WO1996019187A1

WO1996019187A1 - Agent for stimulating hair growth

Info

Publication number: WO1996019187A1
Application number: PCT/RU1994/000287
Authority: WO
Inventors: Andrei Valentinovich Vasiliev
Original assignee: Tovarischestvo S Ogranichennoi Otvetstvennostju 'firma Plus'
Priority date: 1994-12-22
Filing date: 1994-12-22
Publication date: 1996-06-27

Abstract

The invention relates to medicine and cosmetics and can be used in the treatment of baldness (alopecia) and for strengthening hair and stimulating hair growth. The invention in essence is an agent for stimulating hair growth based on a mixture of carboxylic acids of general formula (I) shown in which R is C2H5, C3H7, C4H9, and X is Me+, Me++.

Description

SΡΕDSΤΒΟ FOR SΤΤΜULATION ΡΟСΤΑ ΒΟЛΟС.

The area of technology.

The invention is available in medicine and in medicine, may be used to treat baldness (alopecia), to strengthen hair loss and stimulate the treatment of gastric pain.

The prior art.

It is known for stimulating the growth of the aquatic environment. The closest to the essence, is a medium minoxidil, used outside, stimulating the increase in the occurrence of ankylosing spondylitis. (Α.Ε. ΒiΗΙ, 5.L. SοηgasΙ, ϋ.Χ ^{"νUaΙsΙοη,} Μ.Ν. Βgiηάeη Ροϊaδδϊiηα SΗaηηeΙ SοηάisΙaηse aδ and SοηΙgοΙ ΜesΗaηϊδt ϊη Ηa-ΡοShsΙeδ g, ΤΗe .Ιοigηaϊ οG ΙηνeδΙ-§aΙ-νe ΟegtaΙο1ο§u , ν.101, Ν1, 1993, ρ. 1485-1525). (ΒиΗΙ Α.Ε., ^ аϊёοη S.Α., .ΙοΗηδθη S.Α. Μϊηοχ-сϋϊ δиΙГиΙе ϊδее аϊϊϊϊе гаеδеδе ϊΗаΙ δϊϊгаиΗеϊеδеδеδеδеδеδеδеδеϊΗеδеδ -ΤοштιаΙ οГ ΙηνеδΙϊ§аΙϊνе Οеггааϊοϊθёу, ν.95, ρ.553-557, 1990).

This product improves microcirculation, stimulates the transfer of the cells of the active cell. The product is oxidized, which is used externally in the form of gels, ointments, lotion, or solution, which shows the greatest effect of small incidence,

For disadvantages of use, minoxid should follow the duration of treatment. The effect is observed no earlier than 4 months after the start of treatment. After a change of the drug, after 3-4 months the effect of treatment may disappear. Otherwise, the drug has significant indications: lactation, pregnancy, heart treatment, the use of hypotensive drugs. (The reference is “Drugs abroad for foreign companies in Russia, 1993, Moscow,“ Health insurance ”p. 388-389). „.

A drug is known for the treatment of baldness. This product is manufactured in a wide range of industrialized areas. (Α.СϋΗаг, Α.Εϊг-ош, С. С.Κгигегег. Ηаϊг СгοννϊΗ ϊη Ηигаη 5ρϋΙ- ΤΗϊскηеδδ 5кϊη Sgayδ Τгаηδρϊаηϊесϊ οηϊοеΝе 5 5ϊϊϊ 1990 1990 1990 1990 1990 1990 1990 1990 1990 1990 1990 1990 1990 1990 1990 1990 1990 1990 1990 1990 1990 1990 -121). Κ The dysklosporin accelerates the growth of Volos. However, this product also has a wide list of indications. This is due to the fact that the cyclosphere exhibits a pronounced immune-mediated effect and is a strong immune modulator. ϊο Izvesτny πρeπaρaτy for κοzhi gοlοvy, πρednaznachennye for treating nachinayuschegοsya οblyseniya, κοτορye sοsτοyaτ from ethyl οdnοgο or nesκοlκiχ οκisliτeley, οdnοy or nesκοlκiχ ορganichesκiχ dvuχ or mnοgοοsnοvnyχ κislοτ, οdnοgο or nesκοlκiχ ποveρχnοsτnο-aκτivnyχ veschesτv and πρedποchτiτelnο vοdnοgο 15 naποlniτelya with ρΗ = 3-3.5. DRUGS MAY ALSO CONTAIN FRAGRANCES, COMPANIES, ETC. (See application form of the station - Chz2477871, cl. Α61 Κ7 / 06, οπ.1981)

The main disadvantage of using these products is a poorly expressed form factor in case of an excess of more than 20 years, and also is more rapid.

A commercial composition for accelerating the growth of vol- ume containing glycopyrotein is known.

The main component of this product in the form of 25 lotions for fluids is available as a basic substance, although there is a lot of mixes available for free. С It may also be possible to have added a good acid to enhance microcirculation and / or heparin or hepatic sulphate. zo (See application ΡCΤ-Che λΥΟ 90/09 778, cl. Α61Κ7 / 06, οπ.1990)

The main disadvantage of this system is: weakly expressed form factor and high cost of the drug.

The closest to the proposed invention is the means to prevent the loss of hair and stimulate them

35, manufactured in the form of a shampoo, containing fat

Acids derived from natural vegetable oil and containing 80% of linoleic acid, its salt and / or linoleic acid.

(See application ΦΡГ-Че3430166Α 1, cl. Α61Κ7 / 06, published in 1985)

The main disadvantage of the above described equipment is the lack of an expressed form factor for a long time, in particular 3-4 months.

DISCLOSURE OF INVENTION.

The main objective of the invention is to build a device to stimulate the growth of the hair, which is characterized by a high incidence of the disease, and the fact that the The task posed is resolved by means for stimulating the growth of the environment on the main body of acid, which provides a mixture of acid and saline:

Ο

II ΚСΟΧ, where

I-C ₂ Η ₅ , C ₃ Η ₇ , C4Η9, X - Μе ⁺ , Μе ⁺⁺ . Suschnοsτ izοbρeτeniya zaκlyuchaeτsya in τοm, chτο πρedlagaemaya mixture sοley schelοchnyχ and schelοchnοzemelnyχ meτallοv προπiοnοvοy, valeρianοvοy, maslyanοy κislοτy (buτiρaτοv, προπiοnaτοv, valeρianaτοv) πρi applied to ποveρχnοsτ κοzhi in mazevοy ρasτvορimοy οsnοve or lοsοne aκτiviziρueτ φibροblasτy sοsοchκοvοgο slοya deρmy and τaκzhe κaπillyaρnuyu ρeaκtsiyu and πρivοdiτ activation of the distribution and differential of a cell of a follicle. According to literature data, previously, alkali metal butytes were used in biomedical research as a useful medical agent.

According to the data of the histological analysis of the biological products of animals and people, it was established that after application of animals to the skin for 27 sessions after 15 days . .

aκτivatsiya ποliφeρatsii φibροblasτοv sοsοchκοvοgο slοya deρmy, aκτivnaya κaπilyaρnaya ρeaκtsiya, cheρez 20 suτοκ προisχοdila aκτivatsiya κleτοκ vοlοsyanοgο φοlliκula, uτοlschenie shishκοvaτοgο slοya, aκτivny sinτez κeρaτοgealina and nablyudalοsya vyρazhenny ροsτ vοlοs.

The proposed medicament for stimulating the growth of the environment was used on animals in the laboratory and on patients. The possible implementation of the invention is illustrated by the following specific examples.

BEST MODE FOR CARRYING OUT THE INVENTION.

EXAMPLE 1. (Production of Buta Butylate) - gel.

Β butyric acid (water) when stirring and cooling adds an equivalent amount of water

ΝaΟΗ. Further, the unit is evaporated in a vacuum, the unit is removed from ethanol. The dedicated plant is dried.

The required quantity of butyric acid is dissolved in distilled water and introduced by stirring in a 1% solution of sugar. Гель The resulting gel adds additives, fragrances.

Example 2. (Production of Valeria) - a lotus. Hazardous acid (water) When mixed and cooled, it adds an equivalent amount of water to the product. Further, the device is evaporated in a vacuum, the installation is uninstalled.

Example 3. (Production of Ca προπinata) - ointment. In addition to a mixture of acid (30%), when added, it adds a half of the CaC1 environmentally friendly solution ₂ . The mixture obtained is heated and added equal to the quantity of ethyl alcohol. The filtering plant is filtered and dried in a vacuum. Essential quantities of material are introduced into the ointment base, with active mixing. When mixed, add preservative and scent. Example 4. (Use of the butyrate on live). Butropium is apertured and sold in experiments on laboratory live animals. Ыρysys males, weight 1 10-150 gρamm. In blue, with scissors, we won a Baltic outburst at an area of 4 cm. On top of the skin, the preparation was applied in 0.5 grams of ointment base and rubbed the ointment into the skin. The procedure was carried out daily for 18 days. Κ For 6 days, on an otherwise well-known group of live animals, active growing waves were observed. Κ 8-12 days ago, the Easter cake was restored and became convenient to the skin. The live group, on top of that, they applied the ointment base without the preparation, but the end of the period of the invasion of the United Kingdom was not a part of the Great Territory.

Gisτοmορφοlοgichesκοe study biοπaτοv κοzhi zhivοτnyχ ποκazalο, chτο ποd influence buτiρaτa naτρiya προisχοdila aκτivatsiya φibροblasτοv sοsοchκοvοgο slοya dρemy, κaπillyaρnaya ρeaκtsiya, aκτiviροvalas προliφeρatsiya κleτοκ vοlοsyanοgο φοlliκula. Also, there was an increase in the incidence of hair, i.e. Quantities per unit area of the skin. Example 5. (buta) on the person.

Patient 33 years old, male, πρ. health On the left and the right hand side were excluded from the area of 5x 10 cm. Buttery in the concentration of 4 m in lotion were paid twice a day. After 6 days, the country experienced an increase in the growth rate of growth, and for 10-12 days, the European Union was affected by the influence of the United States. But on a regular basis (a lotus without bombing), the restoration of a fluffy flu in this environment is not an accident. Example 6.

The patient is 24 years old, the diagnosis is alopecia areata. Two overexposed sections of the head inflicted an ointment base containing 6 m of bombardment. Business was done twice a day. One deprived part of the head treated the ointment base without a preparation. The effect of the drug was seen at 6 _ -

days. The effective growth of the environment was observed only at the sites of the skin processed by the drug.

Information on the use of alkali and alkaline earth metals and metals is given in the table.

Intended use.

The use of a dispensing device to stimulate the growth of the environment of the world ensures the following benefits: - a pronounced illness during the course of time

(20-30 days);

- Stable disease after the end of the course of treatment;

- the manufacture of the preparation;

- the possibility of its long-term storage without the addition of an adjuvant;

- low cost of the preparation and ease of manufacture of ointment and floss on its base.

Claims

„- -

Description of the invention.

Medium for stimulating the growth of the environment of the Russian Federation, mainly based on carboxylic acids, which is different from the fact that it contains a mixture of carboxylic acids:

Ο

ΚСΟΧ, where Κ. - С ₂ Η ₅₎ С ₃ Η ₇ , С ₄ Η ₉ . Χ - Μе ⁺ , Μе ⁺⁺ .