Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
  • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
  • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
  • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
  • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
  • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
  • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles

Definitions

• the invention relates to new 4-(sulfur containing substituent) derivatives of 1- arylpyrazoles, and derivatives thereof.
• the invention further pertains to compositions of said compounds and methods, using said compounds, for the control of arthropod, nematode, helminth or protozoan pests, in particular, to the application of said compounds or compositions in agricultural methods of use, particularly as pesticides, especially for controlling arthropods, most especially insects by systemic action.
• a second object of the present invention is to provide pesticidal compositions and pesticidal methods of use of the pesticidal pyrazole compounds against arthropods, especially insects, plant nematodes, or helminth or protozoan pests, particularly in agricultural or horticultural crops, forestry, veterinary medicine or livestock husbandry, or in public health.
• a third object of the present invention is to provide compounds with improved systemicity, that is, having improved systemic activity. A high systemicity enables the compounds to work well, even under dry conditions.
• a fourth object of the present invention is to provide compounds with improved mammalian safety, that is to say, with less toxicity.
• This invention provides improved insecticidal pyrazoles having the formula:
• each of R2 and R ⁇ which are identical or different, is hydrogen, halogen, CN, alkyl, haloalkyl or alkylthio;
• R4 is lower alkyl; n is 0, 1 or 2; each of Rl and R ⁇ , which are identical or different, is H, lower alkyl, lower alkyl- S(O) n , formyl, alkenyl, alkynyl, alkoxycarbonyl, alkylthiocarbonyl, aroyl or alkylcarbonyl, the alkyl portion of which radicals is optionally substituted by one or more R ⁇ ; or R!
• R ⁇ are joined so as together to form a divalent radical having 4 to 6 atoms in the chain, this divalent radical being alkylene, alkyleneoxyalkylene or alkyleneaminoalkylene;
• R5 is cyano, nitro, alkoxy, haloalkoxy, R ⁇ S(O) n , alkoxycarbonyl, alkylcarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, hydroxycarbonyl, halogen, hydroxy, aminosulfonyl, alkylaminosulfonyl or dialkylaminosulfonyl; and R ⁇ is lower alkyl or lower haloalkyl.
• hydroxycarbonyl means a carboxyl radical, that is, -COOH.
• aminonosulfonyl means a sulfamoyl radical, that is, -SO2NH2.
• alkylaminosulfonyl means an alkylsulfamoyl radical, that is, a radical of the formula -SO2NH-alkyl; while the term “dialkylaminosulfonyl” means a dialkylsulfamoyl radical, which has the formula -SO2N(alkyl)2 wherein the alkyl moieties can be the same or different.
• halo before the name of a radical means that this radical is partially or completely halogenated, that is to say, substituted by F, Cl, Br or I, in any combination, preferably by F or Cl.
• halogen means F, Cl, Br or I.
• aryl is an aromatic radical, preferably phenyl, optionally substituted with one or more substituents such as halogen, methyl and methoxy; most preferably, the aroyl radical is a benzoyl, methylbenzoyl, halobenzoyl or xylylcarbonyl radical.
• the various individual aliphatic hydrocarbon moieties that is, radicals and portions thereof having a non-cyclic, non-aromatic hydrocarbon skeleton (such as, for example, alkenyl. alkynyl, the alkyl portions of alkoxycarbonyl and alkylthiocarbonyl, etc.) generally have up to 7 carbon atoms.
• Use of the term "lower” before the name of such an aliphatic hydrocarbon moiety means that the moiety has up to 4 carbon atoms; for example, "lower alkyl” means C1-C4 alkyl.
• the various aliphatic hydrocarbon moieties are preferably lower radicals. When the name of a substituent is repeated, it retains the same meaning unless otherwise specified.
• Particularly preferred compounds of formula (I) above are those wherein R ⁇ is methyl, ethyl or propyl, and/or wherein R 1 is hydrogen and R ⁇ is hydrogen or alkyl, and/or wherein each of R ⁇ and R ⁇ , which are identical or different, is H, Cl, Br or F.
• a preferred class of compound of formula (I) are those wherein:
• R ! and R3 each represent hydrogen; R- and R ⁇ each represent chlorine; R represents methyl or ethyl; and n is zero, 1 or 2.
• the compounds of formula (I) can be prepared according to the manufacturing processes described in International Patent Publications Nos. WO 94/21606 and WO 93/06089 or International Patent Publication No. WO 87/03781 as well as in European Patent Publication No. 02951 17 and Hatton et al U.S. Patent No. 5,232,940. Those skilled in the art will choose the proper initial reactant in these known methods and adapt these known methods to the said reactant so as to obtain the corresponding desired products.
• the first method of preparation proceeds according to the following scheme:
• R ⁇ , R4 and R ⁇ are as defined above.
• Transformation of (II) to (HI) can be achieved by reducing the disulfide (II) with an appropriate reducing agent such as sodium borohydride, to the intermediate sulfide or thiolate, followed by reacting the intermediate with an appropriate alkylating agent, such as an alkyl halide or a dialkyl sulfate, in a suitable solvent such as alcohol, water or ether or a mixture thereof.
• an appropriate alkylating agent such as an alkyl halide or a dialkyl sulfate
• a suitable solvent such as alcohol, water or ether or a mixture thereof.
• the reaction can be carried out at a temperature of from about -20°C to about 150°C, preferably at room temperature.
• the transformation of the compounds of formula (IV) to the compounds of formula (HI) can be achieved by the direct alkylation of the appropriate alkylsulfenyl halides (also known as alkylthio halides), such as methylsulfenyl chloride or ethylsulfenyl chloride.
• alkylsulfenyl halides also known as alkylthio halides
• the alkylsulfenyl halides can be prepared in a separate pot or they can be generated in situ in the reaction medium for the alkylation of the analogs of the formula (IV).
• the solvent to be used can be protic or aprotic or a mixture of both.
• aprotic solvents for use in the above process include: amides, such as dimethylformamide (DMF); ethers, such as methyl t-butyl ether, ethyl ether, tetrahydrofuran and dimethoxyethane; haloalkanes, such as methylene chloride; and aromatic solvents such as toluene and chlorobenzene.
• protic solvents for use herein are: alcohols, such as methanol and ethanol; amines; and water.
• the reaction can be conducted in the presence of a catalyst such as a basic catalyst, for example, a metal carbonate, a metal hydride, such as sodium hydride, or a metal hydroxide, such as sodium hydroxide.
• a catalyst such as a basic catalyst, for example, a metal carbonate, a metal hydride, such as sodium hydride, or a metal hydroxide, such as sodium hydroxide.
• the reaction can be carried out at a temperature of from about -20°C to about 150°C, preferably at a temperature of from about 0°C to about 1CXTC.
• the first method includes direct alkylation of precursor compounds of formula (III) or (III') with alkylating agents.
• the second method involves a two-step sequence, with formation of the imino ethers, followed by a reduction.
• the third method of preparation is through a conjugate addition, e.g., a Michael-type addition.
• R ⁇ is/are lower alkyl-S(O) n , formyl, alkenyl, alkynyl, alkoxycarbonyl, alkylthiocarbonyl, aroyl or alkylcarbonyl can be prepared by methods described in one or more of International Publications No. WO 94/21606, WO 93/06089 and WO 87/03781, European Patent Publication No. 0295117 and Hatton et al U.S. Patent No. 5,232,940.
• the present invention provides a method for controlling pests at a locus comprising applying to said locus a pesticidally effective amount of a compound of formula (I).
• the compound of formula (I) can be conveniently used in the form of a composition comprising said compound and an agriculturally acceptable inert carrier therefor.
• the pests whose control is desired are arthropods, and an arthropodicidally effective amount of said compounds is applied to the locus.
• the arthropods whose control is desired are insects, and to that end the invention provides a method for controlling insects at a locus comprising applying to said locus an insecticidally effective amount of a compound of formula (I), or an insecticidally effective amount of an insecticidal composition comprising an insecticidally effective amount of a compound of formula (I) and an agriculturally acceptable inert carrier therefor.
• control of nematodes is desired, and to that end the invention provides a method of controlling nematodes at a locus comprising applying to said locus a nematocidally effective amount of a compound of formula (I), or a nematocidally effective amount of a nematocidal composition comprising a nematocidally effective amount of a compound of formula (I) and an agriculturally acceptable inert carrier therefor.
• the locus to which the pesticidally, particularly arthropodicidally (especially insecticidally) or nematocidally, effective amount is applied is a crop or a crop-growing area, that is, an area in which a crop is growing or in which a crop has been planted, or an area in which a crop will be planted/grown, particularly where a pesticidal attack is expected or has started.
• compositions which can be used in the invention for the pesticidal, particularly the arthropodicidal (especially insecticidal) or nematocidal, treatment of the invention can comprise from about 0.001 to about 95% of the active ingredient of formula (I).
• active ingredient of formula (I) or “active ingredient” as used herein refers to a compound of formula (I) as defined hereinabove unless otherwise specified.
• the diluted liquid formulations as applied to the crop or to the locus where insects are expected to be, generally comprise from about 0.001 to about 3% of active ingredient of formula (I), preferably from about 0.1 to about 0.5%.
• the solid formulations as applied to the locus or crop generally comprise from about
• active ingredient of formula (I) preferably from about 0.5 to about 1.5%.
• the concentrated compositions are the compositions which are commercialized or transported or stored. For application to plants, they are normally diluted in water and applied in such diluted form.
• the diluted forms are part of the invention as well as the concentrated forms.
• the concentrated formulations generally comprise from about 5 to about 95% of active ingredient of formula (I), preferably from about 10 to about 50%.
• insecticidal compositions of the invention can be applied once, or more than once, or throughout the whole insect season.
• Insecticidal compositions according to the invention are usually applied to the crop area (or the locus at which a pesticidal attack is expected or started) at a rate of from about 0.04 to about 1 kg/ha of active ingredient, preferably from about 0.1 to about 0.5 kg/ha.
• the concentrated insecticidal compositions according to the invention can be in the form of a solid, e.g., dusts or granules or wettable powders, or, preferably, in the form of a liquid, such as an emulsifiable concentrate or a true solution.
• compositions according to the instant invention generally comprise from about 0.5 to about 95% of active ingredient.
• the remainder of the composition up to 100% comprises a carrier as well as various additives such as those hereafter indicated.
• carrier there is meant herein an organic or inorganic material, which may be natural or artificial or synthetic, and which is associated with the active ingredient and which facilitates its application to the crop or other locus to be treated. This carrier is thus generally inert and should be agriculturally acceptable, especially on the contemplated or treated locus or crop.
• the carrier can be solid (clay, silicates, silica, resins, wax, fertilizers, etc.) or liquid (water, alcohols, ketones, oil solvents, saturated or unsaturated hydrocarbons, chlorinated hydrocarbons, liquefied gas, etc.).
• compositions of the invention can comprise surfactants as well as other ingredients such as dispersants, stickers, antifoam agents, antifreezing agents, dyestuffs, thickeners, adhesives, protecting colloids, penetrating agents, stabilizing agents, sequestering agents, antiflocculating agents, corrosion inhibitors, pigments and polymers. More generally, the compositions of the invention can comprise all kind of solid or liquid additives which are known in the art of insecticides and insecticidal treatments.
• the surfactants can be of the emulsifying or wetting type, ionic or non-ionic.
• Possible surfactants are salts of poly aery lie or lignosulfonic acids; salts of phenolsulfonic or naphthalenesulfonic acids; polycondensates of ethylene oxide with fatty alcohols or fatty acids or fatty amines or substituted phenols (particularly alkylphenols or arylphenols); ester-salts of sulfosuccinic acids; taurine derivatives such as alkyl taurates; phosphoric esters; or esters of alcohols or polyoxyethylated phenols.
• the spraying vehicle is water
• the use of at least one surfactant is generally required because the active ingredients are not water-soluble.
• the method of application of the compositions of the invention is generally the spraying of a mixture which has been previously made by dilution of more concentrated formulations according to the invention.
• Solid compositions can be powders for dusting or for dispersion (wherein the content of active ingredient can be up to 100%) and granules, especially extruded or compacted granules, or granules which have been made by impregnation of a powder (the content of active ingredients in such powders then being between about 1 and about 80%).
• Liquid compositions or compositions which have to be liquid when applied include solutions, water-soluble concentrates, emulsifiable concentrates, emulsions, wettable powders or pastes, or water-dispersible granules.
• Emulsifiable concentrates generally comprise from about 10 to about 80% of active ingredient; the emulsions when applied generally comprise from about 0.01 to about 20% of active ingredient.
• the emulsifiable concentrates can comprise the solvent and further, to the extent needed, from about 2 to about 20% of suitable additives such as stabilizers, surfactants, penetrating agents, corrosion inhibitors or other additives already recited.
• suitable additives such as stabilizers, surfactants, penetrating agents, corrosion inhibitors or other additives already recited.
• the concentrated suspensions can also be applied by spraying and have to be fluid without allowing any solid to separate and fall to the bottom.
• they comprise from about 1 to about 75% of active ingredient (preferably from about 2 to about 50%), from about 0.5 to about 15% of surfactant, from about 0.1 to about 10% of thickener, and from 0 to about 10% of other suitable additives as already indicated, the remainder being water or an organic liquid in which the active ingredient is insoluble or has a low solubility.
• the wettable powders generally comprise the active ingredient (from about 1 to about
• the solid carrier preferably from about 2 to about 80%
• a wetting agent from 0 to about 5%
• a dispersing agent from about 3 to about 10%
• other additives such as stabilizers and other as already listed.
• Dispersible granules are generally made by agglomeration of a powder followed by an appropriate granulation process.
• the emulsions herein described can be of oil-in-water or water-in-oil types. They can be more or less thick, even approaching the viscosity of a gel.
• compositions or formulations one skilled in the art can choose the most appropriate one according the specific conditions of the treatment problem that exists.
• the compounds and compositions of the invention can also be used in admixtures with another pesticide, e.g., an insecticide, acaricide or herbicide.
• another pesticide e.g., an insecticide, acaricide or herbicide.
• the invention is illustrated by the following examples which are not considered as limiting the invention but are given to better enable use of it.
• Test compound was applied to the soil surface as solutions that delivered the equivalent of 20, 5 and 1.25 ppm soil concentration by weight. Aphid counts were obtained at 5 DAT (days after treatment). The number of aphids on the treated plants was compared to the number of those on the untreated control plants. An LC50 value was calculated for each compound. The following results were obtained: LC50 RESULTS (ppm) SPECIES
• Soil is treated with the test compound to obtain a soil concentration of 10.0 ppm. Juveniles collected and separated from infected tomato roots are introduced to the treated soil. The treated and nematode-infested soil are either planted with tomato seedlings or cotton seeds (both susceptible to nematode attack). After the appropriate interval for plant growth and root- knot formation, the plants are removed from the soil and the roots examined for root-knot formation. Untreated, uninoculated plants has roots free of knots as do plants where the test compounds elicit high activity.
• Aphid-infested cotton plants and snapbean plants were placed on a revolving turntable and sprayed to runoff with a 100 ppm formulation of the test compound.
• the counts of live and dead larvae were made at 5 DAT.
• the treated APHIGO infested plants were held for three days after treatment, after which the dead aphids were counted.

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• Chemical & Material Sciences (AREA)
• Organic Chemistry (AREA)
• Life Sciences & Earth Sciences (AREA)
• Agronomy & Crop Science (AREA)
• Pest Control & Pesticides (AREA)
• Plant Pathology (AREA)
• Health & Medical Sciences (AREA)
• Engineering & Computer Science (AREA)
• Dentistry (AREA)
• General Health & Medical Sciences (AREA)
• Wood Science & Technology (AREA)
• Zoology (AREA)
• Environmental Sciences (AREA)
• Agricultural Chemicals And Associated Chemicals (AREA)
• Plural Heterocyclic Compounds (AREA)

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Cited By (7)

Citations (2)

• 1996
  • 1996-02-08 CN CN96191987A patent/CN1066717C/zh not_active Expired - Fee Related
  • 1996-02-08 EP EP96904023A patent/EP0809633A1/en not_active Withdrawn
  • 1996-02-08 AU AU47887/96A patent/AU704664B2/en not_active Ceased
  • 1996-02-08 JP JP8524636A patent/JPH11500428A/ja not_active Withdrawn
  • 1996-02-08 BR BR9607395A patent/BR9607395A/pt not_active Application Discontinuation
  • 1996-02-08 WO PCT/EP1996/000527 patent/WO1996025401A1/en not_active Application Discontinuation
  • 1996-02-14 TW TW085101835A patent/TW333526B/zh active
  • 1996-02-16 AR ARP960101412A patent/AR002032A1/es not_active Application Discontinuation

Patent Citations (2)

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