WO1996023070A3 - HUMAN RETINOID X RECEPTOR - GAMMA (hRXR-GAMMA) - Google Patents

HUMAN RETINOID X RECEPTOR - GAMMA (hRXR-GAMMA) Download PDF

Info

Publication number
WO1996023070A3
WO1996023070A3 PCT/US1996/000847 US9600847W WO9623070A3 WO 1996023070 A3 WO1996023070 A3 WO 1996023070A3 US 9600847 W US9600847 W US 9600847W WO 9623070 A3 WO9623070 A3 WO 9623070A3
Authority
WO
WIPO (PCT)
Prior art keywords
hrxrη
polypeptides
retinoid
receptor
gamma
Prior art date
Application number
PCT/US1996/000847
Other languages
French (fr)
Other versions
WO1996023070A2 (en
Inventor
William W Lamph
Original Assignee
Ligand Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ligand Pharm Inc filed Critical Ligand Pharm Inc
Priority to EP96903616A priority Critical patent/EP0812354A2/en
Priority to AU47637/96A priority patent/AU4763796A/en
Publication of WO1996023070A2 publication Critical patent/WO1996023070A2/en
Publication of WO1996023070A3 publication Critical patent/WO1996023070A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors

Abstract

The present invention relates to a novel retinoid receptor, human retinoid X receptor η. hRXRη modulates transcription of certain genes in the presence of certain retinoid compounds. hRXRη differs from known retinoid receptors in nucleotide sequence, amino acid sequence, and expression pattern in tissues. The invention provides isolated, purified, or enriched nucleic acid encoding hRXRη polypeptides and vectors containing thereof, cells transformed with such vectors, and methods of screening for compounds capable of binding hRXRη polypeptides. The invention also provides isolated, purified, enriched, or recombinant hRXRη polypeptides, antibodies having specific binding affinity to hRXRη polypeptides, and hybridomas producing such antibodies.
PCT/US1996/000847 1995-01-23 1996-01-19 HUMAN RETINOID X RECEPTOR - GAMMA (hRXR-GAMMA) WO1996023070A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP96903616A EP0812354A2 (en) 1995-01-23 1996-01-19 HUMAN RETINOID X RECEPTOR - GAMMA (hRXR-GAMMA)
AU47637/96A AU4763796A (en) 1995-01-23 1996-01-19 Human retinoid x receptor - gamma (hrxr-gamma)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37742395A 1995-01-23 1995-01-23
US08/377,423 1995-01-23

Publications (2)

Publication Number Publication Date
WO1996023070A2 WO1996023070A2 (en) 1996-08-01
WO1996023070A3 true WO1996023070A3 (en) 1996-09-26

Family

ID=23489051

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/000847 WO1996023070A2 (en) 1995-01-23 1996-01-19 HUMAN RETINOID X RECEPTOR - GAMMA (hRXR-GAMMA)

Country Status (4)

Country Link
EP (1) EP0812354A2 (en)
AU (1) AU4763796A (en)
CA (1) CA2211142A1 (en)
WO (1) WO1996023070A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9907461D0 (en) * 1999-03-31 1999-05-26 King S College London Neurite regeneration
CA2399399A1 (en) * 2000-03-30 2001-10-11 Oxford Biomedica (Uk) Limited Retinoic acid receptor beta-2, its antagonists, and gene therapy vectors for the treatment of neurological disorders
WO2005101008A1 (en) * 2004-04-15 2005-10-27 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with retinoid x receptor gamma (rxrg)
CN110592095A (en) * 2019-09-26 2019-12-20 浙江海洋大学 Clone and expression of sepiella maindroni tretinoin X receptor gene

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991012258A1 (en) * 1990-02-09 1991-08-22 The Salk Institute For Biological Studies Retinoid receptor compositions and methods
WO1993011755A1 (en) * 1991-12-18 1993-06-24 The Salk Institute For Biological Studies Means for the modulation of processes mediated by retinoid receptors and compounds useful therefor
WO1993015216A1 (en) * 1992-01-24 1993-08-05 Institut National De La Sante Et De La Recherche Medicale Novel heterodimeric nuclear receptors proteins, genes encoding same, and usage thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991012258A1 (en) * 1990-02-09 1991-08-22 The Salk Institute For Biological Studies Retinoid receptor compositions and methods
WO1993011755A1 (en) * 1991-12-18 1993-06-24 The Salk Institute For Biological Studies Means for the modulation of processes mediated by retinoid receptors and compounds useful therefor
WO1993015216A1 (en) * 1992-01-24 1993-08-05 Institut National De La Sante Et De La Recherche Medicale Novel heterodimeric nuclear receptors proteins, genes encoding same, and usage thereof

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ALLEGRETTO, E.A., ET AL.: "Transactivation properties of retinoic acid and retinoic X receptors in mammalian cells and yeast", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, 15 December 1993 (1993-12-15), pages 26625 - 26633, XP002007755 *
ALMASAN A ET AL: "Chromosomal localization of the human retinoid X receptors.", GENOMICS 20 (3). 1994. 397-403., XP000574901 *
COOKE, T.A., ET AL.: "Human retinoid X receptor-gamma mRNA, complete cds.", EMBL SEQUENCE DATABASE.RELEASE 45. 10-NOV-1995. ACESSION NO. U38480, XP002007757 *
DOWHAN D H ET AL: "Identification of deoxyribonucleic acid sequences that bind retinoid-X receptor-gamma with high affinity.", ENDOCRINOLOGY 135 (6). 1994. 2595-2607., XP000575863 *
KANE K F ET AL: "1,25-dihydroxyvitamin D-3 and retinoid X receptor expression in human colorectal neoplasms.", GUT 36 (2). 1995. 255-258., XP000574906 *
KUMARENDRAN, M. KUMAR ET AL: "Estrogen and progesterone do not regulate the expression of retinoic acid receptors and retinoid "X" receptors in human endometrial stromal cells in vitro", HUM. REPROD. (1994), 9(2), 229-34, XP000574898 *
ROCHETTE-EGLY C ET AL: "Detection of retinoid X receptors using specific monoclonal and polyclonal antibodies.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 204 (2). 1994. 525-536., XP002007756 *
TITCOMB M W ET AL: "Sensitive and specific detection of retinoid receptor subtype proteins in cultured cell and tumor extracts.", MOLECULAR ENDOCRINOLOGY 8 (7). 1994. 870-877., XP000574900 *

Also Published As

Publication number Publication date
WO1996023070A2 (en) 1996-08-01
CA2211142A1 (en) 1996-08-01
EP0812354A2 (en) 1997-12-17
AU4763796A (en) 1996-08-14

Similar Documents

Publication Publication Date Title
HU9600692D0 (en) Human metabotropic glutamate receptor subtypes (hmr4, hmr6, hmr7) and related dna compounds
WO1988009818A3 (en) Growth hormone receptor
AU642403B2 (en) Method for the use and synthesis of peptides
EP1746162A3 (en) Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
WO1995009872B1 (en) Dna encoding prostaglandin receptor ip
WO1999015666A3 (en) Macrophage derived chemokine (mdc), mdc analogs, mdc inhibitor sustances, and uses thereof
CA2220447A1 (en) Novel fusion protein recovery and purification methods
IL141869A0 (en) Mammalian transforming growth factor beta-9 (ztgfss9)
MX9705172A (en) Il-2r-associated polypeptide and dna molecules coding therefor.
WO1996023884A3 (en) Human peroxisome proliferator activated receptors
CA2088068A1 (en) Protein structure of the plant toxin gelonin
WO1996023070A3 (en) HUMAN RETINOID X RECEPTOR - GAMMA (hRXR-GAMMA)
WO1998032858A3 (en) Mammalian chemokines; receptors; reagents; uses
AU7450096A (en) Cloning of vertebrate pheromone receptors and uses thereof
DE69328060D1 (en) Angiotensin-II type 1 receptor and its production
WO1995000552B1 (en) Prostaglandin receptor ep3 and dna encoding it
PL324518A1 (en) Polypeptide showing affinity to enamel matrix
WO1998031810A3 (en) Mammalian chemokines; receptors; reagents; uses
WO1998027200A3 (en) Human and mammalian dna replication origin consensus sequences
CA2194032A1 (en) Fused dna sequence, fused protein expressed from said fused dna sequence and method for expressing said fused protein
WO1999063094A3 (en) Nucleotide and protein sequences of gpr1 and methods based thereon
WO1997008317A3 (en) Human hypothalmic ('hr') receptor polypeptide compositions, methods and uses thereof
EP0723014A3 (en) cDNA of DOCK180 gene and DOCK180 protein
WO1999019480A3 (en) Human receptor proteins; related reagents and methods
Ohno Of words, genes and music

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG UZ VN AZ BY KG KZ RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN

AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG UZ VN AZ BY KG KZ RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2211142

Country of ref document: CA

Ref country code: CA

Ref document number: 2211142

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1996903616

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1996903616

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1996903616

Country of ref document: EP