WO1996009547A3 - Verfahren zur untersuchung der wechselwirkung von biomolekülen mittels oberflächen-plasmon-resonanz - Google Patents

Verfahren zur untersuchung der wechselwirkung von biomolekülen mittels oberflächen-plasmon-resonanz Download PDF

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Publication number
WO1996009547A3
WO1996009547A3 PCT/EP1995/003731 EP9503731W WO9609547A3 WO 1996009547 A3 WO1996009547 A3 WO 1996009547A3 EP 9503731 W EP9503731 W EP 9503731W WO 9609547 A3 WO9609547 A3 WO 9609547A3
Authority
WO
WIPO (PCT)
Prior art keywords
biomolecules
investigating
interaction
plasmon resonance
surface plasmon
Prior art date
Application number
PCT/EP1995/003731
Other languages
English (en)
French (fr)
Other versions
WO1996009547A2 (de
Inventor
Peter Steinlein
Wolfgang Zauner
Bianca Habermann
Original Assignee
Boehringer Ingelheim Int
Peter Steinlein
Wolfgang Zauner
Bianca Habermann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int, Peter Steinlein, Wolfgang Zauner, Bianca Habermann filed Critical Boehringer Ingelheim Int
Priority to EP95933414A priority Critical patent/EP0784792A2/de
Priority to JP8510606A priority patent/JPH10505910A/ja
Priority to BR9509077A priority patent/BR9509077A/pt
Priority to AU36089/95A priority patent/AU3608995A/en
Priority to PL95319354A priority patent/PL319354A1/xx
Publication of WO1996009547A2 publication Critical patent/WO1996009547A2/de
Publication of WO1996009547A3 publication Critical patent/WO1996009547A3/de
Priority to KR1019970701787A priority patent/KR970706494A/ko

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Verfahren und regenerierbare Biosensoreinheit sowie geeignete Kits zur Untersuchung der Wechselwirkung von Biomolekülen mittels Oberflächen-Plasmon-Resonanz (SPR), wobei einer der Reaktionspartner, ein (Poly)Peptid, mittels Metallchelat an die Oberfläche der Biosensoreinheit gekoppelt ist. Bevorzugt als Chelatbildner sind Nitrilotriessigsäure-Derivate, mit denen Proteine mit einem Histidin-Reste enthaltenden Affinitätspeptid gebunden werden können.
PCT/EP1995/003731 1994-09-23 1995-09-21 Verfahren zur untersuchung der wechselwirkung von biomolekülen mittels oberflächen-plasmon-resonanz WO1996009547A2 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP95933414A EP0784792A2 (de) 1994-09-23 1995-09-21 Verfahren zur untersuchung der wechselwirkung von biomolekülen mittels oberflächen-plasmon-resonanz
JP8510606A JPH10505910A (ja) 1994-09-23 1995-09-21 表面プラズモン共鳴を使用する生物分子の相互作用の研究方法
BR9509077A BR9509077A (pt) 1994-09-23 1995-09-21 Processo para análise da interação de biomoléculas pro meio de ressonância superficial com plasmon
AU36089/95A AU3608995A (en) 1994-09-23 1995-09-21 Process of investigating the interaction between biomolecules by means of surface plasmon resonance
PL95319354A PL319354A1 (en) 1994-09-23 1995-09-21 Method examining biological particles for their mutual interactions using surface-type plasma resonance
KR1019970701787A KR970706494A (ko) 1994-09-23 1996-09-21 표면 플라즈몬 공명을 사용하여 생체분자의 상호작용을 조사하는 방법(Process of investigating the interaction between biomolecules by means of surface plasmon resonance)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4433980A DE4433980C2 (de) 1994-09-23 1994-09-23 Verfahren und Biosensorhit zur Untersuchung der Wechselwirkung von Biomolekülen mittels Oberflächen-Plasma-Resonanz
DEP4433980.1 1994-09-23

Publications (2)

Publication Number Publication Date
WO1996009547A2 WO1996009547A2 (de) 1996-03-28
WO1996009547A3 true WO1996009547A3 (de) 1996-05-30

Family

ID=6528988

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1995/003731 WO1996009547A2 (de) 1994-09-23 1995-09-21 Verfahren zur untersuchung der wechselwirkung von biomolekülen mittels oberflächen-plasmon-resonanz

Country Status (12)

Country Link
EP (1) EP0784792A2 (de)
JP (1) JPH10505910A (de)
KR (1) KR970706494A (de)
CN (1) CN1158658A (de)
AU (1) AU3608995A (de)
BR (1) BR9509077A (de)
CA (1) CA2198615A1 (de)
CO (1) CO4410395A1 (de)
DE (1) DE4433980C2 (de)
PL (1) PL319354A1 (de)
WO (1) WO1996009547A2 (de)
ZA (1) ZA958024B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6107080A (en) * 1996-04-25 2000-08-22 Mcgill University Biosensor device and method
US6165335A (en) 1996-04-25 2000-12-26 Pence And Mcgill University Biosensor device and method
US6130037A (en) * 1996-04-25 2000-10-10 Pence And Mcgill University Biosensor device and method
US5955379A (en) * 1996-04-25 1999-09-21 Mcgill University Biosensor device and method
CA2286761A1 (en) * 1997-04-24 1998-10-29 Borris Y. Cheskis Method for the identification and characterization of nuclear receptor ligands
WO2000014545A1 (en) * 1998-09-03 2000-03-16 Trellis Bioinformatics, Inc. Multihued labels
AUPP856399A0 (en) * 1999-02-08 1999-03-04 Australian Membrane And Biotechnology Research Institute Improved compounds for protein binding
WO2000052456A1 (en) 1999-03-02 2000-09-08 Helix Biopharma Corporation Biosensor device and method
US7804592B2 (en) 2003-10-16 2010-09-28 Nard Institute, Ltd. Method for measuring a surface plasmon resonance and noble metal compound used for the same
WO2005038442A1 (ja) * 2003-10-16 2005-04-28 Kabushiki Kaisha Nard Kenkyusho 表面プラズモン共鳴の測定方法および該方法に使用される貴金属化合物
CN101261226B (zh) * 2007-03-08 2010-12-08 北京宏荣博曼生物科技有限责任公司 一种基于聚乙二醇的表面等离子共振仪芯片
JP2010197046A (ja) * 2007-05-28 2010-09-09 Tanaka Holdings Kk バイオセンサー
EP2015071A1 (de) 2007-07-13 2009-01-14 FUJIFILM Corporation Träger, Herstellungsverfahren dafür, Bioreaktor und Chip für die Oberflächenplasmon-Resonanzanalyse
KR100953558B1 (ko) 2007-12-12 2010-04-21 한국전자통신연구원 표면 플라즈몬 공명을 이용한 ｐｓ-ｓｐｃｌ 탐색 장치 및방법
CN114797804B (zh) * 2022-03-29 2023-08-04 翌圣生物科技(上海)股份有限公司 一种具有长连接臂的nta色谱介质及其制备方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4569794A (en) * 1984-12-05 1986-02-11 Eli Lilly And Company Process for purifying proteins and compounds useful in such process
EP0253303A2 (de) * 1986-07-10 1988-01-20 F. Hoffmann-La Roche Ag Neue Metallchelatharze
EP0282042A2 (de) * 1987-03-10 1988-09-14 F. Hoffmann-La Roche Ag Neue Fusionsproteine und deren Reinigung
EP0339389A1 (de) * 1988-04-25 1989-11-02 F. Hoffmann-La Roche Ag Diagnose-Hilfsmittel
WO1990005303A1 (en) * 1988-11-10 1990-05-17 Pharmacia Ab Sensing surfaces capable of selective biomolecular interactions, to be used in biosensor systems
WO1990012803A1 (en) * 1989-04-14 1990-11-01 Biogen, Inc. Process for purifying a protein
EP0485874A2 (de) * 1990-11-14 1992-05-20 F. Hoffmann-La Roche Ag Immunsensorischer Wandler und Verfahren zu seiner Herstellung

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85137A (en) * 1987-01-21 1992-02-16 Ares Serono Res & Dev Ltd Method of assaying for a ligand using surface plasmon resonance effect

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4569794A (en) * 1984-12-05 1986-02-11 Eli Lilly And Company Process for purifying proteins and compounds useful in such process
EP0184355A2 (de) * 1984-12-05 1986-06-11 Eli Lilly And Company Verfahren zur Reinigung von Proteinen
EP0253303A2 (de) * 1986-07-10 1988-01-20 F. Hoffmann-La Roche Ag Neue Metallchelatharze
EP0282042A2 (de) * 1987-03-10 1988-09-14 F. Hoffmann-La Roche Ag Neue Fusionsproteine und deren Reinigung
EP0339389A1 (de) * 1988-04-25 1989-11-02 F. Hoffmann-La Roche Ag Diagnose-Hilfsmittel
WO1990005303A1 (en) * 1988-11-10 1990-05-17 Pharmacia Ab Sensing surfaces capable of selective biomolecular interactions, to be used in biosensor systems
WO1990012803A1 (en) * 1989-04-14 1990-11-01 Biogen, Inc. Process for purifying a protein
EP0485874A2 (de) * 1990-11-14 1992-05-20 F. Hoffmann-La Roche Ag Immunsensorischer Wandler und Verfahren zu seiner Herstellung

Also Published As

Publication number Publication date
AU3608995A (en) 1996-04-09
CO4410395A1 (es) 1997-01-09
PL319354A1 (en) 1997-08-04
CA2198615A1 (en) 1996-03-28
EP0784792A2 (de) 1997-07-23
JPH10505910A (ja) 1998-06-09
KR970706494A (ko) 1997-11-03
WO1996009547A2 (de) 1996-03-28
CN1158658A (zh) 1997-09-03
BR9509077A (pt) 1997-11-25
ZA958024B (en) 1996-03-25
DE4433980A1 (de) 1996-03-28
DE4433980C2 (de) 1996-08-22

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