WO1996012791A1 - Human abh - Google Patents
Human abh Download PDFInfo
- Publication number
- WO1996012791A1 WO1996012791A1 PCT/US1994/012058 US9412058W WO9612791A1 WO 1996012791 A1 WO1996012791 A1 WO 1996012791A1 US 9412058 W US9412058 W US 9412058W WO 9612791 A1 WO9612791 A1 WO 9612791A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polypeptide
- habh
- polynucleotide
- dna
- sequence
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Definitions
- the tagA gene has been mapped to an E. Coli chromosome and controls a constitutive enzyme 3-methyladenine-DNA glycosylase I that releases 3-methyladenine from alkylated DNA (Karran, P. et al. , Nature (London), 296:770-773 (1982)).
- the alkA gene has also been mapped and it too controls an inducible enzyme, 3-methyladenine-DNA glycosylase II, which catalyzes the liberation of 3-methyladenine, 3-methylguanine, and 7-methylguanine from the DNA (Evensen, G. and Seeberg, E., Nature (London), 296:773-775 (1982).
- a novel mature polypeptide which is hABH, as well as fragments, analogs and derivatives thereof.
- the polypeptide of the present invention is of human origin.
- polynucleotides DNA or RNA which encode such polypeptides.
- the polynucleotide which encodes for the mature polypeptide of Figure 1 or for the mature polypeptide encoded by the deposited cDNA may include: only the coding sequence for the mature polypeptide; the coding sequence for the mature polypeptide and additional coding sequence such as a leader or secretory sequence or a proprotein sequence; the coding sequence for the mature polypeptide (and optionally additional coding sequence) and non-coding sequence, such as intron ⁇ or non-coding sequence 5' and/or 3' of the coding sequence for the mature polypeptide.
- the present invention includes polynucleotides encoding the same mature polypeptide as shown in Figure 1 or the same mature polypeptide encoded by the cDNA of the deposited clone as well as variants of such polynucleotides which variants encode for a fragment, derivative or analog of the polypeptide of Figure 1 or the polypeptide encoded by the cDNA of the deposited clone.
- Such nucleotide variants include deletion variants, substitution variants and addition or insertion variants.
- the present invention also provides a diagnostic assay for detecting mutated hABH genes, which is indicative of a susceptibility to mutation of DNA by various agents, such as chemical mutation.
- a diagnostic assay for detecting mutated hABH genes, which is indicative of a susceptibility to mutation of DNA by various agents, such as chemical mutation.
- an assay is the RT- PCR method.
- RT-PCR Reverse Transcriptase Polymerase Chain Reaction
- the RNA encoding hABH is isolated from the total cellular RNA removed from a cell sample.
- the coding region of the RT-PCR products are then sequenced and compared to the hABH gene to detect mutations.
- oligonucleotide probes may be prepared which are highly specific for the mRNA to be detected.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8513858A JPH10507634A (ja) | 1994-10-21 | 1994-10-21 | ヒトabh |
EP95901018A EP0788540A4 (de) | 1994-10-21 | 1994-10-21 | Meschliches abh |
PCT/US1994/012058 WO1996012791A1 (en) | 1994-10-21 | 1994-10-21 | Human abh |
AU10411/95A AU1041195A (en) | 1994-10-21 | 1994-10-21 | Human abh |
US09/023,327 US5929225A (en) | 1994-10-21 | 1998-02-13 | Human ABH |
US09/296,623 US6573360B1 (en) | 1994-10-21 | 1999-04-23 | Human ABH |
US10/322,780 US20030153738A1 (en) | 1994-10-21 | 2002-12-19 | Human ABH |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1994/012058 WO1996012791A1 (en) | 1994-10-21 | 1994-10-21 | Human abh |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/463,975 Continuation-In-Part US5618717A (en) | 1994-10-21 | 1995-06-05 | DNA encoding human AlkB |
US09/023,327 Continuation-In-Part US5929225A (en) | 1994-10-21 | 1998-02-13 | Human ABH |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996012791A1 true WO1996012791A1 (en) | 1996-05-02 |
Family
ID=22243169
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1994/012058 WO1996012791A1 (en) | 1994-10-21 | 1994-10-21 | Human abh |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0788540A4 (de) |
JP (1) | JPH10507634A (de) |
AU (1) | AU1041195A (de) |
WO (1) | WO1996012791A1 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004019959A2 (en) * | 2002-08-30 | 2004-03-11 | Imperial Cancer Research Technology | Dna repair enzymes |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007000002A (ja) * | 2003-07-16 | 2007-01-11 | Genecare Research Institute Co Ltd | アルキル化薬感受性を上昇させる方法 |
-
1994
- 1994-10-21 WO PCT/US1994/012058 patent/WO1996012791A1/en not_active Application Discontinuation
- 1994-10-21 AU AU10411/95A patent/AU1041195A/en not_active Abandoned
- 1994-10-21 JP JP8513858A patent/JPH10507634A/ja not_active Ceased
- 1994-10-21 EP EP95901018A patent/EP0788540A4/de not_active Withdrawn
Non-Patent Citations (6)
Title |
---|
ANNUAL REVIEW OF BIOCHEMISTRY, Volume 57, issued 1988, T. LINDAHL et al., "Regulation and Expression of the Adaptive Response to Alkylating Agents", pages 133-157. * |
JOURNAL OF BACTERIOLOGY, Volume 176, No. 20, issued October 1994, B.J. CHEN et al., "The Escherichia Coli alkB Protein Protects Human Cells Against Alkylation-Induced Toxicity", pages 6255-6261. * |
JOURNAL OF BIOLOGICAL CHEMISTRY, Volume 261, No. 33, issued 25 November 1986, H. KONDO et al., "Structure and Expression of the alkB Gene of Eschericha Coli Related to the Repair of Alkylated DNA", pages 15772-15777. * |
MOLECULAR AND GENERAL GENETICS, Volume 198, issued 1985, H. KATAOKA et al., "Molecular Cloning and Characterization of the alkB Gene of Escherichia Coli", pages 263-269. * |
PROC. NATL. ACAD. SCI. U.S.A., Volume 86, issued October 1989, J. CHEN et al., "Cloning a Eukaryotic DNA Glycosylase Repair Gene by the Suppression of a DNA Repair Defect in Escherichia Coli", pages 7961-7965. * |
See also references of EP0788540A4 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004019959A2 (en) * | 2002-08-30 | 2004-03-11 | Imperial Cancer Research Technology | Dna repair enzymes |
WO2004019959A3 (en) * | 2002-08-30 | 2005-01-06 | Imp Cancer Res Technology | Dna repair enzymes |
Also Published As
Publication number | Publication date |
---|---|
AU1041195A (en) | 1996-05-15 |
EP0788540A1 (de) | 1997-08-13 |
EP0788540A4 (de) | 2000-01-12 |
JPH10507634A (ja) | 1998-07-28 |
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