WO1996025859A1 - Use of l-carnitine as a feed-additive for crustaceans - Google Patents
Use of l-carnitine as a feed-additive for crustaceans Download PDFInfo
- Publication number
- WO1996025859A1 WO1996025859A1 PCT/EP1996/000742 EP9600742W WO9625859A1 WO 1996025859 A1 WO1996025859 A1 WO 1996025859A1 EP 9600742 W EP9600742 W EP 9600742W WO 9625859 A1 WO9625859 A1 WO 9625859A1
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- carnitine
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- crustaceans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
Definitions
- the present invention relates to the use of L-carnitine as a feed additive for crustaceans. 5
- L-carnitine has so far been used exclusively as a feed additive for useful animals and pets.
- L-camitine as a feed additive z. B. for dogs and cats (PCT WO 89/10 065) and that L-camitin increases the hatching rate in laying hens (EP-A 0 620 981).
- the object of the present invention was therefore to provide a feed additive with which the production of crustaceans can be increased.
- L-camitin increases both the growth rate and the survival rate of crustaceans and is therefore suitable as a feed additive for siblings.
- rust animals are crabs in the following example, crabs, Suss- and saltwater crustaceans such as shrimp (Sh ⁇ mps), crabs, lobsters and lobster beach and Wollhand- 2 "> referred
- L-carnitine is preferably used as a feed additive for shrimp (shrimp), such as those of the genus Penaeus vammamei, Penaeus esculentus and Penaeus monodon
- the feed contains L-carnitine in a concentration range from 40 to 2400 ppm, preferably from 800 to 2000 ppm. In particular, the feed contains about 1200 ppm L-carnitine
- the usual feed for crustaceans can be used as a feed base
- Animal proteins such as fish meal and plant proteins such as soybean meal can be used as proteins.
- the daily dosage of L-carnitine is expediently 10 to 1 150 ppm L-carnitine per g body weight, preferably 120 to 950 ppm L-carnitine per g body weight.
- the experiments were carried out in tanks, which were divided into 8 compartments of approximately the same size and filled with approx. 5 liters of water. Each "feeding" group comprised 24 animals. A total of 240 animals were tested.
- the best survival rate (not shown) was achieved at an L-carnitine concentration of 800 and above 2000 ppm.
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- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
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- Marine Sciences & Fisheries (AREA)
- Insects & Arthropods (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention concerns the use of L-carnitine as a feed-additive for crustaceans and feed containing L-carnitine.
Description
Verwendung von L-Carnitin als Futtermittel-Zusatz für Knistentiere Use of L-carnitine as a feed additive for knee animals
Die vorliegende Erfindung betrifft die Verwendung von L-Carnitin als Futtermittel-Zusatz für Krustentiere. 5The present invention relates to the use of L-carnitine as a feed additive for crustaceans. 5
Im Rahmen der Tierernährung wird L-Carnitin bisher ausschhesslich als Futtermittel-Zusatz für Nutz- und Haustiere verwendet. Beispielsweise ist bekannt, dass L-Camitin als Futtermittel-Zusatz z. B. für Hunde und Katzen (PCT WO 89/10 065) verwendet werden kann und dass L-Camitin die Schlüpfrate bei Legehennen erhöht (EP-A 0 620 981).In the context of animal nutrition, L-carnitine has so far been used exclusively as a feed additive for useful animals and pets. For example, it is known that L-camitine as a feed additive z. B. for dogs and cats (PCT WO 89/10 065) and that L-camitin increases the hatching rate in laying hens (EP-A 0 620 981).
1010
In Asien expandiert die Erzeugung für Futtermittel von Krustentieren wie von Garnelen, aufgrund erhöhter Nachfrage beträchtlich (New & Csavas, 1993, "Aquafeeds in Asia - a icgional overview, p 1 - 23. In: New, M B , Tacon, A G J and Csavas, I. (eds). Farm-made aquafeeds Proceedings of the FAO / AADCP Regional Expert consultation on Farm-MadeIn Asia, the production of feed for crustaceans and shrimps is expanding considerably due to increased demand (New & Csavas, 1993, "Aquafeeds in Asia - a icgional overview, p 1 - 23. In: New, MB, Tacon, AGJ and Csavas, I. (eds). Farm-made aquafeeds Proceedings of the FAO / AADCP Regional Expert consultation on Farm-Made
15 Aquafeeds)15 aquafeeds)
Die Aufgabe der vorliegenden Erfindung war daher, einen Futtermittel-Zusatz bereit zu stellen, mit welchem die Produktion von Krustentieren gesteigert werden kann. Überraschenderweise wurde nun gefunden, dass L-Camitin sowohl die Wachstumsrate als 20 auch die Uberlebensrate von Krustentieren erhöht und somit als Futtermittel-Zusatz für Knistentiere geeignet ist.The object of the present invention was therefore to provide a feed additive with which the production of crustaceans can be increased. Surprisingly, it has now been found that L-camitin increases both the growth rate and the survival rate of crustaceans and is therefore suitable as a feed additive for siblings.
Als rustentiere werden im folgenden beispielsweise Krabben, Suss- und Salzwasser-Krebse wie Garnelen (Shπmps), Taschenkrebse, Langusten Hummer sowie Strand- und Wollhand- 2"> krabben bezeichnetAs rust animals are crabs in the following example, crabs, Suss- and saltwater crustaceans such as shrimp (Shπmps), crabs, lobsters and lobster beach and Wollhand- 2 "> referred
Vorzugsweise wird L-Carnitin als Futtermittel-Zusatz für Garnelen (Shrimps) wie z B die der Gattung Penaeus vammamei, Penaeus esculentus und Penaeus monodon verwendetL-carnitine is preferably used as a feed additive for shrimp (shrimp), such as those of the genus Penaeus vammamei, Penaeus esculentus and Penaeus monodon
30 Zweckmassig enthalt das Futtermittel L-Carnitin in einem Konzentrationsbereich von 40 bis 2400 ppm, vorzugsweise von 800 bis 2000 ppm Insbesondere enthalt das Futtermittel ca 1200 ppm L-Carnitin30 Appropriately, the feed contains L-carnitine in a concentration range from 40 to 2400 ppm, preferably from 800 to 2000 ppm. In particular, the feed contains about 1200 ppm L-carnitine
Als Futtermittel-Basis können die für Krustentiere üblichen Futtermittel verwendet werdenThe usual feed for crustaceans can be used as a feed base
J Γ Übliche Futtermittel für Krustentiere enthalten Proteine, Kohlenhydrate, Fette sowie essentielle Komponenten wie Cholesteπn, Vitamine, Mineralien, essentielle und nicht- cssentielle Fettsauren, Aminosäuren etc (Akiyama & Dominy, 1990, "Penaeid shrimp
nutrition for the commercial feed industry". Texas Shrimp Farming Manual, Volume 1 : Grow-out technology, Technical Report of Texas Agricultural Extension Service and Texas A & M University).J Γ Common feed for crustaceans contains proteins, carbohydrates, fats and essential components such as cholesterol, vitamins, minerals, essential and non-essential fatty acids, amino acids etc. (Akiyama & Dominy, 1990, "Penaeid shrimp nutrition for the commercial feed industry ". Texas Shrimp Farming Manual, Volume 1: Grow-out technology, Technical Report of Texas Agricultural Extension Service and Texas A & M University).
Als Proteine können tierische Proteine wie Fischmehl und Pflanzen-Proteine wie Sojabohnenmehl verwendet werden.Animal proteins such as fish meal and plant proteins such as soybean meal can be used as proteins.
Die tägliche Dosierung an L-Carnitin beträgt zweckmassig 10 bis 1 150 ppm L-Carnitin pro g Körpergewicht, vorzugsweise 120 bis 950 ppm L-Carnitin pro g Körpergewicht.The daily dosage of L-carnitine is expediently 10 to 1 150 ppm L-carnitine per g body weight, preferably 120 to 950 ppm L-carnitine per g body weight.
Beispiel;Example;
Als Garnele wurden jugendliche Garnelen der Spezies Penaeus monodon (erhältlich von der shrimp farm in Leganes, Iloilo auf den Philippinen) mit einem Gewicht zwischen 2,1 und 15,7 g eingesetzt.Juvenile shrimp of the species Penaeus monodon (available from the shrimp farm in Leganes, Iloilo in the Philippines) with a weight between 2.1 and 15.7 g were used.
Als Futtermittel-Basis wurden zwei Formulierungen f r "starter" und "grower" -Nahrung von importiertem Futter (ALMA, Deutschland) mit hohem und niedrigem L-Carnitin-Gehalt (2178/2183 und 60/310 ppm) hergestellt. Um 6 verschiedene L-Carnitin-Konzentrationen (300, 450, 600, 800, 1200 und 2200 ppm) herzustellen, wurden die beiden zu bestimmtenTwo formulations for "starter" and "grower" food from imported feed (ALMA, Germany) with high and low L-carnitine content (2178/2183 and 60/310 ppm) were produced as the feed basis. In order to produce 6 different L-carnitine concentrations (300, 450, 600, 800, 1200 and 2200 ppm), the two were determined
Teilen gemischt und schliesslich repelletiert (2-mm Durchmesser). Die L-Camitin-Gehalte der eingesetzten Futtermittel sind in Tabelle 1 zusammengestellt. Zusätzlich wurde eine "Standard-shrimp-feed"-Formulierung von lokalem Futter (SEAFDEC/AQD, Philippinen) hergestellt, dessen Zusammensetzung in Tabelle 2 dargestellt ist.
Parts mixed and finally repelletized (2 mm diameter). The L-camitin contents of the feed used are summarized in Table 1. In addition, a "standard shrimp-feed" formulation of local feed (SEAFDEC / AQD, Philippines) was prepared, the composition of which is shown in Table 2.
Tabelle 1 : L-Carnitingehalte der eingesetzten FuttermittelTable 1: L-carnitine content of the feed used
Futtersorte (importiert): Starter GrowerType of food (imported): Starter Grower
Behandlung eff. L-Carnitin-Gehalt* eff. L-Carnitin-Gehalt*Treatment eff. L-carnitine content * eff. L-carnitine content *
Nicht supplementiert 54 320Not supplemented 54 320
+150 mg L-Carnitin 458 444+150 mg L-carnitine 458 444
+300 mg L-Camitin 603 610+300 mg L-Camitin 603 610
+500 mg L-Camitin 832 799+500 mg L-Camitin 832 799
+900 mg L-Carnitin 1190 1131+900 mg L-carnitine 1190 1131
+1900 mg L-Camitin 2360 2041 j * Gemäss Analyse des Schweizer Vitamin-Instituts, Basel+1900 mg L-Camitin 2360 2041 j * According to an analysis by the Swiss Vitamin Institute, Basel
Futtersorte (lokal):Type of food (local):
Behandlung eff. L-Carnitin-Gehalt*Treatment eff. L-carnitine content *
Nicht supplementiert 39Not supplemented 39
+210 mg L-Carnitin 254+210 mg L-carnitine 254
* Gemäss Analyse des Schweizer Vitamin-Instituts, Basel
* According to analysis by the Swiss Vitamin Institute, Basel
Tabelle 2: SEAFDEC/AQD Formulierung für lokal hergestelltes Garnelen-FutterTable 2: SEAFDEC / AQD formulation for locally produced shrimp feed
Die Experimente wurden in Tanks durchgef hrt, die in 8 Kompartimenten mit annähernd gleicher Grosse aufgeteilt waren und mit ca. 5 1 Wasser gefüllt waren. Jede "feeding"-Gruppe umfasste 24 Tiere. Insgesamt wurden 240 Tiere getestet.The experiments were carried out in tanks, which were divided into 8 compartments of approximately the same size and filled with approx. 5 liters of water. Each "feeding" group comprised 24 animals. A total of 240 animals were tested.
Der Einfluss von L-Carnitin auf die Wachstumsrate bzw. auf das relative Körpergewicht von Penaeus monodon ist in Fig. 1 dargestellt. Dargestellt sind die Mittelwerte plus Standard¬ abweichung. Wie aus Fig. la und lb ersichtlich wurde die beste Wachstumsrate bei einer L- Carnitin-Konzentration von 1200 ppm erreicht.The influence of L-carnitine on the growth rate or on the relative body weight of Penaeus monodon is shown in FIG. 1. The mean values plus standard deviation are shown. As can be seen from FIGS. 1 a and 1 b, the best growth rate was achieved at an L-carnitine concentration of 1200 ppm.
Die beste Überlebensrate (nicht dargestellt) wurde bei einer L-Carnitin-Konzentration von 800 und über 2000 ppm erreicht.
The best survival rate (not shown) was achieved at an L-carnitine concentration of 800 and above 2000 ppm.
Claims
1. Verwendung von L-Camitin zur Herstellung eines Futtermittels für Krustentiere.1. Use of L-Camitin for the production of a feed for crustaceans.
2. Verwendung von L-Camitin nach Anspruch 1 , worin das Futtermittel 40 bis 2400 ppm L-Camitin enthält.2. Use of L-camitine according to claim 1, wherein the feed contains 40 to 2400 ppm L-camitine.
3. Verwendung von L-Camitin nach Anspmch 1 oder 2, worin das Futtermittel 800 bis 2000 ppm L-Camitin enthält. 3. Use of L-camitin according to claim 1 or 2, in which the feed contains 800 to 2000 ppm of L-camitine.
GEÄNDERTE ANSPRÜCHECHANGED REQUIREMENTS
[beim Internationalen Büro am 10-Juni 1996 (10.06.96) eingegangen; ursprüngliche Anprüche 1-3 durch neue Ansprüche[Received at the International Bureau on June 10, 1996 (June 10, 1996); original claims 1-3 through new claims
1 und 2 ersetzt (1 Seite)]1 and 2 replaced (1 page)]
Verwendung von L-Carnitin zur Herstellung eines Futtermittels für Krustentiere, worin das Futtermittel 40 bis 2400 ppm L-Carnitin enthält.Use of L-carnitine for the manufacture of a feed for crustaceans, wherein the feed contains 40 to 2400 ppm of L-carnitine.
Verwendung von L-Carnitin nach Anspruch 1, worin das Futter- mittel 800 bis 2000 ppm L-Carnitin enthält.Use of L-carnitine according to claim 1, wherein the feed contains 800 to 2000 ppm L-carnitine.
GEÄNDERTES BLAU (ARTIKEL 19) CHANGED BLUE (ARTICLE 19)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU49408/96A AU4940896A (en) | 1995-02-24 | 1996-02-22 | Use of l-carnitine as a feed-additive for crustaceans |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH537/95-8 | 1995-02-24 | ||
| CH1316/95-8 | 1995-05-08 | ||
| CH131695 | 1995-05-08 |
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| Publication Number | Publication Date |
|---|---|
| WO1996025859A1 true WO1996025859A1 (en) | 1996-08-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP1996/000742 WO1996025859A1 (en) | 1995-02-24 | 1996-02-22 | Use of l-carnitine as a feed-additive for crustaceans |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997020474A1 (en) * | 1995-12-07 | 1997-06-12 | Lonza Ag | Method of increasing the reproduction rate of fish |
| WO2000056294A2 (en) * | 1999-03-23 | 2000-09-28 | Lonza Ag | Carnitine supplemented diet to prevent sudden death syndrome in broiler breeder type poultry |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56121441A (en) * | 1980-02-27 | 1981-09-24 | Shimahisa Yakuhin Kk | Feed additive for culturing fish or shell |
| WO1991005554A1 (en) * | 1989-10-23 | 1991-05-02 | University Of Georgia Research Foundation, Inc. | Carnitine supplemented cat fish diet |
-
1996
- 1996-02-22 WO PCT/EP1996/000742 patent/WO1996025859A1/en active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56121441A (en) * | 1980-02-27 | 1981-09-24 | Shimahisa Yakuhin Kk | Feed additive for culturing fish or shell |
| WO1991005554A1 (en) * | 1989-10-23 | 1991-05-02 | University Of Georgia Research Foundation, Inc. | Carnitine supplemented cat fish diet |
Non-Patent Citations (2)
| Title |
|---|
| DATABASE WPI Week 8145, Derwent World Patents Index; AN 81-82356 * |
| PATENT ABSTRACTS OF JAPAN vol. 5, no. 200 (C - 084) 18 December 1981 (1981-12-18) * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997020474A1 (en) * | 1995-12-07 | 1997-06-12 | Lonza Ag | Method of increasing the reproduction rate of fish |
| WO2000056294A2 (en) * | 1999-03-23 | 2000-09-28 | Lonza Ag | Carnitine supplemented diet to prevent sudden death syndrome in broiler breeder type poultry |
| WO2000056294A3 (en) * | 1999-03-23 | 2001-08-23 | Lonza Ag | Carnitine supplemented diet to prevent sudden death syndrome in broiler breeder type poultry |
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