et de produits. La matrice est de préférence une phase cubique à haute viscosité d'un ou de plusieurs composés amphiphiles adaptés, tels que le monooléate de glycéryle. Des procédés préférés de l'invention consistent à formuler la composition sous la forme d'une phase injectable à faible viscosité, laquelle subit une transition de phase lors d'une exposition à des conditions physiologiques.
PCT/US1996/009262 1995-06-06 1996-06-06 Composition et procede d'administration de catalyseurs bio-influants WO1996039125A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU62577/96A AU6257796A (en) 1995-06-06 1996-06-06 Composition and method for administration of bio-affecting c atalysts

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65262395A 1995-06-06 1995-06-06
US08/652,623 1995-06-06

Publications (1)

Publication Number Publication Date
WO1996039125A1 true WO1996039125A1 (fr) 1996-12-12

Family

ID=24617515

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/009262 WO1996039125A1 (fr) 1995-06-06 1996-06-06 Composition et procede d'administration de catalyseurs bio-influants

Country Status (2)

Country Link
AU (1) AU6257796A (fr)
WO (1) WO1996039125A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001010411A2 (fr) * 1999-08-06 2001-02-15 Max-Delbrück-Centrum für Molekulare Medizin Depot de principe actif implantable
EP1322422A1 (fr) * 2000-07-18 2003-07-02 The Regents Of The University Of California Procede et appareil de preparation de mesophases lipidiques
US6773703B1 (en) 1999-01-29 2004-08-10 Beiersdorf Ag Protein-containing hydrogels
WO2007070561A2 (fr) * 2005-12-13 2007-06-21 Southeastern Medical Technologies Agents pour controler des fluides biologiques et leurs procedes d’utilisation
JP2008523149A (ja) * 2004-12-13 2008-07-03 サウスイースタン メディカル テクノロジーズ 体液を調節する薬剤及びその使用方法
US20090325171A1 (en) * 2008-05-13 2009-12-31 Thomas Hirt Vesicles for use in biosensors
KR101340586B1 (ko) 2011-12-12 2013-12-11 강원대학교산학협력단 광 응답성을 나타내는 큐빅상 조성물 및 그 제조방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6773703B1 (en) 1999-01-29 2004-08-10 Beiersdorf Ag Protein-containing hydrogels
WO2001010411A2 (fr) * 1999-08-06 2001-02-15 Max-Delbrück-Centrum für Molekulare Medizin Depot de principe actif implantable
WO2001010411A3 (fr) * 1999-08-06 2001-06-21 Max Delbrueck Centrum Depot de principe actif implantable
JP2003506397A (ja) * 1999-08-06 2003-02-18 マックス−デルブルック−セントルム フュア モレキュラー メディツィン 埋め込み可能な有効成分デポ剤
US7556827B1 (en) 1999-08-06 2009-07-07 Max-Delbrück-Centrum-für Molekulare Medizin Implantable active ingredient depot
US7410803B2 (en) 2000-07-18 2008-08-12 The Regents Of The University Of California Method and apparatus for preparing lipidic mesophase material
EP1322422A4 (fr) * 2000-07-18 2004-11-17 Univ California Procede et appareil de preparation de mesophases lipidiques
US7482166B2 (en) 2000-07-18 2009-01-27 The Regents Of The University Of California Method and apparatus for preparing lipidic mesophase material
EP1322422A1 (fr) * 2000-07-18 2003-07-02 The Regents Of The University Of California Procede et appareil de preparation de mesophases lipidiques
JP2008523149A (ja) * 2004-12-13 2008-07-03 サウスイースタン メディカル テクノロジーズ 体液を調節する薬剤及びその使用方法
US8535709B2 (en) 2004-12-13 2013-09-17 Southeastern Medical Technologies, Llc Agents for controlling biological fluids and methods of use thereof
WO2007070561A2 (fr) * 2005-12-13 2007-06-21 Southeastern Medical Technologies Agents pour controler des fluides biologiques et leurs procedes d’utilisation
WO2007070561A3 (fr) * 2005-12-13 2008-03-20 Southeastern Medical Technolog Agents pour controler des fluides biologiques et leurs procedes d’utilisation
US20090325171A1 (en) * 2008-05-13 2009-12-31 Thomas Hirt Vesicles for use in biosensors
KR101340586B1 (ko) 2011-12-12 2013-12-11 강원대학교산학협력단 광 응답성을 나타내는 큐빅상 조성물 및 그 제조방법

Also Published As

Publication number Publication date
AU6257796A (en) 1996-12-24

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