WO1995031137A1 - Dispositif pour la distribution d'un agent adhesif a plusieurs composants pour tissus - Google Patents

Dispositif pour la distribution d'un agent adhesif a plusieurs composants pour tissus Download PDF

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Publication number
WO1995031137A1
WO1995031137A1 PCT/EP1995/001770 EP9501770W WO9531137A1 WO 1995031137 A1 WO1995031137 A1 WO 1995031137A1 EP 9501770 W EP9501770 W EP 9501770W WO 9531137 A1 WO9531137 A1 WO 9531137A1
Authority
WO
WIPO (PCT)
Prior art keywords
storage containers
holding
head piece
coupling element
holder
Prior art date
Application number
PCT/EP1995/001770
Other languages
German (de)
English (en)
Inventor
Freddy Zinger
Original Assignee
Omrix Biopharmaceuticals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omrix Biopharmaceuticals S.A. filed Critical Omrix Biopharmaceuticals S.A.
Publication of WO1995031137A1 publication Critical patent/WO1995031137A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A61B2017/00495—Surgical glue applicators for two-component glue

Definitions

  • the invention relates to a dispensing device for dispensing fluids, in particular a multicomponent tissue adhesive, with a plurality of essentially cylindrical storage containers for one fluid each, in particular for at least one component of the tissue adhesive, each storage container having a front end with an opening for dispensing the fluid, in particular the at least one component and a rear end opposite this end and a sliding piston with a piston rod protruding from the rear end for actuating the piston, and a holding device for holding the storage containers Arrangement of the same side by side with longitudinal axes running essentially parallel to one another and in a common plane, the holding device having projecting projections facing away from one another for gripping with the fingers of one hand.
  • a dispensing device for dispensing fluids, in particular a multicomponent tissue adhesive
  • a plurality of essentially cylindrical storage containers for one fluid each, in particular for at least one component of the tissue adhesive each storage container having a front end with an opening for dispensing the fluid, in particular the at least one component and a
  • the invention relates to a holder for holding a plurality of storage containers for fluid, in particular for at least one component in each case, in particular a tissue adhesive, with a holding device for holding the storage containers when they are arranged side by side with longitudinal axes running essentially parallel to one another and in a common plane, wherein the holding device has mutually facing, protruding projections for reaching under with the fingers of one hand.
  • Dispensing devices and holders of the aforementioned types are known in the technical field for dispensing multicomponent adhesives and in the medical field for dispensing multicomponent tissue adhesives. Examples of such dispensing devices and holders can be found in US Pat. No. 4,874,368, US Pat. No. 4,978,336 and EP 0 037 393 B1. All known dispensing devices or holders have in common that the holder device for holding the adhesive Components containing storage containers have under-gripping projections which extend in the plane which is spanned by the longitudinal axes of the storage containers held next to one another, which are generally syringe bodies with pistons and piston rods.
  • Each syringe body must be inserted into the two receiving openings assigned to it, the flanges of the syringe body being screwed into mutually facing, facing C-shaped clamping receptacles of the holding element.
  • the syringe bodies In addition to an axial movement, the syringe bodies must also be rotated in the state inserted into the holding element until they are held securely against axial displacements by the holding element. On the one hand, this complicates the handling and, on the other hand, the construction of the holding element.
  • the clamping receptacles of the known mounting device for the flanges of the syringe bodies protrude from the common (arrangement) plane of the syringe bodies arranged side by side.
  • a connecting web extends, which in the area of its connections to the plates has their width and is otherwise narrower.
  • the upper plate on the common sides of the double syringes cannot be reached under with the fingers of one hand; as with the other double syringe arrangements above, this only works if the upper plate is undermined at its projections which face away from one another and are arranged in an extension of the axis extending through the syringes arranged next to one another (see column 3, lines 58 to 61 of the US) -PS 5 104 375).
  • the invention has for its object an output device and / or a holder for substantially to create cylindrical storage containers for holding multicomponent fluids, in particular tissue adhesives, which allow simple handling, in particular also when dispensing the fluid components.
  • the under-gripping projections extend out of the ends spanned by the essentially cylindrical storage containers or their longitudinal axes, or in other words, extend at right angles to this plane.
  • the distance between the index and middle fingers under the projections when holding the dispensing device and dispensing adhesive is considerably reduced compared to the known devices and holders, which is noticeable for people with small hands in particular facilitated.
  • the holding device of the dispensing device and / or holder also fulfills the task of being able to hold the entire application device by hand, by the index and middle fingers of one hand holding the projections of the holding device reach under.
  • the (underneath) projections expediently only extend in the area between adjacent storage areas. Relationships or neighboring bracket recordings of the bracket device.
  • the introduction of the storage containers is extremely simple, since they only have to be pressed (and laterally) into the holder receptacles and / or locked into place. An axial displacement and / or rotation of the storage containers into a holding end position for locking on the holding device is not necessary.
  • the holding device is designed in the manner of a holding clip, which has elastically designed receptacles for inserting and removing the storage containers.
  • These receptacles are expediently of C-shaped design, each C-shaped receptacle (also referred to below as a clamp) extending over more than 180 ° and enclosing the associated storage container in a clamping manner.
  • the storage containers can be pressed into these open mounting receptacles conveniently and simply in order to then be held in a clamping manner due to the elasticity of the receptacles.
  • the openings of the receptacles can point to sides facing away from one another or to a common side of the holding device or are directed at any other angle.
  • the gripping projections are arranged between the openings of the mounting receptacles without impairing their accessibility.
  • the holder can be moved on the storage containers. So that the movement of the bracket device towards the rear end of the storage containers, from each of which a piston rod protrudes, is limited, cooperating stops are provided on the mounting device and the rear ends of the storage containers. In the case of the storage containers, these are the mutually repelling flanges of the syringe bodies with which they are usually equipped. The holding device rests on these flanges, which precludes any further relative movement towards the ends of the piston rods.
  • a common connecting head piece with in particular separate channels for the fluid components dispensed from the storage containers is expediently attached to the front ends of the storage containers.
  • the channels, the inlets of which are spaced apart from one another in accordance with the spacings of the front ends arranged next to one another, end at their outlets in close proximity to one another.
  • a multi-lumen catheter is arranged at the end of the connecting head piece which has the outlets of the channels. Examples of such connecting head pieces with and without a multi-lumen catheter are described in DE-OS 42 23 356, EP 0 037 393 A and EP 0 315 222 B.
  • the mounting device is mechanically connected in particular detachably to the connecting head piece by means of a coupling element such that unintentional removal of the connecting head piece from the mounting device can be prevented or, in other words, the Connection head piece is secured against unintentional loosening on the holding device.
  • a coupling element such that unintentional removal of the connecting head piece from the mounting device can be prevented or, in other words, the Connection head piece is secured against unintentional loosening on the holding device.
  • the coupling element preferably extends in the space between two adjacent storage containers, and essentially in parallel, to their axial extents.
  • the arrangement of the connecting head piece and the holding device connected via the coupling element is equipped with the storage containers in such a way that the front ends are first inserted into the connections of the connecting head piece and the storage containers are then pressed laterally into the receptacles of the holding element of the holding device .
  • the storage containers can also be attached to the holding device first, in order to then connect the front ends of the storage containers to the connections of the connection head piece by axial displacement in the direction of the connecting head piece.
  • the type of connecting head pieces mostly used have, in addition to the channels for the components of the tissue adhesive, also a channel for a medical gas (oxygen).
  • This gas channel also has a gas connection and a gas outlet at the discharge end of the connecting header.
  • the coupling element is expediently connected to the connection head piece at the gas connection. It is also advantageous here if the coupling element has a gas channel, the outlet end of which is arranged at the end of the coupling element which is coupled to the gas connection of the connecting head piece and which furthermore has a gas inlet, in particular which is led out laterally from the coupling element.
  • a gas delivery hose is expediently passed through this gas channel of the coupling element; alternatively, it can also be provided that the gas delivery hose is connected to the gas inlet of the coupling element.
  • a cannula or a catheter can expediently be connected detachably to the connection head piece of the dispensing device.
  • care must be taken that the lumens at the output end of the connection head are aligned with the component channels or the gas channel.
  • the output end of the connector head is provided with a rotatable luer lock connector which has a rotatable locking sleeve which is connected to the connector head.
  • the rotatable locking sleeve is provided with an internal thread which can be brought into threaded engagement with a shoulder piece, on which in turn the catheter or the cannula is held.
  • the shoulder piece By screwing the shoulder piece to the Luer lock connection, the shoulder piece is pushed axially onto the conical output end of the connecting head piece.
  • the Luer lock connection thus ensures, on the one hand, that the catheter or cannula is securely held on the connection head piece and on the other hand, the locking sleeve enables the catheter or cannula to be detached from the connecting head piece even if the shoulder piece is clamped or glued to the connecting head piece.
  • connection head piece and the shoulder piece of the multi-lumen catheter or the multi-lumen cannula can be provided with complementary guide projections / recesses in order to axially guide the shoulder piece relative to the discharge end of the connection head piece when the locking sleeve of the Luer lock connection possible.
  • This axial guidance has the advantage that the arrangement of the lumens of the catheter or of the cannula is aligned with the outlets of the channels of the connecting head piece.
  • a spray head or a spray device can also be connected to the connecting head piece, by means of which the components can be mixed and sprayed.
  • the components can be atomized in a purely mechanical manner (by appropriate configuration of the outlet openings) or using the medical gas.
  • FIG. 1 shows a side view of the dispensing device with a hand indicated by dash-dotted lines in the gripping position for holding and actuating the dispensing device
  • Fig. 2 is a view of the dispenser in the direction II of FIG. 1 without hand and
  • FIG. 3 shows a view of the holding device in the direction III of FIG. 2, the storage containers being indicated by dash-dotted lines.
  • FIG. 1 shows a side view of a dispensing device 10 for multi-component tissue adhesive.
  • the dispensing device 10 has two storage containers in the form of commercially available syringes 12 for solutions of proteins and blood coagulation-promoting coagulation factors of a two-component tissue adhesive.
  • Each syringe 12 is provided with a hollow cylindrical syringe body 14 which has a front end 16 with a dispensing opening 18 and nozzle 20 and an open rear end 22.
  • a plunger 24 Arranged in each syringe body 14 is a plunger 24 which lies sealingly on the inner surface of the syringe body 14 and is held by a plunger rod 20 which is guided out of the syringe body 14 through the rear end 22.
  • the piston rods 26 each extend in the longitudinal extent of the syringe bodies 14 (see the longitudinal axes 28 of the syringe bodies 14 indicated in the figures).
  • the free ends 30 of the piston rod 26 facing away from the piston 24 are provided with ring flanges 32.
  • These ring flanges 32 are mechanically connected to one another via a connecting element 34.
  • the connecting element 34 is provided with two receiving recesses 36 which are open at the side and into which the ring flanges 32 can be inserted.
  • connection head 38 is plugged onto ends 16 of the syringe body 14.
  • the connection header 38 is provided with integrated separate through-channels (not shown), which are appropriately spaced at their inlet ends facing the syringe bodies 14 and the connecting pieces 20 of the syringe bodies 14 and immediately adjoin one another at the outlet ends facing away from the syringe bodies 14.
  • the connection head 38 has a further channel to which a hose 40 carrying a medical gas (for example 0 2 ) is connected. This channel also ends in close proximity to the other two channels.
  • the connection head 38 is provided with a three-lumen catheter 42, the lumens of which are aligned with the three channels of the connection head 38.
  • the two syringe bodies 14 are connected to one another by means of a clip holding device 44 (hereinafter referred to as holding element).
  • the holding element 44 is provided with two C-shaped holding clamps 46, the openings 48 of which face away from one another and which in their central sections
  • Openings 48 point in the direction of the extension of the
  • protrusions 54 are connected to the clamps 46. These protrusions 54 extend in opposite directions, being rotated by 90 ° to the two clamps 46 or their openings 48.
  • the two projections 54 thus each protrude at right angles from the plane 52 in which the longitudinal axes 28 of the syringe bodies 14 lie in the state held by the holding element 44 or in the longitudinal axis of the clamps 46 coinciding with the longitudinal axes 28 of the syringe bodies 14.
  • the projections 54 thus run in the opposite direction along the axis of symmetry 55 of the double clamp menan angel (Fig. 3).
  • the syringe bodies 14 are slidably mounted on the holding element 44, because the spring-elastic holding clamps 46 extend over more than 180 ° and preferably up to 200 ° around the syringe body, with which they enclose them with a clamping force that a relative Shift allowed.
  • the holding element 44 bears against the laterally projecting flanges 56 at the rear ends 22 of the syringe body 14, so that there is a stop between the holding element 44 and the syringe body 14.
  • the axial extent of the holding element 44 and in particular the holding clamps 46 is dimensioned such that the scale arranged on the outside of the syringe bodies 14 remains free and is not covered by the holding element 44.
  • the entire device 10 including the connection head 38 is made of plastic.
  • the hand position during handling for holding and actuating the device 10 is indicated in FIG. 1.
  • the device 10, ie the double syringe arrangement of the device 10, is held between the index and middle fingers 58, 60 of a hand 62, while the thumb 64 of the hand 62 rests on the connecting element 34.
  • the projections 54 of the holding element 44 are gripped by the index and middle fingers 58, 60 of the hand 62, ie they rest on the side of the projections 54 facing away from the connecting element 34.
  • the index and middle fingers 58, 60 only have to be correspondingly wide according to the dimension of an outer diameter of the syringe body 14 be spread to handle the device 10. This is noticeably easier than if the fingers 58, 60 had to be spread by the extent of the greatest transverse extent of the device 10 (ie twice the outer diameter of the syringe bodies 14 plus the distance that the two syringe bodies 14 are at a distance from one another).
  • the device 10 described here and shown in the drawing is therefore very easy to handle, in particular for people with small hands.
  • the holding element 44 is connected to the connecting head piece 38 via a rod-shaped coupling element 70.
  • This mechanical connection contributes to the fact that the connecting head piece 38 cannot unintentionally detach from the holding element 44 when the device 10 is in operation, which is for example due to a blockage of the channels for the components of the tissue adhesive indicated at 72 in FIG. 1 can be caused.
  • the coupling element 70 extends through the space between the two storage containers 14 and parallel to their axial extent.
  • the length of the coupling element 70 is selected such that, in the case of storage containers 14 held by the holding element 44 and connected to the connecting head piece 38, the projections 54 of the holding element 44 on the undersides of the flanges 56 of the syringe bodies facing the connecting head 38 Storage containers 14 are present (see in particular also FIG. 2). If pressure is exerted on the components of the tissue adhesive when the piston rods 26 are pressed into the syringe body 14, this pressure becomes the force acting on the connection head 38 in the event of a blockage in the further delivery channel system (the connection head 38 and the catheter 42) via the coupling element 70, which in this case applies to train is transferred to the holding element 44. Furthermore, the syringe bodies 14 are supported via their flanges 56 on the projections 54 of the holding element 44. The coupling element 70 thus prevents the unintentional detachment of the connecting head piece 38 when the device 10 is in operation.
  • connection head end 74 of the coupling element 70 is attached to a gas connection 76 of the connection head 38, from which the gas channel indicated at 78 passes through the connection head 38 to its output end 80 leads.
  • the gas-carrying hose 40 is connected to a lateral branch 82 of the coupling element 70, from where a channel 84 extends through the coupling element 70 to its end 74.
  • the output end 80 of the connector head 38 is provided with a rotatable luer lock connector 86.
  • This connection 86 has a locking sleeve 88 with an internal thread 90 which is arranged rotatably on the connecting head piece 38.
  • the locking sleeve 88 projects beyond the conical output end 80 (not shown in the figures) of the connecting head piece 38 or surrounds it coaxially.
  • the multi-lumen catheter 42 is held by a shoulder piece 92 which, in a known manner, has diametrically opposite projections (not shown) which are brought into threaded engagement with the locking sleeve 88. This allows the catheter 42 to be connected to and removed from the connection head 38 in a convenient manner.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Dispositif pour la distribution de fluides, notamment d'un agent adhésif à plusieurs composants pour tissus, présentant plusieurs récipients de stockage sensiblement cylindriques (14) renfermant chacun un fluide, notamment au moins un composant de l'agent adhésif. Chaque récipient (14) comprend une extrémité antérieure (16) munie d'un orifice (18) pour la distribution du fluide, en particulier d'au moins un composant, ainsi qu'une extrémité postérieure (22) opposée à ladite extrémité (16), et un piston coulissant (24) présentant une tige (26) émergeant de l'extrémité postérieure (22) pour l'actionnement dudit piston (24). L'ensemble formant le logement des récipients présente un dispositif de fixation (44) assurant le maintien desdits récipients (14), ces derniers étant disposés les uns à côté des autres et leurs axes longitudinaux (28) s'étendant sensiblement parallèlement entre eux, dans un plan commun (52). Le dispositif de fixation (44) présente des saillies (54) à distance entre elles, opposées l'une à l'autre, permettant la préhension avec les doigts (58, 60) d'une main (62). Les saillies (54) émergent du plan (52) dans lequel sont disposés les récipients (14) maintenus par le dispositif de fixation (44).
PCT/EP1995/001770 1994-05-18 1995-05-10 Dispositif pour la distribution d'un agent adhesif a plusieurs composants pour tissus WO1995031137A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4417368.7 1994-05-18
DE4417368 1994-05-18

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WO1995031137A1 true WO1995031137A1 (fr) 1995-11-23

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Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998010704A1 (fr) 1996-09-10 1998-03-19 Omrix Biopharmaceuticals S.A. Dispositif pour l'application d'un adhesif a plusieurs composants pour tissus, et support pour un tel dispositif
WO1999039642A1 (fr) 1998-02-04 1999-08-12 Omrix Biopharmaceuticals S.A. Dispositif pour stocker une substance medicinale liquide
US5971956A (en) * 1997-04-15 1999-10-26 Biosurgical Corporation Medical suctioning apparatus and methods of use
WO2000053339A1 (fr) 1999-03-09 2000-09-14 Omrix Biopharmaceuticals Sa Dispositif pour appliquer une substance coulante, notamment un adhesif tissulaire
WO2001037889A2 (fr) * 1999-11-24 2001-05-31 Universitätsklinikum Freiburg Materiau substitut osseux injectable
US6331172B1 (en) 1997-04-14 2001-12-18 Baxter International Inc. Applicator for dispensing measured quantities with use of controlled suction
US6454786B1 (en) 1996-11-15 2002-09-24 Bristol-Myers Squibb Company Devices and methods for applying a mixture of two or more liquid components to form a biomaterial
US6461361B1 (en) 1998-05-01 2002-10-08 Baxter International Inc. Gas-driven spraying of mixed sealant agents
US6568434B2 (en) 1998-02-04 2003-05-27 Omrix Biopharmaceuticals S.A. Receiver cup for a vessel housing a medicinal substance
US6613020B1 (en) 1996-12-06 2003-09-02 Bristol-Myers Squibb Company Method of applying a mixture of two liquid components as well as a device for carrying out the method
WO2003105933A1 (fr) * 2002-06-01 2003-12-24 Medtronic, Inc. Distributeur de fluides a rapport multiple
US7635343B2 (en) 2005-04-21 2009-12-22 Arteriocyte Medical Systems, Inc. Fluid dispenser
US7658305B2 (en) 2006-10-25 2010-02-09 Ethicon Endo-Surgery, Inc. Adhesive applier with articulating tip
WO2010031197A1 (fr) * 2008-09-22 2010-03-25 Medmix Systems Ag Raccord doté d'un élément de mélange pour système d'extraction
US7749235B2 (en) 2006-10-20 2010-07-06 Ethicon Endo-Surgery, Inc. Stomach invagination method and apparatus
US7833216B2 (en) 2006-11-08 2010-11-16 Ethicon Endo-Surgery, Inc. Fluid plunger adhesive dispenser
US7892250B2 (en) 2006-11-01 2011-02-22 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive on inflatable device for gastric restriction
US7914511B2 (en) 2006-10-18 2011-03-29 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive as bulking agent
JP4820876B2 (ja) * 2005-11-22 2011-11-24 オムリクス，バイオファーマシューティカルズ，エスエー 多成分液体を塗布するための塗布器
US8608642B2 (en) 2010-02-25 2013-12-17 Ethicon Endo-Surgery, Inc. Methods and devices for treating morbid obesity using hydrogel
US8876844B2 (en) 2006-11-01 2014-11-04 Ethicon Endo-Surgery, Inc. Anastomosis reinforcement using biosurgical adhesive and device
US10259635B2 (en) 2014-11-28 2019-04-16 Sulzer Mixpac Ag Apparatus and methods for storing and mixing separate substances

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US5104375A (en) * 1989-10-16 1992-04-14 Johnson & Johnson Medical, Inc. Locking holder for a pair of syringes and method of use
FR2668060A1 (fr) * 1990-10-17 1992-04-24 Fondation Nale Transfusion San Dispositif d'application d'un melange extemporane de plusieurs composants.
US5290259A (en) * 1993-02-18 1994-03-01 Ultradent Products, Inc. Double syringe delivery system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104375A (en) * 1989-10-16 1992-04-14 Johnson & Johnson Medical, Inc. Locking holder for a pair of syringes and method of use
FR2668060A1 (fr) * 1990-10-17 1992-04-24 Fondation Nale Transfusion San Dispositif d'application d'un melange extemporane de plusieurs composants.
US5290259A (en) * 1993-02-18 1994-03-01 Ultradent Products, Inc. Double syringe delivery system

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19636622C1 (de) * 1996-09-10 1998-06-10 Omrix Biopharm Sa Auftragvorrichtung zum Auftragen eines Mehrkomponenten-Gewebeklebstoffs und Halterung für eine solche Auftragvorrichtung
US6234994B1 (en) * 1996-09-10 2001-05-22 Omrix Biopharmaceuticals Sa Multicomponent tissue adhesive application device and holder for such device
WO1998010704A1 (fr) 1996-09-10 1998-03-19 Omrix Biopharmaceuticals S.A. Dispositif pour l'application d'un adhesif a plusieurs composants pour tissus, et support pour un tel dispositif
US6454786B1 (en) 1996-11-15 2002-09-24 Bristol-Myers Squibb Company Devices and methods for applying a mixture of two or more liquid components to form a biomaterial
US6613020B1 (en) 1996-12-06 2003-09-02 Bristol-Myers Squibb Company Method of applying a mixture of two liquid components as well as a device for carrying out the method
US6331172B1 (en) 1997-04-14 2001-12-18 Baxter International Inc. Applicator for dispensing measured quantities with use of controlled suction
US5971956A (en) * 1997-04-15 1999-10-26 Biosurgical Corporation Medical suctioning apparatus and methods of use
US6357489B1 (en) 1998-02-04 2002-03-19 Omrix Biopharmaceuticals S.A. Device for storing a liquid medicinal substance and method for filling an applicator for a liquid medicinal substance by use of said storing device
WO1999039642A1 (fr) 1998-02-04 1999-08-12 Omrix Biopharmaceuticals S.A. Dispositif pour stocker une substance medicinale liquide
US6568434B2 (en) 1998-02-04 2003-05-27 Omrix Biopharmaceuticals S.A. Receiver cup for a vessel housing a medicinal substance
US6461361B1 (en) 1998-05-01 2002-10-08 Baxter International Inc. Gas-driven spraying of mixed sealant agents
US6565539B1 (en) 1999-03-09 2003-05-20 Omrix Biopharmaceuticals Sa Device for applying a flowable medium, notably a tissue adhesive
DE19910972C1 (de) * 1999-03-09 2000-10-26 Omrix Biopharm Sa Vorrichtung zum Auftragen eines fließfähigen Mediums, insbesondere eines Gewebeklebstoffs
WO2000053339A1 (fr) 1999-03-09 2000-09-14 Omrix Biopharmaceuticals Sa Dispositif pour appliquer une substance coulante, notamment un adhesif tissulaire
WO2001037889A3 (fr) * 1999-11-24 2002-02-21 Universitaetsklinikum Freiburg Materiau substitut osseux injectable
WO2001037889A2 (fr) * 1999-11-24 2001-05-31 Universitätsklinikum Freiburg Materiau substitut osseux injectable
WO2003105933A1 (fr) * 2002-06-01 2003-12-24 Medtronic, Inc. Distributeur de fluides a rapport multiple
US7604626B2 (en) 2002-06-14 2009-10-20 Arteriocyte Medical Systems, Inc. Multiple ratio fluid dispenser
US7883501B2 (en) 2002-06-14 2011-02-08 Arteriocyte Medical Systems, Inc. Multiple ratio fluid dispenser
US6936033B2 (en) 2002-06-14 2005-08-30 Medtronic, Inc. Multiple ratio fluid dispenser
US7635343B2 (en) 2005-04-21 2009-12-22 Arteriocyte Medical Systems, Inc. Fluid dispenser
US8088099B2 (en) 2005-04-21 2012-01-03 Arteriocyte Medical Systems, Inc. Fluid dispenser
JP4820876B2 (ja) * 2005-11-22 2011-11-24 オムリクス，バイオファーマシューティカルズ，エスエー 多成分液体を塗布するための塗布器
US8403882B2 (en) 2005-11-22 2013-03-26 Omrix Biopharmaceuticals, S.A. Applicator device for applying a multi-component fluid
US7914511B2 (en) 2006-10-18 2011-03-29 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive as bulking agent
US7749235B2 (en) 2006-10-20 2010-07-06 Ethicon Endo-Surgery, Inc. Stomach invagination method and apparatus
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